18592-1-AP

antibody from Proteintech Group

Targeting: FOXO1 FKH1, FKHR, FOXO1A

Provider product page for 18592-1-AP

Western blot

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Antibody data

Antibody Data
Antigen structure
References [56]
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Product number: 18592-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18592-1-AP, RRID:AB_10860103
Product name: FOXO1 antibody
Antibody type: Polyclonal
Description: FOXO1 antibody (Cat. #18592-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FOXO1 protein structure - 18592-1-AP shown in red.

Submitted references FoxO1 Regulates Neuropeptide Y and Pro-opiomelanocortin in the Hypothalamus of Rat Offspring Small for Gestational Age.

Zhang L, Shi Q, Sun Y
Reproductive sciences (Thousand Oaks, Calif.) 2022 Jan;29(1):173-183

Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity.

Zhang J, Jiao L, Song J, Wu T, Bai H, Liu T, Zhao Z, Hu X, Ying B
Evidence-based complementary and alternative medicine : eCAM 2021;2021:3185874

Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy.

Li W, Zhou Y, Wu Z, Shi Y, Tian E, Zhu Y, Wang T, Dou W, Meng X, Chen M, Zhai B, Zhu D
Frontiers in pharmacology 2021;12:724306

EZH2-Mediated microRNA-375 Upregulation Promotes Progression of Breast Cancer via the Inhibition of FOXO1 and the p53 Signaling Pathway.

Guan X, Shi A, Zou Y, Sun M, Zhan Y, Dong Y, Fan Z
Frontiers in genetics 2021;12:633756

TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.

Yu HF, Zheng LW, Yang ZQ, Wang YS, Wang TT, Yue ZP, Guo B
Experimental & molecular medicine 2021 Sep;53(9):1307-1318

LncRNA SNHG8 sponges miR-449c-5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood-brain barrier permeability in ischemic stroke.

Zhang D, Pan N, Jiang C, Hao M
Journal of leukocyte biology 2021 Sep 29;

Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway.

Luo M, Zheng LW, Wang YS, Huang JC, Yang ZQ, Yue ZP, Guo B
Food & function 2021 Sep 20;12(18):8800-8811

Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.

Dang R, Yang M, Cui C, Wang C, Zhang W, Geng C, Han W, Jiang P
Aging cell 2021 Oct;20(10):e13480

Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance.

Shu L, Hou X, Song G, Wang C, Ma H
International journal of molecular medicine 2021 Nov;48(5)

1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.

Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578

Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.

Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB
Autophagy 2021 Nov 25;:1-21

Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.

Xin C, Zhao M, Wang J, Wang Z
Journal of food biochemistry 2021 Jul;45(7):e13771

FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression.

Tang Y, Jiang L, Zhao X, Hu D, Zhao G, Luo S, Du X, Tang W
Cell biology international 2021 Dec;45(12):2510-2520

PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells.

Li X, Yao X, Xie H, Zhang G, Deng M, Deng K, Gao X, Bao Y, Li K, Wang F
Theriogenology 2021 Dec;176:149-162

circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer.

Yan M, Niu L, Liu J, Yao Y, Li H
Cell death & disease 2021 Aug 5;12(8):774

Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling.

Chen F, Guo L, Di J, Li M, Dong D, Pei D
Journal of genetics and genomics = Yi chuan xue bao 2021 Aug 18;

Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.

Dai J, Chen Q, Huang W, Shi K, Zhang Y, Li T, Mou T, Huang Z, Wu Z
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611

FOXO1 and hsa-microRNA-204-5p affect the biologic behavior of MDA-MB-231 breast cancer cells.

Liang CY, Huang ZG, Tang ZQ, Xiao XL, Zeng JJ, Feng ZB
International journal of clinical and experimental pathology 2020;13(5):1146-1158

Resveratrol Upregulates mmu-miR-363-3p via the PI3K-Akt Pathway to Improve Insulin Resistance Induced by a High-Fat Diet in Mice.

