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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Immunohistochemistry [1]
- Other assay [1]
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- Product number
- PA5-63051 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- FOCAD Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full-length protein
- Description
- Immunogen sequence: NWAALLSPLM RLNFGEEIQQ LCLEIMVTQA QSSQNAAALL GLWVTPPLIH SLSLNTKRYL LISAPLWIKH ISDEQILGFV ENLMVAVFKA ASPLGSPELC PSALHGLSQA MKLPSPAHHL WSLLSEA
- Concentration
- 0.08 mg/mL
Submitted references NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway.
Liu P, Wu D, Duan J, Xiao H, Zhou Y, Zhao L, Feng Y
Redox biology 2020 Oct;37:101702
Redox biology 2020 Oct;37:101702
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical staining of FOCAD in human small intestine shows strong cytoplasmic positivity in glandular cells. Samples were probed using a FOCAD Polyclonal Antibody (Product # PA5-63051).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig. 1 The expression of NRF2 and FOCAD in human NSCLC tissues. The cancer tissues and paracancer tissues from 6 NSCLC patients (Patient-001 to Patient-006) were harvested for NRF2 and FOCAD via IHC staining (A). In the negative control, non-specific IgG was used to replace the first antibody. The cancer slice from patient-001 was used in the negative control of NRF2 staining (A1), and the paracancer slice from patient-001 was used in the negative control of FOCAD staining (A2). The relative intensity of NRF2 (B) and FOCAD (C) were calculated respectively, and the level in Cancer group was considered as ""1"". Results were expressed as mean +- SD, and the P value less than 0.05 was considered statistically significant. *: P < 0.05 compared between cancer tissue and paracancer. Fig. 1
