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LearnNB100-143
antibody from Novus Biologicals
Targeting: NBN
AT-V1, AT-V2, ATV, NBS, NBS1
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ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [184]
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- Western blot [4]
- Immunohistochemistry [1]
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- Product number
- NB100-143 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-143, RRID:AB_10078050
- Product name
- Rabbit Polyclonal Nbs1 Antibody
- Antibody type
- Polyclonal
- Description
- Unpurified.
- Reactivity
- Human, Mouse, Hamster, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.05 ml
- Storage
- Store at 4C. Do not freeze.
Submitted references FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses.
Human RAD50 deficiency: Confirmation of a distinctive phenotype.
The internal region of CtIP negatively regulates DNA end resection.
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.
RAD50 regulates mitotic progression independent of DNA repair functions.
Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair.
Prognostic effects of abnormal DNA damage response protein expression in breast cancer.
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.
UFL1 promotes histone H4 ufmylation and ATM activation.
Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays.
Viral replication centers and the DNA damage response in JC virus-infected cells.
Increased error-free DNA repair gene expression through reprogramming in human iPS cells.
NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation.
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.
Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex.
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria.
AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair.
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
DEK is required for homologous recombination repair of DNA breaks.
Association of Human Papillomavirus 16 E2 with Rad50-Interacting Protein 1 Enhances Viral DNA Replication.
Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells.
NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein.
Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency.
H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation.
An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.
DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.
Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction.
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.
Generation of iPSC lines from a Nijmegen Breakage Syndrome patient.
USP4 Auto-Deubiquitylation Promotes Homologous Recombination.
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.
Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
Notch is a direct negative regulator of the DNA-damage response.
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.
Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.
Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complex.
Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation.
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer.
Listeria monocytogenes dampens the DNA damage response.
Functional characterization of the TERRA transcriptome at damaged telomeres.
The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.
Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.
TopBP1 deficiency impairs V(D)J recombination during lymphocyte development.
Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response.
Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer.
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.
DNA damage to a single chromosome end delays anaphase onset.
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.
Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways.
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.
Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters.
Host DNA damage response facilitates African swine fever virus infection.
DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.
Inhibition of DNA damage repair by artificial activation of PARP with siDNA.
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
CtIP is required to initiate replication-dependent interstrand crosslink repair.
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors.
Prognostic significance of NBS1 and Snail expression in esophageal squamous cell carcinoma.
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
The papillomavirus E1 helicase activates a cellular DNA damage response in viral replication foci.
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation.
Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.
Growth suppression of human hepatocellular carcinoma xenografts by a monoclonal antibody CH12 directed to epidermal growth factor receptor variant III.
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Identification of increased NBS1 expression as a prognostic marker of squamous cell carcinoma of the oral cavity.
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.
Small-molecule drugs mimicking DNA damage: a new strategy for sensitizing tumors to radiotherapy.
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses.
Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
A role for DEAD box 1 at DNA double-strand breaks.
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.
ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner.
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.
Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity.
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.
Mdm2 promotes genetic instability and transformation independent of p53.
Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif.
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.
Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity.
Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity.
Inhibition of hsp90 compromises the DNA damage response to radiation.
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity.
Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres.
Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability.
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Mild Nijmegen breakage syndrome phenotype due to alternative splicing.
Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation.
Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients.
Involvement of novel autophosphorylation sites in ATM activation.
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1.
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle.
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells.
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability.
Evasion of early cellular response mechanisms following low level radiation-induced DNA damage.
Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.
Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation.
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H.
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
The mismatch repair system is required for S-phase checkpoint activation.
Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3' overhang specific DNA.
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts.
Human MRE11 is inactivated in mismatch repair-deficient cancers.
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.
Interaction of FANCD2 and NBS1 in the DNA damage response.
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
Chk2 activation dependence on Nbs1 after DNA damage.
NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres.
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Independence of R/M/N focus formation and the presence of intact BRCA1.
Independence of R/M/N focus formation and the presence of intact BRCA1.
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Qi F, Meng Q, Hayashi I, Kobayashi J
Journal of radiation research 2020 May 22;61(3):368-375
Journal of radiation research 2020 May 22;61(3):368-375
Human RAD50 deficiency: Confirmation of a distinctive phenotype.
Ragamin A, Yigit G, Bousset K, Beleggia F, Verheijen FW, de Wit MY, Strom TM, Dörk T, Wollnik B, Mancini GMS
American journal of medical genetics. Part A 2020 Jun;182(6):1378-1386
American journal of medical genetics. Part A 2020 Jun;182(6):1378-1386
The internal region of CtIP negatively regulates DNA end resection.
Howard SM, Ceppi I, Anand R, Geiger R, Cejka P
Nucleic acids research 2020 Jun 4;48(10):5485-5498
Nucleic acids research 2020 Jun 4;48(10):5485-5498
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.
Mooser C, Symeonidou IE, Leimbacher PA, Ribeiro A, Shorrocks AK, Jungmichel S, Larsen SC, Knechtle K, Jasrotia A, Zurbriggen D, Jeanrenaud A, Leikauf C, Fink D, Nielsen ML, Blackford AN, Stucki M
Nature communications 2020 Jan 8;11(1):123
Nature communications 2020 Jan 8;11(1):123
RAD50 regulates mitotic progression independent of DNA repair functions.
Völkening L, Vatselia A, Asgedom G, Bastians H, Lavin M, Schindler D, Schambach A, Bousset K, Dörk T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2812-2820
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2812-2820
Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair.
Korsholm LM, Gál Z, Lin L, Quevedo O, Ahmad DA, Dulina E, Luo Y, Bartek J, Larsen DH
Nucleic acids research 2019 Sep 5;47(15):8019-8035
Nucleic acids research 2019 Sep 5;47(15):8019-8035
Prognostic effects of abnormal DNA damage response protein expression in breast cancer.
