Ab102061

antibody from Aladdin Scientific Corporation

Targeting: ERBB2 CD340, HER-2, HER2, NEU, NGL

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab102061

Provider

Aladdin Scientific Corporation

Product name

ErbB2/Her2 Mouse mAb

Antibody type

Monoclonal

Description

Mouse anti Human ErbB 2 Antibody, Monoclonal(1C4-1H3-1H3), could be used for WB, IHC and so on .Application:WB: 1/500-1/1000IHC: 1/50-1/100Protein FunctionProtein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA 1094-1111


Antibody clone number

1C4-1H3-1H3

Vial size

100μl,10μl,1ml,50μl

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.