613802

antibody from BioLegend
Targeting: NBN AT-V1, AT-V2, ATV, NBS, NBS1
Provider product page for 613802
Western blot
Immunocytochemistry

Antibody data

Product number
613802 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#613802, RRID:AB_2149251
Product name
Purified anti-NBS1
Antibody type
Polyclonal
Antigen
Recombinant (partial), C-terminal
Description
NBS1 (Nijmegen breakage syndrome 1, p95 protein of the MRE11/RAD50 complex) is a 95 kD nuclear protein that contains a FHA domain and BRCT domain. NBS1 is involved in DNA double-strand break repair, and DNA damage-induced checkpoint activation. NBS1 mutations are associated with Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. This protein is activated by irradiation, upregulated by c-Myc, and modified by phosphorylation. NBS1 is a component of the double-strand break repair complex consisting of DNL IV/XRCC4, Ku, MRE11, and RAD50. NBS1 has also been shown to associate with FANCD2. The Poly6138 antibody recognizes the C-terminal region of human and mouse NBS1 and has been shown to be useful for Western blotting.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
200 µl
Storage
Upon receipt, store frozen at -20° C.
NBN protein structure - 613802 shown in red.