Suh KJ, Ryu HS, Lee KH, Kim H, Min A, Kim TY, Yang Y, Lee HB, Moon HG, Han SW, Oh DY, Han W, Park IA, Noh DY, Im SA
Breast cancer research and treatment 2019 May;175(1):117-127
Breast cancer research and treatment 2019 May;175(1):117-127
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.
Leimbacher PA, Jones SE, Shorrocks AK, de Marco Zompit M, Day M, Blaauwendraad J, Bundschuh D, Bonham S, Fischer R, Fink D, Kessler BM, Oliver AW, Pearl LH, Blackford AN, Stucki M
Molecular cell 2019 May 2;74(3):571-583.e8
Molecular cell 2019 May 2;74(3):571-583.e8
UFL1 promotes histone H4 ufmylation and ATM activation.
Qin B, Yu J, Nowsheen S, Wang M, Tu X, Liu T, Li H, Wang L, Lou Z
Nature communications 2019 Mar 18;10(1):1242
Nature communications 2019 Mar 18;10(1):1242
Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays.
Lamarche BJ, Orazio NI, Goben B, Meisenhelder J, You Z, Weitzman MD, Hunter T
DNA repair 2019 Feb;74:80-90
DNA repair 2019 Feb;74:80-90
Viral replication centers and the DNA damage response in JC virus-infected cells.
Erickson KD, Garcea RL
Virology 2019 Feb;528:198-206
Virology 2019 Feb;528:198-206
Increased error-free DNA repair gene expression through reprogramming in human iPS cells.
Yoshimura Y
Regenerative therapy 2019 Dec;11:101-105
Regenerative therapy 2019 Dec;11:101-105
NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation.
Anand R, Jasrotia A, Bundschuh D, Howard SM, Ranjha L, Stucki M, Cejka P
The EMBO journal 2019 Apr 1;38(7)
The EMBO journal 2019 Apr 1;38(7)
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Gustafsson NMS, Färnegårdh K, Bonagas N, Ninou AH, Groth P, Wiita E, Jönsson M, Hallberg K, Lehto J, Pennisi R, Martinsson J, Norström C, Hollers J, Schultz J, Andersson M, Markova N, Marttila P, Kim B, Norin M, Olin T, Helleday T
Nature communications 2018 Sep 24;9(1):3872
Nature communications 2018 Sep 24;9(1):3872
The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.
Gao Y, Kardos J, Yang Y, Tamir TY, Mutter-Rottmayer E, Weissman B, Major MB, Kim WY, Vaziri C
Scientific reports 2018 Oct 17;8(1):15304
Scientific reports 2018 Oct 17;8(1):15304
Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex.
Pancholi NJ, Weitzman MD
Virology 2018 May;518:221-231
Virology 2018 May;518:221-231
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria.
Qian M, Liu Z, Peng L, Tang X, Meng F, Ao Y, Zhou M, Wang M, Cao X, Qin B, Wang Z, Zhou Z, Wang G, Gao Z, Xu J, Liu B
eLife 2018 May 2;7
eLife 2018 May 2;7
AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair.
Moyal L, Goldfeiz N, Gorovitz B, Rephaeli A, Tal E, Tarasenko N, Nudelman A, Ziv Y, Hodak E
Investigational new drugs 2018 Feb;36(1):1-9
Investigational new drugs 2018 Feb;36(1):1-9
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Ward TA, McHugh PJ, Durant ST
PloS one 2017;12(6):e0179278
PloS one 2017;12(6):e0179278
DEK is required for homologous recombination repair of DNA breaks.
Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI
Scientific reports 2017 Mar 20;7:44662
Scientific reports 2017 Mar 20;7:44662
Association of Human Papillomavirus 16 E2 with Rad50-Interacting Protein 1 Enhances Viral DNA Replication.
Campos-León K, Wijendra K, Siddiqa A, Pentland I, Feeney KM, Knapman A, Davies R, Androphy EJ, Parish JL
Journal of virology 2017 Mar 1;91(5)
Journal of virology 2017 Mar 1;91(5)
Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells.
Burke RT, Marcus JM, Orth JD
Oncotarget 2017 Jun 13;8(24):39460-39475
Oncotarget 2017 Jun 13;8(24):39460-39475
NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein.
Zhou H, Kawamura K, Yanagihara H, Kobayashi J, Zhang-Akiyama QM
Journal of radiation research 2017 Jul 1;58(4):487-494
Journal of radiation research 2017 Jul 1;58(4):487-494
Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency.
Mariggiò G, Koch S, Zhang G, Weidner-Glunde M, Rückert J, Kati S, Santag S, Schulz TF
PLoS pathogens 2017 Apr;13(4):e1006335
PLoS pathogens 2017 Apr;13(4):e1006335
H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation.
Xu Z, Song Z, Li G, Tu H, Liu W, Liu Y, Wang P, Wang Y, Cui X, Liu C, Shang Y, de Rooij DG, Gao F, Li W
Nucleic acids research 2016 Nov 16;44(20):9681-9697
Nucleic acids research 2016 Nov 16;44(20):9681-9697
An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates.
Lou DI, Kim ET, Meyerson NR, Pancholi NJ, Mohni KN, Enard D, Petrov DA, Weller SK, Weitzman MD, Sawyer SL
Cell host & microbe 2016 Aug 10;20(2):178-88
Cell host & microbe 2016 Aug 10;20(2):178-88
DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.
Francia S, Cabrini M, Matti V, Oldani A, d'Adda di Fagagna F
Journal of cell science 2016 Apr 1;129(7):1468-76
Journal of cell science 2016 Apr 1;129(7):1468-76
Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction.
Mano M, Ippodrino R, Zentilin L, Zacchigna S, Giacca M
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 8;112(36):11276-81
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 8;112(36):11276-81
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF
Nucleic acids research 2015 Sep 30;43(17):8352-67
Nucleic acids research 2015 Sep 30;43(17):8352-67
EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.
