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Targeting: DNMT3B
Western blot
Immunocytochemistry
Immunoprecipitation Immunohistochemistry Flow cytometry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [97]
- Comments [0]
- Validations
- Western blot [4]
- Flow cytometry [1]
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- Product number
- ABIN252478 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 52A1018
- Vial size
- 0.1 mg
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.
Intragenic DNA methylation prevents spurious transcription initiation.
Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma.
Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood.
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas.
Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway.
RISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells.
Mapping global changes in nuclear cytosine base modifications in the early mouse embryo.
Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.
Increased DNA methyltransferase 1 protein expression correlates significantly with intestinal histological type and gender in gastric carcinomas.
Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1.
Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.
DNA methyltransferase immunohistochemical expression in odontogenic tumours.
MicroRNA-196b promotes cell proliferation and suppress cell differentiation in vitro.
Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics.
The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences.
Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer.
Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis.
Novel epigenetic target therapy for prostate cancer: a preclinical study.
DNA methylation analysis of the macrosatellite repeat associated with FSHD muscular dystrophy at single nucleotide level.
Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway.
The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer.
Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications.
DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy.
Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.
Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells.
miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells.
Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
Induction of mouse germ-cell fate by transcription factors in vitro.
Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions.
Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression.
Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.
Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes.
Naive pluripotency is associated with global DNA hypomethylation.
DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation.
Pericentric heterochromatin generated by HP1 protein interaction-defective histone methyltransferase Suv39h1.
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver.
Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.
Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA.
Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b.
Role of DNMT3B in the regulation of early neural and neural crest specifiers.
Loss of post-transcriptional regulation of DNMT3b by microRNAs: a possible molecular mechanism for the hypermethylation defect observed in a subset of breast cancer cell lines.
Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity.
Mothers matter too: benefits of temperature oviposition preferences in newts.
Reduced expression of DNMT3B in the germ cells of patients with bilateral spermatogenic arrest does not lead to changes in the global methylation status.
B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.
De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state.
Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina.
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.
Epigenetic reprogramming as a key contributor to melanocyte malignant transformation.
V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.
Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation.
DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding.
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
DNMT3A mutations in acute myeloid leukemia.
Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor.
Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression.
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.
Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies.
DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen.
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos.
Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells.
Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex.
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus.
Helicobacter pylori regulates p21(WAF1) by histone H4 acetylation.
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.
Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.
Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells.
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.
Coordinate regulation of DNA methyltransferase expression during oogenesis.
Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L.
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.
Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development.
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b.
Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse.
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells.
Inhibition of DNA methyltransferase reverses cisplatin induced drug resistance in murine neuroblastoma cells.
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system.
Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.
Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development.
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Induction of DNA methylation and gene silencing by short interfering RNAs in human cells.
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer.
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation.
Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation.
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.
Mahadevan S, Sathappan V, Utama B, Lorenzo I, Kaskar K, Van den Veyver IB
Scientific reports 2017 Mar 20;7:44667
Scientific reports 2017 Mar 20;7:44667
Intragenic DNA methylation prevents spurious transcription initiation.
Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S
Nature 2017 Mar 2;543(7643):72-77
Nature 2017 Mar 2;543(7643):72-77
Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma.
Kumar SR, Bryan JN, Esebua M, Amos-Landgraf J, May TJ
BMC cancer 2017 Feb 24;17(1):158
BMC cancer 2017 Feb 24;17(1):158
Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood.
Li Y, Ma Q, Dasgupta C, Halavi S, Hartman RE, Xiao D, Zhang L
Molecular neurobiology 2017 Aug;54(6):3988-3999
Molecular neurobiology 2017 Aug;54(6):3988-3999
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Haney SL, Upchurch GM, Opavska J, Klinkebiel D, Appiah AK, Smith LM, Heavican TB, Iqbal J, Joshi S, Opavsky R
Scientific reports 2016 Sep 28;6:34222
Scientific reports 2016 Sep 28;6:34222
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas.
Daniel FI, Alves SR, Vieira DS, Biz MT, Daniel IW, Modolo F
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 Nov;45(10):774-779
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 Nov;45(10):774-779
Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway.
