FNab00513

antibody from FineTest Biotech
Targeting: APP AD1
Provider product page for FNab00513
Western blot
ELISA
Immunohistochemistry

Antibody data

Product number
FNab00513 - Provider product page
Provider
FineTest Biotech
Product name
APP antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
Reactivity
Human, Porcine
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
amyloid beta A4 precursor protein
Epitope
IgG2a
Isotype
IgG
Antibody clone number
8B9
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
APP protein structure - FNab00513 shown in red.