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- Antibody Data
- Antigen structure
- References [424]
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- Western blot [1]
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- Product number
- 10380-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10380-1-AP, RRID:AB_2068632
- Product name
- Caspase 9/p35/p10 antibody
- Antibody type
- Polyclonal
- Description
- Caspase 9/p35/p10 antibody (Cat. #10380-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Interference of KLF9 relieved the development of gestational diabetes mellitus by upregulating DDAH2.
Inhibition of gap junction communication between cells can induce apoptosis of corpus cavernosum smooth muscle in guinea pigs.
Comprehensive analysis of abnormal expression, prognostic value and oncogenic role of the hub gene FN1 in pancreatic ductal adenocarcinoma via bioinformatic analysis and in vitro experiments.
MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11.
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Tea Polyphenols Prevent Sepsis-Induced Lung Injury via Promoting Translocation of DJ-1 to Mitochondria.
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway.
PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway.
Resistance of bone marrow mesenchymal stem cells in a stressed environment - Comparison with osteocyte cells.
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment.
miR-21-5p inhibits inflammation injuries in LPS-treated H9c2 cells by regulating PDCD4.
LncRNA TMPO-AS1 serves as a sponge for miR-4731-5p modulating breast cancer progression through FOXM1.
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Baicalin Attenuates Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron-Astrocyte Cocultures.
siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.
SNHG9, a Papillary Thyroid Cancer Cell Exosome-Enriched lncRNA, Inhibits Cell Autophagy and Promotes Cell Apoptosis of Normal Thyroid Epithelial Cell Nthy-ori-3 Through YBOX3/P21 Pathway.
Remarkable inhibition effects of afatinib alone or combining with paclitaxel in esophageal squamous cell carcinoma.
Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Prolonged exposure to the herbicide atrazine suppresses immune cell functions by inducing spleen cell apoptosis in rats.
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca2+ homeostasis.
UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer.
Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats.
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice.
Protective effect of Huyang Yangkun Formula on ovarian function in premature ovarian insufficiency rats based on apoptotic mechanism.
NAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth.
Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.
Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats.
PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway.
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Cordyceps acid alleviates lung cancer in nude mice.
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation.
Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling.
Lenvatinib Induces AKT/NF-κB Inactivation, Apoptosis Signal Transduction and Growth Inhibition of Non-small Cell Lung Cancer In Vivo.
Effects of homocysteine and memantine on oxidative stress related TRP cation channels in in-vitro model of Alzheimer's disease.
miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Psychosocial and behavioral problems of children and adolescents in the early stage of reopening schools after the COVID-19 pandemic: a national cross-sectional study in China.
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis.
MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Neferine promotes the apoptosis of HNSCC through the accumulation of p62/SQSTM1 caused by autophagic flux inhibition.
Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway.
Timolol induces necroptosis, apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro.
Topotecan induces hepatocellular injury via ASCT2 mediated oxidative stress.
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
The inhibition of colorectal cancer growth by the natural product macrocarpal I.
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury.
LncRNA SNHG16 contributes to tumor progression via the miR-302b-3p/SLC2A4 axis in pancreatic adenocarcinoma.
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
A newly identified small molecular compound acts as a protein kinase inhibitor to suppress metastasis of colorectal cancer.
RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
Stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the TRPV2 channel protein.
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca2+ Homeostasis, and Bcl2 Expression.
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression.
Thyroid stimulating hormone aggravates diabetic retinopathy through the mitochondrial apoptotic pathway.
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
MicroRNA-1 affects the development of the neural crest and craniofacial skeleton via the mitochondrial apoptosis pathway.
Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
A novel amphibian-derived peptide alleviated ultraviolet B-induced photodamage in mice.
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
C2C12 Mouse Myoblasts Damage Induced by Oxidative Stress Is Alleviated by the Antioxidant Capacity of the Active Substance Phloretin.
The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.
Glycyrrhizic Acid Modulates Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits Protein Kinase B- and Extracellular Signal-Regulated Kinase-Mediated Metastatic Potential in Hepatocellular Carcinoma In Vitro and In Vivo.
Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway.
Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction.
Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways.
Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.
Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats.
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/β‑catenin pathway.
Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway.
A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.
Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway.
miR-149-5p Regulates Goat Hair Follicle Stem Cell Proliferation and Apoptosis by Targeting the CMTM3/AR Axis During Superior-Quality Brush Hair Formation.
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.
A novel antisense lncRNA NT5E promotes progression by modulating the expression of SYNCRIP and predicts a poor prognosis in pancreatic cancer.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy.
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Protective effects of alfalfa saponins on oxidative stress-induced apoptotic cells.
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer.
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine.
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Gastrodin alleviates bone damage by modulating protein expression and tissue redox state.
Therapeutic Efficacy and Inhibitory Mechanism of Regorafenib Combined With Radiation in Colorectal Cancer.
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin.
Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury.
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Antihypertensive and renal protective effect of Shunaoxin pill combined with captopril on spontaneous hypertension rats.
MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells.
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Matrine and baicalin inhibit apoptosis induced by Panton-Valentine leukocidin of Staphylococcus aureus in bovine mammary epithelial cells.
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following β‑catenin silencing.
Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell.
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and -resistant chronic myeloid leukaemia cells.
The roles of SHANK1 in the development of colon cancer.
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
The In Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma.
An integrated transcriptomics and network pharmacology approach to exploring the mechanism of adriamycin-induced kidney injury.
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis.
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy.
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis.
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Polymethoxyflavones from citrus inhibited gastric cancer cell proliferation through inducing apoptosis by upregulating RARβ, both in vitro and in vivo.
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum.
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Caspase-8 Induces Lysosome-Associated Cell Death in Cancer Cells.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
PNS-R1 inhibits Dex-induced bronchial epithelial cells apoptosis in asthma through mitochondrial apoptotic pathway.
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.
Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress- and Ca2+ Imbalance-Mediated Endoplasmic Reticulum Stress.
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway.
SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism.
Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells.
The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.
Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: in vitro and in vivo studies.
The oncogenic role of GNL3 in the progression and metastasis of osteosarcoma.
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Lyn Kinase Promotes the Proliferation of Malignant Melanoma Cells through Inhibition of Apoptosis and Autophagy via the PI3K/Akt Signaling Pathway.
Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma.
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer.
Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury.
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway.
α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation.
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.
Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide.
Mitochondrial Pathway Is Involved in Advanced Glycation End Products-Induced Apoptosis of Rabbit Annulus Fibrosus Cells.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
H2S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling.
Iron chelation effect of curcumin and baicalein on aplastic anemia mouse model with iron overload.
Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.
The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells.
Synthesized glucocorticoid-induced leucine zipper peptide inhibits photoreceptor apoptosis and protects retinal function in light-induced retinal degeneration model.
HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway.
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats.
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.
The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy.
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy.
Moderate activation of Wnt/β-catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence.
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
VceC Mediated IRE1 Pathway and Inhibited CHOP-induced Apoptosis to Support Brucella Replication in Goat Trophoblast Cells.
Protective effects of ethyl gallate on H2O2-induced mitochondrial dysfunction in PC12 cells.
Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro.
Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non-small cell lung cancer by modulating Wnt/β-catenin pathway.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.
Knockdown MTMR14 promotes cell apoptosis and inhibits migration in liver cancer cells.
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Add-On therapy with Chinese herb medicine Bo-Er-Ning capsule (BENC) improves outcomes of gastric cancer patients: a randomized clinical trial followed with bioinformatics-assisted mechanism study.
Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.
HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an Autocrine Fashion and Predicts Poor Survival in Gastric Cancer.
Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.
Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer.
MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
Toosendanin induces caspase-dependent apoptosis through the p38 MAPK pathway in human gastric cancer cells.
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition.
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Exogenous hydrogen sulfide protects human umbilical vein endothelial cells against high glucose‑induced injury by inhibiting the necroptosis pathway.
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.
Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis.
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.
Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.
Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Inhibition of the TRPM2 and TRPV1 Channels through Hypericum perforatum in Sciatic Nerve Injury-induced Rats Demonstrates their Key Role in Apoptosis and Mitochondrial Oxidative Stress of Sciatic Nerve and Dorsal Root Ganglion.
Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy.
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway.
Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems.
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice.
Cloning, expression pattern, and potential role of apoptosis inhibitor 5 in the termination of embryonic diapause and early embryo development of Artemia sinica.
Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide.
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury.
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Inhibited effects of CAPE-pNO2 on cervical carcinoma in vivo and in vitro and its detected metabolites.
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways.
Protective Effects of Fucoidan on Aβ25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice.
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1.
Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Antitumor effects of baicalin on ovarian cancer cells through induction of cell apoptosis and inhibition of cell migration in vitro.
Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium.
Epigallocatechin-3-gallate inhibits H2O2-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.
Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis.
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway.
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels.
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
Inhibition of Human Glioma Cell Proliferation Caused by Knockdown of Utrophin Using a Lentivirus-Mediated System.
Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells.
Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure.
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways.
HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis.
Enhanced anti-tumor activity of trichosanthin after combination with a human-derived cell-penetrating peptide, and a possible mechanism of activity.
Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway.
Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells.
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice.
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin.
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway.
CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice.
Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis.
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Impaired unfolded protein response in the degeneration of cochlea cells in a mouse model of age-related hearing loss.
Cold-inducible RNA-binding protein inhibits neuron apoptosis through the suppression of mitochondrial apoptosis.
XRCC2 as a predictive biomarker for radioresistance in locally advanced rectal cancer patients undergoing preoperative radiotherapy.
Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells.
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis.
Lentivirus mediated silencing of ubiquitin specific peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro.
MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Role of gap junction intercellular communication in testicular leydig cell apoptosis induced by oxaliplatin via the mitochondrial pathway.
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis.
Potent effects of dioscin against liver fibrosis.
IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1.
Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice.
Total flavonoids of litsea coreana enhance the cytotoxicity of oxaliplatin by increasing gap junction intercellular communication.
Apoptosis Induction by the Total Flavonoids from Arachniodes exilis in HepG2 Cells through Reactive Oxygen Species-Mediated Mitochondrial Dysfunction Involving MAPK Activation.
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Protective effects of dioscin against alcohol-induced liver injury.
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.
Inhibition of autophagy promotes caspase-mediated apoptosis by tunicamycin in HepG2 cells.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice.
Emodin regulates apoptotic pathway in human liver cancer cells.
Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer.
TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Khat (Catha edulis) generates reactive oxygen species and promotes hepatic cell apoptosis via MAPK activation.
The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents.
Alantolactone induces activation of apoptosis in human hepatoma cells.
Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-κB.
Characterization of 9-nitrocamptothecin liposomes: anticancer properties and mechanisms on hepatocellular carcinoma in vitro and in vivo.
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes.
Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Interference of KLF9 relieved the development of gestational diabetes mellitus by upregulating DDAH2.
Chen W, Wang H, Liu J, Li K
Bioengineered 2022 Jan;13(1):395-406
Bioengineered 2022 Jan;13(1):395-406
Inhibition of gap junction communication between cells can induce apoptosis of corpus cavernosum smooth muscle in guinea pigs.
Wang Y, Wang J, Hao Z, Yang H, Li Y, Tan M, Liu L, Feng S, Mei L, Qian B
Andrologia 2022 Feb;54(1):e14287
Andrologia 2022 Feb;54(1):e14287
Comprehensive analysis of abnormal expression, prognostic value and oncogenic role of the hub gene FN1 in pancreatic ductal adenocarcinoma via bioinformatic analysis and in vitro experiments.
Lei X, Chen G, Li J, Wen W, Gong J, Fu J
PeerJ 2021;9:e12141
PeerJ 2021;9:e12141
MicroRNA-222 Transferred From Semen Extracellular Vesicles Inhibits Sperm Apoptosis by Targeting BCL2L11.
Ding Y, Ding N, Zhang Y, Xie S, Huang M, Ding X, Dong W, Zhang Q, Jiang L
Frontiers in cell and developmental biology 2021;9:736864
Frontiers in cell and developmental biology 2021;9:736864
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806
Frontiers in cell and developmental biology 2021;9:679806
Tea Polyphenols Prevent Sepsis-Induced Lung Injury via Promoting Translocation of DJ-1 to Mitochondria.
