BS5751

antibody from Bioworld Technology, Inc

Targeting: GPR50 H9, Mel1c

Immunocytochemistry

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Validation data

Product number: BS5751 - Provider product page
Provider: Bioworld Technology, Inc
Product name: GPR50 polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 345-390 of Human GPR50.
Description: G protein-coupled receptors (GPCRs) play a central role in mediating the intracellular effects of numerous neurotransmitters and hormones, including melatonin. GPR50, also designated Melatonin-related receptor, GPCR50 and H9, does not bind melatonin. It is a multi-pass membrane protein primarily detected in hypothalamus and pituitary. GPR50 is a 613 amino acid protein that contains the seven hydrophobic segments that are characteristic of GPCRs, as well as the distinguishing sequence motifs of the melatonin receptor GPCR family. The GPR50 protein is 45% identical to the melatonin receptors 1A and 1B and has an unusually long proline-rich C-terminal tail. Research suggests that a deletion variant within the GPR50 gene is a sex-specific risk factor for susceptibility to BPAD (bipolar affective disorder) and that other variants in the gene may be sex-specific risk factors in the development of schizophrenia.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

GPR50 protein structure - BS5751 shown in red.