Rein K, Yanez DA, Terré B, Palenzuela L, Aivio S, Wei K, Edelmann W, Stark JM, Stracker TH
Nucleic acids research 2015 Sep 3;43(15):7371-87
Nucleic acids research 2015 Sep 3;43(15):7371-87
Generation of iPSC lines from a Nijmegen Breakage Syndrome patient.
Mlody B, Adjaye J
Stem cell research 2015 Nov;15(3):629-32
Stem cell research 2015 Nov;15(3):629-32
USP4 Auto-Deubiquitylation Promotes Homologous Recombination.
Wijnhoven P, Konietzny R, Blackford AN, Travers J, Kessler BM, Nishi R, Jackson SP
Molecular cell 2015 Nov 5;60(3):362-73
Molecular cell 2015 Nov 5;60(3):362-73
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.
Xing M, Wang X, Palmai-Pallag T, Shen H, Helleday T, Hickson ID, Ying S
Oncotarget 2015 Nov 10;6(35):37638-46
Oncotarget 2015 Nov 10;6(35):37638-46
Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, Kiyono T
Journal of virology 2015 May;89(9):5040-59
Journal of virology 2015 May;89(9):5040-59
Notch is a direct negative regulator of the DNA-damage response.
Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F
Nature structural & molecular biology 2015 May;22(5):417-24
Nature structural & molecular biology 2015 May;22(5):417-24
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.
Chen WT, Ebelt ND, Stracker TH, Xhemalce B, Van Den Berg CL, Miller KM
eLife 2015 Jun 1;4
eLife 2015 Jun 1;4
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.
Lee KY, Im JS, Shibata E, Park J, Handa N, Kowalczykowski SC, Dutta A
Nature communications 2015 Jul 28;6:7744
Nature communications 2015 Jul 28;6:7744
Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.
Goldstein M, Kastan MB
Cancer research 2015 Jul 1;75(13):2699-707
Cancer research 2015 Jul 1;75(13):2699-707
Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complex.
Lentz TB, Samulski RJ
Journal of virology 2015 Jan;89(1):181-94
Journal of virology 2015 Jan;89(1):181-94
Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation.
Xie M, Park D, You S, Li R, Owonikoko TK, Wang Y, Doetsch PW, Deng X
Nucleic acids research 2015 Jan;43(2):960-72
Nucleic acids research 2015 Jan;43(2):960-72
Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs).
Patel JP, Puck JM, Srinivasan R, Brown C, Sunderam U, Kundu K, Brenner SE, Gatti RA, Church JA
Journal of clinical immunology 2015 Feb;35(2):227-33
Journal of clinical immunology 2015 Feb;35(2):227-33
Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
Kobayashi J, Saito Y, Okui M, Miwa N, Komatsu K
Mutation research. Genetic toxicology and environmental mutagenesis 2015 Apr;782:42-50
Mutation research. Genetic toxicology and environmental mutagenesis 2015 Apr;782:42-50
Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer.
Boulware SB, Christensen LA, Thames H, Coghlan L, Vasquez KM, Finch RA
Molecular carcinogenesis 2014 Sep;53(9):744-52
Molecular carcinogenesis 2014 Sep;53(9):744-52
Listeria monocytogenes dampens the DNA damage response.
Samba-Louaka A, Pereira JM, Nahori MA, Villiers V, Deriano L, Hamon MA, Cossart P
PLoS pathogens 2014 Oct;10(10):e1004470
PLoS pathogens 2014 Oct;10(10):e1004470
Functional characterization of the TERRA transcriptome at damaged telomeres.
Porro A, Feuerhahn S, Delafontaine J, Riethman H, Rougemont J, Lingner J
Nature communications 2014 Oct 31;5:5379
Nature communications 2014 Oct 31;5:5379
The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
Tahara M, Inoue T, Sato F, Miyakura Y, Horie H, Yasuda Y, Fujii H, Kotake K, Sugano K
Molecular cancer therapeutics 2014 May;13(5):1170-80
Molecular cancer therapeutics 2014 May;13(5):1170-80
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.
Pessina F, Lowndes NF
PLoS biology 2014 May;12(5):e1001856
PLoS biology 2014 May;12(5):e1001856
Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.
Schröder-Heurich B, Wieland B, Lavin MF, Schindler D, Dörk T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Mar;28(3):1331-41
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Mar;28(3):1331-41
TopBP1 deficiency impairs V(D)J recombination during lymphocyte development.
Kim J, Lee SK, Jeon Y, Kim Y, Lee C, Jeon SH, Shim J, Kim IH, Hong S, Kim N, Lee H, Seong RH
The EMBO journal 2014 Feb 3;33(3):217-28
The EMBO journal 2014 Feb 3;33(3):217-28
Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response.
Ciccia A, Huang JW, Izhar L, Sowa ME, Harper JW, Elledge SJ
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 30;111(52):18631-6
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 30;111(52):18631-6
Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer.
Lajud SA, Nagda DA, Yamashita T, Zheng J, Tanaka N, Abuzeid WM, Civantos A, Bezpalko O, O'Malley BW Jr, Li D
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Dec 15;20(24):6465-78
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Dec 15;20(24):6465-78
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.
Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M
Nature cell biology 2014 Aug;16(8):792-803
Nature cell biology 2014 Aug;16(8):792-803
DNA damage to a single chromosome end delays anaphase onset.
Silva BA, Stambaugh JR, Yokomori K, Shah JV, Berns MW
The Journal of biological chemistry 2014 Aug 15;289(33):22771-22784
The Journal of biological chemistry 2014 Aug 15;289(33):22771-22784
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.
Gatei M, Kijas AW, Biard D, Dörk T, Lavin MF
Human molecular genetics 2014 Aug 15;23(16):4232-48
Human molecular genetics 2014 Aug 15;23(16):4232-48
Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
Wang JQ, Chen JH, Chen YC, Chen MY, Hsieh CY, Teng SC, Wu KJ
PloS one 2013;8(6):e65586
PloS one 2013;8(6):e65586
Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways.
