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- References [403]
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- Product number
- 17168-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17168-1-AP, RRID:AB_2716755
- Product name
- Histone-H3 antibody
- Antibody type
- Polyclonal
- Description
- Histone-H3 antibody (Cat. #17168-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia.
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway.
Immobilized Titanium (IV) Ion Affinity Chromatography Contributes to Efficient Proteomics Analysis of Cellular Nucleic Acid-Binding Proteins.
ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.
Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Attenuated lncRNA NKILA Enhances the Secretory Function of Airway Epithelial Cells Stimulated by Mycoplasma pneumoniae via NF-κB.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Identification of Histone Modifications Reveals a Role of H2b Monoubiquitination in Transcriptional Regulation of dmrt1 in Monopterus albus.
GABAB receptor inhibits tumor progression and epithelial-mesenchymal transition via the regulation of Hippo/YAP1 pathway in colorectal cancer.
ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes.
ADAM17 and NF-κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability.
Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.
Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Calcitriol Alleviates MPP+- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway-Dependent Cerebral Microvascular Protection.
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway.
Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.
Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis.
Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway.
The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells.
Exogenous H2 S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca2+]m-PDP1-PDH-histone acetylation retrograde signaling.
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod.
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Lactobacillus casei relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin-induced inflammatory response in rats cotreated with alcohol and iron.
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction.
PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression.
The p38 MAPK/NF-κB pathway mediates GLT-1 up-regulation during cerebral ischemic preconditioning-induced brain ischemic tolerance in rats.
SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis.
Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA.
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models.
Discovery of Phenolic Glycoside from Hyssopus cuspidatus Attenuates LPS-Induced Inflammatory Responses by Inhibition of iNOS and COX-2 Expression through Suppression of NF-κB Activation.
LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation.
Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice.
Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type Ⅰ interferon signaling by targeting STAT1.
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2.
A phase-separated nuclear GBPL circuit controls immunity in plants.
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation.
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis.
Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ.
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Activation of microglial G‑protein-coupled receptor 30 protects neurons against excitotoxicity through NF-κB/MAPK pathways.
Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage.
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.
Core Histones Are Constituents of the Perinuclear Theca of Murid Spermatozoa: An Assessment of Their Synthesis and Assembly during Spermiogenesis and Function after Gametic Fusion.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons.
Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis.
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway.
p53 induces ARTS to promote mitochondrial apoptosis.
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling.
NOD2-mediated P2Y12 upregulation increases platelet activation and thrombosis in sepsis.
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice.
miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition.
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation.
Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming.
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Downregulation of miR-497-5p prevents liver ischemia-reperfusion injury in association with MED1/TIMP-2 axis and the NF-κB pathway.
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice.
Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity.
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1.
MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis.
miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the β-Catenin Signaling Pathway in Osteosarcoma Cells.
LncRNA MALAT1 Affects Mycoplasma pneumoniae Pneumonia via NF-κB Regulation.
A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium.
CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species.
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro.
Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain.
lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.
NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/β‑catenin pathway.
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression.
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.
Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of β-catenin and β-catenin-mediated transcription.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Extracellular Vesicles From Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice.
Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling.
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma.
FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis.
The interaction of lead exposure and CCM3 defect plays an important role in regulating angiogenesis through eNOS/NO pathway.
An NF-κB-driven lncRNA orchestrates colitis and circadian clock.
Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.
Mechanisms by which electroacupuncture‑mediated histone acetylation mitigates bone loss in rats with ovariectomy‑induced osteoporosis.
Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Ochratoxin A induces reprogramming of glucose metabolism by switching energy metabolism from oxidative phosphorylation to glycolysis in human gastric epithelium GES-1 cells in vitro.
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling.
Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.
Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose.
Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.
Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma.
ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer.
PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.
Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco.
Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression.
The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.
Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia.
The Wnt/β-catenin/VASP positive feedback loop drives cell proliferation and migration in breast cancer.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.
LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis.
Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation.
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
ABA-responsive ABRE-BINDING FACTOR3 activates DAM3 expression to promote bud dormancy in Asian pear.
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.
CaCBL1 Acts as a Positive Regulator in Pepper Response to Ralstonia solanacearum.
EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling.
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding.
Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling.
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.
CHK2-FOXK axis promotes transcriptional control of autophagy programs.
MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy.
Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation.
Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway.
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Silibinin ameliorats H2O2-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
lncMGPF is a novel positive regulator of muscle growth and regeneration.
Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling.
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway.
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis.
PGN and LTA from Staphylococcus aureus Induced Inflammation and Decreased Lactation through Regulating DNA Methylation and Histone H3 Acetylation in Bovine Mammary Epithelial Cells.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy.
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.
Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer.
Role of Antioxidants in the Protection from Aging-Related Diseases.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways.
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway.
Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation.
Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.
The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro.
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway.
MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp.
Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-κB pathway.
MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway.
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.
The therapeutic effect of verapamil in lipopolysaccharide-induced acute lung injury.
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.
SIRT4 enhances the sensitivity of ER-positive breast cancer to tamoxifen by inhibiting the IL-6/STAT3 signal pathway.
PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.
Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF-κB Pathway.
LncRNA HOTAIRM1 promotes osteogenesis by controlling JNK/AP-1 signalling-mediated RUNX2 expression.
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
TFEB Mediates Immune Evasion and Resistance to mTOR Inhibition of Renal Cell Carcinoma via Induction of PD-L1.
Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.
HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.
Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.
Abnormal expression of TBX4 during anorectal development in rat embryos with ethylenethiourea-induced anorectal malformations.
Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis.
Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
Suppression of puerarin on polymethylmethacrylate-induced lesion of peri-implant by inhibiting NF-κB activation in vitro and in vivo.
MicroRNA-126 Regulates Angiogenesis and Neurogenesis in a Mouse Model of Focal Cerebral Ischemia.
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats.
The perforatorium and postacrosomal sheath of rat spermatozoa share common developmental origins and protein constituents†.
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.
A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.
In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3.
HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.
Activation of brain endothelium by Escherichia coli K1 virulence factor cglD promotes polymorphonuclear leukocyte transendothelial migration.
CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation.
Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.
m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition.
Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro.
Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.
5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1.
Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.
Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming.
Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.
3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.
XPO1-mediated nuclear export of RNF146 protects from angiotensin II-induced endothelial cellular injury.
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.
BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway.
Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop.
Inhibition of microRNA-143-3p attenuates myocardial hypertrophy by inhibiting inflammatory response.
Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.
Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway.
Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.
Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.
The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation.
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway.
Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.
DNase-1 Treatment Exerts Protective Effects in a Rat Model of Intestinal Ischemia-Reperfusion Injury.
Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.
Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-κB signalling pathway in human peritoneal mesothelial cells.
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice.
Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation.
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.
Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.
MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer.
YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.
Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients.
Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition.
Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline.
Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling.
miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia.
BTP2, a Store-Operated Calcium Channel Inhibitor, Attenuates Lung Ischemia-Reperfusion Injury in Rats.
Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways.
RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.
Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.
CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP+-induced Parkinson's disease model.
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.
Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy.
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.
Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Compositional Analysis of Asymmetric and Symmetric Dimethylated H3R2 Using Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Proteomics.
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.
Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.
Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.
Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core.
Early ketamine exposure results in cardiac enlargement and heart dysfunction in Xenopus embryos.
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death.
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.
Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Role of NSD1 in H2O2-induced GSTM3 suppression.
Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.
Wang E, Zhang Y, Ding R, Wang X, Zhang S, Li X
Molecular medicine reports 2022 Jan;25(1)
Molecular medicine reports 2022 Jan;25(1)
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway.
Huang Y, Chen Q, Jiang Q, Zhao Z, Fang J, Chen L
Peptides 2022 Jan;147:170688
Peptides 2022 Jan;147:170688
Immobilized Titanium (IV) Ion Affinity Chromatography Contributes to Efficient Proteomics Analysis of Cellular Nucleic Acid-Binding Proteins.
Wang H, Qian L, Shang Z, Wang Z, Zhang Y, Cao C, Xiao H
Journal of proteome research 2022 Jan 7;21(1):220-231
Journal of proteome research 2022 Jan 7;21(1):220-231
ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.
Li S, Ma Y, Ye S, Hu D, Xiao F
Journal of hazardous materials 2022 Jan 5;421:126758
Journal of hazardous materials 2022 Jan 5;421:126758
Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
Zhang R, Xue T, Shao A, Lang Y, Qin C, Zhao M, Kuang Y, Yu Z, Geng Y, Zhao C, Tang J
EMBO reports 2022 Jan 5;23(1):e52702
EMBO reports 2022 Jan 5;23(1):e52702
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.
Xi H, Ren F, Li Y, Xian M, Wang L, Hu J
Molecular and cellular endocrinology 2022 Jan 15;540:111505
Molecular and cellular endocrinology 2022 Jan 15;540:111505
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H
Oxidative medicine and cellular longevity 2021;2021:8186877
Oxidative medicine and cellular longevity 2021;2021:8186877
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxidative medicine and cellular longevity 2021;2021:6670497
Attenuated lncRNA NKILA Enhances the Secretory Function of Airway Epithelial Cells Stimulated by Mycoplasma pneumoniae via NF-κB.
Zhang F, Zhang J, Liu F, Zhou Y, Guo Y, Duan Q, Zhu Y, Zhao D, Gu H
BioMed research international 2021;2021:6656298
BioMed research international 2021;2021:6656298
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Lin Y, Xie Y, Hao Z, Bi H, Liu Y, Yang X, Xia Y
Journal of immunology research 2021;2021:5151168
Journal of immunology research 2021;2021:5151168
Identification of Histone Modifications Reveals a Role of H2b Monoubiquitination in Transcriptional Regulation of dmrt1 in Monopterus albus.
Lai F, Cheng Y, Zou J, Wang H, Zhu W, Wang X, Cheng H, Zhou R
International journal of biological sciences 2021;17(8):2009-2020
International journal of biological sciences 2021;17(8):2009-2020
GABAB receptor inhibits tumor progression and epithelial-mesenchymal transition via the regulation of Hippo/YAP1 pathway in colorectal cancer.
Wang H, Zhang H, Sun Z, Chen W, Miao C
International journal of biological sciences 2021;17(8):1953-1962
International journal of biological sciences 2021;17(8):1953-1962
ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.
Li Y, Sun C, Tan Y, Zhang H, Li Y, Zou H
International journal of biological sciences 2021;17(2):635-650
International journal of biological sciences 2021;17(2):635-650
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Bai M, Cui M, Li M, Yao X, Wu Y, Zheng L, Sun L, Song Q, Wang S, Liu L, Yu C, Huang Y
International journal of biological sciences 2021;17(13):3493-3507
International journal of biological sciences 2021;17(13):3493-3507
Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes.
Doke M, Pendyala G, Samikkannu T
PloS one 2021;16(6):e0252895
PloS one 2021;16(6):e0252895
ADAM17 and NF-κB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability.
Gao L, Liu H, Xu R, Qiu J, Peng X, Yang Y, Zhang D, Qian J
International journal of clinical and experimental pathology 2021;14(7):845-854
International journal of clinical and experimental pathology 2021;14(7):845-854
Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy.
Dai L, Wang J, He M, Xiong M, Tian Y, Liu C, Zhang Z
Frontiers in molecular neuroscience 2021;14:682320
Frontiers in molecular neuroscience 2021;14:682320
Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia.
Wang Z, Huang Y, Chu F, Ji S, Liao K, Cui Z, Chen J, Tang S
Journal of inflammation research 2021;14:5901-5918
Journal of inflammation research 2021;14:5901-5918
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.
Wang C, Liu T, Tong Y, Cui R, Qu K, Liu C, Zhang J
American journal of translational research 2021;13(6):6031-6042
American journal of translational research 2021;13(6):6031-6042
Calcitriol Alleviates MPP+- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Hu J, Wu J, Wan F, Kou L, Yin S, Sun Y, Li Y, Zhou Q, Wang T
Frontiers in aging neuroscience 2021;13:657095
Frontiers in aging neuroscience 2021;13:657095
Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway-Dependent Cerebral Microvascular Protection.