Jia CM, Zhang FW, Wang SJ, Wang W, Li Y
Frontiers in cell and developmental biology 2021;9:622507
Frontiers in cell and developmental biology 2021;9:622507
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.
Shang Y, Wang Q, Li J, Liu H, Zhao Q, Huang X, Dong H, Chen W, Gui R, Nie X
Frontiers in chemistry 2021;9:522708
Frontiers in chemistry 2021;9:522708
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY
Journal of immunology research 2021;2021:6696606
Journal of immunology research 2021;2021:6696606
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Zhang J, Cheng P, Dai W, Ji J, Wu L, Feng J, Wu J, Yu Q, Li J, Guo C
PPAR research 2021;2021:6658944
PPAR research 2021;2021:6658944
Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway.
Cheng Z, Guo C
PPAR research 2021;2021:6632137
PPAR research 2021;2021:6632137
PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway.
Wu L, Yu Q, Cheng P, Guo C
PPAR research 2021;2021:6626295
PPAR research 2021;2021:6626295
Resistance of bone marrow mesenchymal stem cells in a stressed environment - Comparison with osteocyte cells.
Shimasaki M, Ueda S, Ichiseki T, Hirata H, Kawahara N, Ueda Y
International journal of medical sciences 2021;18(6):1375-1381
International journal of medical sciences 2021;18(6):1375-1381
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment.
Wang K, Miao X, Kong F, Huang S, Mo J, Jin C, Zheng Y
Drug design, development and therapy 2021;15:3749-3764
Drug design, development and therapy 2021;15:3749-3764
miR-21-5p inhibits inflammation injuries in LPS-treated H9c2 cells by regulating PDCD4.
Xue J, Liu J, Xu B, Yu J, Zhang A, Qin L, Liu C, Yang Y
American journal of translational research 2021;13(10):11450-11460
American journal of translational research 2021;13(10):11450-11460
LncRNA TMPO-AS1 serves as a sponge for miR-4731-5p modulating breast cancer progression through FOXM1.
Wang Y, Ma J, Li R, Gao X, Wang H, Jiang G
American journal of translational research 2021;13(10):11094-11106
American journal of translational research 2021;13(10):11094-11106
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Chu BX, Li YN, Liu N, Yuan LX, Chen SY, Zhu YH, Wang JF
Frontiers in immunology 2021;12:757909
Frontiers in immunology 2021;12:757909
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306
Frontiers in pharmacology 2021;12:653306
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Zhang KK, Wang H, Qu D, Chen LJ, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xu JT, Xie XL, Li DR
Frontiers in pharmacology 2021;12:641917
Frontiers in pharmacology 2021;12:641917
Baicalin Attenuates Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron-Astrocyte Cocultures.
Li C, Sui C, Wang W, Yan J, Deng N, Du X, Cheng F, Ma X, Wang X, Wang Q
Frontiers in pharmacology 2021;12:599543
Frontiers in pharmacology 2021;12:599543
siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.
Chen YR, Feng WY, Cheng YX, Zhu H, Liu HJ, Gao Y, Zhou WJ
Frontiers in oncology 2021;11:662444
Frontiers in oncology 2021;11:662444
SNHG9, a Papillary Thyroid Cancer Cell Exosome-Enriched lncRNA, Inhibits Cell Autophagy and Promotes Cell Apoptosis of Normal Thyroid Epithelial Cell Nthy-ori-3 Through YBOX3/P21 Pathway.
Wen D, Liu WL, Lu ZW, Cao YM, Ji QH, Wei WJ
Frontiers in oncology 2021;11:647034
Frontiers in oncology 2021;11:647034
Remarkable inhibition effects of afatinib alone or combining with paclitaxel in esophageal squamous cell carcinoma.
Yang LY, Cheng ZJ, Liu Z, Wang D, Zhang N, Fan ZL, Cai HQ, Zhang Y, Cai Y, Xu X, Wang JH, Du GH, Hao JJ, Wang MR
Journal of gastroenterology and hepatology 2021 Sep;36(9):2513-2522
Journal of gastroenterology and hepatology 2021 Sep;36(9):2513-2522
Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.
Huang YL, Zhang GH, Zhu Q, Wu X, Wu LG
Cancer reports (Hoboken, N.J.) 2021 Sep 23;:e1561
Cancer reports (Hoboken, N.J.) 2021 Sep 23;:e1561
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Li L, Wang J, Feng L, Fan J, Wang J, Tan N, Wang Z
Journal of ethnopharmacology 2021 Sep 15;277:114184
Journal of ethnopharmacology 2021 Sep 15;277:114184
Prolonged exposure to the herbicide atrazine suppresses immune cell functions by inducing spleen cell apoptosis in rats.
Ge J, Liu J, Wang T, Huang D, Li J, Zhang S, Wang M, Liu W, Zhao L
Ecotoxicology and environmental safety 2021 Sep 1;220:112386
Ecotoxicology and environmental safety 2021 Sep 1;220:112386
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca2+ homeostasis.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809
Cell biology and toxicology 2021 Oct;37(5):795-809
UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer.
Wang D, He J, Dong J, Wu S, Liu S, Zhu H, Xu T
Cancer letters 2021 Oct 28;519:2-19
Cancer letters 2021 Oct 28;519:2-19
Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats.
Wang S, Li Y, Li W, Zhang K, Yuan Z, Cai Y, Xu K, Zhou J, Du Z
Journal of ethnopharmacology 2021 Oct 28;279:113703
Journal of ethnopharmacology 2021 Oct 28;279:113703
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Feng X, Cao A, Qin T, Zhang Q, Fan S, Wang B, Song B, Yu X, Li L
Oncology reports 2021 Nov;46(5)
Oncology reports 2021 Nov;46(5)
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide.
Wang N, Zhu P, Huang R, Sun L, Dong D, Gao Y
Experimental and therapeutic medicine 2021 Nov;22(5):1246
Experimental and therapeutic medicine 2021 Nov;22(5):1246
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice.
Li M, Cheng W, Zhang L
Metallomics : integrated biometal science 2021 Nov 19;13(11)
Metallomics : integrated biometal science 2021 Nov 19;13(11)
Protective effect of Huyang Yangkun Formula on ovarian function in premature ovarian insufficiency rats based on apoptotic mechanism.
