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Learn14273-1-AP
antibody from Proteintech Group
Targeting: SRXN1
C20orf139, dJ850E9.2, Npn3, SRX1, YKL086W
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 14273-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14273-1-AP, RRID:AB_2195030
- Product name
- SRX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SRX1 antibody (Cat. #14273-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
SRXN1 stimulates hepatocellular carcinoma tumorigenesis and metastasis through modulating ROS/p65/BTG2 signalling.
Sulfiredoxin-1 is a promising novel prognostic biomarker for hepatocellular carcinoma.
The redox regulator sulfiredoxin forms a complex with thioredoxin domain-containing 5 protein in response to ER stress in lung cancer cells.
Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1.
Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.
Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis.
Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle.
A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.
Sulfiredoxin may promote metastasis and invasion of cervical squamous cell carcinoma by epithelial-mesenchymal transition.
Sulfiredoxin May Promote Cervical Cancer Metastasis via Wnt/β-Catenin Signaling Pathway.
Myeloperoxidase-Oxidized LDLs Enhance an Anti-Inflammatory M2 and Antioxidant Phenotype in Murine Macrophages.
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Dysregulation of redox-state-regulating enzymes in melanocytic skin tumours and the surrounding microenvironment.
Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage.
Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling.
Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis.
Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma.
Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.
Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer.
Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer.
Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia.
Martinez R 3rd, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S, Shapiro P
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):84-97
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):84-97
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Zhu F, Shao J, Tian Y, Xu Z
International immunopharmacology 2021 Dec;101(Pt B):108221
International immunopharmacology 2021 Dec;101(Pt B):108221
SRXN1 stimulates hepatocellular carcinoma tumorigenesis and metastasis through modulating ROS/p65/BTG2 signalling.
Lv X, Yu H, Zhang Q, Huang Q, Hong X, Yu T, Lan H, Mei C, Zhang W, Luo H, Pang P, Shan H
Journal of cellular and molecular medicine 2020 Sep;24(18):10714-10729
Journal of cellular and molecular medicine 2020 Sep;24(18):10714-10729
Sulfiredoxin-1 is a promising novel prognostic biomarker for hepatocellular carcinoma.
Rao QW, Zhang SL, Guo MZ, Yuan FF, Sun JL, Qi F, Wang LS, Yang BW, Xia JL
Cancer medicine 2020 Nov;9(22):8318-8332
Cancer medicine 2020 Nov;9(22):8318-8332
The redox regulator sulfiredoxin forms a complex with thioredoxin domain-containing 5 protein in response to ER stress in lung cancer cells.
Chawsheen HA, Jiang H, Ying Q, Ding N, Thapa P, Wei Q
The Journal of biological chemistry 2019 May 31;294(22):8991-9006
The Journal of biological chemistry 2019 May 31;294(22):8991-9006
Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1.
Harlan BA, Pehar M, Killoy KM, Vargas MR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7084-7091
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7084-7091
Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.
Romanello KS, Teixeira KKL, Silva JPMO, Nagamatsu ST, Bezerra MAC, Domingos IF, Martins DAP, Araujo AS, Lanaro C, Breyer CA, Ferreira RA, Franco-Penteado C, Costa FF, Malavazi I, Netto LES, de Oliveira MA, Cunha AF
PloS one 2018;13(12):e0208316
PloS one 2018;13(12):e0208316
Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis.
Mishra M, Jiang H, Chawsheen HA, Gerard M, Toledano MB, Wei Q
Cancer letters 2018 Sep 28;432:216-226
Cancer letters 2018 Sep 28;432:216-226
Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle.
Olthoff JT, Lindsay A, Abo-Zahrah R, Baltgalvis KA, Patrinostro X, Belanto JJ, Yu DY, Perrin BJ, Garry DJ, Rodney GG, Lowe DA, Ervasti JM
Nature communications 2018 Nov 30;9(1):5104
Nature communications 2018 Nov 30;9(1):5104
A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.
Choi EJ, Jung BJ, Lee SH, Yoo HS, Shin EA, Ko HJ, Chang S, Kim SY, Jeon SM
Oncogene 2017 Sep 14;36(37):5285-5295
Oncogene 2017 Sep 14;36(37):5285-5295
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.