Fan XD, Yao MJ, Yang B, Han X, Zhang YH, Wang GR, Li P, Xu L, Liu JX
Frontiers in pharmacology 2021;12:748568
Frontiers in pharmacology 2021;12:748568
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Ying C, Dai J, Fan G, Zhou Z, Gan T, Zhang Y, Song Y, Zhou X
Frontiers in physiology 2021;12:679166
Frontiers in physiology 2021;12:679166
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway.
Li S, Lei Z, Zhao M, Hou Y, Wang D, Xu X, Lin X, Li J, Tang S, Yu J, Meng T
Frontiers in pharmacology 2021;12:655726
Frontiers in pharmacology 2021;12:655726
Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress.
Li S, Jin H, Sun G, Zhang C, Wang J, Xu H, Zhang D, Wang S
Frontiers in pharmacology 2021;12:634115
Frontiers in pharmacology 2021;12:634115
Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis.
Mao L, Chen J, Lu X, Yang C, Ding Y, Wang M, Zhang Y, Tian Y, Li X, Fu Y, Yang Y, Gu Y, Gao F, Huang J, Liao L
Theranostics 2021;11(19):9705-9720
Theranostics 2021;11(19):9705-9720
Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway.
Hu C, Wu Z, Huang Z, Hao X, Wang S, Deng J, Yin Y, Tan C
Redox biology 2021 Sep;45:102051
Redox biology 2021 Sep;45:102051
The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells.
Birladeanu AM, Rogalska M, Potiri M, Papadaki V, Andreadou M, Kontoyiannis DL, Lewis JD, Erpapazoglou Z, Kafasla P
Oncogene 2021 Sep;40(36):5518-5532
Oncogene 2021 Sep;40(36):5518-5532
Exogenous H2 S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Zhang L, Jiang X, Liu N, Li M, Kang J, Chen L, Tang J, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
Ge X, Peng X, Li M, Ji F, Chen J, Zhang D
Pathology, research and practice 2021 Sep;225:153580
Pathology, research and practice 2021 Sep;225:153580
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca2+]m-PDP1-PDH-histone acetylation retrograde signaling.
Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837
Cell death & disease 2021 Sep 6;12(9):837
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod.
Gao J, Zhao BR, Zhang H, You YL, Li F, Wang XW
Cell reports 2021 Sep 28;36(13):109761
Cell reports 2021 Sep 28;36(13):109761
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Chen S, Li Y, Chu B, Yuan L, Liu N, Zhu Y, Wang J
Microorganisms 2021 Sep 17;9(9)
Microorganisms 2021 Sep 17;9(9)
Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome.
Zhang H, Li L, Hao M, Chen K, Lu Y, Qi J, Chen W, Ren L, Cai X, Chen C, Liu Z, Zhao B, Li Z, Hou P
Journal of ethnopharmacology 2021 Sep 15;277:114254
Journal of ethnopharmacology 2021 Sep 15;277:114254
Lactobacillus casei relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin-induced inflammatory response in rats cotreated with alcohol and iron.
Li X, Han J, Liu Y, Liang H
Food science & nutrition 2021 Oct;9(10):5391-5401
Food science & nutrition 2021 Oct;9(10):5391-5401
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Qiu C, Wang M, Yu W, Rong Z, Zheng HS, Sun T, Liu SB, Zhao MG, Wu YM
Molecular neurobiology 2021 Oct;58(10):5272-5288
Molecular neurobiology 2021 Oct;58(10):5272-5288
Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction.
Wang C, Meng L, Wang J, Zhang K, Duan S, Ren P, Wei Y, Fu X, Yu B, Wu J, Yu X
Virologica Sinica 2021 Oct;36(5):981-996
Virologica Sinica 2021 Oct;36(5):981-996
PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression.
Yan HY, Wang HQ, Zhong M, Wu S, Yang L, Li K, Li YH
Virologica Sinica 2021 Oct;36(5):1154-1164
Virologica Sinica 2021 Oct;36(5):1154-1164
The p38 MAPK/NF-κB pathway mediates GLT-1 up-regulation during cerebral ischemic preconditioning-induced brain ischemic tolerance in rats.
Sun YW, Zhang LY, Gong SJ, Hu YY, Zhang JG, Xian XH, Li WB, Zhang M
Brain research bulletin 2021 Oct;175:224-233
Brain research bulletin 2021 Oct;175:224-233
SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis.
Ren D, Sun Y, Zhang D, Li D, Liu Z, Jin X, Wu H
Cancer letters 2021 Oct 28;519:277-288
Cancer letters 2021 Oct 28;519:277-288
Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA.
Mao S, Zhang W, Yang F, Guo Y, Wang H, Wu Y, Wang R, Maskey N, Zheng Z, Li C, Ma W, Zhang J, Yan Y, Yao X
Journal of experimental & clinical cancer research : CR 2021 Oct 25;40(1):336
Journal of experimental & clinical cancer research : CR 2021 Oct 25;40(1):336
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Ma Y, Li S, Ye S, Tang S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2021 Oct 13;
Journal of molecular neuroscience : MN 2021 Oct 13;
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Zhong CC, Zhao T, Hogstrand C, Chen F, Song CC, Luo Z
The Journal of nutritional biochemistry 2021 Oct 12;:108883
The Journal of nutritional biochemistry 2021 Oct 12;:108883
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653
Chemico-biological interactions 2021 Oct 1;348:109653
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse Models.
Aoki Y, Yamamoto J, Tome Y, Hamada K, Masaki N, Inubushi S, Tashiro Y, Bouvet M, Endo I, Nishida K, Hoffman RM
Cancer genomics & proteomics 2021 Nov-Dec;18(6):715-721
Cancer genomics & proteomics 2021 Nov-Dec;18(6):715-721
Discovery of Phenolic Glycoside from Hyssopus cuspidatus Attenuates LPS-Induced Inflammatory Responses by Inhibition of iNOS and COX-2 Expression through Suppression of NF-κB Activation.
Liu X, Su J, Wang G, Zheng L, Wang G, Sun Y, Bao Y, Wang S, Huang Y
International journal of molecular sciences 2021 Nov 9;22(22)
International journal of molecular sciences 2021 Nov 9;22(22)
LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.
Wang G, Jin S, Huang W, Li Y, Wang J, Ling X, Huang Y, Hu Y, Li C, Meng Y, Li X
Cell death discovery 2021 Nov 6;7(1):337
Cell death discovery 2021 Nov 6;7(1):337
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F, Yang S
Chinese medicine 2021 Nov 29;16(1):127
Chinese medicine 2021 Nov 29;16(1):127
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Qi H, Wang L, Zhang M, Wang Z, Gao X, Li M
The Journal of nutritional biochemistry 2021 Nov 27;101:108924
The Journal of nutritional biochemistry 2021 Nov 27;101:108924
Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation.
Lu L, Yang LK, Yue J, Wang XS, Qi JY, Yang F, Feng B, Liu SB
Neuroscience letters 2021 Nov 20;765:136284
Neuroscience letters 2021 Nov 20;765:136284
Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway.
Ma X, Tian Y, Xue K, Huai Y, Patil S, Deng X, Hao Q, Li D, Miao Z, Zhang W, Qian A
European journal of pharmacology 2021 Nov 15;911:174555
European journal of pharmacology 2021 Nov 15;911:174555
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
Huang C, Hao Q, Shi G, Zhou X, Zhang Y
Journal of molecular cell biology 2021 May 7;13(2):141-150
Journal of molecular cell biology 2021 May 7;13(2):141-150
BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.
Xu C, Fu Y, Liu S, Trittipo J, Lu X, Qi R, Du H, Yan C, Zhang C, Wan J, Kaplan MH, Yang K
Journal of immunology (Baltimore, Md. : 1950) 2021 May 1;206(9):2088-2100
Journal of immunology (Baltimore, Md. : 1950) 2021 May 1;206(9):2088-2100
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Luo X, Bai Y, He S, Sun S, Jiang X, Yang Z, Lu D, Wei P, Liang Y, Peng C, Wang Y, Sheng R, Han S, Li X, Zhang B
Cell proliferation 2021 Mar;54(3):e12991
Cell proliferation 2021 Mar;54(3):e12991
Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D.
Ling B, Wei P, Xiao J, Cen B, Wei H, Feng X, Ye G, Li S, Zhang Z, Liang W, Huang S, Huang W
Oncology reports 2021 Mar;45(3):1044-1058
Oncology reports 2021 Mar;45(3):1044-1058
Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice.
Huang C, Zheng Y, Bai J, Shi C, Shi X, Shan H, Zhou X
Journal of orthopaedic translation 2021 Mar;27:9-16
Journal of orthopaedic translation 2021 Mar;27:9-16
Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type Ⅰ interferon signaling by targeting STAT1.
Li Z, Lu D, Yang H, Li Z, Zhu P, Xie J, Liao D, Zheng Y, Li H
Veterinary microbiology 2021 Mar;254:108986
Veterinary microbiology 2021 Mar;254:108986
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Zhang T, Yang X, Xu W, Wang J, Wu D, Hong Z, Yuan S, Zeng Z, Jia X, Lu S, Safadi R, Han S, Yang Z, Neckers LM, Liangpunsakul S, Zhou W, Lu Y
Cancer biology & medicine 2021 Mar 25;
Cancer biology & medicine 2021 Mar 25;
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Mar 17;70(1):67-78
Physiological research 2021 Mar 17;70(1):67-78
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2.
Han Z, Zhang Z, Guan Y, Chen B, Yu M, Zhang L, Fang J, Gao Y, Guo Z
International journal of biological macromolecules 2021 Mar 15;173:379-398
International journal of biological macromolecules 2021 Mar 15;173:379-398
A phase-separated nuclear GBPL circuit controls immunity in plants.
Huang S, Zhu S, Kumar P, MacMicking JD
Nature 2021 Jun;594(7863):424-429
Nature 2021 Jun;594(7863):424-429
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation.
Wang X, Hu X, Song W, Xu H, Xiao Z, Huang R, Bai Q, Zhang F, Chen Y, Liu Y, Fang J, Li X, Shen Q, Zhao H, Yang X
Cell research 2021 Jun;31(6):664-683
Cell research 2021 Jun;31(6):664-683
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
Liu D, Wu H, Li YZ, Yang J, Yang J, Ding JW, Zhou G, Zhang J, Wang X, Fan ZX
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 Jun 7;31(6):1916-1928
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 Jun 7;31(6):1916-1928
Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis.
Yu Y, Fu W, Xu J, Lei Y, Song X, Liang Z, Zhu T, Liang Y, Hao Y, Yuan L, Li C
Molecular plant 2021 Jun 7;14(6):888-904
Molecular plant 2021 Jun 7;14(6):888-904
Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.
Duan Y, Jia Y, Wang J, Liu T, Cheng Z, Sang M, Lv W, Qin J, Liu L
Cell death & disease 2021 Jun 7;12(6):587
Cell death & disease 2021 Jun 7;12(6):587
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Liu W, Wang Y, Xie Y, Dai T, Fan M, Li C, Zou Y
Cell death discovery 2021 Jun 5;7(1):136
Cell death discovery 2021 Jun 5;7(1):136
Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ.
Williams AL, Walton CB, Pinell B, Khadka VS, Dunn B, Lee K, Anagaran MCT, Avelar A, Shohet RV
Scientific reports 2021 Jun 23;11(1):13116
Scientific reports 2021 Jun 23;11(1):13116
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
Cui Y, Xie R, Zhang X, Liu Y, Hu Y, Li Y, Liu X, Yu X, Wu C
Cell death & disease 2021 Jun 16;12(7):622
Cell death & disease 2021 Jun 16;12(7):622
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
Chen Y, Zhang H, Chen Y, Jia P, Ji S, Zhang Y, Wang T
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection.
Liao Y, Liu C, Wang J, Song Y, Sabir N, Hussain T, Yao J, Luo L, Wang H, Cui Y, Yang L, Zhao D, Zhou X
Veterinary microbiology 2021 Jul;258:109126
Veterinary microbiology 2021 Jul;258:109126
Activation of microglial G‑protein-coupled receptor 30 protects neurons against excitotoxicity through NF-κB/MAPK pathways.