Silva BA, Stambaugh JR, Berns MW
Journal of biomedical optics 2013 Sep;18(9):095003
Journal of biomedical optics 2013 Sep;18(9):095003
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.
Wang WY, Pan L, Su SC, Quinn EJ, Sasaki M, Jimenez JC, Mackenzie IR, Huang EJ, Tsai LH
Nature neuroscience 2013 Oct;16(10):1383-91
Nature neuroscience 2013 Oct;16(10):1383-91
Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.
Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 15;110(42):16874-9
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 15;110(42):16874-9
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Murad NA, Cullen JK, McKenzie M, Ryan MT, Thorburn D, Gueven N, Kobayashi J, Birrell G, Yang J, Dörk T, Becherel O, Grattan-Smith P, Lavin MF
Mitochondrion 2013 May;13(3):235-45
Mitochondrion 2013 May;13(3):235-45
Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters.
Watanabe S, Shirogane Y, Suzuki SO, Ikegame S, Koga R, Yanagi Y
Journal of virology 2013 Mar;87(5):2648-59
Journal of virology 2013 Mar;87(5):2648-59
Host DNA damage response facilitates African swine fever virus infection.
Simões M, Martins C, Ferreira F
Veterinary microbiology 2013 Jul 26;165(1-2):140-7
Veterinary microbiology 2013 Jul 26;165(1-2):140-7
DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.
Degl'Innocenti D, Romeo P, Tarantino E, Sensi M, Cassinelli G, Catalano V, Lanzi C, Perrone F, Pilotti S, Seregni E, Pierotti MA, Greco A, Borrello MG
Endocrine-related cancer 2013 Feb;20(1):23-37
Endocrine-related cancer 2013 Feb;20(1):23-37
Inhibition of DNA damage repair by artificial activation of PARP with siDNA.
Croset A, Cordelières FP, Berthault N, Buhler C, Sun JS, Quanz M, Dutreix M
Nucleic acids research 2013 Aug;41(15):7344-55
Nucleic acids research 2013 Aug;41(15):7344-55
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
Britton S, Coates J, Jackson SP
The Journal of cell biology 2013 Aug 5;202(3):579-95
The Journal of cell biology 2013 Aug 5;202(3):579-95
CtIP is required to initiate replication-dependent interstrand crosslink repair.
Duquette ML, Zhu Q, Taylor ER, Tsay AJ, Shi LZ, Berns MW, McGowan CH
PLoS genetics 2012;8(11):e1003050
PLoS genetics 2012;8(11):e1003050
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Someya M, Sakata K, Matsumoto Y, Tauchi H, Kai M, Hareyama M, Fukushima M
Journal of radiation research 2012;53(2):250-6
Journal of radiation research 2012;53(2):250-6
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Someya M, Sakata K, Matsumoto Y, Tauchi H, Kai M, Hareyama M, Fukushima M
Journal of radiation research 2012;53(2):250-6
Journal of radiation research 2012;53(2):250-6
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.
Sohn SY, Hearing P
Journal of virology 2012 Sep;86(18):9656-65
Journal of virology 2012 Sep;86(18):9656-65
A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors.
Ou HD, Kwiatkowski W, Deerinck TJ, Noske A, Blain KY, Land HS, Soria C, Powers CJ, May AP, Shu X, Tsien RY, Fitzpatrick JA, Long JA, Ellisman MH, Choe S, O'Shea CC
Cell 2012 Oct 12;151(2):304-19
Cell 2012 Oct 12;151(2):304-19
Prognostic significance of NBS1 and Snail expression in esophageal squamous cell carcinoma.
Kuo KT, Chou TY, Hsu HS, Chen WL, Wang LS
Annals of surgical oncology 2012 Jul;19 Suppl 3:S549-57
Annals of surgical oncology 2012 Jul;19 Suppl 3:S549-57
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Vogel R, Seyffert M, Strasser R, de Oliveira AP, Dresch C, Glauser DL, Jolinon N, Salvetti A, Weitzman MD, Ackermann M, Fraefel C
Journal of virology 2012 Jan;86(1):143-55
Journal of virology 2012 Jan;86(1):143-55
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Kanai R, Rabkin SD, Yip S, Sgubin D, Zaupa CM, Hirose Y, Louis DN, Wakimoto H, Martuza RL
Journal of the National Cancer Institute 2012 Jan 4;104(1):42-55
Journal of the National Cancer Institute 2012 Jan 4;104(1):42-55
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, Dobner T, Taylor AM, Turnell AS, Stewart GS, Grand RJ, Jackson SP
Molecular cell 2012 Feb 24;45(4):505-16
Molecular cell 2012 Feb 24;45(4):505-16
Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Zhang T, Penicud K, Bruhn C, Loizou JI, Kanu N, Wang ZQ, Behrens A
Cell reports 2012 Dec 27;2(6):1498-504
Cell reports 2012 Dec 27;2(6):1498-504
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP
PLoS genetics 2012 Aug;8(8):e1002935
PLoS genetics 2012 Aug;8(8):e1002935
The papillomavirus E1 helicase activates a cellular DNA damage response in viral replication foci.
Sakakibara N, Mitra R, McBride AA
Journal of virology 2011 Sep;85(17):8981-95
Journal of virology 2011 Sep;85(17):8981-95
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF
The Journal of biological chemistry 2011 Sep 9;286(36):31542-56
The Journal of biological chemistry 2011 Sep 9;286(36):31542-56
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K
Molecular cell 2011 Sep 2;43(5):788-97
Molecular cell 2011 Sep 2;43(5):788-97
De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation.
Chung I, Leonhardt H, Rippe K
Journal of cell science 2011 Nov 1;124(Pt 21):3603-18
Journal of cell science 2011 Nov 1;124(Pt 21):3603-18
Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.
