HPA012878

antibody from MilliporeSigma / Merck KGaA

Targeting: NLRP3 AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1

Immunohistochemistry (Recommended by provider)

Protein array (Recommended by provider)

Antibody Data

Product number

HPA012878

Provider

MilliporeSigma / Merck KGaA

Product name

Anti-NLRP3 antibody produced in rabbit

Antibody type

Polyclonal

Antigen

NACHT, LRR and PYD domains-containing protein 3 recombinant protein epitope signature tag (PrEST)

Description

affinity isolated antibody

Reactivity

Human

Antigen sequence

FKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMI
DFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKW
GSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI
CKMKKDYRKKYR


Storage

-20C

References

Submitted references

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.

Saïd-Sadier N, Padilla E, Langsley G, Ojcius DM
PloS one 2010 Apr 2;5(4):e10008

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Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis.

Abdul-Sater AA, Koo E, Häcker G, Ojcius DM
The Journal of biological chemistry 2009 Sep 25;284(39):26789-96