Yang LK, Lu L, Yue J, Wang XS, Qi JY, Yang F, Liu SB
Brain research bulletin 2021 Jul;172:22-30
Brain research bulletin 2021 Jul;172:22-30
Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
Diouf B, Wing C, Panetta JC, Eddins D, Lin W, Yang W, Fan Y, Pei D, Cheng C, Delaney SM, Zhang W, Bonten EJ, Crews KR, Paugh SW, Li L, Freeman BB 3rd, Autry RJ, Beard JA, Ferguson DC, Janke LJ, Ness KK, Chen T, Zakharenko SS, Jeha S, Pui CH, Relling MV, Eileen Dolan M, Evans WE
Clinical and translational science 2021 Jul;14(4):1490-1504
Clinical and translational science 2021 Jul;14(4):1490-1504
PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage.
Hanaki S, Habara M, Masaki T, Maeda K, Sato Y, Nakanishi M, Shimada M
Cancer science 2021 Jul;112(7):2739-2752
Cancer science 2021 Jul;112(7):2739-2752
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.
Verma DK, Seo BA, Ghosh A, Ma SX, Hernandez-Quijada K, Andersen JK, Ko HS, Kim YH
Cells 2021 Jul 5;10(7)
Cells 2021 Jul 5;10(7)
Core Histones Are Constituents of the Perinuclear Theca of Murid Spermatozoa: An Assessment of Their Synthesis and Assembly during Spermiogenesis and Function after Gametic Fusion.
Hamilton LE, Lion M, Aguila L, Suzuki J, Acteau G, Protopapas N, Xu W, Sutovsky P, Baker M, Oko R
International journal of molecular sciences 2021 Jul 29;22(15)
International journal of molecular sciences 2021 Jul 29;22(15)
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons.
Wen S, Wang L, Zhang W, Xu M, Song R, Zou H, Gu J, Bian J, Yuan Y, Liu Z
Metallomics : integrated biometal science 2021 Jul 12;13(7)
Metallomics : integrated biometal science 2021 Jul 12;13(7)
Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
Liu C, Liu H, Zhang H, Wang L, Li M, Cai F, Wang X, Wang L, Zhang R, Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W, Chen ZJ
The EMBO journal 2021 Jul 1;40(13):e106864
The EMBO journal 2021 Jul 1;40(13):e106864
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
Xiong X, Xu W, Gong J, Wang L, Dai M, Chen G, Yuan L
Cellular signalling 2021 Jan;77:109818
Cellular signalling 2021 Jan;77:109818
Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.
Vellky JE, Ricke EA, Huang W, Ricke WA
The American journal of pathology 2021 Jan;191(1):168-179
The American journal of pathology 2021 Jan;191(1):168-179
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Jan 14;70(1)
Physiological research 2021 Jan 14;70(1)
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
Huang YH, Cai K, Xu PP, Wang L, Huang CX, Fang Y, Cheng S, Sun XJ, Liu F, Huang JY, Ji MM, Zhao WL
Signal transduction and targeted therapy 2021 Jan 11;6(1):10
Signal transduction and targeted therapy 2021 Jan 11;6(1):10
The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis.
Yuan L, Song X, Zhang L, Yu Y, Liang Z, Lei Y, Ruan J, Tan B, Liu J, Li C
Nucleic acids research 2021 Jan 11;49(1):98-113
Nucleic acids research 2021 Jan 11;49(1):98-113
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress.
Li Z, Wang Y, Zhang Y, Wang X, Gao B, Li Y, Li R, Wang J
Archives of medical research 2021 Feb;52(2):163-173
Archives of medical research 2021 Feb;52(2):163-173
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Qiu C, Yang LD, Yu W, Tian DD, Gao MR, Wang WJ, Li XB, Wu YM, Wang M
Metabolic brain disease 2021 Feb;36(2):273-283
Metabolic brain disease 2021 Feb;36(2):273-283
Panax notoginseng saponins promote endothelial progenitor cell angiogenesis via the Wnt/β-catenin pathway.
Zhu P, Jiang W, He S, Zhang T, Liao F, Liu D, An X, Huang X, Zhou N
BMC complementary medicine and therapies 2021 Feb 8;21(1):53
BMC complementary medicine and therapies 2021 Feb 8;21(1):53
p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H, Zhou X
Cell death & disease 2021 Feb 24;12(2):204
Cell death & disease 2021 Feb 24;12(2):204
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Chen N, Song S, Yang Z, Wu M, Mu L, Zhou T, Shi Y
Journal of diabetes and its complications 2021 Dec;35(12):108050
Journal of diabetes and its complications 2021 Dec;35(12):108050
Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling.
Jin H, Ge X, Huan Z, Yao H, Xu C, Cai J
Journal of cellular and molecular medicine 2021 Dec;25(24):11075-11084
Journal of cellular and molecular medicine 2021 Dec;25(24):11075-11084
NOD2-mediated P2Y12 upregulation increases platelet activation and thrombosis in sepsis.
Zhong H, Waresi M, Zhang W, Han L, Zhao Y, Chen Y, Zhou P, Chang L, Pan G, Wu B, Li J, Zhang S, Shi H, Luo X, Gao W, Qi Z, Ding Z
Biochemical pharmacology 2021 Dec;194:114822
Biochemical pharmacology 2021 Dec;194:114822
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Li F, Xu D, Hou K, Gou X, Lv N, Fang W, Li Y
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2021 Dec;16(4):835-853
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Tong J, Fang J, Zhu T, Xiang P, Shang J, Chen L, Zhao J, Wang Y, Tong L, Sun M
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Li M, Lu H, Wang X, Duan C, Zhu X, Zhang Y, Ge X, Ji F, Wang X, Su J, Zhang D
Molecular immunology 2021 Dec;140:250-266
Molecular immunology 2021 Dec;140:250-266
Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice.
Gao J, Wang L, Zhao C, Wu Y, Lu Z, Gu Y, Ba Z, Wang X, Wang J, Xu Y
Journal of leukocyte biology 2021 Dec;110(6):1005-1022
Journal of leukocyte biology 2021 Dec;110(6):1005-1022
miR-140-3p enhanced the osteo/odontogenic differentiation of DPSCs via inhibiting KMT5B under hypoxia condition.
Zheng H, Wang N, Li L, Ge L, Jia H, Fan Z
International journal of oral science 2021 Dec 7;13(1):41
International journal of oral science 2021 Dec 7;13(1):41
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Cui X, Wang Y, Lan W, Wang S, Cui Y, Zhang X, Lin Z, Piao J
Cellular oncology (Dordrecht) 2021 Dec 2;
Cellular oncology (Dordrecht) 2021 Dec 2;
Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.
Ye S, Li S, Ma Y, Hu D, Xiao F
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Ecotoxicology and environmental safety 2021 Dec 1;225:112779
Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation.
Jia Y, Tong Y, Min L, Li Y, Cheng Y
Tissue & cell 2021 Aug;71:101514
Tissue & cell 2021 Aug;71:101514
Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming.
Wang L, Xu Z, Wang L, Liu C, Wei H, Zhang R, Chen Y, Wang L, Liu W, Xiao S, Li W, Li W
Cell proliferation 2021 Aug;54(8):e13080
Cell proliferation 2021 Aug;54(8):e13080
Glutaredoxin 1 protects neurons from oxygen-glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling.
Qiu Z, Li X, Duan C, Li R, Han L
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
Journal of bioenergetics and biomembranes 2021 Aug;53(4):369-379
PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3β.
Fan Y, Wang J, He N, Feng H
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22815
Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage.
Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z
Cell death and differentiation 2021 Aug;28(8):2367-2384
Cell death and differentiation 2021 Aug;28(8):2367-2384
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Hou X, Liu H, Ping Y, Zhang F, Zhi L, Jiang X, Zhang F, Song C, Zhang Z, Song J
Brain research bulletin 2021 Aug;173:74-81
Brain research bulletin 2021 Aug;173:74-81
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378
Free radical biology & medicine 2021 Aug 1;171:365-378
Downregulation of miR-497-5p prevents liver ischemia-reperfusion injury in association with MED1/TIMP-2 axis and the NF-κB pathway.
Wu K, Tao G, Xu T, An Y, Yu X, Wang Y, Wang S, Guo W, Ma L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21180
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21180
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Chen X, Guan Y, Zhang Y, Jia Y, Li W, Guo C, Li Y, Wang X, Shi Y, Wang Q, Zhu F, Li Y, Zhang L
Cell death and differentiation 2021 Apr;28(4):1237-1250
Cell death and differentiation 2021 Apr;28(4):1237-1250
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Zhang Y, Huang W, Zheng Z, Wang W, Yuan Y, Hong Q, Lin J, Li X, Meng Y
Free radical biology & medicine 2021 Apr;166:116-127
Free radical biology & medicine 2021 Apr;166:116-127
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice.
Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, Tohyama J, Nomura Y, Hoshino K, Ago Y, Tanaka R, Epstein O, Ben-Haim R, Heyman E, Miyazaki T, Belal H, Takabayashi S, Ohba C, Takata A, Mizuguchi T, Miyatake S, Miyake N, Fukuda A, Matsumoto N, Saitsu H
Nature communications 2021 Apr 8;12(1):2107
Nature communications 2021 Apr 8;12(1):2107
Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats.
Zhang W, Huang B, Gao L, Huang C
International journal of molecular sciences 2021 Apr 21;22(9)
International journal of molecular sciences 2021 Apr 21;22(9)
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Liu L, Zhang P, Zhang Z, Liang Y, Chen H, He Z, Sun X, Guo Z, Deng Y
Aging 2021 Apr 20;13(8):11752-11761
Aging 2021 Apr 20;13(8):11752-11761
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Chen J, Zhang W, Pan C, Fan J, Zhong X, Tang S
Life sciences 2021 Apr 15;271:119185
Life sciences 2021 Apr 15;271:119185
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
Torres-Odio S, Lei Y, Gispert S, Maletzko A, Key J, Menissy SS, Wittig I, Auburger G, West AP
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1890-1900
PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity.
Qu S, Jiao Z, Lu G, Yao B, Wang T, Rong W, Xu J, Fan T, Sun X, Yang R, Wang J, Yao Y, Xu G, Yan X, Wang T, Liang H, Zen K
Genome biology 2021 Apr 13;22(1):104
Genome biology 2021 Apr 13;22(1):104
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Wang Y, Wang HL, Xing GD, Qian Y, Zhong JF, Chen KL
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1.
Yang F, Zhang Y, Zhu J, Wang J, Jiang Z, Zhao C, Yang Q, Huang Y, Yao W, Pang W, Han L, Zhou J
Frontiers in bioengineering and biotechnology 2020;8:647
Frontiers in bioengineering and biotechnology 2020;8:647
MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis.
Chen J, Chen T, Zhou J, Zhao X, Sheng Q, Lv Z
Frontiers in cell and developmental biology 2020;8:594143
Frontiers in cell and developmental biology 2020;8:594143
miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the β-Catenin Signaling Pathway in Osteosarcoma Cells.
Zhang S, Chen H, Liu W, Fang L, Qian Z, Kong R, Zhang Q, Li J, Cao X
Frontiers in cell and developmental biology 2020;8:594135
Frontiers in cell and developmental biology 2020;8:594135
LncRNA MALAT1 Affects Mycoplasma pneumoniae Pneumonia via NF-κB Regulation.
Gu H, Zhu Y, Zhou Y, Huang T, Zhang S, Zhao D, Liu F
Frontiers in cell and developmental biology 2020;8:563693
Frontiers in cell and developmental biology 2020;8:563693
A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium.
Zhou L, Ning H, Wei H, Xu T, Zhao X, Fu A, Qian Q, Yang Z, Dou X, Li S
Oxidative medicine and cellular longevity 2020;2020:6584059
Oxidative medicine and cellular longevity 2020;2020:6584059
CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
Li T, Cai X, Wang X, Zhang X, Zhang H, Xu B, Li S, Hu J, Wu Q
Journal of diabetes research 2020;2020:2789209
Journal of diabetes research 2020;2020:2789209
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Peng S, Sun Y, Luo Y, Ma S, Sun W, Tang G, Li S, Zhang N, Ren J, Xiao Y, Liu X, Zhang J, Gong Y, Xie C
International journal of biological sciences 2020;16(12):2145-2158
International journal of biological sciences 2020;16(12):2145-2158
Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species.
