CABT-B1764

antibody from Creative Diagnostics

Targeting: STX11

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoelectron microscopy (Recommended by provider)

Antibody Data

Product number

CABT-B1764

Provider

Creative Diagnostics

Product name

Anti-Syntaxin-11 polyclonal antibody

Antibody type

Polyclonal

Description

Syntaxin-11 (UniProt O75558) is encoded by the STX11 (also known as FHL4, HLH4, HPLH4) gene (Gene ID 8676) in human. Syntaxin-11 belongs to the Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE) family of proteins that mediate membrane fusion events. Syntaxin-11 is an atypical syntaxin lacking a transmembrane domain and associates with intermediate compartment (IC) and post-Golgi membranes through a putative palmitoylation domain, as well as through interaction with other proteins via its coiled-coil forming H3 domain. Syntaxin 11 is enriched in immune cells, although lower levels of the protein can also be found in non-immune system tissues. Syntaxin-11 plays a key role in lymphocyte cytotoxicity, cytokine production and secretion. Stx11-knockout natural killer (NK) cells and cytotoxic T-lymphocytes (TLCs) show impaired degranulation, despite a comparable activation, maturation and expression of the complex-forming partners MUNC18-2 and VTI1B. STX11 gene mutations are linked to the rare autosomal recessive disorder familial hemophagocytic lymphohistiocytosis (FHL) characterized by an increased inflammatory response with abnormal secretion of proinflammatory cytokines.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _L

Concentration

Please refer to lot specific datasheet.

Storage

Stable for 1 year at 2-8°C from date of receipt.