658102

antibody from BioLegend
Targeting: FOXO1 FKH1, FKHR, FOXO1A
Provider product page for 658102
Western blot
Immunocytochemistry

Antibody data

Product number
658102 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#658102, RRID:AB_2562793
Product name
Purified anti-FOXO1
Antibody type
Monoclonal
Antigen
Partial human FOXO1 recombinant protein (544-655aa)
Description
FOXO1 is a transcription factor, belonging to the O subfamily of forkhead box-containing proteins. The forkhead proteins are substrates of Akt/PKB and glucocorticoid-induced kinases that mediate insulin signaling. FOXO1 binds to the conserved insulin-responsive elements and acts as a transcriptional activator. The FOXO1 target genes are involved in cell metabolism, growth, and differentiation. Upon insulin stimulation, FOXO1 proteins are phosphorylated by AKT/PKB through the PI3K pathway, resulting in the translocation of FOXO1 proteins from the nucleus to the cytoplasm. The expression of FOXO1 target genes are then inhibited by FOXO1. FOXO1 has been reported to regulate maturation and class-switch recombination of B cells, as well as participating in regulatory T cell function. FOXO1-deficient mice are embryonic lethal, suggesting that FOXO1 has crucial functions in development which cannot be compensated by other FoxO family members.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
2F8B08
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
FOXO1 protein structure - 658102 shown in red.