Hong B, Su Z, Zhang C, Yang Y, Guo Y, Li W, Kong AN
The AAPS journal 2016 May;18(3):659-69
The AAPS journal 2016 May;18(3):659-69
RISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells.
Pandolfini L, Luzi E, Bressan D, Ucciferri N, Bertacchi M, Brandi R, Rocchiccioli S, D'Onofrio M, Cremisi F
Genome biology 2016 May 6;17(1):94
Genome biology 2016 May 6;17(1):94
Mapping global changes in nuclear cytosine base modifications in the early mouse embryo.
Li Y, Seah MK, O'Neill C
Reproduction (Cambridge, England) 2016 Feb;151(2):83-95
Reproduction (Cambridge, England) 2016 Feb;151(2):83-95
Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.
Williams CA, Fernandez-Alonso R, Wang J, Toth R, Gray NS, Findlay GM
Cell reports 2016 Aug 16;16(7):1820-8
Cell reports 2016 Aug 16;16(7):1820-8
Increased DNA methyltransferase 1 protein expression correlates significantly with intestinal histological type and gender in gastric carcinomas.
Ksiâa F, Ziadi S, Dhiab MB, Gacem RB, Trimeche M
Advances in medical sciences 2015 Mar;60(1):50-7
Advances in medical sciences 2015 Mar;60(1):50-7
Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1.
Guo Y, Shu L, Zhang C, Su ZY, Kong AN
Biochemical pharmacology 2015 Mar 15;94(2):69-78
Biochemical pharmacology 2015 Mar 15;94(2):69-78
Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.
Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH
Development (Cambridge, England) 2015 Jun 15;142(12):2163-72
Development (Cambridge, England) 2015 Jun 15;142(12):2163-72
DNA methyltransferase immunohistochemical expression in odontogenic tumours.
Guimarães DM, Antunes DM, Duarte CM, Ferro LB, Nunes FD
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2015 Jan;44(1):59-66
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2015 Jan;44(1):59-66
MicroRNA-196b promotes cell proliferation and suppress cell differentiation in vitro.
Cao D, Hu L, Lei D, Fang X, Zhang Z, Wang T, Lin M, Huang J, Yang H, Zhou X, Zhong L
Biochemical and biophysical research communications 2015 Jan 30;457(1):1-6
Biochemical and biophysical research communications 2015 Jan 30;457(1):1-6
Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
Teneng I, Tellez CS, Picchi MA, Klinge DM, Yingling CM, Snider AM, Liu Y, Belinsky SA
Oncogene 2015 Jan 29;34(5):621-30
Oncogene 2015 Jan 29;34(5):621-30
Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics.
Neri F, Incarnato D, Krepelova A, Rapelli S, Anselmi F, Parlato C, Medana C, Dal Bello F, Oliviero S
Cell reports 2015 Feb 4;
Cell reports 2015 Feb 4;
The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences.
Ren J, Briones V, Barbour S, Yu W, Han Y, Terashima M, Muegge K
Nucleic acids research 2015 Feb 18;43(3):1444-55
Nucleic acids research 2015 Feb 18;43(3):1444-55
Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer.
Joensuu EI, Nieminen TT, Lotsari JE, Pavicic W, Abdel-Rahman WM, Peltomäki P
Genes, chromosomes & cancer 2015 Dec;54(12):776-87
Genes, chromosomes & cancer 2015 Dec;54(12):776-87
Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis.
Robaina MC, Mazzoccoli L, Arruda VO, Reis FR, Apa AG, de Rezende LM, Klumb CE
Experimental and molecular pathology 2015 Apr;98(2):200-7
Experimental and molecular pathology 2015 Apr;98(2):200-7
Novel epigenetic target therapy for prostate cancer: a preclinical study.
Naldi I, Taranta M, Gherardini L, Pelosi G, Viglione F, Grimaldi S, Pani L, Cinti C
PloS one 2014;9(5):e98101
PloS one 2014;9(5):e98101
DNA methylation analysis of the macrosatellite repeat associated with FSHD muscular dystrophy at single nucleotide level.