Schultz MA, Diaz AM, Smite S, Lay AR, DeCant B, McKinney R, Mascarinas WE, Xia Y, Neumann C, Bentrem D, Dawson DW, Grippo PJ
Oncotarget 2017 Nov 3;8(54):92667-92681
Oncotarget 2017 Nov 3;8(54):92667-92681
Sulfiredoxin may promote metastasis and invasion of cervical squamous cell carcinoma by epithelial-mesenchymal transition.
Chen X, Lan K, Liu Q, Yang X, Wang H
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Mar;39(3):1010428317695942
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Mar;39(3):1010428317695942
Sulfiredoxin May Promote Cervical Cancer Metastasis via Wnt/β-Catenin Signaling Pathway.
Lan K, Zhao Y, Fan Y, Ma B, Yang S, Liu Q, Linghu H, Wang H
International journal of molecular sciences 2017 Apr 27;18(5)
International journal of molecular sciences 2017 Apr 27;18(5)
Myeloperoxidase-Oxidized LDLs Enhance an Anti-Inflammatory M2 and Antioxidant Phenotype in Murine Macrophages.
Pireaux V, Sauvage A, Bihin B, Van Steenbrugge M, Rousseau A, Van Antwerpen P, Zouaoui Boudjeltia K, Raes M
Mediators of inflammation 2016;2016:8249476
Mediators of inflammation 2016;2016:8249476
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Starheim KK, Holien T, Misund K, Johansson I, Baranowska KA, Sponaas AM, Hella H, Buene G, Waage A, Sundan A, Bjørkøy G
Blood cancer journal 2016 Jul 15;6(7):e446
Blood cancer journal 2016 Jul 15;6(7):e446
Dysregulation of redox-state-regulating enzymes in melanocytic skin tumours and the surrounding microenvironment.
Hintsala HR, Soini Y, Haapasaari KM, Karihtala P
Histopathology 2015 Sep;67(3):348-57
Histopathology 2015 Sep;67(3):348-57
Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage.
Yu S, Wang X, Lei S, Chen X, Liu Y, Zhou Y, Zhou Y, Wu J, Zhao Y
Neurochemistry international 2015 Mar;82:19-27
Neurochemistry international 2015 Mar;82:19-27
Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling.
Jiang H, Wu L, Chen J, Mishra M, Chawsheen HA, Zhu H, Wei Q
Molecular cancer research : MCR 2015 Dec;13(12):1554-66
Molecular cancer research : MCR 2015 Dec;13(12):1554-66
Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis.
Wu L, Jiang H, Chawsheen HA, Mishra M, Young MR, Gerard M, Toledano MB, Colburn NH, Wei Q
Carcinogenesis 2014 May;35(5):1177-84
Carcinogenesis 2014 May;35(5):1177-84
Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma.
Soini Y, Eskelinen M, Juvonen P, Kärjä V, Haapasaari KM, Saarela A, Karihtala P
Pathology, research and practice 2014 Jan;210(1):35-9
Pathology, research and practice 2014 Jan;210(1):35-9
Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.
Wei Q, Jiang H, Baker A, Dodge LK, Gerard M, Young MR, Toledano MB, Colburn NH
Carcinogenesis 2013 Jun;34(6):1403-10
Carcinogenesis 2013 Jun;34(6):1403-10
Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer.
Hartikainen JM, Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y
Cancer research 2012 Nov 1;72(21):5537-46
Cancer research 2012 Nov 1;72(21):5537-46
Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer.
Merikallio H, Pääkkö P, Kinnula VL, Harju T, Soini Y
Human pathology 2012 Apr;43(4):577-84
Human pathology 2012 Apr;43(4):577-84
Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
Wei Q, Jiang H, Xiao Z, Baker A, Young MR, Veenstra TD, Colburn NH
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 26;108(17):7004-9
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 26;108(17):7004-9
Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia.
Mazur W, Lindholm P, Vuorinen K, Myllärniemi M, Salmenkivi K, Kinnula VL
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010 Sep 1;118(9):703-12
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010 Sep 1;118(9):703-12
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 14273-1-AP(SRX1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SRX1 (IP:14273-1-AP, 3ug; Detection:14273-1-AP 1:400) with A549 cells lysate 3300ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SRX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SRX1. This antibody recognizes human, mouse antigen. The SRX1 antibody has been validated for the following applications: ELISA, IP, IHC, WB analysis.