Piao M, Wang Y, Liu N, Wang X, Chen R, Qin J, Ge P, Feng C
Frontiers in cellular neuroscience 2020;14:583782
Frontiers in cellular neuroscience 2020;14:583782
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro.
Yu X, Yang F, Jiang H, Fan L
Drug design, development and therapy 2020;14:121-128
Drug design, development and therapy 2020;14:121-128
Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain.
Ma Y, Zhang X, Li C, Liu S, Xing Y, Tao F
Journal of pain research 2020;13:2065-2072
Journal of pain research 2020;13:2065-2072
lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.
Luo T, Gao Y, Zhangyuan G, Xu X, Xue C, Jin L, Zhang W, Zhu C, Sun B, Qin X
Cancer management and research 2020;12:5395-5408
Cancer management and research 2020;12:5395-5408
NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/β‑catenin pathway.
Ren Y, Wang Y, Hao S, Yang Y, Xiong W, Qiu L, Tao J, Tang A
Journal of Cancer 2020;11(23):6939-6949
Journal of Cancer 2020;11(23):6939-6949
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression.
Jin Y, Liu J, Liu Y, Liu Y, Guo G, Yu S, An R
Frontiers in pharmacology 2020;11:808
Frontiers in pharmacology 2020;11:808
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Gan P, Ding L, Hang G, Xia Q, Huang Z, Ye X, Qian X
Frontiers in pharmacology 2020;11:776
Frontiers in pharmacology 2020;11:776
TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages.
Jin Z, Zhu Z, Liu S, Hou Y, Tang M, Zhu P, Tian Y, Li D, Yan D, Zhu X
Frontiers in immunology 2020;11:263
Frontiers in immunology 2020;11:263
Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosis via modulating protein stability of β-catenin and β-catenin-mediated transcription.
Chen DQ, Wu XQ, Chen L, Hu HH, Wang YN, Zhao YY
Therapeutic advances in chronic disease 2020;11:2040622320962648
Therapeutic advances in chronic disease 2020;11:2040622320962648
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Chen S, Ding R, Hu Z, Yin X, Xiao F, Zhang W, Yan S, Lv C
Frontiers in immunology 2020;11:1829
Frontiers in immunology 2020;11:1829
Extracellular Vesicles From Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice.
Bai X, Li J, Li L, Liu M, Liu Y, Cao M, Tao K, Xie S, Hu D
Frontiers in immunology 2020;11:1391
Frontiers in immunology 2020;11:1391
Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag.
Qu M, Wang W, Li W, Cao J, Zhang X, Wang C, Wu J, Yu B, Zhang H, Wu H, Kong W, Yu X
Frontiers in microbiology 2020;11:1230
Frontiers in microbiology 2020;11:1230
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
Li Y, Xia L, Tan K, Ye X, Zuo Z, Li M, Xiao R, Wang Z, Liu X, Deng M, Cui J, Yang M, Luo Q, Liu S, Cao X, Zhu H, Liu T, Hu J, Shi J, Xiao S, Xia L
Nature genetics 2020 Sep;52(9):870-877
Nature genetics 2020 Sep;52(9):870-877
HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling.
Ge S, Wu X, Xiong Y, Xie J, Liu F, Zhang W, Yang L, Zhang S, Lai L, Huang J, Li M, Yu YQ
DNA and cell biology 2020 Sep;39(9):1711-1722
DNA and cell biology 2020 Sep;39(9):1711-1722
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
Wang H, Wang N, Xu D, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM, Wang G, Ying Z
Autophagy 2020 Sep;16(9):1683-1696
Autophagy 2020 Sep;16(9):1683-1696
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Li H, Che J, Jiang M, Cui M, Feng G, Dong J, Zhang S, Lu L, Liu W, Fan S
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma.
Zhao X, Bao M, Zhang F, Wang W
Experimental cell research 2020 Sep 15;394(2):112148
Experimental cell research 2020 Sep 15;394(2):112148
FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis.
Fan H, Zhang S, Zhang Y, Liang W, Cao B
Cancer biology & therapy 2020 Sep 1;21(9):815-825
Cancer biology & therapy 2020 Sep 1;21(9):815-825
The interaction of lead exposure and CCM3 defect plays an important role in regulating angiogenesis through eNOS/NO pathway.
Sun Y, Zhao Z, Zhang H, Li J, Chen J, Luan X, Min W, He Y
Environmental toxicology and pharmacology 2020 Oct;79:103407
Environmental toxicology and pharmacology 2020 Oct;79:103407
An NF-κB-driven lncRNA orchestrates colitis and circadian clock.
Wang S, Lin Y, Li F, Qin Z, Zhou Z, Gao L, Yang Z, Wang Z, Wu B
Science advances 2020 Oct;6(42)
Science advances 2020 Oct;6(42)
Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
Ren AJ, Chen C, Zhang S, Liu M, Wei C, Wang K, Ma X, Song Y, Wang R, Zhang H, Chen YX, Wu H, Xie Z, Zhang Y, Zhang WJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13862-13876
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13862-13876
Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.
Zhou L, Gao R, Hong H, Li X, Yang J, Shen W, Wang Z, Yang J
Journal of cellular and molecular medicine 2020 Oct;24(20):11998-12007
Journal of cellular and molecular medicine 2020 Oct;24(20):11998-12007
Mechanisms by which electroacupuncture‑mediated histone acetylation mitigates bone loss in rats with ovariectomy‑induced osteoporosis.
Shu Q, Shao Y, Liu R, Hu Y, Peng Z, Tian J
Molecular medicine reports 2020 Oct;22(4):3453-3463
Molecular medicine reports 2020 Oct;22(4):3453-3463
Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
Chen F, Zhang W, Xie D, Gao T, Dong Z, Lu X
Nucleic acids research 2020 Oct 9;48(18):10211-10225
Nucleic acids research 2020 Oct 9;48(18):10211-10225
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Wu L, Lin W, Liao Q, Wang H, Lin C, Tang L, Lian W, Chen Z, Li K, Xu L, Zhou R, Ding Y, Zhao L
Cell reports 2020 Oct 27;33(4):108327
Cell reports 2020 Oct 27;33(4):108327
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Lv R, Du L, Zhou F, Yuan X, Liu X, Zhang L
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
Ochratoxin A induces reprogramming of glucose metabolism by switching energy metabolism from oxidative phosphorylation to glycolysis in human gastric epithelium GES-1 cells in vitro.
Wang Y, Zhao M, Cui J, Wu X, Li Y, Wu W, Zhang X
Toxicology letters 2020 Oct 15;333:232-241
Toxicology letters 2020 Oct 15;333:232-241
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Zhang H, Lang W, Wang S, Li B, Li G, Shi Q
International immunopharmacology 2020 Nov;88:106974
International immunopharmacology 2020 Nov;88:106974
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Zhao B, Xu P, Rowlett CM, Jing T, Shinde O, Lei Y, West AP, Liu WR, Li P
Nature 2020 Nov;587(7835):673-677
Nature 2020 Nov;587(7835):673-677
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
Zhai J, Li Z, Zhang H, Ma L, Ma Z, Zhang Y, Zou J, Li M, Ma L, Wang X, Li X
Molecular medicine reports 2020 Nov;22(5):4227-4235
Molecular medicine reports 2020 Nov;22(5):4227-4235
Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling.
Yang S, Zhang Y, Zhang Z, Dan J, Zhou Q, Wang X, Li W, Zhou L, Yang L, Xie L
The American journal of pathology 2020 Nov;190(11):2237-2250
The American journal of pathology 2020 Nov;190(11):2237-2250
Interaction of BACH2 with FUS promotes malignant progression of glioma cells via the TSLNC8-miR-10b-5p-WWC3 pathway.
Yang Y, Liu X, Zheng J, Xue Y, Liu L, Ma J, Wang P, Yang C, Wang D, Shao L, Ruan X, Liu Y
Molecular oncology 2020 Nov;14(11):2936-2959
Molecular oncology 2020 Nov;14(11):2936-2959
Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose.
Wang Y, Cui X, Lin Q, Cai J, Tang L, Liang Y
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12271-12283
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12271-12283
Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.
Zhang Z, Wang Y, Shan Y, Yin W
Molecules (Basel, Switzerland) 2020 Nov 25;25(23)
Molecules (Basel, Switzerland) 2020 Nov 25;25(23)
Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma.
Li W, Yan Y, Zheng Z, Zhu Q, Long Q, Sui S, Luo M, Chen M, Li Y, Hua Y, Deng W, Lai R, Li L
Cell death & disease 2020 Nov 25;11(11):1011
Cell death & disease 2020 Nov 25;11(11):1011
ARID1A-dependent permissive chromatin accessibility licenses estrogen-receptor signaling to regulate circadian rhythms genes in endometrial cancer.
Hu H, Chen Z, Ji L, Wang Y, Yang M, Lai R, Zhong Y, Zhang X, Wang L
Cancer letters 2020 Nov 1;492:162-173
Cancer letters 2020 Nov 1;492:162-173
PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape.
Wei X, Yang W, Zhang F, Cheng F, Rao J, Lu L
Life sciences 2020 Nov 1;260:118476
Life sciences 2020 Nov 1;260:118476
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.
Sun J, Piao J, Li N, Yang Y, Kim KY, Lin Z
The FEBS journal 2020 May;287(10):2118-2133
The FEBS journal 2020 May;287(10):2118-2133
Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco.
Chen GH, Lv W, Xu YH, Wei XL, Xu YC, Luo Z
Chemosphere 2020 May;246:125792
Chemosphere 2020 May;246:125792
Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression.
Romero N, Van Waesberghe C, Favoreel HW
Journal of virology 2020 May 4;94(10)
Journal of virology 2020 May 4;94(10)
The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair.
Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, Zhang Y, Nowsheen S, Zhu Q, Deng M, Chen Y, Qin B, Luo K, Liu B, Lou Z, Mutter RW, Yuan J
Nature communications 2020 May 26;11(1):2639
Nature communications 2020 May 26;11(1):2639
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Zhan W, Liao X, Liu J, Tian T, Yu L, Li R
Oncogenesis 2020 May 13;9(5):48
Oncogenesis 2020 May 13;9(5):48
δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.
Ju L, Shan L, Yin B, Song Y
Cancer medicine 2020 Mar;9(6):2201-2212
Cancer medicine 2020 Mar;9(6):2201-2212
Bclaf1 is a direct target of HIF-1 and critically regulates the stability of HIF-1α under hypoxia.
Shao A, Lang Y, Wang M, Qin C, Kuang Y, Mei Y, Lin D, Zhang S, Tang J
Oncogene 2020 Mar;39(13):2807-2818
Oncogene 2020 Mar;39(13):2807-2818
The Wnt/β-catenin/VASP positive feedback loop drives cell proliferation and migration in breast cancer.
Li K, Zhang J, Tian Y, He Y, Xu X, Pan W, Gao Y, Chen F, Wei L
Oncogene 2020 Mar;39(11):2258-2274
Oncogene 2020 Mar;39(11):2258-2274
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.
Liang C, Xu J, Meng Q, Zhang B, Liu J, Hua J, Zhang Y, Shi S, Yu X
Autophagy 2020 Mar;16(3):486-500
Autophagy 2020 Mar;16(3):486-500
LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis.
Wang H, Liu Z, Guan L, Li J, Chen S, Yu W, Lai M
Pharmacological research 2020 Mar;153:104661
Pharmacological research 2020 Mar;153:104661
Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation.
He T, Bai X, Jing J, Liu Y, Wang H, Zhang W, Li X, Li Y, Wang L, Xie S, Hu D
Archives of biochemistry and biophysics 2020 Mar 30;682:108286
Archives of biochemistry and biophysics 2020 Mar 30;682:108286
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Fan C, Zhong T, Yang H, Yang Y, Wang D, Yang X, Xu Y, Fan Y
European journal of medicinal chemistry 2020 Mar 15;190:112108
European journal of medicinal chemistry 2020 Mar 15;190:112108
ABA-responsive ABRE-BINDING FACTOR3 activates DAM3 expression to promote bud dormancy in Asian pear.