Huichalaf C, Micheloni S, Ferri G, Caccia R, Gabellini D
PloS one 2014;9(12):e115278
PloS one 2014;9(12):e115278
Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway.
Wang L, Zhang C, Guo Y, Su ZY, Yang Y, Shu L, Kong AN
The AAPS journal 2014 Nov;16(6):1214-25
The AAPS journal 2014 Nov;16(6):1214-25
The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer.
Chuang CH, Wang WJ, Li CF, Ko CY, Chou YH, Chuu CP, Cheng TL, Wang JM
Cell death & disease 2014 May 8;5:e1220
Cell death & disease 2014 May 8;5:e1220
Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.
Su ZY, Zhang C, Lee JH, Shu L, Wu TY, Khor TO, Conney AH, Lu YP, Kong AN
Cancer prevention research (Philadelphia, Pa.) 2014 Mar;7(3):319-29
Cancer prevention research (Philadelphia, Pa.) 2014 Mar;7(3):319-29
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
Serra RW, Fang M, Park SM, Hutchinson L, Green MR
eLife 2014 Mar 12;3:e02313
eLife 2014 Mar 12;3:e02313
Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications.
Paredes-Gonzalez X, Fuentes F, Su ZY, Kong AN
The AAPS journal 2014 Jul;16(4):727-35
The AAPS journal 2014 Jul;16(4):727-35
DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy.
Tajrishi MM, Shin J, Hetman M, Kumar A
The Journal of biological chemistry 2014 Jul 18;289(29):19985-99
The Journal of biological chemistry 2014 Jul 18;289(29):19985-99
Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.
Watson CJ, Collier P, Tea I, Neary R, Watson JA, Robinson C, Phelan D, Ledwidge MT, McDonald KM, McCann A, Sharaf O, Baugh JA
Human molecular genetics 2014 Apr 15;23(8):2176-88
Human molecular genetics 2014 Apr 15;23(8):2176-88
Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells.
Sheikh MA, Malik YS, Yu H, Lai M, Wang X, Zhu X
PloS one 2013;8(2):e55826
PloS one 2013;8(2):e55826
miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells.
Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK, Kuboki T
PloS one 2013;8(12):e83545
PloS one 2013;8(12):e83545
Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
Neri F, Krepelova A, Incarnato D, Maldotti M, Parlato C, Galvagni F, Matarese F, Stunnenberg HG, Oliviero S
Cell 2013 Sep 26;155(1):121-34
Cell 2013 Sep 26;155(1):121-34
Induction of mouse germ-cell fate by transcription factors in vitro.
Nakaki F, Hayashi K, Ohta H, Kurimoto K, Yabuta Y, Saitou M
Nature 2013 Sep 12;501(7466):222-6
Nature 2013 Sep 12;501(7466):222-6
Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions.
Ueda H, Tanaka H, Ichikawa K, Itabashi M, Kameoka S, Fujii S, Saito N, Kimura R, Shida Y, Fujimori Y, Ohtake S, Tomita S, Imura J, Yasuda Y, Tanigawa N, Uchiyama K, Fujimori T
Surgery today 2013 Nov;43(11):1275-80
Surgery today 2013 Nov;43(11):1275-80
Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression.
Gao J, Wang L, Xu J, Zheng J, Man X, Wu H, Jin J, Wang K, Xiao H, Li S, Li Z
Journal of experimental & clinical cancer research : CR 2013 Nov 5;32:86
Journal of experimental & clinical cancer research : CR 2013 Nov 5;32:86
Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.
Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E, Torres-Padilla ME
Cell reports 2013 Nov 14;5(3):687-701
Cell reports 2013 Nov 14;5(3):687-701
Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes.
Takahashi M, Kamei Y, Ehara T, Yuan X, Suganami T, Takai-Igarashi T, Hatada I, Ogawa Y
Biochemical and biophysical research communications 2013 May 17;434(4):873-8
Biochemical and biophysical research communications 2013 May 17;434(4):873-8
Naive pluripotency is associated with global DNA hypomethylation.
