BS60773

antibody from Bioworld Technology, Inc
Targeting: CYFIP1 KIAA0068, P140SRA-1, SHYC
Provider product page for BS60773

Antibody data

Product number
BS60773 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CYFIP1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human CYFIP1
Description
Fragile X syndrome is the most frequent form of inherited mental retardation and is a result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 protein (also designated FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. FMR1 can also interact with two fragile X syndrome related factors, FXR1 (also designated FXR1P) and FXR2 (also designated FXR2P). These proteins form heterodimers through their N-terminal coiled-coiled domains. CYFIP1 and CYFIP2 (also known as cytoplasmic FMRP interacting proteins 1 and 2, respectively, and as Sra-1 in mouse) both interact with FMR1 but CYFIP2 also reacts with FXR1 and FXR2. CYFIP1 and CYFIP2 bind GTP-bound Rac1 to release FMRP in its active state, which is thought to regulate mRNA translation of neural cytoskeletal proteins. A loss of CYFIP1 and CYFIP2 leads to mutant neurons with defective axonal growth and motor function.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CYFIP1 protein structure - BS60773 shown in red.