Yang Q, Yang B, Li J, Wang Y, Tao R, Yang F, Wu X, Yan X, Ahmad M, Shen J, Bai S, Teng Y
Plant, cell & environment 2020 Jun;43(6):1360-1375
Plant, cell & environment 2020 Jun;43(6):1360-1375
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Liu H, Chen C, Ma D, Li Y, Yin Q, Li Q, Xiang C
Journal of cellular and molecular medicine 2020 Jun;24(11):6308-6323
Journal of cellular and molecular medicine 2020 Jun;24(11):6308-6323
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Ouyang L, Yan B, Liu Y, Mao C, Wang M, Liu N, Wang Z, Liu S, Shi Y, Chen L, Wang X, Cheng Y, Cao Y, Xiao D, Zhang L, Liu S, Tao Y
Signal transduction and targeted therapy 2020 Jun 17;5(1):78
Signal transduction and targeted therapy 2020 Jun 17;5(1):78
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.
Selvaraju V, Thirunavukkarasu M, Joshi M, Oriowo B, Shaikh IA, Rishi MT, Tapias L, Coca-Soliz V, Saad I, Campbell J, Pradeep SR, Swaminathan S, Yee SP, McFadden DW, Alexander Palesty J, Maulik N
Basic research in cardiology 2020 Jun 14;115(4):45
Basic research in cardiology 2020 Jun 14;115(4):45
CaCBL1 Acts as a Positive Regulator in Pepper Response to Ralstonia solanacearum.
Shen L, Yang S, Yang F, Guan D, He S
Molecular plant-microbe interactions : MPMI 2020 Jul;33(7):945-957
Molecular plant-microbe interactions : MPMI 2020 Jul;33(7):945-957
EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling.
Wang L, Ai M, Nie M, Zhao L, Deng G, Hu S, Han Y, Zeng W, Wang Y, Yang M, Wang S
Cancer science 2020 Jul;111(7):2310-2324
Cancer science 2020 Jul;111(7):2310-2324
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
Ding H, Song Y, Huang X, Wang L, Luo S, Zhang H, Pan H, Jiang W, Qian J, Yao G, Wen L, Zhang Y
Biomaterials science 2020 Jul 28;8(15):4358-4369
Biomaterials science 2020 Jul 28;8(15):4358-4369
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, Quan C, Yao Y, Zheng Z
BMC cancer 2020 Jul 16;20(1):665
BMC cancer 2020 Jul 16;20(1):665
TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding.
Zhang X, Ye P, Huang H, Wang B, Dong F, Ling Q
Aging 2020 Jul 10;12(13):13365-13387
Aging 2020 Jul 10;12(13):13365-13387
Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling.
Chen Y, Chen J, Jiang M, Fu Y, Zhu Y, Jiao N, Liu L, Du Q, Wu H, Xu H, Sun J
Life sciences 2020 Jul 1;252:117653
Life sciences 2020 Jul 1;252:117653
Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells.
Yang F, Li S, Cheng Y, Li J, Han X
Life sciences 2020 Jul 1;252:117611
Life sciences 2020 Jul 1;252:117611
A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.
Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, Xin X, Li H, Wang R, Wang W, Jiang F, Liu S, Ding J, Zhang B, Li L, Wang H
Hepatology (Baltimore, Md.) 2020 Jan;71(1):130-147
Hepatology (Baltimore, Md.) 2020 Jan;71(1):130-147
CHK2-FOXK axis promotes transcriptional control of autophagy programs.
Chen Y, Wu J, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C, Li Y, Li L, Kim W, Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z, Chen Y, Lou Z, Luo K, Yuan J
Science advances 2020 Jan;6(1):eaax5819
Science advances 2020 Jan;6(1):eaax5819
MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.
Fei Y, Chaulagain A, Wang T, Chen Y, Liu J, Yi M, Wang Y, Huang Y, Lin L, Chen S, Xu W, Tong L, Wu X, Zhao D, Zhang F, Zhao W, Zhong Z
RNA (New York, N.Y.) 2020 Jan;26(1):91-100
RNA (New York, N.Y.) 2020 Jan;26(1):91-100
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
Majumder M, Palanisamy V
PLoS genetics 2020 Jan;16(1):e1008580
PLoS genetics 2020 Jan;16(1):e1008580
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
Wang K, Wei H, Zhan J, Liang X, Zhang C, Liu Y, Xu G
Chemico-biological interactions 2020 Jan 25;316:108926
Chemico-biological interactions 2020 Jan 25;316:108926
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Jia L, Xiong Y, Zhang W, Ma X, Xu X
Experimental cell research 2020 Jan 15;386(2):111717
Experimental cell research 2020 Jan 15;386(2):111717
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.
Li S, Li Q, Zhu Y, Hu W
Experimental cell research 2020 Feb 1;387(1):111745
Experimental cell research 2020 Feb 1;387(1):111745
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy.
Zhu L, Duan W, Wu G, Zhang D, Wang L, Chen D, Chen Z, Yang B
Annals of translational medicine 2020 Dec;8(23):1586
Annals of translational medicine 2020 Dec;8(23):1586
Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation.
Wang M, Hu HH, Chen YY, Chen L, Wu XQ, Zhao YY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153323
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153323
Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway.
Tian J, Yang L, Wang P, Yang L, Fan Z
Neurochemical research 2020 Dec;45(12):2926-2938
Neurochemical research 2020 Dec;45(12):2926-2938
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Dong X, Sun R, Wang J, Yu S, Cui J, Guo Z, Pan X, Sun J, Yang J, Pan LL
Biochemical pharmacology 2020 Dec;182:114289
Biochemical pharmacology 2020 Dec;182:114289
Silibinin ameliorats H2O2-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
lncMGPF is a novel positive regulator of muscle growth and regeneration.
Lv W, Jin J, Xu Z, Luo H, Guo Y, Wang X, Wang S, Zhang J, Zuo H, Bai W, Peng Y, Tang J, Zhao S, Zuo B
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling.
Wang Y, Chen J, Chen J, Dong C, Yan X, Zhu Z, Lu P, Song Z, Liu H, Chen S
Toxicology and applied pharmacology 2020 Dec 15;409:115333
Toxicology and applied pharmacology 2020 Dec 15;409:115333
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways.
Li Z, Lian Y, Wei R, Jin L, Cao H, Zhao T, Ma X, Zhong M, Gao Y, Zhang K
Life sciences 2020 Dec 1;262:118546
Life sciences 2020 Dec 1;262:118546
BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes.
Yu Y, Liang Z, Song X, Fu W, Xu J, Lei Y, Yuan L, Ruan J, Chen C, Fu W, Cui Y, Huang S, Li C
Nature plants 2020 Aug;6(8):996-1007
Nature plants 2020 Aug;6(8):996-1007
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
Liu D, Zhang H, Cui M, Chen C, Feng Y
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.
Si Y, Huang J, Li X, Fu Y, Xu R, Du Y, Cheng J, Jiang H
Cell communication and signaling : CCS 2020 Aug 31;18(1):139
Cell communication and signaling : CCS 2020 Aug 31;18(1):139
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, Leng X
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Jia Z, Zhang Y, Yan A, Wang M, Han Q, Wang K, Wang J, Qiao C, Pan Z, Chen C, Hu D, Ding X
Cell death & disease 2020 Aug 20;11(8):670
Cell death & disease 2020 Aug 20;11(8):670
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway.
Zhu M, Yu X, Zheng Z, Huang J, Yang X, Shi H
Phytotherapy research : PTR 2020 Apr;34(4):817-824
Phytotherapy research : PTR 2020 Apr;34(4):817-824
WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
Ji X, Liu T, Zhao S, Li J, Li L, Wang E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4904-4917
C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis.
Wang M, Wang H, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G, Ying Z
Aging cell 2020 Apr;19(4):e13126
Aging cell 2020 Apr;19(4):e13126
PGN and LTA from Staphylococcus aureus Induced Inflammation and Decreased Lactation through Regulating DNA Methylation and Histone H3 Acetylation in Bovine Mammary Epithelial Cells.
Wu Y, Chen J, Sun Y, Dong X, Wang Z, Chen J, Dong G
Toxins 2020 Apr 9;12(4)
Toxins 2020 Apr 9;12(4)
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Apr 19;397:115014
Toxicology and applied pharmacology 2020 Apr 19;397:115014
Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy.
Zhang X, Qi Z, Yin H, Yang G
Theranostics 2019;9(4):1096-1114
Theranostics 2019;9(4):1096-1114
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.
Huang S, Wang LL, Xue NN, Li C, Guo HH, Ren TK, Zhan Y, Li WB, Zhang J, Chen XG, Han YX, Zhang JL, Jiang JD
Theranostics 2019;9(23):6745-6763
Theranostics 2019;9(23):6745-6763
Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer.
Jin H, Liu P, Kong L, Fei X, Gao Y, Wu T, Sun D, Tan X
Frontiers in oncology 2019;9:291
Frontiers in oncology 2019;9:291
Role of Antioxidants in the Protection from Aging-Related Diseases.
Monti DM, Rigano MM, Monti SM, Peixoto HS
Oxidative medicine and cellular longevity 2019;2019:7450693
Oxidative medicine and cellular longevity 2019;2019:7450693
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M
Mediators of inflammation 2019;2019:1082497
Mediators of inflammation 2019;2019:1082497
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways.
Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, Zheng H, Liang Y, Xia N
Drug design, development and therapy 2019;13:4065-4074
Drug design, development and therapy 2019;13:4065-4074
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
Cheng D, Tan Q, Zhu Q, Zhang J, Han X, Fang P, Jin W, Liu X
Frontiers in human neuroscience 2019;13:108
Frontiers in human neuroscience 2019;13:108
β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway.
Yu X, Li Z, Zhang Y, Xu M, Che Y, Tian X, Wang R, Zou K, Zou L
OncoTargets and therapy 2019;12:4203-4211
OncoTargets and therapy 2019;12:4203-4211
Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation.
Chen Y, Wu T, Li H, Li X, Li Q, Zhu X, Yu M, Kuo SH, Huang F, Wu YC
Frontiers in aging neuroscience 2019;11:44
Frontiers in aging neuroscience 2019;11:44
Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells.
Zhou D, Zhuang J, Wang Y, Zhao D, Zhao L, Zhu S, Pu J, Yin M, Zhang H, Wang Z, Hong J
Frontiers in physiology 2019;10:223
Frontiers in physiology 2019;10:223
The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro.
Zhang H, Ji L, Yang Y, Wei Y, Zhang X, Gang Y, Lu J, Bai L
Frontiers in physiology 2019;10:1060
Frontiers in physiology 2019;10:1060
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Lu MC, Zhao J, Liu YT, Liu T, Tao MM, You QD, Jiang ZY
Redox biology 2019 Sep;26:101266
Redox biology 2019 Sep;26:101266
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Ge LN, Yan L, Li C, Cheng K
Molecular medicine reports 2019 Sep;20(3):2805-2811
Molecular medicine reports 2019 Sep;20(3):2805-2811
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H
Molecular cell 2019 Sep 5;75(5):967-981.e9
Molecular cell 2019 Sep 5;75(5):967-981.e9
Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway.
Sirri V, Grob A, Berthelet J, Jourdan N, Roussel P
Journal of cell science 2019 Sep 2;132(17)
Journal of cell science 2019 Sep 2;132(17)
MD-2 Homologue Recognizes the White Spot Syndrome Virus Lipid Component and Induces Antiviral Molecule Expression in Shrimp.
Gao J, Wang JX, Wang XW
Journal of immunology (Baltimore, Md. : 1950) 2019 Sep 1;203(5):1131-1141
Journal of immunology (Baltimore, Md. : 1950) 2019 Sep 1;203(5):1131-1141
Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-κB pathway.
Sun LJ, Qiao W, Xiao YJ, Cui L, Wang X, Ren WD
International immunopharmacology 2019 Oct;75:105782
International immunopharmacology 2019 Oct;75:105782
MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway.
Sun L, Li Z, Xue H, Ma T, Ren C, Li M, Lu Y, Sun H, Zhang K
Molecular and cellular biochemistry 2019 Oct;460(1-2):165-173
Molecular and cellular biochemistry 2019 Oct;460(1-2):165-173
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Song G, Zhang Y, Yu S, Lv W, Guan Z, Sun M, Wang J
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.
