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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [3]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- GTX108820 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX108820, RRID:AB_11166562
- Product name
- DNA ligase IV antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
Submitted references Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation.
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes.
A nonsense mutation of human XRCC4 is associated with adult-onset progressive encephalocardiomyopathy.
c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.
Chen SH, Yu X
Nucleic acids research 2018 Nov 28;
Nucleic acids research 2018 Nov 28;
Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes.
Chakraborty A, Tapryal N, Venkova T, Horikoshi N, Pandita RK, Sarker AH, Sarkar PS, Pandita TK, Hazra TK
Nature communications 2016 Oct 5;7:13049
Nature communications 2016 Oct 5;7:13049
A nonsense mutation of human XRCC4 is associated with adult-onset progressive encephalocardiomyopathy.
Bee L, Nasca A, Zanolini A, Cendron F, d'Adamo P, Costa R, Lamperti C, Celotti L, Ghezzi D, Zeviani M
EMBO molecular medicine 2015 Jul;7(7):918-29
EMBO molecular medicine 2015 Jul;7(7):918-29
c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.
Muvarak N, Kelley S, Robert C, Baer MR, Perrotti D, Gambacorti-Passerini C, Civin C, Scheibner K, Rassool FV
Molecular cancer research : MCR 2015 Apr;13(4):699-712
Molecular cancer research : MCR 2015 Apr;13(4):699-712
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Sample (30 ug of whole cell lysate) A: U87-MG 7.5% SDS PAGE GTX108820 diluted at 1:1000
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Mouse tissue extract (50 £gg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with DNA ligase IV antibody (GTX108820) diluted at 1:500.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Rat tissue extract (50 £gg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with DNA ligase IV antibody (GTX108820) diluted at 1:500.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using DNA ligase IV(GTX108820) antibody at 1:500 dilution.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of paraffin-embedded human ovarian cancer, using DNA ligase IV(GTX108820) antibody at 1:250 dilution.