Leitch HG, McEwen KR, Turp A, Encheva V, Carroll T, Grabole N, Mansfield W, Nashun B, Knezovich JG, Smith A, Surani MA, Hajkova P
Nature structural & molecular biology 2013 Mar;20(3):311-6
Nature structural & molecular biology 2013 Mar;20(3):311-6
DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation.
Lai AY, Mav D, Shah R, Grimm SA, Phadke D, Hatzi K, Melnick A, Geigerman C, Sobol SE, Jaye DL, Wade PA
Genome research 2013 Dec;23(12):2030-41
Genome research 2013 Dec;23(12):2030-41
Pericentric heterochromatin generated by HP1 protein interaction-defective histone methyltransferase Suv39h1.
Muramatsu D, Singh PB, Kimura H, Tachibana M, Shinkai Y
The Journal of biological chemistry 2013 Aug 30;288(35):25285-96
The Journal of biological chemistry 2013 Aug 30;288(35):25285-96
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
Huidobro C, Urdinguio RG, Rodríguez RM, Mangas C, Calvanese V, Martínez-Camblor P, Ferrero C, Parra-Blanco A, Rodrigo L, Obaya AJ, Suárez-Fernández L, Astudillo A, Hernando H, Ballestar E, Fernández AF, Fraga MF
European journal of cancer (Oxford, England : 1990) 2012 Sep;48(14):2270-81
European journal of cancer (Oxford, England : 1990) 2012 Sep;48(14):2270-81
Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver.
Ehara T, Kamei Y, Takahashi M, Yuan X, Kanai S, Tamura E, Tanaka M, Yamazaki T, Miura S, Ezaki O, Suganami T, Okano M, Ogawa Y
Diabetes 2012 Oct;61(10):2442-50
Diabetes 2012 Oct;61(10):2442-50
Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.
Hong GM, Bain LJ
Toxicology and applied pharmacology 2012 May 1;260(3):250-9
Toxicology and applied pharmacology 2012 May 1;260(3):250-9
Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA.
Zhou JC, Blackledge NP, Farcas AM, Klose RJ
Molecular and cellular biology 2012 Jan;32(2):479-89
Molecular and cellular biology 2012 Jan;32(2):479-89
Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b.
Sandhu R, Rivenbark AG, Coleman WB
Breast cancer research and treatment 2012 Jan;131(2):385-99
Breast cancer research and treatment 2012 Jan;131(2):385-99
Role of DNMT3B in the regulation of early neural and neural crest specifiers.
Martins-Taylor K, Schroeder DI, LaSalle JM, Lalande M, Xu RH
Epigenetics 2012 Jan 1;7(1):71-82
Epigenetics 2012 Jan 1;7(1):71-82
Loss of post-transcriptional regulation of DNMT3b by microRNAs: a possible molecular mechanism for the hypermethylation defect observed in a subset of breast cancer cell lines.
Sandhu R, Rivenbark AG, Coleman WB
International journal of oncology 2012 Aug;41(2):721-32
International journal of oncology 2012 Aug;41(2):721-32
Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity.
Freudenberg JM, Ghosh S, Lackford BL, Yellaboina S, Zheng X, Li R, Cuddapah S, Wade PA, Hu G, Jothi R
Nucleic acids research 2012 Apr;40(8):3364-77
Nucleic acids research 2012 Apr;40(8):3364-77
Mothers matter too: benefits of temperature oviposition preferences in newts.
Kurdíková V, Smolinský R, Gvoždík L
PloS one 2011;6(8):e23842
PloS one 2011;6(8):e23842
Reduced expression of DNMT3B in the germ cells of patients with bilateral spermatogenic arrest does not lead to changes in the global methylation status.
Adiga SK, Ehmcke J, Schlatt S, Kliesch S, Westernströer B, Luetjens CM, Wistuba J, Gromoll J
Molecular human reproduction 2011 Sep;17(9):545-9
Molecular human reproduction 2011 Sep;17(9):545-9
B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.
Hamel KM, Cao Y, Ashaye S, Wang Y, Dunn R, Kehry MR, Glant TT, Finnegan A
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 1;187(9):4900-6
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 1;187(9):4900-6
De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state.
