AF1807

antibody from R&D Systems

Targeting: C1R

Western blot (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

AF1807

Provider

R&D Systems

Product name

Human Complement Component C1r Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects human Complement Component C1r in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human Complement Component C1s is observed.

Reactivity

Human

Host

Goat

Conjugate

Unconjugated

Antigen sequence

NP_001724


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Effect of the Anti-C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody-Induced Complement Activation-A Preclinical In Vitro Study.

Wahrmann M, Mühlbacher J, Marinova L, Regele H, Huttary N, Eskandary F, Cohen G, Fischer GF, Parry GC, Gilbert JC, Panicker S, Böhmig GA
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Sep;17(9):2300-2311

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Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.

Hovingh ES, van den Broek B, Kuipers B, Pinelli E, Rooijakkers SHM, Jongerius I
PLoS pathogens 2017 Jul;13(7):e1006531