Qi Y, Wang D, Huang W, Wang B, Huang D, Xiong F, Chen X, Chen Y
Journal of experimental & clinical cancer research : CR 2019 Oct 7;38(1):413
Journal of experimental & clinical cancer research : CR 2019 Oct 7;38(1):413
The therapeutic effect of verapamil in lipopolysaccharide-induced acute lung injury.
Song Z, Li S, Zhang C, Yuan L, Han L, Liu Y
Biochemical and biophysical research communications 2019 Oct 1;517(4):648-654
Biochemical and biophysical research communications 2019 Oct 1;517(4):648-654
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Xu J, Sheng Z, Li F, Wang S, Yuan Y, Wang M, Yu Z
Experimental cell research 2019 Oct 1;383(1):111505
Experimental cell research 2019 Oct 1;383(1):111505
Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.
Zhao Y, Deng H, Li K, Wang L, Wu Y, Dong X, Wang X, Chen Y, Xu Y
Brain, behavior, and immunity 2019 Nov;82:45-62
Brain, behavior, and immunity 2019 Nov;82:45-62
SIRT4 enhances the sensitivity of ER-positive breast cancer to tamoxifen by inhibiting the IL-6/STAT3 signal pathway.
Xing J, Li J, Fu L, Gai J, Guan J, Li Q
Cancer medicine 2019 Nov;8(16):7086-7097
Cancer medicine 2019 Nov;8(16):7086-7097
PI3K p110α inhibition sensitizes cervical cancer cells with aberrant PI3K signaling activation to PARP inhibitor BMN673.
Cao P, Wang Y, Lv Y, Jiang N, Zhong L, Ma X, Xiao X, Ding D, Gu J, Lin L, Li S
Oncology reports 2019 Nov;42(5):2097-2107
Oncology reports 2019 Nov;42(5):2097-2107
Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF-κB Pathway.
Xu D, Xia N, Hou K, Li F, Chen S, Hu Y, Fang W, Li Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Nov;28(11):104288
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Nov;28(11):104288
LncRNA HOTAIRM1 promotes osteogenesis by controlling JNK/AP-1 signalling-mediated RUNX2 expression.
Fu L, Peng S, Wu W, Ouyang Y, Tan D, Fu X
Journal of cellular and molecular medicine 2019 Nov;23(11):7517-7524
Journal of cellular and molecular medicine 2019 Nov;23(11):7517-7524
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, Ge X, Guo X, Han J, Yang H
PLoS pathogens 2019 Nov;15(11):e1008169
PLoS pathogens 2019 Nov;15(11):e1008169
ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.
Kim W, Zhao F, Wu R, Qin S, Nowsheen S, Huang J, Zhou Q, Chen Y, Deng M, Guo G, Luo K, Lou Z, Yuan J
Nature communications 2019 Nov 22;10(1):5304
Nature communications 2019 Nov 22;10(1):5304
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H
Cell death & disease 2019 Nov 18;10(12):872
Cell death & disease 2019 Nov 18;10(12):872
TFEB Mediates Immune Evasion and Resistance to mTOR Inhibition of Renal Cell Carcinoma via Induction of PD-L1.
Zhang C, Duan Y, Xia M, Dong Y, Chen Y, Zheng L, Chai S, Zhang Q, Wei Z, Liu N, Wang J, Sun C, Tang Z, Cheng X, Wu J, Wang G, Zheng F, Laurence A, Li B, Yang XP
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6827-6838
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6827-6838
Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.
Wang S, Ai H, Liu L, Zhang X, Gao F, Zheng L, Yi J, Sun L, Yu C, Zhao H, Li Y
American journal of physiology. Endocrinology and metabolism 2019 Nov 1;317(5):E911-E924
American journal of physiology. Endocrinology and metabolism 2019 Nov 1;317(5):E911-E924
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.
Fu XH, Zhang X, Yang H, Xu XW, Hu ZL, Yan J, Zheng XL, Wei RR, Zhang ZQ, Tang SR, Geng MY, Huang X
Acta pharmacologica Sinica 2019 May;40(5):677-688
Acta pharmacologica Sinica 2019 May;40(5):677-688
HepaCAM Regulates Warburg Effect of Renal Cell Carcinoma via HIF-1α/NF-κB Signaling Pathway.
Fan Y, Ou L, Fan J, Li L, Wu X, Luo C, Gao Y, Niu L
Urology 2019 May;127:61-67
Urology 2019 May;127:61-67
Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway.
Liu Y, Li R, Chen XX, Zhi Y, Deng R, Zhou EM, Qiao S, Zhang G
mBio 2019 May 7;10(3)
mBio 2019 May 7;10(3)
Abnormal expression of TBX4 during anorectal development in rat embryos with ethylenethiourea-induced anorectal malformations.
Li M, Zhang H, Liu H, Tian H, Tang X, Bai Y, Wang W
Biological research 2019 May 4;52(1):27
Biological research 2019 May 4;52(1):27
Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.
Du W, Dong Q, Zhang Z, Liu B, Zhou T, Xu RM, Wang H, Zhu B, Li Y
The Journal of biological chemistry 2019 May 31;294(22):8907-8917
The Journal of biological chemistry 2019 May 31;294(22):8907-8917
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, Sun T, Peng X, Zhuang C, Yu J
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis.
Chen YX, Zhu DY, Gao J, Xu ZL, Tao SC, Yin WJ, Zhang YL, Gao YS, Zhang CQ
The FEBS journal 2019 Mar;286(6):1101-1119
The FEBS journal 2019 Mar;286(6):1101-1119
Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.
Yu HX, Yao Y, Bu FT, Chen Y, Wu YT, Yang Y, Chen X, Zhu Y, Wang Q, Pan XY, Meng XM, Huang C, Li J
Molecular immunology 2019 Mar;107:29-40
Molecular immunology 2019 Mar;107:29-40
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
Sun X, Xie Y, Sun X, Yao Y, Li H, Li Z, Yao R, Xu K
Bioscience reports 2019 Mar 29;39(3)
Bioscience reports 2019 Mar 29;39(3)
Suppression of puerarin on polymethylmethacrylate-induced lesion of peri-implant by inhibiting NF-κB activation in vitro and in vivo.
Yan B, Zhou H, Chu J, Cao X
Pathology, research and practice 2019 Jun;215(6):152372
Pathology, research and practice 2019 Jun;215(6):152372
MicroRNA-126 Regulates Angiogenesis and Neurogenesis in a Mouse Model of Focal Cerebral Ischemia.
Qu M, Pan J, Wang L, Zhou P, Song Y, Wang S, Jiang L, Geng J, Zhang Z, Wang Y, Tang Y, Yang GY
Molecular therapy. Nucleic acids 2019 Jun 7;16:15-25
Molecular therapy. Nucleic acids 2019 Jun 7;16:15-25
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
Wang Y, Ai L, Hai B, Cao Y, Li R, Li H, Li Y
Physiological research 2019 Jun 30;68(3):445-455
Physiological research 2019 Jun 30;68(3):445-455
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.
Li YJ, Zhang K, Sun T, Wang J, Guo YY, Yang L, Yang Q, Li YJ, Liu SB, Zhao MG, Wu YM
Journal of neuroinflammation 2019 Jun 29;16(1):132
Journal of neuroinflammation 2019 Jun 29;16(1):132
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats.
Liu L, Zhang P, Zhang Z, Hu Q, He J, Liu H, Zhao J, Liang Y, He Z, Li X, Sun X, Guo Z
Neuroscience 2019 Jun 1;408:105-114
Neuroscience 2019 Jun 1;408:105-114
The perforatorium and postacrosomal sheath of rat spermatozoa share common developmental origins and protein constituents†.
Protopapas N, Hamilton LE, Warkentin R, Xu W, Sutovsky P, Oko R
Biology of reproduction 2019 Jun 1;100(6):1461-1472
Biology of reproduction 2019 Jun 1;100(6):1461-1472
Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.
Wang Y, Zhang J, Ren S, Sun D, Huang HY, Wang H, Jin Y, Li F, Zheng C, Yang L, Deng L, Jiang Z, Jiang T, Han X, Hou S, Guo C, Li F, Gao D, Qin J, Gao D, Chen L, Lin SH, Wong KK, Li C, Hu L, Zhou C, Ji H
Cell reports 2019 Jul 9;28(2):512-525.e6
Cell reports 2019 Jul 9;28(2):512-525.e6
A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway.
Zhang S, Xu S, Duan H, Zhu Z, Yang Z, Cao J, Zhao Y, Huang Z, Wu Q, Duan J
European journal of pharmacology 2019 Jul 15;855:208-215
European journal of pharmacology 2019 Jul 15;855:208-215
In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.
Zhang MZ, Cao XM, Xu FQ, Liang XW, Fu LL, Li B, Liu WG, Li SG, Sun FZ, Huang XY, Huang WH
Biology open 2019 Jul 10;8(7)
Biology open 2019 Jul 10;8(7)
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3.
Qin C, Zhang R, Lang Y, Shao A, Xu A, Feng W, Han J, Wang M, He W, Yu C, Tang J
PLoS pathogens 2019 Jan;15(1):e1007559
PLoS pathogens 2019 Jan;15(1):e1007559
HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization.
Kong Q, Li N, Cheng H, Zhang X, Cao X, Qi T, Dai L, Zhang Z, Chen X, Li C, Li Y, Xue B, Fang L, Liu L, Ding Z
Diabetes 2019 Feb;68(2):361-376
Diabetes 2019 Feb;68(2):361-376
Activation of brain endothelium by Escherichia coli K1 virulence factor cglD promotes polymorphonuclear leukocyte transendothelial migration.
Zhang K, Shi MJ, Niu Z, Chen X, Wei JY, Miao ZW, Zhao WD, Chen YH
Medical microbiology and immunology 2019 Feb;208(1):59-68
Medical microbiology and immunology 2019 Feb;208(1):59-68
CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation.
Yang X, Zhao Y, Jia X, Wang C, Wu Y, Zhang L, Chang Y, Wei W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Feb;110:834-843
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Feb;110:834-843
Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.
Zhao Y, Wang Q, Zang B
Acta cirurgica brasileira 2019 Feb 28;34(2):e201900209
Acta cirurgica brasileira 2019 Feb 28;34(2):e201900209
m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X
Cell death & disease 2019 Feb 20;10(3):171
Cell death & disease 2019 Feb 20;10(3):171
SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.
Han W, Wang C, Yang Z, Mu L, Wu M, Chen N, Du C, Duan H, Shi Y
The Journal of endocrinology 2019 Feb 1;
The Journal of endocrinology 2019 Feb 1;
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition.
Zhang KL, Shen QQ, Fang YF, Sun YM, Ding J, Chen Y
Acta pharmacologica Sinica 2019 Dec;40(12):1587-1595
Acta pharmacologica Sinica 2019 Dec;40(12):1587-1595
Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro.
Zhao CC, Jiang MY, Zhang LY, Hu YY, Hu ZJ, Zhang MY, Qi J, Su AC, Lou N, Xian XH, Zhang JG, Li WB, Zhang M
Journal of neurochemistry 2019 Dec;151(5):608-625
Journal of neurochemistry 2019 Dec;151(5):608-625
Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.
Li X, Han ZN, Liu Y, Hong L, Cui BR, Cui X
Peptides 2019 Dec;122:170150
Peptides 2019 Dec;122:170150
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.
Yang L, Lei Q, Li L, Yang J, Dong Z, Cui H
Clinical epigenetics 2019 Dec 30;11(1):199
Clinical epigenetics 2019 Dec 30;11(1):199
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
Lin Y, Wang S, Yang Z, Gao L, Zhou Z, Yu P, Wu B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
He R, Wang M, Zhao C, Shen M, Yu Y, He L, Zhao Y, Chen H, Shi X, Zhou M, Pan S, Liu Y, Guo X, Li X, Qin R
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.