Pawlak M, Jaenisch R
Genes & development 2011 May 15;25(10):1035-40
Genes & development 2011 May 15;25(10):1035-40
Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina.
Nasonkin IO, Lazo K, Hambright D, Brooks M, Fariss R, Swaroop A
The Journal of comparative neurology 2011 Jul 1;519(10):1914-30
The Journal of comparative neurology 2011 Jul 1;519(10):1914-30
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
Mutze K, Langer R, Schumacher F, Becker K, Ott K, Novotny A, Hapfelmeier A, Höfler H, Keller G
European journal of cancer (Oxford, England : 1990) 2011 Aug;47(12):1817-25
European journal of cancer (Oxford, England : 1990) 2011 Aug;47(12):1817-25
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.
Ibrahim AE, Arends MJ, Silva AL, Wyllie AH, Greger L, Ito Y, Vowler SL, Huang TH, Tavaré S, Murrell A, Brenton JD
Gut 2011 Apr;60(4):499-508
Gut 2011 Apr;60(4):499-508
Epigenetic reprogramming as a key contributor to melanocyte malignant transformation.
Molognoni F, Cruz AT, Meliso FM, Morais AS, Souza CF, Xander P, Bischof JM, Costa FF, Soares MB, Liang G, Jones PA, Jasiulionis MG
Epigenetics 2011 Apr;6(4):450-64
Epigenetics 2011 Apr;6(4):450-64
V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.
Carragher LA, Snell KR, Giblett SM, Aldridge VS, Patel B, Cook SJ, Winton DJ, Marais R, Pritchard CA
EMBO molecular medicine 2010 Nov;2(11):458-71
EMBO molecular medicine 2010 Nov;2(11):458-71
Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation.
Park CW, Zeng Y, Steer CJ
Journal of cardiovascular translational research 2010 Jun;3(3):290-5
Journal of cardiovascular translational research 2010 Jun;3(3):290-5
DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding.
Pierard V, Guiguen A, Colin L, Wijmeersch G, Vanhulle C, Van Driessche B, Dekoninck A, Blazkova J, Cardona C, Merimi M, Vierendeel V, Calomme C, Nguyên TL, Nuttinck M, Twizere JC, Kettmann R, Portetelle D, Burny A, Hirsch I, Rohr O, Van Lint C
The Journal of biological chemistry 2010 Jun 18;285(25):19434-49
The Journal of biological chemistry 2010 Jun 18;285(25):19434-49
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Wu Y, Alvarez M, Slamon DJ, Koeffler P, Vadgama JV
BMC cancer 2010 Feb 4;10:32
BMC cancer 2010 Feb 4;10:32
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Daniel FI, Rivero ER, Modolo F, Lopes TG, Salum FG
Archives of oral biology 2010 Dec;55(12):1024-30
Archives of oral biology 2010 Dec;55(12):1024-30
DNMT3A mutations in acute myeloid leukemia.
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
The New England journal of medicine 2010 Dec 16;363(25):2424-33
The New England journal of medicine 2010 Dec 16;363(25):2424-33
Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor.
Hwang CK, Song KY, Kim CS, Choi HS, Guo XH, Law PY, Wei LN, Loh HH
Journal of cellular and molecular medicine 2009 Sep;13(9B):3591-615
Journal of cellular and molecular medicine 2009 Sep;13(9B):3591-615
Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression.
Palakurthy RK, Wajapeyee N, Santra MK, Gazin C, Lin L, Gobeil S, Green MR
Molecular cell 2009 Oct 23;36(2):219-30
Molecular cell 2009 Oct 23;36(2):219-30
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.
Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F, Leonhardt H
EMBO reports 2009 Nov;10(11):1259-64
EMBO reports 2009 Nov;10(11):1259-64
Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies.
Ye Y, McDevitt MA, Guo M, Zhang W, Galm O, Gore SD, Karp JE, Maciejewski JP, Kowalski J, Tsai HL, Gondek LP, Tsai HC, Wang X, Hooker C, Smith BD, Carraway HE, Herman JG
Cancer research 2009 Nov 1;69(21):8482-90
Cancer research 2009 Nov 1;69(21):8482-90
DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen.
