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- References [12]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16605-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16605-1-AP, RRID:AB_2157149
- Product name
- OTUD7B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OTUD7B antibody (Cat. #16605-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling.
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.
Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis.
Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R.
The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.
Upregulation of OTUD7B (Cezanne) Promotes Tumor Progression via AKT/VEGF Pathway in Lung Squamous Carcinoma and Adenocarcinoma.
Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3.
Cheng J, Fan YQ, Jiang HX, Chen SF, Chen J, Liao XY, Zou YY, Lan HY, Cui Y, Chen ZB, Chen QX, Wan Q
Experimental neurology 2021 Nov;345:113818
Experimental neurology 2021 Nov;345:113818
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.
Gong Z, Li A, Ding J, Li Q, Zhang L, Li Y, Meng Z, Chen F, Huang J, Zhou D, Hu R, Ye J, Liu W, You H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(15):e2004504
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(15):e2004504
Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis.
Yang GS, Zheng B, Qin Y, Zhou J, Yang Z, Zhang XH, Zhao HY, Yang HJ, Wen JK
Theranostics 2020;10(17):7787-7811
Theranostics 2020;10(17):7787-7811
Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R.
Chen X, Pang Z, Wang Y, Zhu L, Liu J, Du J
American journal of cancer research 2020;10(12):4342-4356
American journal of cancer research 2020;10(12):4342-4356
The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.
Qi F, Jiang Z, Hou W, Peng B, Cheng S, Zhang X, Luo Z, Dai Z, Wang Y, Liu Y, Wang Y, Wang Z
Journal of biological rhythms 2020 Dec;35(6):542-554
Journal of biological rhythms 2020 Dec;35(6):542-554
Upregulation of OTUD7B (Cezanne) Promotes Tumor Progression via AKT/VEGF Pathway in Lung Squamous Carcinoma and Adenocarcinoma.
Lin DD, Shen Y, Qiao S, Liu WW, Zheng L, Wang YN, Cui N, Wang YF, Zhao S, Shi JH
Frontiers in oncology 2019;9:862
Frontiers in oncology 2019;9:862
Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.
Cui CP, Zhang Y, Wang C, Yuan F, Li H, Yao Y, Chen Y, Li C, Wei W, Liu CH, He F, Liu Y, Zhang L
Nature communications 2018 Nov 7;9(1):4648
Nature communications 2018 Nov 7;9(1):4648
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Ji Y, Cao L, Zeng L, Zhang Z, Xiao Q, Guan P, Chen S, Chen Y, Wang M, Guo D
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.
Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S, Thompson AAR, Jo H, Weber C, Ridger V, Schober A, Evans PC
Arteriosclerosis, thrombosis, and vascular biology 2017 Nov;37(11):2087-2101
Arteriosclerosis, thrombosis, and vascular biology 2017 Nov;37(11):2087-2101
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC
The Journal of experimental medicine 2016 Mar 7;213(3):399-414
The Journal of experimental medicine 2016 Mar 7;213(3):399-414
Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC
Circulation research 2013 Jun 7;112(12):1583-91
Circulation research 2013 Jun 7;112(12):1583-91
OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3.
Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC
Nature 2013 Feb 21;494(7437):371-4
Nature 2013 Feb 21;494(7437):371-4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 16605-1-AP(OTUD7B antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 16605-1-AP(OTUD7B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OTUD7B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OTUD7B. This antibody recognizes human, mouse, rat antigen. The OTUD7B antibody has been validated for the following applications: ELISA, WB, IHC analysis.