Wang L, Li M, Liu J, Nie G, Li Y, Yang H
Journal of ethnopharmacology 2021 Nov 15;280:114477
Journal of ethnopharmacology 2021 Nov 15;280:114477
NAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth.
Liu S, Zhang Y, Cui S, Song D, Li B, Chen Q, Yao G, Gong B
Cancer cell international 2021 Nov 13;21(1):605
Cancer cell international 2021 Nov 13;21(1):605
Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.
Zhang S, Liu W, Wang P, Hu B, Lv X, Chen S, Wang B, Shao Z
Molecular and cellular biochemistry 2021 May;476(5):1979-1994
Molecular and cellular biochemistry 2021 May;476(5):1979-1994
Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats.
Liu J, Liu B, Yuan P, Cheng L, Sun H, Gui J, Pan Y, Huang D, Chen H, Jiang L
Ecotoxicology and environmental safety 2021 May;214:112005
Ecotoxicology and environmental safety 2021 May;214:112005
PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway.
Han Z, Liu D, Chen L, He Y, Tian X, Qi L, Chen L, Luo Y, Chen Z, Hu X, Li G, Zhan L, Wang Y, Li Q, Chen P, Liu Z, Guo H
Cell death & disease 2021 May 28;12(6):552
Cell death & disease 2021 May 28;12(6):552
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H
Cell death & disease 2021 May 18;12(6):510
Cell death & disease 2021 May 18;12(6):510
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, Xue H, Wu M, Xu L
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Han B, Jiang P, Jiang L, Li X, Ye X
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation.
Li C, Shi L, Peng C, Yu G, Zhang Y, Du Z
Chemico-biological interactions 2021 Mar 1;337:109331
Chemico-biological interactions 2021 Mar 1;337:109331
Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling.
Wang F, Younis M, Luo Y, Zhang L, Yuan L
International immunopharmacology 2021 Jun;95:107532
International immunopharmacology 2021 Jun;95:107532
Lenvatinib Induces AKT/NF-κB Inactivation, Apoptosis Signal Transduction and Growth Inhibition of Non-small Cell Lung Cancer In Vivo.
Liu YC, Hsu FT, Chung JG, Weng MC, Ting CY, Tsai CJ, Lan A, Wu JY, Lin CC, Lin SS
Anticancer research 2021 Jun;41(6):2867-2874
Anticancer research 2021 Jun;41(6):2867-2874
Effects of homocysteine and memantine on oxidative stress related TRP cation channels in in-vitro model of Alzheimer's disease.
Övey İS, Nazıroğlu M
Journal of receptor and signal transduction research 2021 Jun;41(3):273-283
Journal of receptor and signal transduction research 2021 Jun;41(3):273-283
miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.
Han S, Wang Z, Liu J, Wang HD, Yuan Q
Biochemical pharmacology 2021 Jun;188:114539
Biochemical pharmacology 2021 Jun;188:114539
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Psychosocial and behavioral problems of children and adolescents in the early stage of reopening schools after the COVID-19 pandemic: a national cross-sectional study in China.
Wang L, Zhang Y, Chen L, Wang J, Jia F, Li F, Froehlich TE, Hou Y, Hao Y, Shi Y, Deng H, Zhang J, Huang L, Xie X, Fang S, Xu L, Xu Q, Guan H, Wang W, Shen J, Qian Y, Wang X, Shan L, Tan C, Yu Y, Wang X, Chen F, Zhang L, Li X, Shi X, Ke X, Li T
Translational psychiatry 2021 Jun 3;11(1):342
Translational psychiatry 2021 Jun 3;11(1):342
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
Tian L, Wang S, Zhao L, Lu X, Zhu C, Gong H, Yang W
FEBS open bio 2021 Jun 11;
FEBS open bio 2021 Jun 11;
A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis.
Dong X, Zhang M, Chen Y, Li C, Wang Y, Jin X
Journal of plastic surgery and hand surgery 2021 Jun 10;:1-10
Journal of plastic surgery and hand surgery 2021 Jun 10;:1-10
MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA.
Yang YL, Tsai MC, Chang YH, Wang CC, Chu PY, Lin HY, Huang YH
International journal of molecular sciences 2021 Jun 1;22(11)
International journal of molecular sciences 2021 Jun 1;22(11)
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
Neferine promotes the apoptosis of HNSCC through the accumulation of p62/SQSTM1 caused by autophagic flux inhibition.
Zhu F, Li X, Tang X, Jiang J, Han Y, Li Y, Ma C, Liu Z, He Y
International journal of molecular medicine 2021 Jul;48(1)
International journal of molecular medicine 2021 Jul;48(1)
Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1α-GLUT1 pathway.
Wang S, Cai Y, Feng Q, Gao J, Teng B
Cancer cell international 2021 Jul 19;21(1):382
Cancer cell international 2021 Jul 19;21(1):382
Timolol induces necroptosis, apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro.
Jiang GJ, Li BB, Fan TJ
Life sciences 2021 Jul 15;277:119453
Life sciences 2021 Jul 15;277:119453
Topotecan induces hepatocellular injury via ASCT2 mediated oxidative stress.
Zhou G, Qin M, Zhang X, Yang J, Yu H
Gastroenterologia y hepatologia 2021 Jan;44(1):1-12
Gastroenterologia y hepatologia 2021 Jan;44(1):1-12
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
Cai Y, Yang E, Yao X, Zhang X, Wang Q, Wang Y, Liu J, Fan W, Yi K, Kang C, Wu J
Redox biology 2021 Jan;38:101792
Redox biology 2021 Jan;38:101792
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Wang P, Wang C, Liu C
Oncology letters 2021 Jan;21(1):59
Oncology letters 2021 Jan;21(1):59
The inhibition of colorectal cancer growth by the natural product macrocarpal I.
Qi L, Zhang Y, Zhang W, Wang Y, Han Y, Ding Y
Free radical biology & medicine 2021 Jan;162:383-391
Free radical biology & medicine 2021 Jan;162:383-391
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190
Free radical biology & medicine 2021 Jan;162:181-190
Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury.
Jin P, Li LH, Shi Y, Hu NB
Gene 2021 Jan 30;767:145075
Gene 2021 Jan 30;767:145075
LncRNA SNHG16 contributes to tumor progression via the miR-302b-3p/SLC2A4 axis in pancreatic adenocarcinoma.
