PABPC1L

This gene belongs to the polyadenylate-binding protein type-1 family of proteins. Members of this family bind to the polyA tails of mRNAs to regulate mRNA stability and translation. The mouse ortholog of this gene is required for female fertility. In human, expression of a functional protein is regulated by alternative splicing. The protein-coding splice variant for this gene is abundantly expressed in human oocytes, while a noncoding splice variant subject to nonsense-mediated decay is the predominant splice variant expressed in somatic tissues. [provided by RefSeq, Aug 2019]

Description

Poly(A) binding protein cytoplasmic 1 like

Tissue specificity

Low tissue specificity

Subcell location

Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

20 (44910060 - 44959035)

Ensembl ID

ENSG00000101104  (ver. 103.38)

Orthologs

Mouse Pabpc1l: ENSMUSG00000054582

UniProt

Q4VXU2

neXtProt

NX_Q4VXU2

Human splice variants
Mouse splice variants

Protein structure