Soares DG, Battistella A, Rocca CJ, Matuo R, Henriques JA, Larsen AK, Escargueil AE
The Biochemical journal 2011 Jul 1;437(1):63-73
The Biochemical journal 2011 Jul 1;437(1):63-73
Growth suppression of human hepatocellular carcinoma xenografts by a monoclonal antibody CH12 directed to epidermal growth factor receptor variant III.
Jiang H, Wang H, Tan Z, Hu S, Wang H, Shi B, Yang L, Li P, Gu J, Wang H, Li Z
The Journal of biological chemistry 2011 Feb 18;286(7):5913-20
The Journal of biological chemistry 2011 Feb 18;286(7):5913-20
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R
PLoS genetics 2011 Apr;7(4):e1001381
PLoS genetics 2011 Apr;7(4):e1001381
Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.
Kaur S, Modi P, Srivastava V, Mudgal R, Tikoo S, Arora P, Mohanty D, Sengupta S
Molecular cancer research : MCR 2010 Sep;8(9):1234-47
Molecular cancer research : MCR 2010 Sep;8(9):1234-47
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.
Adeyemi RO, Landry S, Davis ME, Weitzman MD, Pintel DJ
PLoS pathogens 2010 Oct 7;6(10):e1001141
PLoS pathogens 2010 Oct 7;6(10):e1001141
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Boichuk S, Hu L, Hein J, Gjoerup OV
Journal of virology 2010 Aug;84(16):8007-20
Journal of virology 2010 Aug;84(16):8007-20
Identification of increased NBS1 expression as a prognostic marker of squamous cell carcinoma of the oral cavity.
Hsu DS, Chang SY, Liu CJ, Tzeng CH, Wu KJ, Kao JY, Yang MH
Cancer science 2010 Apr;101(4):1029-37
Cancer science 2010 Apr;101(4):1029-37
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Yan T, Seo Y, Kinsella TJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Karen KA, Hoey PJ, Young CS, Hearing P
Journal of virology 2009 May;83(9):4565-73
Journal of virology 2009 May;83(9):4565-73
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Nahas SA, Butch AW, Du L, Gatti RA
Clinical chemistry 2009 Mar;55(3):463-72
Clinical chemistry 2009 Mar;55(3):463-72
Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.
Shimada M, Sagae R, Kobayashi J, Habu T, Komatsu K
Cancer research 2009 Mar 1;69(5):1768-75
Cancer research 2009 Mar 1;69(5):1768-75
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.
Schwartz RA, Carson CT, Schuberth C, Weitzman MD
Journal of virology 2009 Jun;83(12):6269-78
Journal of virology 2009 Jun;83(12):6269-78
Small-molecule drugs mimicking DNA damage: a new strategy for sensitizing tumors to radiotherapy.
Quanz M, Berthault N, Roulin C, Roy M, Herbette A, Agrario C, Alberti C, Josserand V, Coll JL, Sastre-Garau X, Cosset JM, Larue L, Sun JS, Dutreix M
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Feb 15;15(4):1308-16
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Feb 15;15(4):1308-16
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
So S, Davis AJ, Chen DJ
The Journal of cell biology 2009 Dec 28;187(7):977-90
The Journal of cell biology 2009 Dec 28;187(7):977-90
Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses.
Kadaja M, Isok-Paas H, Laos T, Ustav E, Ustav M
PLoS pathogens 2009 Apr;5(4):e1000397
PLoS pathogens 2009 Apr;5(4):e1000397
Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.
Schwartz RA, Lakdawala SS, Eshleman HD, Russell MR, Carson CT, Weitzman MD
Journal of virology 2008 Sep;82(18):9043-55
Journal of virology 2008 Sep;82(18):9043-55
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
Lakdawala SS, Schwartz RA, Ferenchak K, Carson CT, McSharry BP, Wilkinson GW, Weitzman MD
Journal of virology 2008 Sep;82(17):8362-72
Journal of virology 2008 Sep;82(17):8362-72
A role for DEAD box 1 at DNA double-strand breaks.
Li L, Monckton EA, Godbout R
Molecular and cellular biology 2008 Oct;28(20):6413-25
Molecular and cellular biology 2008 Oct;28(20):6413-25
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.
Blickwedehl J, Agarwal M, Seong C, Pandita RK, Melendy T, Sung P, Pandita TK, Bangia N
Proceedings of the National Academy of Sciences of the United States of America 2008 Oct 21;105(42):16165-70
Proceedings of the National Academy of Sciences of the United States of America 2008 Oct 21;105(42):16165-70
ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
Ewald B, Sampath D, Plunkett W
Cancer research 2008 Oct 1;68(19):7947-55
Cancer research 2008 Oct 1;68(19):7947-55
A glycine-arginine domain in control of the human MRE11 DNA repair protein.
Déry U, Coulombe Y, Rodrigue A, Stasiak A, Richard S, Masson JY
Molecular and cellular biology 2008 May;28(9):3058-69
Molecular and cellular biology 2008 May;28(9):3058-69
Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner.
Gatz SA, Keimling M, Baumann C, Dörk T, Debatin KM, Fulda S, Wiesmüller L
Carcinogenesis 2008 Mar;29(3):519-27
Carcinogenesis 2008 Mar;29(3):519-27
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.
Zhao X, Madden-Fuentes RJ, Lou BX, Pipas JM, Gerhardt J, Rigell CJ, Fanning E
Journal of virology 2008 Jun;82(11):5316-28
Journal of virology 2008 Jun;82(11):5316-28
Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity.
Tanaka T, Munshi A, Brooks C, Liu J, Hobbs ML, Meyn RE
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Feb 15;14(4):1266-73
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Feb 15;14(4):1266-73
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.
Cervelli T, Palacios JA, Zentilin L, Mano M, Schwartz RA, Weitzman MD, Giacca M
Journal of cell science 2008 Feb 1;121(Pt 3):349-57
Journal of cell science 2008 Feb 1;121(Pt 3):349-57
Mdm2 promotes genetic instability and transformation independent of p53.
