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- Antigen structure
- References [13]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 13926-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13926-1-AP, RRID:AB_2152050
- Product name
- NPC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NPC1 antibody (Cat. #13926-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Proteomic profile of human dental follicle stem cells and apical papilla stem cells.
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins.
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking.
The non-canonical NF-κB pathway promotes NPC2 expression and regulates intracellular cholesterol trafficking.
The delayed effects of antibiotics in type 2 diabetes, friend or foe?
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.
The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Cholesterol transport through lysosome-peroxisome membrane contacts.
Cholesterol trafficking is required for mTOR activation in endothelial cells.
Lei T, Zhang X, Chen P, Li Q, Du H
Journal of proteomics 2021 Jan 16;231:103928
Journal of proteomics 2021 Jan 16;231:103928
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R
Nature communications 2021 Feb 11;12(1):961
Nature communications 2021 Feb 11;12(1):961
Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV Jr, Walther TC
Proceedings of the National Academy of Sciences of the United States of America 2020 May 12;117(19):10565-10574
Proceedings of the National Academy of Sciences of the United States of America 2020 May 12;117(19):10565-10574
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
Miyamoto T, Hosoba K, Itabashi T, Iwane AH, Akutsu SN, Ochiai H, Saito Y, Yamamoto T, Matsuura S
The EMBO journal 2020 Jun 17;39(12):e103499
The EMBO journal 2020 Jun 17;39(12):e103499
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins.
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL
Science China. Life sciences 2019 Sep;62(9):1117-1135
Science China. Life sciences 2019 Sep;62(9):1117-1135
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking.
Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Chakravarty H, Zhang S, Tam KY, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS
International journal of biological sciences 2018;14(10):1175-1185
International journal of biological sciences 2018;14(10):1175-1185
The non-canonical NF-κB pathway promotes NPC2 expression and regulates intracellular cholesterol trafficking.
Liao Y, Wei J, Wang J, Shi X, Luo J, Song BL
Science China. Life sciences 2018 Oct;61(10):1222-1232
Science China. Life sciences 2018 Oct;61(10):1222-1232
The delayed effects of antibiotics in type 2 diabetes, friend or foe?
Fu L, Qiu Y, Shen L, Cui C, Wang S, Wang S, Xie Y, Zhao X, Gao X, Ning G, Nie A, Gu Y
The Journal of endocrinology 2018 Aug;238(2):137-149
The Journal of endocrinology 2018 Aug;238(2):137-149
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.
Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Yang C, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS
Cancer letters 2017 Nov 28;409:91-103
Cancer letters 2017 Nov 28;409:91-103
The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes.
Wei J, Zhang YY, Luo J, Wang JQ, Zhou YX, Miao HH, Shi XJ, Qu YX, Xu J, Li BL, Song BL
Cell reports 2017 Jun 27;19(13):2823-2835
Cell reports 2017 Jun 27;19(13):2823-2835
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research 2016 Aug;57(8):1398-411
Journal of lipid research 2016 Aug;57(8):1398-411
Cholesterol transport through lysosome-peroxisome membrane contacts.
Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL, Song BL
Cell 2015 Apr 9;161(2):291-306
Cell 2015 Apr 9;161(2):291-306
Cholesterol trafficking is required for mTOR activation in endothelial cells.
Xu J, Dang Y, Ren YR, Liu JO
Proceedings of the National Academy of Sciences of the United States of America 2010 Mar 9;107(10):4764-9
Proceedings of the National Academy of Sciences of the United States of America 2010 Mar 9;107(10):4764-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 13926-1-AP(NPC1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NPC1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NPC1. This antibody recognizes human antigen. The NPC1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
