BS60623

antibody from Bioworld Technology, Inc
Targeting: MFGE8 BA46, EDIL1, hP47, HsT19888, MFG-E8, OAcGD3S, SED1, SPAG10
Provider product page for BS60623

Antibody data

Product number
BS60623 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MFGE8 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human MFGE8
Description
Human milk-fat globule (MFG) is abundant in human breast milk and is composed of secreted lipids encapsulated by plasma membranes from the epithelial cells of mammary glands. MFG membranes are composed of various glycoproteins that serve as markers for differentiated carcinomas. MFG-E8 (Milk fat globule-EGF factor 8), also known as Lactadherin or BA46, is a 387 amino acid peripheral membrane protein that localizes to the membrane of a variety of tissues, including mammary epithelial surfaces, and contains one EGF-like domain and two F5/8 type C domains. Functioning as a specific ligand for Integrin ¡Â5 and Integrin ¡Â3, MFG-E8 is thought to be involved in gamete interactions and cell attachment, possibly playing a role in fertilization and apoptosis. Additionally, MFG-E8 binds to rotavirus and inhibits its replication, thereby protecting the cell from viral infection. Overexpression of MFG-E8 is associated with breast cancer, suggesting that MFG-E8 may be related to tumorigenesis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MFGE8 protein structure - BS60623 shown in red.