Yamagata Y, Asada H, Tamura I, Lee L, Maekawa R, Taniguchi K, Taketani T, Matsuoka A, Tamura H, Sugino N
Human reproduction (Oxford, England) 2009 May;24(5):1126-32
Human reproduction (Oxford, England) 2009 May;24(5):1126-32
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Nosho K, Shima K, Irahara N, Kure S, Baba Y, Kirkner GJ, Chen L, Gokhale S, Hazra A, Spiegelman D, Giovannucci EL, Jaenisch R, Fuchs CS, Ogino S
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jun 1;15(11):3663-71
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jun 1;15(11):3663-71
Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos.
Hirasawa R, Sasaki H
Gene expression patterns : GEP 2009 Jan;9(1):27-30
Gene expression patterns : GEP 2009 Jan;9(1):27-30
Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells.
Zhu X, Mao X, Hurren R, Schimmer AD, Ezzat S, Asa SL
The Journal of clinical endocrinology and metabolism 2008 Sep;93(9):3610-7
The Journal of clinical endocrinology and metabolism 2008 Sep;93(9):3610-7
Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex.
Ko CY, Hsu HC, Shen MR, Chang WC, Wang JM
The Journal of biological chemistry 2008 Nov 7;283(45):30919-32
The Journal of biological chemistry 2008 Nov 7;283(45):30919-32
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus.
Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP
Molecular and cellular biology 2008 May;28(10):3457-64
Molecular and cellular biology 2008 May;28(10):3457-64
Helicobacter pylori regulates p21(WAF1) by histone H4 acetylation.
Xia G, Schneider-Stock R, Diestel A, Habold C, Krueger S, Roessner A, Naumann M, Lendeckel U
Biochemical and biophysical research communications 2008 May 2;369(2):526-31
Biochemical and biophysical research communications 2008 May 2;369(2):526-31
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.
Hirasawa R, Chiba H, Kaneda M, Tajima S, Li E, Jaenisch R, Sasaki H
Genes & development 2008 Jun 15;22(12):1607-16
Genes & development 2008 Jun 15;22(12):1607-16
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.
O'Hagan HM, Mohammad HP, Baylin SB
PLoS genetics 2008 Aug 15;4(8):e1000155
PLoS genetics 2008 Aug 15;4(8):e1000155
Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.
Butcher DT, Rodenhiser DI
European journal of cancer (Oxford, England : 1990) 2007 Jan;43(1):210-9
European journal of cancer (Oxford, England : 1990) 2007 Jan;43(1):210-9
Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells.
Fini L, Selgrad M, Fogliano V, Graziani G, Romano M, Hotchkiss E, Daoud YA, De Vol EB, Boland CR, Ricciardiello L
The Journal of nutrition 2007 Dec;137(12):2622-8
The Journal of nutrition 2007 Dec;137(12):2622-8
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.
Linhart HG, Lin H, Yamada Y, Moran E, Steine EJ, Gokhale S, Lo G, Cantu E, Ehrich M, He T, Meissner A, Jaenisch R
Genes & development 2007 Dec 1;21(23):3110-22
Genes & development 2007 Dec 1;21(23):3110-22
Coordinate regulation of DNA methyltransferase expression during oogenesis.
Lucifero D, La Salle S, Bourc'his D, Martel J, Bestor TH, Trasler JM
BMC developmental biology 2007 Apr 19;7:36
BMC developmental biology 2007 Apr 19;7:36
Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.
Nimura K, Ishida C, Koriyama H, Hata K, Yamanaka S, Li E, Ura K, Kaneda Y
Genes to cells : devoted to molecular & cellular mechanisms 2006 Oct;11(10):1225-37
Genes to cells : devoted to molecular & cellular mechanisms 2006 Oct;11(10):1225-37
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L.
