BS8621

antibody from Bioworld Technology, Inc
Targeting: RFX5
Provider product page for BS8621
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8621 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RFX5 polyclonal antibody
Antibody type
Polyclonal
Antigen
DNA-binding protein RFX5; Regulatory factor X 5; RFX5
Description
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RFX5 protein structure - BS8621 shown in red.