orb385898

antibody from Biorbyt
Targeting: ZAP70 SRK, STD, ZAP-70
Provider product page for orb385898
Immunohistochemistry

Antibody data

Product number
orb385898 - Provider product page
Provider
Biorbyt
Product name
ZAP70 Antibody
Antibody type
Monoclonal
Description
Tyrosine-protein kinase ZAP70 is a tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, it phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. [UniProt]
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
ZTP70-1
Vial size
20 ug
Storage
Store the ZAP-70 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
ZAP70 protein structure - orb385898 shown in red.