Bouska A, Lushnikova T, Plaza S, Eischen CM
Molecular and cellular biology 2008 Aug;28(15):4862-74
Molecular and cellular biology 2008 Aug;28(15):4862-74
Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif.
Chen YC, Chiang HY, Yang MH, Chen PM, Chang SY, Teng SC, Vanhaesebroeck B, Wu KJ
Journal of molecular medicine (Berlin, Germany) 2008 Apr;86(4):401-12
Journal of molecular medicine (Berlin, Germany) 2008 Apr;86(4):401-12
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.
Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M
The Journal of cell biology 2008 Apr 21;181(2):227-40
The Journal of cell biology 2008 Apr 21;181(2):227-40
Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.
Kato T, Sato N, Hayama S, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y, Daigo Y
Cancer research 2007 Sep 15;67(18):8544-53
Cancer research 2007 Sep 15;67(18):8544-53
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16910-5
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 23;104(43):16910-5
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.
Berkovich E, Monnat RJ Jr, Kastan MB
Nature cell biology 2007 Jun;9(6):683-90
Nature cell biology 2007 Jun;9(6):683-90
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
Chan KL, North PS, Hickson ID
The EMBO journal 2007 Jul 25;26(14):3397-409
The EMBO journal 2007 Jul 25;26(14):3397-409
Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.
Krüger L, Demuth I, Neitzel H, Varon R, Sperling K, Chrzanowska KH, Seemanova E, Digweed M
Carcinogenesis 2007 Jan;28(1):107-11
Carcinogenesis 2007 Jan;28(1):107-11
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Compton SA, Choi JH, Cesare AJ, Ozgür S, Griffith JD
Cancer research 2007 Feb 15;67(4):1513-9
Cancer research 2007 Feb 15;67(4):1513-9
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.
Schwartz RA, Palacios JA, Cassell GD, Adam S, Giacca M, Weitzman MD
Journal of virology 2007 Dec;81(23):12936-45
Journal of virology 2007 Dec;81(23):12936-45
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
Jacquemont C, Taniguchi T
Cancer research 2007 Aug 1;67(15):7395-405
Cancer research 2007 Aug 1;67(15):7395-405
Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity.
Wittlinger M, Grabenbauer GG, Sprung CN, Sauer R, Distel LV
International journal of radiation biology 2007 Apr;83(4):245-57
International journal of radiation biology 2007 Apr;83(4):245-57
Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity.
Wittlinger M, Grabenbauer GG, Sprung CN, Sauer R, Distel LV
International journal of radiation biology 2007 Apr;83(4):245-57
International journal of radiation biology 2007 Apr;83(4):245-57
Inhibition of hsp90 compromises the DNA damage response to radiation.
Dote H, Burgan WE, Camphausen K, Tofilon PJ
Cancer research 2006 Sep 15;66(18):9211-20
Cancer research 2006 Sep 15;66(18):9211-20
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity.
Mirzoeva OK, Kawaguchi T, Pieper RO
Molecular cancer therapeutics 2006 Nov;5(11):2757-66
Molecular cancer therapeutics 2006 Nov;5(11):2757-66
Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
Sheen MR, Kim SW, Jung JY, Ahn JY, Rhee JG, Kwon HM, Woo SK
American journal of physiology. Renal physiology 2006 Nov;291(5):F1014-20
American journal of physiology. Renal physiology 2006 Nov;291(5):F1014-20
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres.
Verdun RE, Karlseder J
Cell 2006 Nov 17;127(4):709-20
Cell 2006 Nov 17;127(4):709-20
Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability.
Seemanová E, Sperling K, Neitzel H, Varon R, Hadac J, Butova O, Schröck E, Seeman P, Digweed M
Journal of medical genetics 2006 Mar;43(3):218-24
Journal of medical genetics 2006 Mar;43(3):218-24
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Gueven N, Becherel OJ, Birrell G, Chen P, DelSal G, Carney JP, Grattan-Smith P, Lavin MF
Cancer research 2006 Mar 15;66(6):2907-12
Cancer research 2006 Mar 15;66(6):2907-12
Mild Nijmegen breakage syndrome phenotype due to alternative splicing.
Varon R, Dutrannoy V, Weikert G, Tanzarella C, Antoccia A, Stöckl L, Spadoni E, Krüger LA, di Masi A, Sperling K, Digweed M, Maraschio P
Human molecular genetics 2006 Mar 1;15(5):679-89
Human molecular genetics 2006 Mar 1;15(5):679-89
Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation.
Yang MH, Chiang WC, Chou TY, Chang SY, Chen PM, Teng SC, Wu KJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):507-15
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):507-15
Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients.
Howlett NG, Scuric Z, D'Andrea AD, Schiestl RH
DNA repair 2006 Feb 3;5(2):251-7
DNA repair 2006 Feb 3;5(2):251-7
Involvement of novel autophosphorylation sites in ATM activation.
Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF
The EMBO journal 2006 Aug 9;25(15):3504-14
The EMBO journal 2006 Aug 9;25(15):3504-14
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, Giavara S, O'Connor MJ, Tutt AN, Zdzienicka MZ, Smith GC, Ashworth A
Cancer research 2006 Aug 15;66(16):8109-15
Cancer research 2006 Aug 15;66(16):8109-15
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Myers JS, Cortez D
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1.
Tseng SF, Chang CY, Wu KJ, Teng SC
The Journal of biological chemistry 2005 Nov 25;280(47):39594-600
The Journal of biological chemistry 2005 Nov 25;280(47):39594-600
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle.
Verdun RE, Crabbe L, Haggblom C, Karlseder J
Molecular cell 2005 Nov 23;20(4):551-61
Molecular cell 2005 Nov 23;20(4):551-61
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.
