BS6649

antibody from Bioworld Technology, Inc
Targeting: KRT17 PCHC1
Provider product page for BS6649
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6649 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Cytokeratin 17 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Cytokeratin 17.
Description
Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
KRT17 protein structure - BS6649 shown in red.