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- References [4]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12477-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12477-1-AP, RRID:AB_2136316
- Product name
- LCK antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LCK antibody (Cat. #12477-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references "Drying effect" of fructus aurantii components and the mechanism of action based on network pharmacology and in vitro pharmacodynamic validation.
Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.
Zhu J, Luo Y, Tong H, Zhong L, Gong Q, Wang Y, Yang M, Song Q
Frontiers in pharmacology 2023;14:1114010
Frontiers in pharmacology 2023;14:1114010
Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function.
Wang Y, Sun Z, Ping J, Tang J, He B, Chang T, Zhou Q, Yuan S, Tang Z, Li X, Lu Y, He R, He X, Liu Z, Yin L, Wu N
Nature communications 2023 Nov 4;14(1):7075
Nature communications 2023 Nov 4;14(1):7075
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O
Journal of ovarian research 2023 Jun 27;16(1):122
Journal of ovarian research 2023 Jun 27;16(1):122
Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.
Crean-Tate KK, Braley C, Dey G, Esakov E, Saygin C, Trestan A, Silver DJ, Turaga SM, Connor EV, DeBernardo R, Michener CM, Rose PG, Lathia J, Reizes O
Journal of ovarian research 2021 Apr 22;14(1):55
Journal of ovarian research 2021 Apr 22;14(1):55
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 12477-1-AP(LCK antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LCK antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LCK. This antibody recognizes human,mouse,rat antigen. The LCK antibody has been validated for the following applications: ELISA, WB, IHC analysis.