Lau A, Swinbank KM, Ahmed PS, Taylor DL, Jackson SP, Smith GC, O'Connor MJ
Nature cell biology 2005 May;7(5):493-500
Nature cell biology 2005 May;7(5):493-500
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
Alt JR, Bouska A, Fernandez MR, Cerny RL, Xiao H, Eischen CM
The Journal of biological chemistry 2005 May 13;280(19):18771-81
The Journal of biological chemistry 2005 May 13;280(19):18771-81
Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells.
Pan J, She M, Xu ZX, Sun L, Yeung SC
Cancer research 2005 May 1;65(9):3671-81
Cancer research 2005 May 1;65(9):3671-81
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.
Howlett NG, Taniguchi T, Durkin SG, D'Andrea AD, Glover TW
Human molecular genetics 2005 Mar 1;14(5):693-701
Human molecular genetics 2005 Mar 1;14(5):693-701
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.
Donahue SL, Campbell C
Nucleic acids research 2004;32(10):3248-57
Nucleic acids research 2004;32(10):3248-57
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Cerosaletti K, Concannon P
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability.
Demuth I, Frappart PO, Hildebrand G, Melchers A, Lobitz S, Stöckl L, Varon R, Herceg Z, Sperling K, Wang ZQ, Digweed M
Human molecular genetics 2004 Oct 15;13(20):2385-97
Human molecular genetics 2004 Oct 15;13(20):2385-97
Evasion of early cellular response mechanisms following low level radiation-induced DNA damage.
Collis SJ, Schwaninger JM, Ntambi AJ, Keller TW, Nelson WG, Dillehay LE, Deweese TL
The Journal of biological chemistry 2004 Nov 26;279(48):49624-32
The Journal of biological chemistry 2004 Nov 26;279(48):49624-32
Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation.
Demuth I, Digweed M, Concannon P
Oncogene 2004 Nov 11;23(53):8611-8
Oncogene 2004 Nov 11;23(53):8611-8
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Wilkinson DE, Weller SK
Journal of virology 2004 May;78(9):4783-96
Journal of virology 2004 May;78(9):4783-96
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Wilkinson DE, Weller SK
Journal of virology 2004 May;78(9):4783-96
Journal of virology 2004 May;78(9):4783-96
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Cheng WH, von Kobbe C, Opresko PL, Arthur LM, Komatsu K, Seidman MM, Carney JP, Bohr VA
The Journal of biological chemistry 2004 May 14;279(20):21169-76
The Journal of biological chemistry 2004 May 14;279(20):21169-76
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB
Genes & development 2004 Jun 15;18(12):1423-38
Genes & development 2004 Jun 15;18(12):1423-38
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J
The EMBO journal 2004 Jul 7;23(13):2674-83
The EMBO journal 2004 Jul 7;23(13):2674-83
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK
The Journal of biological chemistry 2004 Jul 23;279(30):31251-8
The Journal of biological chemistry 2004 Jul 23;279(30):31251-8
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F
Molecular and cellular biology 2004 Jan;24(2):708-18
Molecular and cellular biology 2004 Jan;24(2):708-18
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F
Molecular and cellular biology 2004 Jan;24(2):708-18
Molecular and cellular biology 2004 Jan;24(2):708-18
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Kurz EU, Douglas P, Lees-Miller SP
The Journal of biological chemistry 2004 Dec 17;279(51):53272-81
The Journal of biological chemistry 2004 Dec 17;279(51):53272-81
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG
Cancer research 2004 Dec 1;64(23):8526-33
Cancer research 2004 Dec 1;64(23):8526-33
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.
Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K
Oncogene 2003 Sep 4;22(38):5927-37
Oncogene 2003 Sep 4;22(38):5927-37
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks.
Davalos AR, Campisi J
The Journal of cell biology 2003 Sep 29;162(7):1197-209
The Journal of cell biology 2003 Sep 29;162(7):1197-209
Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation.
Gueven N, Keating K, Fukao T, Loeffler H, Kondo N, Rodemann HP, Lavin MF
Genes, chromosomes & cancer 2003 Oct;38(2):157-67
Genes, chromosomes & cancer 2003 Oct;38(2):157-67
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Xu X, Stern DF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation.
Udayakumar D, Bladen CL, Hudson FZ, Dynan WS
The Journal of biological chemistry 2003 Oct 24;278(43):41631-5
The Journal of biological chemistry 2003 Oct 24;278(43):41631-5
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J
Nature cell biology 2003 Mar;5(3):255-60
Nature cell biology 2003 Mar;5(3):255-60
Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.
Cerosaletti KM, Concannon P
The Journal of biological chemistry 2003 Jun 13;278(24):21944-51
The Journal of biological chemistry 2003 Jun 13;278(24):21944-51
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS
Molecular cancer research : MCR 2003 Jul;1(9):674-81
Molecular cancer research : MCR 2003 Jul;1(9):674-81
Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H.
Laposa RR, Feeney L, Cleaver JE
Cancer research 2003 Jul 15;63(14):3909-12
Cancer research 2003 Jul 15;63(14):3909-12
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Siwicki JK, Degerman S, Chrzanowska KH, Roos G
Experimental cell research 2003 Jul 1;287(1):178-89
Experimental cell research 2003 Jul 1;287(1):178-89
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Siwicki JK, Degerman S, Chrzanowska KH, Roos G
Experimental cell research 2003 Jul 1;287(1):178-89
Experimental cell research 2003 Jul 1;287(1):178-89
The mismatch repair system is required for S-phase checkpoint activation.
Brown KD, Rathi A, Kamath R, Beardsley DI, Zhan Q, Mannino JL, Baskaran R
Nature genetics 2003 Jan;33(1):80-4
Nature genetics 2003 Jan;33(1):80-4
Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3' overhang specific DNA.
Eller MS, Li GZ, Firoozabadi R, Puri N, Gilchrest BA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Feb;17(2):152-62
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Feb;17(2):152-62
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP
Nature 2003 Feb 27;421(6926):952-6
Nature 2003 Feb 27;421(6926):952-6
Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts.