Xu H, Miao X, Li X, Chen H, Zhang B, Zhou W
Cancer cell international 2021 Jan 12;21(1):51
Cancer cell international 2021 Jan 12;21(1):51
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways.
Jiao Y, Zhao D, Gao F, Hu X, Hu X, Li M, Cui Y, Wei X, Xie C, Zhao Y, Gao Y
Journal of physiology and biochemistry 2021 Feb;77(1):47-61
Journal of physiology and biochemistry 2021 Feb;77(1):47-61
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer.
Jhou AJ, Chang HC, Hung CC, Lin HC, Lee YC, Liu WT, Han KF, Lai YW, Lin MY, Lee CH
Biochemical pharmacology 2021 Feb;184:114403
Biochemical pharmacology 2021 Feb;184:114403
A newly identified small molecular compound acts as a protein kinase inhibitor to suppress metastasis of colorectal cancer.
Qi L, Zhang Y, Song F, Han Y, Ding Y
Bioorganic chemistry 2021 Feb;107:104625
Bioorganic chemistry 2021 Feb;107:104625
RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
Ling J, Cai H, Lin M, Qi S, Du J, Chen L
Acta biochimica et biophysica Sinica 2021 Feb 4;53(2):170-178
Acta biochimica et biophysica Sinica 2021 Feb 4;53(2):170-178
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
Chen Y, Tian Y, Jin G, Cui Z, Guo W, Zhang X, Liu X
Human & experimental toxicology 2021 Dec;40(12):2074-2086
Human & experimental toxicology 2021 Dec;40(12):2074-2086
Stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the TRPV2 channel protein.
Yu ZH, Ji YC, Li K, Liang T, Liu B, Chen HL, Ni L, Luo ZP, Yang HL
Cellular signalling 2021 Aug;84:110005
Cellular signalling 2021 Aug;84:110005
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca2+ Homeostasis, and Bcl2 Expression.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Zhang Y, Peng X
Molecular nutrition & food research 2021 Aug;65(15):e2001202
Molecular nutrition & food research 2021 Aug;65(15):e2001202
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
Liu J, Liu L, Han YS, Yi J, Guo C, Zhao HQ, Ling J, Wang YH
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
Xianjun F, Xirui X, Jie T, Huiwen M, Shaojun Z, Qiaoyun L, Yunxin L, Xuqun S
Journal of pharmacological sciences 2021 Aug;146(4):249-258
Journal of pharmacological sciences 2021 Aug;146(4):249-258
Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression.
Yao C, Zhou Y, Wang H, Deng F, Chen Y, Zhu X, Kong Y, Pan L, Xue L, Zhou X, Shi C, Sheng X
Stem cell research & therapy 2021 Aug 9;12(1):447
Stem cell research & therapy 2021 Aug 9;12(1):447
Thyroid stimulating hormone aggravates diabetic retinopathy through the mitochondrial apoptotic pathway.
Lin D, Qin R, Guo L
Journal of cellular physiology 2021 Aug 25;
Journal of cellular physiology 2021 Aug 25;
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Xie C, Zhou X, Liang C, Li X, Ge M, Chen Y, Yin J, Zhu J, Zhong C
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Xiaoli F, Yaqing Z, Ruhui L, Xuan L, Aijie C, Yanli Z, Chen H, Lili C, Longquan S
Journal of hazardous materials 2021 Aug 15;416:126158
Journal of hazardous materials 2021 Aug 15;416:126158
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Zhou S, He Y, Zhang W, Xiong Y, Jiang L, Wang J, Cui X, Qu Y, Ge F
Journal of ethnopharmacology 2021 Aug 10;276:114189
Journal of ethnopharmacology 2021 Aug 10;276:114189
MicroRNA-1 affects the development of the neural crest and craniofacial skeleton via the mitochondrial apoptosis pathway.
Zhao N, Qin W, Wang D, Raquel AG, Yuan L, Mao Y, Ma C, Xiao Z, Ma J
Experimental and therapeutic medicine 2021 Apr;21(4):379
Experimental and therapeutic medicine 2021 Apr;21(4):379
Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
Liu J, Han YS, Liu L, Tang L, Yang H, Meng P, Zhao HQ, Wang YH
Neural regeneration research 2021 Apr;16(4):727-733
Neural regeneration research 2021 Apr;16(4):727-733
A novel amphibian-derived peptide alleviated ultraviolet B-induced photodamage in mice.
Zhang X, Feng C, Wang S, Wang Y, Fu Z, Zhang Y, Sun H, Xie C, Fu Y, Tao J, Luo M, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111258
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111258
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
Wang ZD, Feng Y, Sun L, Gan J, Li X, Ding WF, Chen XM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
C2C12 Mouse Myoblasts Damage Induced by Oxidative Stress Is Alleviated by the Antioxidant Capacity of the Active Substance Phloretin.
Li J, Yang Q, Han L, Pan C, Lei C, Chen H, Lan X
Frontiers in cell and developmental biology 2020;8:541260
Frontiers in cell and developmental biology 2020;8:541260
The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.
Feng B, Zhao C, Li J, Yu J, Zhang Y, Zhang X, Tian T, Zhao L
Chemical & pharmaceutical bulletin 2020;68(10):962-970
Chemical & pharmaceutical bulletin 2020;68(10):962-970
Glycyrrhizic Acid Modulates Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits Protein Kinase B- and Extracellular Signal-Regulated Kinase-Mediated Metastatic Potential in Hepatocellular Carcinoma In Vitro and In Vivo.
Tsai JJ, Pan PJ, Hsu FT, Chung JG, Chiang IT
The American journal of Chinese medicine 2020;48(1):223-244
The American journal of Chinese medicine 2020;48(1):223-244
Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway.
Cui G, Li L, Xu W, Wang M, Jiao D, Yao B, Xu K, Chen Y, Yang S, Long M, Li P, Guo Y
Oxidative medicine and cellular longevity 2020;2020:7639109
Oxidative medicine and cellular longevity 2020;2020:7639109
Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction.
Chen S, Tian Q, Shang C, Yang L, Wei N, Shang G, Ji Y, Kou H, Lu S, Liu H
BioMed research international 2020;2020:6976317
BioMed research international 2020;2020:6976317
Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways.