Miao Y, Shen Q, Zhang S, Huang H, Meng X, Zheng X, Yao Z, He Z, Lu S, Cai C, Zou F
Breast cancer research : BCR 2019 Aug 29;21(1):99
Breast cancer research : BCR 2019 Aug 29;21(1):99
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
Jiang Y, Liu F, Zou F, Zhang Y, Wang B, Zhang Y, Lian A, Han X, Liu Z, Liu X, Jin M, Wang D, Li G, Liu J
Stem cell research & therapy 2019 Aug 23;10(1):268
Stem cell research & therapy 2019 Aug 23;10(1):268
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Li SS, Jiang WL, Xiao WQ, Li K, Zhang YF, Guo XY, Dai YQ, Zhao QY, Jiang MJ, Lu ZJ, Wan R
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
World journal of gastrointestinal oncology 2019 Aug 15;11(8):599-621
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Wang Y, Yang C, Elsheikh NAH, Li C, Yang F, Wang G, Li L
Aging 2019 Aug 12;11(15):5535-5547
Aging 2019 Aug 12;11(15):5535-5547
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.
Gan P, Xia Q, Hang G, Zhou Y, Qian X, Wang X, Ding L
Clinical and experimental pharmacology & physiology 2019 Apr;46(4):337-349
Clinical and experimental pharmacology & physiology 2019 Apr;46(4):337-349
5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.
Xu LL, Wu YF, Yan F, Li CC, Dai Z, You QD, Jiang ZY, Di B
Free radical biology & medicine 2019 Apr;134:288-303
Free radical biology & medicine 2019 Apr;134:288-303
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, Zhao H, Xie M, Lu F, Fang Q, Liang W, Yin F, Li Z
Cancer research 2019 Apr 15;79(8):1769-1783
Cancer research 2019 Apr 15;79(8):1769-1783
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG
Cancer cell 2019 Apr 15;35(4):677-691.e10
Cancer cell 2019 Apr 15;35(4):677-691.e10
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
Life sciences 2019 Apr 15;223:158-165
Life sciences 2019 Apr 15;223:158-165
miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1.
Cheng XY, Liu JD, Lu XY, Yan X, Huang C, Meng XM, Li J
Frontiers in pharmacology 2018;9:275
Frontiers in pharmacology 2018;9:275
Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC.
Mao C, Wang M, Qian B, Ouyang L, Shi Y, Liu N, Chen L, Xiao D, Wang X, Cao Y, Liu S, Tao Y, Liu W
American journal of cancer research 2018;8(7):1214-1227
American journal of cancer research 2018;8(7):1214-1227
Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming.
Tan Y, Lin K, Zhao Y, Wu Q, Chen D, Wang J, Liang Y, Li J, Hu J, Wang H, Liu Y, Zhang S, He W, Huang Q, Hu X, Yao Z, Liang B, Liao W, Shi M
Theranostics 2018;8(19):5452-5468
Theranostics 2018;8(19):5452-5468
Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.
Ma Y, Ma B, Shang Y, Yin Q, Wang D, Xu S, Hong Y, Hou X, Liu X
Oxidative medicine and cellular longevity 2018;2018:8938207
Oxidative medicine and cellular longevity 2018;2018:8938207
3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
Xu LL, Liu T, Wang L, Li L, Wu YF, Li CC, Di B, You QD, Jiang ZY
Oxidative medicine and cellular longevity 2018;2018:3271617
Oxidative medicine and cellular longevity 2018;2018:3271617
Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.
Yao R, Sun X, Xie Y, Liu L, Han D, Yao Y, Li H, Li Z, Xu K
American journal of translational research 2018;10(8):2610-2618
American journal of translational research 2018;10(8):2610-2618
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C
Neurobiology of disease 2018 Sep;117:114-124
Neurobiology of disease 2018 Sep;117:114-124
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.
Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M
Cell 2018 Sep 20;175(1):186-199.e19
Cell 2018 Sep 20;175(1):186-199.e19
XPO1-mediated nuclear export of RNF146 protects from angiotensin II-induced endothelial cellular injury.
Sheng Z, Xu Y, Wang S, Yuan Y, Huang T, Lu P
Biochemical and biophysical research communications 2018 Sep 10;503(3):1544-1549
Biochemical and biophysical research communications 2018 Sep 10;503(3):1544-1549
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.
Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B
Nature communications 2018 Oct 12;9(1):4246
Nature communications 2018 Oct 12;9(1):4246
Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERα.
Ge L, Cui Y, Cheng K, Han J
Molecules (Basel, Switzerland) 2018 Oct 11;23(10)
Molecules (Basel, Switzerland) 2018 Oct 11;23(10)
BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway.
Cao P, Zhao S, Sun Z, Jiang N, Shang Y, Wang Y, Gu J, Li S
Experimental cell research 2018 Oct 1;371(1):214-221
Experimental cell research 2018 Oct 1;371(1):214-221
Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop.
Yu Y, Shen X, Liu J, Hu Y, Ran Q, Mu C, Cai K
Colloids and surfaces. B, Biointerfaces 2018 Oct 1;170:1-10
Colloids and surfaces. B, Biointerfaces 2018 Oct 1;170:1-10
Inhibition of microRNA-143-3p attenuates myocardial hypertrophy by inhibiting inflammatory response.
Yu B, Zhao Y, Zhang H, Xie D, Nie W, Shi K
Cell biology international 2018 Nov;42(11):1584-1593
Cell biology international 2018 Nov;42(11):1584-1593
Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.
Kou G, Li Z, Wu C, Liu Y, Hu Y, Guo L, Xu X, Zhou Z
Journal of agricultural and food chemistry 2018 Nov 14;66(45):11917-11925
Journal of agricultural and food chemistry 2018 Nov 14;66(45):11917-11925
Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway.
Li X, Shang E, Dong Q, Li Y, Zhang J, Xu S, Zhao Z, Shao W, Lv C, Zheng Y, Wang H, Lei X, Zhu B, Zhang Z
The Journal of biological chemistry 2018 May 11;293(19):7423-7436
The Journal of biological chemistry 2018 May 11;293(19):7423-7436
Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.
Wei B, Huang C, Liu B, Wang Y, Xia N, Fan Q, Chen GQ, Cheng J
Cancer research 2018 May 1;78(9):2171-2178
Cancer research 2018 May 1;78(9):2171-2178
Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.
Lin J, Liu Y, Wu H, Huang Z, Ma J, Guo C, Gao F, Jin P, Wei P, Zhang Y, Liu L, Zhang R, Qiu L, Gu N, Wen L
Small (Weinheim an der Bergstrasse, Germany) 2018 Mar;14(13):e1703711
Small (Weinheim an der Bergstrasse, Germany) 2018 Mar;14(13):e1703711
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1.
Zhao Y, Liu Y, Lin L, Huang Q, He W, Zhang S, Dong S, Wen Z, Rao J, Liao W, Shi M
Molecular cancer 2018 Mar 6;17(1):69
Molecular cancer 2018 Mar 6;17(1):69
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.
Chen Y, Liu Z, Pan T, Chen E, Mao E, Chen Y, Tan R, Wang X, Tian R, Liu J, Qu H
International immunopharmacology 2018 Jun;59:40-46
International immunopharmacology 2018 Jun;59:40-46
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells.
Yan T, Zhang A, Shi F, Chang F, Mei J, Liu Y, Zhu Y
The Journal of biological chemistry 2018 Jun 29;293(26):10172-10185
The Journal of biological chemistry 2018 Jun 29;293(26):10172-10185
The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
Zuo X, Rong B, Li L, Lv R, Lan F, Tong MH
The Journal of biological chemistry 2018 Jun 15;293(24):9188-9197
The Journal of biological chemistry 2018 Jun 15;293(24):9188-9197
The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation.
Yuan Y, Li M, To CH, Lam TC, Wang P, Yu Y, Chen Q, Hu X, Ke B
Investigative ophthalmology & visual science 2018 Jul 2;59(8):3619-3629
Investigative ophthalmology & visual science 2018 Jul 2;59(8):3619-3629
Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.
Li L, Yang H, He Y, Li T, Feng J, Chen W, Ao L, Shi X, Lin Y, Liu H, Zheng E, Lin Q, Bu J, Zeng Y, Zheng M, Xu Y, Liao Z, Lin J, Lin D
Molecular and cellular biology 2018 Jan 15;38(2)
Molecular and cellular biology 2018 Jan 15;38(2)
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
He X, Yuan W, Li Z, Hou Y, Liu F, Feng J
Toxicology letters 2018 Feb;283:58-68
Toxicology letters 2018 Feb;283:58-68
CDK5-mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress.
Zhang Z, Zhang P, Qi GJ, Jiao FJ, Wang QZ, Yan JG, He F, Zhang Q, Lv ZX, Peng X, Cai HW, Chen X, Sun N, Tian B
Biochimica et biophysica acta. Molecular basis of disease 2018 Feb;1864(2):533-541
Biochimica et biophysica acta. Molecular basis of disease 2018 Feb;1864(2):533-541
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway.
Yuan G, Chen X, Liu Z, Wei W, Shu Q, Abou-Hamdan H, Jiang L, Li X, Chen R, Désaubry L, Zhou F, Xie D
Journal of experimental & clinical cancer research : CR 2018 Feb 7;37(1):21
Journal of experimental & clinical cancer research : CR 2018 Feb 7;37(1):21
Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells.
He J, Bao Q, Zhang Y, Liu M, Lv H, Liu Y, Yao L, Li B, Zhang C, He S, Zhai G, Zhu Y, Liu X, Zhang K, Wang XJ, Zou MH, Zhu Y, Ai D
Circulation research 2018 Feb 16;122(4):591-605
Circulation research 2018 Feb 16;122(4):591-605
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Li Y, Fu S, Li E, Sun X, Xu H, Meng Y, Wang X, Chen Y, Xie C, Geng S, Wu J, Zhong C, Xu P
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.
Wang Y, Hai B, Ai L, Cao Y, Li R, Li H, Li Y
Iranian journal of basic medical sciences 2018 Dec;21(12):1238-1244
Iranian journal of basic medical sciences 2018 Dec;21(12):1238-1244
DNase-1 Treatment Exerts Protective Effects in a Rat Model of Intestinal Ischemia-Reperfusion Injury.
Wang S, Xie T, Sun S, Wang K, Liu B, Wu X, Ding W
Scientific reports 2018 Dec 12;8(1):17788
Scientific reports 2018 Dec 12;8(1):17788
Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K
Bioscience reports 2018 Aug 31;38(4)
Bioscience reports 2018 Aug 31;38(4)
Thymol alleviates lipopolysaccharide-stimulated inflammatory response via downregulation of RhoA-mediated NF-κB signalling pathway in human peritoneal mesothelial cells.
Wang Q, Cheng F, Xu Y, Zhang J, Qi J, Liu X, Wang R
European journal of pharmacology 2018 Aug 15;833:210-220
European journal of pharmacology 2018 Aug 15;833:210-220
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
27-Hydroxycholesterol Inhibits Sterol Regulatory Element-Binding Protein 1 Activation and Hepatic Lipid Accumulation in Mice.
Li D, Long W, Huang R, Chen Y, Xia M
Obesity (Silver Spring, Md.) 2018 Apr;26(4):713-722
Obesity (Silver Spring, Md.) 2018 Apr;26(4):713-722
Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation.
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K
Molecules (Basel, Switzerland) 2018 Apr 30;23(5)
Molecules (Basel, Switzerland) 2018 Apr 30;23(5)
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.
Thompson LW, Morrison KD, Shirran SL, Groen EJN, Gillingwater TH, Botting CH, Sleeman JE
Journal of cell science 2018 Apr 17;131(8)
Journal of cell science 2018 Apr 17;131(8)
Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.
Lu Y, Qin Z, Wang J, Zheng X, Lu J, Zhang X, Wei L, Peng Q, Zheng Y, Ou C, Ye Q, Xiong W, Li G, Fu Y, Yan Q, Ma J
Journal of innate immunity 2017;9(6):574-586
Journal of innate immunity 2017;9(6):574-586
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
Jing C, Qu X, Li Z, Wu C, Zhao M, Wang Y, Sun S, Zhang S, Chen J, Qiao Y, Hu X, Yao X, Jin R, Wang X, Zhang L, Zhou X
American journal of cancer research 2017;7(12):2491-2502
American journal of cancer research 2017;7(12):2491-2502
trans-Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation.