Shu L, Zhao H, Huang W, Hou G, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:391-403

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.

Yang Y, Wang Y, He Z, Liu Y, Chen C, Wang Y, Wang DW, Wang H
Frontiers in pharmacology 2020;11:1136

FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis.

Gao W, Liang J, Ye Y, Lu J, Lin T, Wang N, Dong J, Pan J
BMC cancer 2020 Sep 18;20(1):895

Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.

Yao Q, Zhou Y, Yang Y, Cai L, Xu L, Han X, Guo Y, Li PA
Journal of ethnopharmacology 2020 Oct 28;261:113165

Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway.

Ji JJ, Qian LL, Zhu Y, Wu YP, Guo JQ, Ma GS, Yao YY
Cellular signalling 2020 Nov;75:109745

CDKL3 promotes osteosarcoma progression by activating Akt/PKB.

He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Yuan J, Wu H, Liu L, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R, Xiang D
Life science alliance 2020 May;3(5)

Influence of feature rankers in the construction of molecular activity prediction models.

Cerruela-García G, Pérez-Parra Toledano J, de Haro-García A, García-Pedrajas N
Journal of computer-aided molecular design 2020 Mar;34(3):305-325

Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.

Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, Yang Q, Jia L, Liang Z, Kang L
Pharmacological research 2020 Mar;153:104678

Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma.

Meng Z, Ren D, Zhang K, Zhao J, Jin X, Wu H
Aging 2020 Mar 17;12(6):5048-5070

The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p.

Lan X, Wu N, Wu L, Qu K, Osoro EK, Guan D, Du X, Wang B, Chen S, Miao J, Ren J, Liu L, Li H, Ning Q, Li D, Lu S
Molecular therapy. Nucleic acids 2020 Jun 5;20:468-479

Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway.

Mei ZG, Huang YG, Feng ZT, Luo YN, Yang SB, Du LP, Jiang K, Liu XL, Fu XY, Deng YH, Zhou HJ
Aging 2020 Jul 3;12(13):13187-13205

LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.

Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, Shi L, Song D
Cancer medicine 2020 Jan;9(2):724-736

Tamoxifen induces fatty liver disease in breast cancer through the MAPK8/FoxO pathway.

Gong L, Tang H, Luo Z, Sun X, Tan X, Xie L, Lei Y, Cai M, He C, Ma J, Han S
Clinical and translational medicine 2020 Jan;10(1):137-150

Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.

Wang J, Xu H, Cheng X, Yang J, Yan Z, Ma H, Zhao Y, Ommati MM, Manthari RK, Wang J
Food & function 2020 Jan 29;11(1):1155-1164

Long non-coding RNA expression profiling following treatment with resveratrol to improve insulin resistance.

Shu L, Hou G, Zhao H, Huang W, Song G, Ma H
Molecular medicine reports 2020 Aug;22(2):1303-1316

Self-Therapeutic Nanoparticle That Alters Tau Protein and Ameliorates Tauopathy Toward a Functional Nanomedicine to Tackle Alzheimer's.

Vimal SK, Zuo H, Wang Z, Wang H, Long Z, Bhattacharyya S
Small (Weinheim an der Bergstrasse, Germany) 2020 Apr;16(16):e1906861

MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.

Lin Z, Liu Z, Wang X, Qiu C, Zheng S
BioMed research international 2019;2019:2821731

Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.

Zhao H, Shu L, Huang W, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411

Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.

Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030

Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.

Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z
International journal of molecular sciences 2019 Sep 30;20(19)

Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.

Liu XY, Liu D, Lin GP, Wu YJ, Gao LY, Ai C, Huang YF, Wang MF, El-Seedi HR, Chen XH, Zhao C
International journal of biological macromolecules 2019 Oct 15;139:342-351

Young Blood Rescues the Cognition of Alzheimer's Model Mice by Restoring the Hippocampal Cholinergic Circuit.

