AB0100-200

antibody from SICGEN
Targeting: PTPRC CD45, GP180, LCA, T200
Provider product page for AB0100-200

Antibody data

Product number
AB0100-200 - Provider product page
Provider
SICGEN
Proper citation
SICGEN Cat#AB0100-200, RRID:AB_2333126
Product name
Anti-CD45
Antibody type
Polyclonal
Description
Goat polyclonal antibody to CD45. It is a 180-220 kDa type I transmembrane glycoprotein and a member of the protein tyrosine phosphatase (PTP) family. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. It is expressed in all hematopoietic cells, but highest on lymphocytes. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. It has intrinsic tyrosine phosphatase activity and it is essential for T and B cell antigen receptor-mediated activation. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signalling. CD45 also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signalling. The cross-linking of CD45 induces apoptosis in lymphocytes.
Reactivity
Human, Mouse, Rat, Bovine, Canine, Chicken/Avian, Donkey, Feline, Goat, Guinea Pig, Hamster, Horse, Porcine, Rabbit, Sheep, Simian, Other
Host
Goat
Conjugate
Unconjugated
Antigen sequence
EAEDLQVGQVELGGGPGAGSLQPLALEGSLQGT-E
VEDPQVAQLELGGGPGAGDLQTLALEVARQ
Isotype
IgG
Vial size
600 µg
Concentration
3 mg/ml
Storage
Store at -20 C for long-term storage. Store at 2-8 C for up to one month.
Handling
The antibody solution should be gently mixed before use.
PTPRC protein structure - AB0100-200 shown in red.