Wu X, Liu Y, Zhang E, Chen J, Huang X, Yan H, Cao W, Qu J, Gu H, Xu R, He J, Cai Z
Oxidative medicine and cellular longevity 2020;2020:6096391
Oxidative medicine and cellular longevity 2020;2020:6096391
Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.
Xue W, Liu Y, Xin N, Miao J, Du J, Wang Y, Shi H, Wei Y, Zhang H, Chen Y, Gao Y, Li D, Feng Y, Yan J, Zhang J, Hou N, Huang C, Han J
BioMed research international 2020;2020:5053975
BioMed research international 2020;2020:5053975
Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats.
Li S, Dong J, Ta G, Liu Y, Cui J, Li X, Song J, Liu A, Cheng G
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5041629
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5041629
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548
Oxidative medicine and cellular longevity 2020;2020:4196548
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Kang D, Zuo W, Wu Q, Zhu Q, Liu P
BioMed research international 2020;2020:1358674
BioMed research international 2020;2020:1358674
Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway.
Li C, Wang X, Yan J, Cheng F, Ma X, Chen C, Wang W, Wang Q
Oxidative medicine and cellular longevity 2020;2020:1201624
Oxidative medicine and cellular longevity 2020;2020:1201624
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH
Chinese medicine 2020;15:23
Chinese medicine 2020;15:23
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Zhang X, Chen Y, Wang K, Tang J, Chen Y, Jin G, Liu X
International journal of clinical and experimental pathology 2020;13(9):2228-2239
International journal of clinical and experimental pathology 2020;13(9):2228-2239
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, Liu H, Zhang Y, Zhang J, Gui R, Nie X
OncoTargets and therapy 2020;13:473-486
OncoTargets and therapy 2020;13:473-486
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Xu F, Xu Y, Xiong JH, Zhang JH, Wu J, Luo J, Xiong JP
Cancer management and research 2020;12:1789-1798
Cancer management and research 2020;12:1789-1798
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
Yang B, Bai H, Sa Y, Zhu P, Liu P
Journal of Cancer 2020;11(8):2303-2317
Journal of Cancer 2020;11(8):2303-2317
NFE2L3 promotes malignant behavior and EMT of human hepatocellular carcinoma (HepG2) cells via Wnt/β‑catenin pathway.
Ren Y, Wang Y, Hao S, Yang Y, Xiong W, Qiu L, Tao J, Tang A
Journal of Cancer 2020;11(23):6939-6949
Journal of Cancer 2020;11(23):6939-6949
Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway.
Yu J, Wang W, Yao W, Yang Z, Gao P, Liu M, Wang H, Chen S, Wang D, Wang W, Sun G
Journal of Cancer 2020;11(19):5568-5577
Journal of Cancer 2020;11(19):5568-5577
A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.
Pan B, Wang Y, Wu C, Jia J, Huang C, Fang S, Liu L
Frontiers in pharmacology 2020;11:592903
Frontiers in pharmacology 2020;11:592903
Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway.
Wu D, Zhong P, Wang Y, Zhang Q, Li J, Liu Z, Ji A, Li Y
Frontiers in pharmacology 2020;11:585860
Frontiers in pharmacology 2020;11:585860
miR-149-5p Regulates Goat Hair Follicle Stem Cell Proliferation and Apoptosis by Targeting the CMTM3/AR Axis During Superior-Quality Brush Hair Formation.
Wang J, Qu J, Li Y, Feng Y, Ma J, Zhang L, Chu C, Hu H, Wang Y, Ji D
Frontiers in genetics 2020;11:529757
Frontiers in genetics 2020;11:529757
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
Su W, Zhao J, Fan TJ
Frontiers in pharmacology 2020;11:202
Frontiers in pharmacology 2020;11:202
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Yan Z, Zhan J, Qi W, Lin J, Huang Y, Xue X, Pan X
Frontiers in pharmacology 2020;11:1195
Frontiers in pharmacology 2020;11:1195
Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting.
Ren L, Feng W, Shao J, Ma J, Xu M, Zhu BZ, Zheng N, Liu S
Theranostics 2020;10(14):6384-6398
Theranostics 2020;10(14):6384-6398
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.
An K, Zhang Y, Liu Y, Yan S, Hou Z, Cao M, Liu G, Dong C, Gao J, Liu G
Oncology reports 2020 Sep;44(3):1116-1126
Oncology reports 2020 Sep;44(3):1116-1126
A novel antisense lncRNA NT5E promotes progression by modulating the expression of SYNCRIP and predicts a poor prognosis in pancreatic cancer.
Zhang P, Cao M, Zhang Y, Xu L, Meng F, Wu X, Xia T, Chen Q, Shi G, Wu P, Chen L, Lu Z, Yin J, Cai B, Cao S, Miao Y, Jiang K
Journal of cellular and molecular medicine 2020 Sep;24(18):10898-10912
Journal of cellular and molecular medicine 2020 Sep;24(18):10898-10912
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Liu J, Shangguan Y, Sun J, Cong W, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy.
Hu X, Xia M, Wang J, Yu H, Chai J, Zhang Z, Sun Y, Su J, Sun L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110397
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110397
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Dai GH, Chen X, Ren ZM, Dai CJ, Tong YL, Chai KQ
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
Protective effects of alfalfa saponins on oxidative stress-induced apoptotic cells.
Cui Y, Liu B, Sun X, Li Z, Chen Y, Guo Z, Liu H, Li D, Wang C, Zhu X, Shi Y
Food & function 2020 Sep 23;11(9):8133-8140
Food & function 2020 Sep 23;11(9):8133-8140
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
Liu J, Deng X, Sun X, Dong J, Huang J
Life sciences 2020 Sep 15;257:118040
Life sciences 2020 Sep 15;257:118040
Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer.
Liu A, Zuo Z, Liu L, Liu L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Oct;98(5):548-555
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Oct;98(5):548-555
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Feng AL, Han X, Meng X, Chen Z, Li Q, Shu W, Dai H, Zhu J, Yang Z
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Song Q, He Z, Li B, Liu J, Liu L, Liao W, Xiong Y, Song C, Yang S, Liu Y
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Yu X, Li H, Zhu M, Hu P, Liu X, Qing Y, Wang X, Wang H, Wang Z, Xu J, Tan R, Guo Q, Hui H
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
Anticancer Effects of Honokiol via Mitochondrial Dysfunction Are Strongly Enhanced by the Mitochondria-Targeting Carrier Berberine.