Xie ZH, Huang YN, Chen ZX, Riggs AD, Ding JP, Gowher H, Jeltsch A, Sasaki H, Hata K, Xu GL
Human molecular genetics 2006 May 1;15(9):1375-85
Human molecular genetics 2006 May 1;15(9):1375-85
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.
Ueda Y, Okano M, Williams C, Chen T, Georgopoulos K, Li E
Development (Cambridge, England) 2006 Mar;133(6):1183-92
Development (Cambridge, England) 2006 Mar;133(6):1183-92
Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development.
Jones B, Chen J
The EMBO journal 2006 Jun 7;25(11):2443-52
The EMBO journal 2006 Jun 7;25(11):2443-52
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b.
Tsumura A, Hayakawa T, Kumaki Y, Takebayashi S, Sakaue M, Matsuoka C, Shimotohno K, Ishikawa F, Li E, Ueda HR, Nakayama J, Okano M
Genes to cells : devoted to molecular & cellular mechanisms 2006 Jul;11(7):805-14
Genes to cells : devoted to molecular & cellular mechanisms 2006 Jul;11(7):805-14
Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse.
La Salle S, Trasler JM
Developmental biology 2006 Aug 1;296(1):71-82
Developmental biology 2006 Aug 1;296(1):71-82
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Lin H, Yamada Y, Nguyen S, Linhart H, Jackson-Grusby L, Meissner A, Meletis K, Lo G, Jaenisch R
Molecular and cellular biology 2006 Apr;26(8):2976-83
Molecular and cellular biology 2006 Apr;26(8):2976-83
Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells.
Loriot A, De Plaen E, Boon T, De Smet C
The Journal of biological chemistry 2006 Apr 14;281(15):10118-26
The Journal of biological chemistry 2006 Apr 14;281(15):10118-26
Inhibition of DNA methyltransferase reverses cisplatin induced drug resistance in murine neuroblastoma cells.
Qiu YY, Mirkin BL, Dwivedi RS
Cancer detection and prevention 2005;29(5):456-63
Cancer detection and prevention 2005;29(5):456-63
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system.
Feng J, Chang H, Li E, Fan G
Journal of neuroscience research 2005 Mar 15;79(6):734-46
Journal of neuroscience research 2005 Mar 15;79(6):734-46
Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.
Carlone DL, Lee JH, Young SR, Dobrota E, Butler JS, Ruiz J, Skalnik DG
Molecular and cellular biology 2005 Jun;25(12):4881-91
Molecular and cellular biology 2005 Jun;25(12):4881-91
Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development.
MacDonald JL, Gin CS, Roskams AJ
Developmental biology 2005 Dec 15;288(2):461-73
Developmental biology 2005 Dec 15;288(2):461-73
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Lin TS, Lee H, Chen RA, Ho ML, Lin CY, Chen YH, Tsai YY, Chou MC, Cheng YW
Cancer letters 2005 Aug 8;226(1):77-84
Cancer letters 2005 Aug 8;226(1):77-84
Induction of DNA methylation and gene silencing by short interfering RNAs in human cells.
Kawasaki H, Taira K
Nature 2004 Sep 9;431(7005):211-7
Nature 2004 Sep 9;431(7005):211-7
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer.
Leu YW, Yan PS, Fan M, Jin VX, Liu JC, Curran EM, Welshons WV, Wei SH, Davuluri RV, Plass C, Nephew KP, Huang TH
Cancer research 2004 Nov 15;64(22):8184-92
Cancer research 2004 Nov 15;64(22):8184-92
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation.
Weisenberger DJ, Velicescu M, Cheng JC, Gonzales FA, Liang G, Jones PA
Molecular cancer research : MCR 2004 Jan;2(1):62-72
Molecular cancer research : MCR 2004 Jan;2(1):62-72
Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation.
Leu YW, Rahmatpanah F, Shi H, Wei SH, Liu JC, Yan PS, Huang TH
Cancer research 2003 Oct 1;63(19):6110-5
Cancer research 2003 Oct 1;63(19):6110-5
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.
Santoro R, Li J, Grummt I
Nature genetics 2002 Nov;32(3):393-6
Nature genetics 2002 Nov;32(3):393-6
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