FNab00025

antibody from FineTest Biotech

Targeting: AATF BFR2, CHE-1, CHE1, DED

Western blot

ELISA

Immunocytochemistry

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Validation data

Product number: FNab00025 - Provider product page
Provider: FineTest Biotech
Product name: AATF antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: apoptosis antagonizing transcriptio n factor
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

AATF protein structure - FNab00025 shown in red.