Shi X, Zhang T, Lou H, Song H, Li C, Fan P
Journal of medicinal chemistry 2020 Oct 22;63(20):11786-11800
Journal of medicinal chemistry 2020 Oct 22;63(20):11786-11800
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Gao Z, Dlamini MB, Ge H, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Toxicology letters 2020 Oct 1;331:178-187
Toxicology letters 2020 Oct 1;331:178-187
Role of TLR4/MyD88/NF-κB signaling in the contrast-induced injury of renal tubular epithelial cells.
Wang X, Zhou J, Yang J, Wang S, Yang L
Experimental and therapeutic medicine 2020 Nov;20(5):115
Experimental and therapeutic medicine 2020 Nov;20(5):115
Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Liang Z, Zhong Y, Meng L, Chen Y, Liu Y, Wu A, Li X, Wang M
Thoracic cancer 2020 Nov;11(11):3155-3167
Thoracic cancer 2020 Nov;11(11):3155-3167
Gastrodin alleviates bone damage by modulating protein expression and tissue redox state.
Zheng B, Shi C, Muhammed FK, He J, Abdullah AO, Liu Y
FEBS open bio 2020 Nov;10(11):2404-2416
FEBS open bio 2020 Nov;10(11):2404-2416
Therapeutic Efficacy and Inhibitory Mechanism of Regorafenib Combined With Radiation in Colorectal Cancer.
Liu YC, Chiang IT, Chung JG, Hsieh JH, Chiang CH, Weng MC, Hsu FT, Lee YH, Chang CS, Lin SS
In vivo (Athens, Greece) 2020 Nov-Dec;34(6):3217-3224
In vivo (Athens, Greece) 2020 Nov-Dec;34(6):3217-3224
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
Yuan J, Zhang G, Li X, Ma Q, Cheng W, Wang W, Zhang B, Hu T, Song G
International journal of molecular sciences 2020 Nov 25;21(23)
International journal of molecular sciences 2020 Nov 25;21(23)
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin.
Man S, Lv P, Cui J, Liu F, Peng L, Ma L, Liu C, Gao W
Toxicology and applied pharmacology 2020 Nov 1;406:115206
Toxicology and applied pharmacology 2020 Nov 1;406:115206
Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury.
Torigoe K, Obata Y, Torigoe M, Oka S, Yamamoto K, Koji T, Ueda H, Mukae H, Nishino T
Clinical and experimental nephrology 2020 May;24(5):411-419
Clinical and experimental nephrology 2020 May;24(5):411-419
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933
Biochemical pharmacology 2020 May;175:113933
Antihypertensive and renal protective effect of Shunaoxin pill combined with captopril on spontaneous hypertension rats.
Man S, Yang L, Xiang H, Lu G, Wang Y, Liu C, Gao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109977
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109977
MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells.
Du J, Li J, Gao M, Guan Q, Liu T, Wu Y, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2020 May 25;323:109074
Chemico-biological interactions 2020 May 25;323:109074
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.
Ma Z, Yang J, Yang Y, Wang X, Chen G, Shi A, Lu Y, Jia S, Kang X, Lu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Mar;68:153186
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Mar;68:153186
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Gucer H, Caliskan S, Kefeli M, Mete O
Endocrine pathology 2020 Mar;31(1):33-38
Endocrine pathology 2020 Mar;31(1):33-38
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Dao R, Wudu M, Hui L, Jiang J, Xu Y, Ren H, Qiu X
Pathology, research and practice 2020 Mar;216(3):152823
Pathology, research and practice 2020 Mar;216(3):152823
Matrine and baicalin inhibit apoptosis induced by Panton-Valentine leukocidin of Staphylococcus aureus in bovine mammary epithelial cells.
Jia F, Ma W, Zhang X, Wang D, Zhou X
Journal of dairy science 2020 Mar;103(3):2731-2742
Journal of dairy science 2020 Mar;103(3):2731-2742
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
Zhang X, Wang Z, Li W, Huang R, Zheng D, Bi G
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Wang B, Xu H, Hu X, Ma W, Zhang J, Li Y, Yu M, Zhang Y, Li X, Ye X
Life sciences 2020 Mar 15;245:117387
Life sciences 2020 Mar 15;245:117387
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Yu M, Zeng M, Pan Z, Wu F, Guo L, He G
European journal of medicinal chemistry 2020 Mar 1;189:112076
European journal of medicinal chemistry 2020 Mar 1;189:112076
Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following β‑catenin silencing.
Zhu X, Feng J, Fu W, Shu X, Wan X, Liu J
International journal of molecular medicine 2020 Jun;45(6):1838-1850
International journal of molecular medicine 2020 Jun;45(6):1838-1850
Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell.
Peng F, Li G, Xie Y, Yin HY, Li XJ, Yang YD
Journal of food biochemistry 2020 Jun;44(6):e13222
Journal of food biochemistry 2020 Jun;44(6):e13222
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Zheng Y, Nie P, Xu S
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and -resistant chronic myeloid leukaemia cells.
Jiang L, Wen C, He Q, Sun Y, Wang J, Lan X, Rohondia S, Dou QP, Shi X, Liu J
European journal of pharmacology 2020 Jun 5;876:173064
European journal of pharmacology 2020 Jun 5;876:173064
The roles of SHANK1 in the development of colon cancer.
Wang L, Lv Y, Liu G
Cell biochemistry and function 2020 Jul;38(5):669-675
Cell biochemistry and function 2020 Jul;38(5):669-675
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
The In Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma.
Chen YS, Sun R, Chen WL, Yau YC, Hsu FT, Chung JG, Tsai CJ, Hsieh CL, Chiu YM, Chen JH
In vivo (Athens, Greece) 2020 Jul-Aug;34(4):1789-1796
In vivo (Athens, Greece) 2020 Jul-Aug;34(4):1789-1796
An integrated transcriptomics and network pharmacology approach to exploring the mechanism of adriamycin-induced kidney injury.
