BS4204

antibody from Bioworld Technology, Inc

Targeting: VAV1 VAV

Western blot (Supportive data in Antibodypedia)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS4204

Provider

Bioworld Technology, Inc

Product name

Vav1 (phospho Y174) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human VaV1 around the phosphorylation site of Tyrosine 174.

Description

The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. Contained within its amino terminus are a helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins; deletion of this region of p95Vav causes its oncogenic activation. In addition, p95Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of p95Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term.

Western blot

Supportive validation

Submitted by

Bioworld Technology, Inc (provider)

Main image

Experimental details

Western blot (WB) analysis of p-Vav1(Y174) pAb at 1:500 dilutionLane1:Hela cell lysate treated with UV(4h)Lane2:sp2/0 cell lysate treated with UV(4h)Lane3:PC12 cell lysate treated with UV(4h)