abx016002

antibody from Abbexa

Targeting: STAT3 APRF

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx016002

Provider

Abbexa

Product name

Signal Transducer And Activator of Transcription 3 (STAT3) Antibody

Antibody type

Monoclonal

Description

The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development.Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities.Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding.Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways.Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3 beta (79 kDa) depend on cell type, ligand exposure or cell maturation stage.It is notable that Stat3 beta lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Reactivity

Human, Mouse, Simian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.