BS6854
antibody from Bioworld Technology, Inc
Targeting: CCL4
Act-2, AT744.1, LAG1, MIP-1-beta, SCYA4
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6854 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CCL4 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human CCL4.
- Description
- Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1Ï«, MIP-1ÉÇ, MIP-2, MIP-3Ï«, MIP-3ÉÇ, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1ÉÇ is more selective than MIP-1Ï«, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1Ï« is a more potent lymphocyte chemoattractant than MIP-1ÉÇ and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1Ï« has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1ÉÇ and RANTES. Recombinant human MIP-1Ï« acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of CCL4 pAb