Fu Y, Yang P, Zhao Y, Zhang L, Zhang Z, Dong X, Wu Z, Xu Y, Chen Y
Evidence-based complementary and alternative medicine : eCAM 2017;2017:4730878
Evidence-based complementary and alternative medicine : eCAM 2017;2017:4730878
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.
Wang J, Zhou Y, Li D, Sun X, Deng Y, Zhao Q
FEBS letters 2017 Sep;591(18):2905-2918
FEBS letters 2017 Sep;591(18):2905-2918
MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury.
Xu W, Li F, Liu Z, Xu Z, Sun B, Cao J, Liu Y
Oncotarget 2017 Sep 19;8(41):70669-70684
Oncotarget 2017 Sep 19;8(41):70669-70684
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.
Guan J, Zhao Q, Lv J, Zhang Z, Sun S, Mao W
Oncology letters 2017 Oct;14(4):4965-4970
Oncology letters 2017 Oct;14(4):4965-4970
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Yan S, Wei X, Xu S, Sun H, Wang W, Liu L, Jiang X, Zhang Y, Che Y
Oncotarget 2017 Oct 6;8(46):80909-80922
Oncotarget 2017 Oct 6;8(46):80909-80922
Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer.
Ling Z, Wang X, Tao T, Zhang L, Guan H, You Z, Lu K, Zhang G, Chen S, Wu J, Qian J, Liu H, Xu B, Chen M
Journal of experimental & clinical cancer research : CR 2017 Nov 15;36(1):159
Journal of experimental & clinical cancer research : CR 2017 Nov 15;36(1):159
YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.
Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H
Cancer research 2017 Nov 1;77(21):5769-5781
Cancer research 2017 Nov 1;77(21):5769-5781
Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients.
Xiang D, Cheng Z, Liu H, Wang X, Han T, Sun W, Li X, Yang W, Chen C, Xia M, Liu N, Yin S, Jin G, Lee T, Dong L, Hu H, Wang H, Ding J
Hepatology (Baltimore, Md.) 2017 May;65(5):1566-1580
Hepatology (Baltimore, Md.) 2017 May;65(5):1566-1580
Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition.
Wei H, Xu Z, Liu F, Wang F, Wang X, Sun X, Li J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317691684
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317691684
Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline.
Wang HT, Huang FL, Hu ZL, Zhang WJ, Qiao XQ, Huang YQ, Dai RP, Li F, Li CQ
Neurotoxicity research 2017 May;31(4):505-520
Neurotoxicity research 2017 May;31(4):505-520
Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling.
Yang G, Wang Y, Feng J, Liu Y, Wang T, Zhao M, Ye L, Zhang X
Biochemical and biophysical research communications 2017 May 6;486(3):827-832
Biochemical and biophysical research communications 2017 May 6;486(3):827-832
miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia.
Lyu X, Li J, Yun X, Huang R, Deng X, Wang Y, Chen Y, Xiao G
Oncology reports 2017 Mar;37(3):1469-1476
Oncology reports 2017 Mar;37(3):1469-1476
BTP2, a Store-Operated Calcium Channel Inhibitor, Attenuates Lung Ischemia-Reperfusion Injury in Rats.
Zhang W, Qi Z, Wang Y
Inflammation 2017 Jun;40(3):778-787
Inflammation 2017 Jun;40(3):778-787
Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways.
Jiang H, Wang Y, Ai M, Wang H, Duan Z, Wang H, Zhao L, Yu J, Ding Y, Wang S
Cell death & disease 2017 Jun 8;8(6):e2862
Cell death & disease 2017 Jun 8;8(6):e2862
RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.
Fei L, Ma Y, Zhang M, Liu X, Luo Y, Wang C, Zhang H, Zhang W, Han Y
Oncotarget 2017 Jun 20;8(25):40501-40513
Oncotarget 2017 Jun 20;8(25):40501-40513
Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.
Yang X, Tang S, Dai C, Li D, Zhang S, Deng S, Zhou Y, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jul;105:161-176
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jul;105:161-176
CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP+-induced Parkinson's disease model.
Jiao FJ, Wang QZ, Zhang P, Yan JG, Zhang Z, He F, Zhang Q, Lv ZX, Peng X, Cai HW, Tian B
Scientific reports 2017 Jul 17;7(1):5622
Scientific reports 2017 Jul 17;7(1):5622
Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Cheng W, Qi Y, Tian L, Wang B, Huang W, Chen Y
Cell death & disease 2017 Feb 23;8(2):e2628
Cell death & disease 2017 Feb 23;8(2):e2628
Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.
Stanic J, Mellone M, Napolitano F, Racca C, Zianni E, Minocci D, Ghiglieri V, Thiolat ML, Li Q, Longhi A, De Rosa A, Picconi B, Bezard E, Calabresi P, Di Luca M, Usiello A, Gardoni F
Neurobiology of disease 2017 Dec;108:54-64
Neurobiology of disease 2017 Dec;108:54-64
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Xue X, Zhang J, Lan H, Xu Y, Wang H
Scientific reports 2017 Aug 2;7(1):7116
Scientific reports 2017 Aug 2;7(1):7116
Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Chemico-biological interactions 2017 Aug 1;273:28-36
Chemico-biological interactions 2017 Aug 1;273:28-36
Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy.
Wang Q, Jiang H, Li Y, Chen W, Li H, Peng K, Zhang Z, Sun X
Biomaterials 2017 Apr;122:10-22
Biomaterials 2017 Apr;122:10-22
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
Li T, Hu J, Gao F, Du X, Chen Y, Wu Q
Scientific reports 2017 Apr 4;7:45807
Scientific reports 2017 Apr 4;7:45807
Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.
Yan Y, Zhao W, Huang Y, Tong H, Xia Y, Jiang Q, Qin J
Scientific reports 2017 Apr 10;7:46276
Scientific reports 2017 Apr 10;7:46276
Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.
Liu J, Chen Q, Jian Z, Xiong X, Shao L, Jin T, Zhu X, Wang L
BioMed research international 2016;2016:2816056
BioMed research international 2016;2016:2816056
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C
PloS one 2016;11(2):e0149032
PloS one 2016;11(2):e0149032
Compositional Analysis of Asymmetric and Symmetric Dimethylated H3R2 Using Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Proteomics.
Xu Q, Xu F, Liu L, Chen Y
Analytical chemistry 2016 Sep 6;88(17):8441-9
Analytical chemistry 2016 Sep 6;88(17):8441-9
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Sun B, Gao L, Ahsan A, Chu P, Song Y, Li H, Zhang Z, Lin Y, Peng J, Song Z, Wang S, Tang Z
International immunopharmacology 2016 Nov;40:400-409
International immunopharmacology 2016 Nov;40:400-409
Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents.
Zhang PY, Li G, Deng ZJ, Liu LY, Chen L, Tang JZ, Wang YQ, Cao ST, Fang YX, Wen F, Xu Y, Chen X, Shi KQ, Li WF, Xie C, Tang KF
Nucleic acids research 2016 May 5;44(8):3629-42
Nucleic acids research 2016 May 5;44(8):3629-42
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Jayaram H, Hoelper D, Jain SU, Cantone N, Lundgren SM, Poy F, Allis CD, Cummings R, Bellon S, Lewis PW
Proceedings of the National Academy of Sciences of the United States of America 2016 May 31;113(22):6182-7
Proceedings of the National Academy of Sciences of the United States of America 2016 May 31;113(22):6182-7
TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.
Ma ZY, Zhong ZG, Qiu MY, Zhong YH, Zhang WX
Biochemical and biophysical research communications 2016 Mar 18;471(4):576-81
Biochemical and biophysical research communications 2016 Mar 18;471(4):576-81
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR, Gardoni F, Di Luca M
eLife 2016 Mar 15;5:e12430
eLife 2016 Mar 15;5:e12430
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, Hu N, Xue J, Li H, Jiang W, Li G, Zhang X
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.
Cheng W, Tian L, Wang B, Qi Y, Huang W, Li H, Chen YJ
Oncotarget 2016 Jul 26;7(30):48107-48119
Oncotarget 2016 Jul 26;7(30):48107-48119
Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.
Huo Y, Zheng Z, Chen Y, Wang Q, Zhang Z, Deng H
Oncotarget 2016 Jul 19;7(29):45876-45888
Oncotarget 2016 Jul 19;7(29):45876-45888
Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.
Yu C, Tang W, Wang Y, Shen Q, Wang B, Cai C, Meng X, Zou F
Cancer letters 2016 Jul 1;376(2):268-77
Cancer letters 2016 Jul 1;376(2):268-77
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.
Gao Q, Liu Y, Wu Y, Zhao Q, Wang L, Gao S, Wen W, Zhang W, Guo N, Zhou J, Yuan Z
International journal of molecular medicine 2016 Feb;37(2):347-58
International journal of molecular medicine 2016 Feb;37(2):347-58
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.
Lingzi X, Zhihua Y, Xuelian L, Yangwu R, Haibo Z, Yuxia Z, Baosen Z
Oncotarget 2016 Dec 13;7(50):83101-83114
Oncotarget 2016 Dec 13;7(50):83101-83114
Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core.
Xu LL, Zhang X, Jiang ZY, You QD
Bioorganic & medicinal chemistry 2016 Aug 15;24(16):3540-7
Bioorganic & medicinal chemistry 2016 Aug 15;24(16):3540-7
Early ketamine exposure results in cardiac enlargement and heart dysfunction in Xenopus embryos.
Guo R, Liu G, Du M, Shi Y, Jiang P, Liu X, Liu L, Liu J, Xu Y
BMC anesthesiology 2016 Apr 18;16:23
BMC anesthesiology 2016 Apr 18;16:23
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY
PLoS genetics 2015 Sep;11(9):e1005357
PLoS genetics 2015 Sep;11(9):e1005357
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X, Ye L
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine Kinase Hippo to Induce Programmed Cell Death.
Dong DJ, Jing YP, Liu W, Wang JX, Zhao XF
The Journal of biological chemistry 2015 Oct 9;290(41):24738-46
The Journal of biological chemistry 2015 Oct 9;290(41):24738-46
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.
Qian Z, Wu Z, Huang L, Qiu H, Wang L, Li L, Yao L, Kang K, Qu J, Wu Y, Luo J, Liu JJ, Yang Y, Yang W, Gou D
Scientific reports 2015 Nov 30;5:17348
Scientific reports 2015 Nov 30;5:17348
Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP
Journal of medicinal chemistry 2015 Jul 23;58(14):5419-36
Journal of medicinal chemistry 2015 Jul 23;58(14):5419-36
Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.
Shi X, Chen G, Liu X, Qiu Y, Yang S, Zhang Y, Fang X, Zhang C, Liu X
International journal of molecular medicine 2015 Jan;35(1):31-8
International journal of molecular medicine 2015 Jan;35(1):31-8
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Gao L, Wang Y, Xu Z, Li X, Wu J, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Tao H, Li H, Su Y, Feng D, Wang X, Zhang C, Ma H, Hu Q
Molecular and cellular biochemistry 2014 Sep;394(1-2):23-30
Molecular and cellular biochemistry 2014 Sep;394(1-2):23-30
Role of NSD1 in H2O2-induced GSTM3 suppression.
Chu G, Li Y, Dong X, Liu J, Zhao Y
Cellular signalling 2014 Dec;26(12):2757-64
Cellular signalling 2014 Dec;26(12):2757-64
Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.
Tian D, Qiu Y, Zhan Y, Li X, Zhi X, Wang X, Yin L, Ning Y
Cardiovascular diabetology 2012 Nov 21;11:144
Cardiovascular diabetology 2012 Nov 21;11:144
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
Gong K, Xie J, Yi H, Li W
The Biochemical journal 2012 May 1;443(3):735-46
The Biochemical journal 2012 May 1;443(3):735-46
The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.
Liu S, Li L, Zhang Y, Zhang Y, Zhao Y, You X, Lin Z, Zhang X, Ye L
The Journal of biological chemistry 2012 Aug 31;287(36):30228-39
The Journal of biological chemistry 2012 Aug 31;287(36):30228-39
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 17168-1-AP(Histone-H3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Histone-H3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Histone-H3. This antibody recognizes human,mouse,rat antigen. The Histone-H3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