Donahue SL, Lundberg R, Saplis R, Campbell C
The Journal of biological chemistry 2003 Aug 8;278(32):29487-95
The Journal of biological chemistry 2003 Aug 8;278(32):29487-95
Human MRE11 is inactivated in mismatch repair-deficient cancers.
Giannini G, Ristori E, Cerignoli F, Rinaldi C, Zani M, Viel A, Ottini L, Crescenzi M, Martinotti S, Bignami M, Frati L, Screpanti I, Gulino A
EMBO reports 2002 Mar;3(3):248-54
EMBO reports 2002 Mar;3(3):248-54
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Stracker TH, Carson CT, Weitzman MD
Nature 2002 Jul 18;418(6895):348-52
Nature 2002 Jul 18;418(6895):348-52
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.
Huang J, Dynan WS
Nucleic acids research 2002 Feb 1;30(3):667-74
Nucleic acids research 2002 Feb 1;30(3):667-74
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.
Huang J, Dynan WS
Nucleic acids research 2002 Feb 1;30(3):667-74
Nucleic acids research 2002 Feb 1;30(3):667-74
Interaction of FANCD2 and NBS1 in the DNA damage response.
Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, Mathew CG, Kastan MB, Weaver DT, D'Andrea AD
Nature cell biology 2002 Dec;4(12):913-20
Nature cell biology 2002 Dec;4(12):913-20
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
Heffernan TP, Simpson DA, Frank AR, Heinloth AN, Paules RS, Cordeiro-Stone M, Kaufmann WK
Molecular and cellular biology 2002 Dec;22(24):8552-61
Molecular and cellular biology 2002 Dec;22(24):8552-61
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.
Heffernan TP, Simpson DA, Frank AR, Heinloth AN, Paules RS, Cordeiro-Stone M, Kaufmann WK
Molecular and cellular biology 2002 Dec;22(24):8552-61
Molecular and cellular biology 2002 Dec;22(24):8552-61
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.
Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, Beresten S, Gueven N, Purdie D, Lees-Miller S, Ellis N, Kondo N, Lavin MF
The Journal of biological chemistry 2002 Aug 23;277(34):30515-23
The Journal of biological chemistry 2002 Aug 23;277(34):30515-23
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
Franchitto A, Pichierri P
The Journal of cell biology 2002 Apr 1;157(1):19-30
The Journal of cell biology 2002 Apr 1;157(1):19-30
Chk2 activation dependence on Nbs1 after DNA damage.
Buscemi G, Savio C, Zannini L, Miccichè F, Masnada D, Nakanishi M, Tauchi H, Komatsu K, Mizutani S, Khanna K, Chen P, Concannon P, Chessa L, Delia D
Molecular and cellular biology 2001 Aug;21(15):5214-22
Molecular and cellular biology 2001 Aug;21(15):5214-22
NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres.
Wu G, Lee WH, Chen PL
The Journal of biological chemistry 2000 Sep 29;275(39):30618-22
The Journal of biological chemistry 2000 Sep 29;275(39):30618-22
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K
Nature genetics 2000 May;25(1):115-9
Nature genetics 2000 May;25(1):115-9
Independence of R/M/N focus formation and the presence of intact BRCA1.
Wu X, Petrini JH, Heine WF, Weaver DT, Livingston DM, Chen J
Science (New York, N.Y.) 2000 Jul 7;289(5476):11
Science (New York, N.Y.) 2000 Jul 7;289(5476):11
Independence of R/M/N focus formation and the presence of intact BRCA1.
Wu X, Petrini JH, Heine WF, Weaver DT, Livingston DM, Chen J
Science (New York, N.Y.) 2000 Jul 7;289(5476):11
Science (New York, N.Y.) 2000 Jul 7;289(5476):11
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes & development 2000 Apr 15;14(8):927-39
Genes & development 2000 Apr 15;14(8):927-39
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Nbs1 Antibody [NB100-143] - Detection of NBS1 in Human Bone Osteosarcoma Epithelial Cells (U2OS whole cell lysate) using Nbs1 Antibody [NB100-143] at a dilution of 1:1000. Specificity was confirmed using a siRNA anti-NBS1 (targeting sequence: GGAAGAAACGUGAACUCAA). Image provided by Sebastien Britton of the Institute of Pharmacology and Structural Biology.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Nbs1 Antibody [NB100-143] - Analysis of HeLa whole cell lysate [NB800-PC1] using rabbit polyclonal NBS1 antibody [NB100-143]. Observed Molecular Weight at ~95 kDa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Nbs1 Antibody [NB100-143] - Western Blot with Nbs1 Antibody [NB100-143]. TIG-1 human primary fibroblasts, whole cell lysate (30 ug). Image from verified customer review.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Nbs1 Antibody [NB100-143] - Western Blot with Nbs1 Antibody [NB100-143]. KSHV LANA recruits MRN (Mre11-Rad50-NBS1) complex. Co-immunoprecipitation of endogenous LANA and MRN proteins in BC3 cells. Cells were lysed using TBS-T buffer and the cell lysate was incubated with benzonase. After centrifugation, supernatant was incubated overnight with anti-LANA or IgG-control beads. The precipitated complexes were analyzed for the presence of endogenous Rad50, Mre11 and NBS1 by SDS-PAGE and immunoblotting. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.ppat.1006335), licensed under a CC-BY licence.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Nbs1 Antibody [NB100-143] - FFPE human testis using Nbs1 antibody [NB100-143] at 1:200 on a Bond Rx autostainer (Leica Biosystems). The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10 mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with primary antibody for 30 minutes and Bond Polymer Refine Detection (Leica Biosystems) with DAB was used for signal development followed by counterstaining with hematoxylin. Whole slide scanning and capturing of representative images was performed using Aperio AT2 (Leica Biosystems). Staining was performed by Histowiz.
