60153PE

antibody from STEMCELL Technologies Inc

Targeting: ADA ADA1

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60153PE

Provider

STEMCELL Technologies Inc

Product name

Anti-Human CD25 Antibody, Clone 2A3, PE

Antibody type

Monoclonal

Description

The 2A3 antibody reacts with human CD25, a 55 kDa type I integral transmembrane glycoprotein also known as low-affinity interleukin 2 receptor alpha chain (IL-2R?) or Tac antigen. CD25 is present on activated T and B cells, monocytes, macrophages, and regulatory T cells. CD25 has role in T lymphocyte activations and identification of T cell subsets in viral infections like HIV and HTLV. CD25 associates with IL-2 receptor ? (CD122) and common ? (CD132) chains to form a high affinity IL-2R complex. The 2A3 antibody binds to an epitope on p55 at or near the IL-2 binding site and prevents high-affinity IL-2 binding to T lymphocytes. Daclizumab, a therapeutic humanised monoclonal antibody, blocks the binding of 2A3 antibody.

Reactivity

Human

Host

Human

Isotype

IgG

Vial size

50 Tests

Storage

2 - 8°C