APG01107G

antibody from Leading Biology

Targeting: PARP3 ADPRT3, ADPRTL3, ARTD3, hPARP-3, IRT1, pADPRT-3

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APG01107G

Provider

Leading Biology

Product name

PARP3 Antibody (Internal)

Antibody type

Polyclonal

Description

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Reactivity

Human

Host

Goat

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.