BS60627

antibody from Bioworld Technology, Inc
Targeting: CX3CR1 CCRL1, CMKBRL1, CMKDR1, GPR13, V28
Provider product page for BS60627

Antibody data

Product number
BS60627 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CX3CR1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human CX3CR1
Description
Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Fractalkine, also designated CX3CL1, contains the CX3C motif and is widely ex-pressed in brain and upregulated in endothelial cells in response to inflammatory signals, such as LPS, IL-1, TNF and CD40L. Fractalkine exists both as a membrane-bound form and as a chemotactic soluble form, and binds its cognate receptor, CX3CR1, with high affinity, to induce leukocyte adhesion and migration or chemotactic functions. CX3CR1, previously designated V28 and chemokine ÉÇ receptor-like 1 (CMKBRL1), is expressed in neutrophils, monocytes, T lymphocytes and several organs including brain. CX3CR1 also functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. CX3CR1 may also be involved in the pathogenesis of atherosclerotic coronary artery disease (CAD) and is considered a potential drug target for therapeutic intervention of endothelium-related inflammatory diseases.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CX3CR1 protein structure - BS60627 shown in red.