BS8191

antibody from Bioworld Technology, Inc
Targeting: RBP3 D10S64, D10S65, D10S66, RP66
Provider product page for BS8191
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8191 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RBP3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human RBP3.
Description
Interphotoreceptor retinoid-binding protein (IRBP) is a retinoid and fatty acid binding protein expressed exclusively in the photoreceptor cells of the retina and pinealocytes of the pineal gland. The gene encoding human IRBP maps to chromosome 10q11.2. A putative trans-acting complex binds a cis-element in the IRBP promoter and fully activates transcription of the IRBP gene. Hypomethylation of cysteine residues in the IRBP promoters of bovine and murine photoreceptor cells permits expression of the IRBP gene. IRBP may be involved in shuttling retinoids between photoreceptors and the retinal pigment epithelium. IRBP exists as a glycoprotein with a four-fold repeat structure. Each 300 amino acid repeat contains one A and one B domain corresponding to the first 80 amino acids (A) and the other 220 amino acids (B). Along with S-antigen and opsin, the antigenic properties of IRBP induce posterior uveitis, which is characterized by the inflammation of the choroid and photoreceptor cell death.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RBP3 protein structure - BS8191 shown in red.