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LearnAF478
antibody from Novus Biologicals
Targeting: CCL5
D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228
Western blot
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF478 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal CCL5/RANTES Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse CCL5/RANTES in direct ELISAs and Western blots. In direct ELISAs, less than 50% cross-reactivity with recombinant human CCL5/RANTES and recombinant cotton rat CCL5/RANTES is observed and less than 10% cross-reactivity with recombinant mouse CCL3/MIP-1 alpha is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity.
Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T cells.
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.
Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3β facilitated NFkB activation.
Pro-angiogenic effect of RANTES-loaded polysaccharide-based microparticles for a mouse ischemia therapy.
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation.
Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.
IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury.
Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease.
Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice.
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells.
Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.
Changes in gene expression of pial vessels of the blood brain barrier during murine neurocysticercosis.
Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression.
Comprehensive assessment of chemokine expression profiles by flow cytometry.
Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes.
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes.
Viral infection of the lungs through the eye.
TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus.
TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus.
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
Chen L, Gu J, Qian Y, Li M, Qian Y, Xu M, Li J, Wen Y, Xia L, Li J, Xia Q, Kong X, Wu H
Cellular and molecular gastroenterology and hepatology 2019;7(3):623-639
Cellular and molecular gastroenterology and hepatology 2019;7(3):623-639
Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T cells.
William M, Leroux LP, Chaparro V, Graber TE, Alain T, Jaramillo M
European journal of immunology 2019 Aug;49(8):1200-1212
European journal of immunology 2019 Aug;49(8):1200-1212
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.
Böttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S, Rogers NC, Sahai E, Zelenay S, Reis e Sousa C
Cell 2018 Feb 22;172(5):1022-1037.e14
Cell 2018 Feb 22;172(5):1022-1037.e14
Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3β facilitated NFkB activation.
Wang P, Zhou S, Ge Y, Lu M, Liu Z, Gong R
Oncotarget 2017 Oct 24;8(51):88332-88344
Oncotarget 2017 Oct 24;8(51):88332-88344
Pro-angiogenic effect of RANTES-loaded polysaccharide-based microparticles for a mouse ischemia therapy.
Suffee N, Le Visage C, Hlawaty H, Aid-Launais R, Vanneaux V, Larghero J, Haddad O, Oudar O, Charnaux N, Sutton A
Scientific reports 2017 Oct 16;7(1):13294
Scientific reports 2017 Oct 16;7(1):13294
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation.
Chu YT, Wan SW, Chang YC, Lee CK, Wu-Hsieh BA, Anderson R, Lin YS
Laboratory investigation; a journal of technical methods and pathology 2017 Feb 27;
Laboratory investigation; a journal of technical methods and pathology 2017 Feb 27;
Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.
Wang C, Yeo S, Haas MA, Guan JL
The Journal of cell biology 2017 Aug 7;216(8):2581-2596
The Journal of cell biology 2017 Aug 7;216(8):2581-2596
IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury.
Thaney VE, O'Neill AM, Hoefer MM, Maung R, Sanchez AB, Kaul M
Scientific reports 2017 Apr 20;7:46514
Scientific reports 2017 Apr 20;7:46514
Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease.
Chandra G, Rangasamy SB, Roy A, Kordower JH, Pahan K
The Journal of biological chemistry 2016 Jul 15;291(29):15267-81
The Journal of biological chemistry 2016 Jul 15;291(29):15267-81
Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice.
Karkeni E, Marcotorchino J, Tourniaire F, Astier J, Peiretti F, Darmon P, Landrier JF
Endocrinology 2015 May;156(5):1782-93
Endocrinology 2015 May;156(5):1782-93
Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells.
Herz J, Johnson KR, McGavern DB
The Journal of experimental medicine 2015 Jul 27;212(8):1153-69
The Journal of experimental medicine 2015 Jul 27;212(8):1153-69
Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.
Cekanaviciute E, Dietrich HK, Axtell RC, Williams AM, Egusquiza R, Wai KM, Koshy AA, Buckwalter MS
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):139-49
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):139-49
Changes in gene expression of pial vessels of the blood brain barrier during murine neurocysticercosis.
Mishra PK, Teale JM
PLoS neglected tropical diseases 2013;7(3):e2099
PLoS neglected tropical diseases 2013;7(3):e2099
Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression.
Iida Y, Xu B, Xuan H, Glover KJ, Tanaka H, Hu X, Fujimura N, Wang W, Schultz JR, Turner CR, Dalman RL
Arteriosclerosis, thrombosis, and vascular biology 2013 Apr;33(4):718-26
Arteriosclerosis, thrombosis, and vascular biology 2013 Apr;33(4):718-26
Comprehensive assessment of chemokine expression profiles by flow cytometry.
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
The Journal of clinical investigation 2010 Mar;120(3):907-23
The Journal of clinical investigation 2010 Mar;120(3):907-23
Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes.
Läubli H, Spanaus KS, Borsig L
Blood 2009 Nov 12;114(20):4583-91
Blood 2009 Nov 12;114(20):4583-91
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
Wu Y, Li YY, Matsushima K, Baba T, Mukaida N
Journal of immunology (Baltimore, Md. : 1950) 2008 Nov 1;181(9):6384-93
Journal of immunology (Baltimore, Md. : 1950) 2008 Nov 1;181(9):6384-93
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
Wu Y, Li YY, Matsushima K, Baba T, Mukaida N
Journal of immunology (Baltimore, Md. : 1950) 2008 Nov 1;181(9):6384-93
Journal of immunology (Baltimore, Md. : 1950) 2008 Nov 1;181(9):6384-93
Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes.
Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Mar 26;28(13):3277-90
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Mar 26;28(13):3277-90
Viral infection of the lungs through the eye.
Bitko V, Musiyenko A, Barik S
Journal of virology 2007 Jan;81(2):783-90
Journal of virology 2007 Jan;81(2):783-90
TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus.
Zhao Z, Burkly LC, Campbell S, Schwartz N, Molano A, Choudhury A, Eisenberg RA, Michaelson JS, Putterman C
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 1;179(11):7949-58
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 1;179(11):7949-58
TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus.
Zhao Z, Burkly LC, Campbell S, Schwartz N, Molano A, Choudhury A, Eisenberg RA, Michaelson JS, Putterman C
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 1;179(11):7949-58
Journal of immunology (Baltimore, Md. : 1950) 2007 Dec 1;179(11):7949-58
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).
Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Vincenzo B, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A
Blood 2006 Mar 1;107(5):2112-22
Blood 2006 Mar 1;107(5):2112-22
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
Cardona AE, Gonzalez PA, Teale JM
Infection and immunity 2003 May;71(5):2634-42
Infection and immunity 2003 May;71(5):2634-42
CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
Cardona AE, Gonzalez PA, Teale JM
Infection and immunity 2003 May;71(5):2634-42
Infection and immunity 2003 May;71(5):2634-42
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Chemotaxis Induced by CCL5/RANTES and Neutralization by Mouse CCL5/RANTES Antibody. Chemotaxis Induced by CCL5/RANTES and Neutralization by Mouse CCL5/RANTES Antibody.