Xia E, Xu F, Hu C, Kumal JPP, Tang X, Mao D, Li Y, Wu D, Zhang R, Wu S, Sun L
Neuroscience 2019 Oct 1;417:57-69

Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.

Cheng FY, Lee YH, Hsu YH, Chiu IJ, Chiu YJ, Lin YF, Chiu HW
Aging 2019 Nov 12;11(21):9875-9892

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells.

Wang R, Dong Z, Lan X, Liao Z, Chen M
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)

Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.

Guo Y, Zhao M, Bo T, Ma S, Yuan Z, Chen W, He Z, Hou X, Liu J, Zhang Z, Zhu Q, Wang Q, Lin X, Yang Z, Cui M, Liu L, Li Y, Yu C, Qi X, Wang Q, Zhang H, Guan Q, Zhao L, Xuan S, Yan H, Lin Y, Wang L, Li Q, Song Y, Gao L, Zhao J
Cell research 2019 Feb;29(2):151-166

Oxaliplatin reverses the GLP-1R-mediated promotion of intrahepatic cholangiocarcinoma by altering FoxO1 signaling.

Chen B, Zhou W, Zhao W, Yuan P, Tang C, Wang G, Leng J, Ma J, Wang X, Hui Y, Wang Q
Oncology letters 2019 Aug;18(2):1989-1998

Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.

Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236

Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.

Zhang J, An H, Ni K, Chen B, Li H, Li Y, Sheng G, Zhou C, Xie M, Chen S, Zhou T, Yang G, Chen X, Wu G, Jin S, Li M
Cell death & disease 2019 Apr 11;10(4):321

Identification of the key genes and pathways in prostate cancer.

Fan S, Liang Z, Gao Z, Pan Z, Han S, Liu X, Zhao C, Yang W, Pan Z, Feng W
Oncology letters 2018 Nov;16(5):6663-6669

AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.

Liu JQ, Zhang L, Yao J, Yao S, Yuan T
Biochemical and biophysical research communications 2018 Mar 4;497(2):564-570

Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway.

Guo F, Yu X, Xu A, Xu J, Wang Q, Guo Y, Wu X, Tang Y, Ding Z, Zhang Y, Gong T, Pan Z, Li S, Kong L
Veterinary microbiology 2018 Jul;220:73-82

Amino acid starvation-induced autophagy is involved in reduced subcutaneous fat deposition in weaning piglets derived from sows fed low-protein diet during gestation and lactation : Autophagy is involved in reduced fat deposition in maternal low-protein piglets.

Pan S, Jia Y, Yang X, Cai D, Liu Z, Song H, Zhao R
European journal of nutrition 2018 Apr;57(3):991-1001

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.

Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480

High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.

Zhang XQ, Dong JJ, Cai T, Shen X, Zhou XJ, Liao L
Oncotarget 2017 Apr 11;8(15):24119-24129

RGD liposome-protamine-siRNA (LPR) nanoparticles targeting PAX3-FOXO1 for alveolar rhabdomyosarcoma therapy.

Rengaswamy V, Zimmer D, Süss R, Rössler J
Journal of controlled release : official journal of the Controlled Release Society 2016 Aug 10;235:319-327

MicroRNA-96 plays an oncogenic role by targeting FOXO1 and regulating AKT/FOXO1/Bim pathway in papillary thyroid carcinoma cells.

Song HM, Luo Y, Li DF, Wei CK, Hua KY, Song JL, Xu H, Maskey N, Fang L
International journal of clinical and experimental pathology 2015;8(9):9889-900

VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.

Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA
PLoS genetics 2013;9(9):e1003738

Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.

Tolba MF, Esmat A, Al-Abd AM, Azab SS, Khalifa AE, Mosli HA, Abdel-Rahman SZ, Abdel-Naim AB
IUBMB life 2013 Aug;65(8):716-29

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FOXO1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FOXO1. This antibody recognizes human, mouse, rat antigen. The FOXO1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 18592-1-AP.pdf

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