He S, Li A, Zhang W, Zhang L, Liu Y, Li K, Qin X
Chemico-biological interactions 2020 Jul 1;325:109096
Chemico-biological interactions 2020 Jul 1;325:109096
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Yang QY, Yang KP, Li ZZ
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis.
Zheng Y, Nie P, Xu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109628
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109628
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, Yuan X, Sha Q
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy.
Lin JZ, Wang WW, Hu TT, Zhu GY, Li LN, Zhang CY, Xu Z, Yu HB, Wu HF, Zhu JG
Cancer letters 2020 Jan 28;469:481-489
Cancer letters 2020 Jan 28;469:481-489
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Zhou Y, Fu X, Guan Y, Gong M, He K, Huang B
Biochemical pharmacology 2020 Feb;172:113752
Biochemical pharmacology 2020 Feb;172:113752
Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis.
Bronowicka-Adamska P, Bentke A, Lasota M, Wróbel M
International journal of molecular sciences 2020 Feb 6;21(3)
International journal of molecular sciences 2020 Feb 6;21(3)
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
Fan J, Ren D, Wang J, Liu X, Zhang H, Wu M, Yang G
Cell death & disease 2020 Feb 18;11(2):126
Cell death & disease 2020 Feb 18;11(2):126
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
Polymethoxyflavones from citrus inhibited gastric cancer cell proliferation through inducing apoptosis by upregulating RARβ, both in vitro and in vivo.
Wang Y, Chen Y, Zhang H, Chen J, Cao J, Chen Q, Li X, Sun C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Dec;146:111811
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Dec;146:111811
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum.
Long P, He M, Yan W, Chen W, Wei D, Wang S, Zhang Z, Ge W, Chen T
Aging 2020 Dec 19;13(2):2750-2767
Aging 2020 Dec 19;13(2):2750-2767
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Guan S, Tao S, Huang Y, Jin Y, Hu Y, Lu J
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Yang T, Fan TJ, Xu B
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Su Q, Wang J, Liu F, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
Zhang X, Zhang P, An L, Sun N, Peng L, Tang W, Ma D, Chen J
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
Caspase-8 Induces Lysosome-Associated Cell Death in Cancer Cells.
Zhong B, Liu M, Bai C, Ruan Y, Wang Y, Qiu L, Hong Y, Wang X, Li L, Li B
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Apr 8;28(4):1078-1091
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Apr 8;28(4):1078-1091
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Apr 19;397:115014
Toxicology and applied pharmacology 2020 Apr 19;397:115014
PNS-R1 inhibits Dex-induced bronchial epithelial cells apoptosis in asthma through mitochondrial apoptotic pathway.
Zou W, Niu C, Fu Z, Gong C
Cell & bioscience 2019;9:18
Cell & bioscience 2019;9:18
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z
Oxidative medicine and cellular longevity 2019;2019:6521218
Oxidative medicine and cellular longevity 2019;2019:6521218
Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.
Wang W, Wu L, Li J, Ji J, Chen K, Yu Q, Li S, Feng J, Liu T, Zhang J, Chen J, Zhou Y, Mao Y, Wang F, Dai W, Fan X, Guo C, Wu J
Mediators of inflammation 2019;2019:3240713
Mediators of inflammation 2019;2019:3240713
Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress- and Ca2+ Imbalance-Mediated Endoplasmic Reticulum Stress.
Cui J, Liu Y, Chang X, Gou W, Zhou X, Liu Z, Li Z, Wu Y, Zuo D
Oxidative medicine and cellular longevity 2019;2019:2593742
Oxidative medicine and cellular longevity 2019;2019:2593742
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Liu H, Zhao J, Fu R, Zhu C, Fan D
PloS one 2019;14(5):e0216759
PloS one 2019;14(5):e0216759
Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway.
Wang Y, Pang B, Zhang R, Fu Y, Pang Q
Drug design, development and therapy 2019;13:3217-3228
Drug design, development and therapy 2019;13:3217-3228
SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism.
Chen Z, Lin J, Feng S, Chen X, Huang H, Wang C, Yu Y, He Y, Han S, Zheng L, Huang G
OncoTargets and therapy 2019;12:2397-2408
OncoTargets and therapy 2019;12:2397-2408
Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells.
Shi S, Zheng G, Yang C, Chen X, Yan Q, Jiang F, Jiang X, Xin Y, Jiang G
OncoTargets and therapy 2019;12:11715-11727
OncoTargets and therapy 2019;12:11715-11727
The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.
Cao X, He Y, Li X, Xu Y, Liu X
American journal of translational research 2019;11(2):641-654
American journal of translational research 2019;11(2):641-654
Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: in vitro and in vivo studies.
Jiang J, Wang X, Gao G, Liu X, Chang H, Xiong R, Lu J, Sun Z
American journal of translational research 2019;11(10):6382-6392
American journal of translational research 2019;11(10):6382-6392
The oncogenic role of GNL3 in the progression and metastasis of osteosarcoma.
Li T, Li L, Wu X, Tian K, Wang Y
Cancer management and research 2019;11:2179-2188
Cancer management and research 2019;11:2179-2188
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, Liu Z, Zheng M, Wang H, Wang J, Teng T, Zhang L, Ji X, Xie Z, Ji A, Li Y
Journal of Cancer 2019;10(7):1693-1706
Journal of Cancer 2019;10(7):1693-1706
Lyn Kinase Promotes the Proliferation of Malignant Melanoma Cells through Inhibition of Apoptosis and Autophagy via the PI3K/Akt Signaling Pathway.
Zhang Q, Meng X, Qin G, Xue X, Dang N
Journal of Cancer 2019;10(5):1197-1208
Journal of Cancer 2019;10(5):1197-1208
Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma.
Tian N, Shangguan W, Zhou Z, Yao Y, Fan C, Cai L
Journal of Cancer 2019;10(24):6074-6087
Journal of Cancer 2019;10(24):6074-6087
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Suo L, Chang X, Xu N, Ji H
Frontiers in endocrinology 2019;10:370
Frontiers in endocrinology 2019;10:370
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Ge LN, Yan L, Li C, Cheng K
Molecular medicine reports 2019 Sep;20(3):2805-2811
Molecular medicine reports 2019 Sep;20(3):2805-2811
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, Wang J, Bao Y
Pharmacological research 2019 Sep;147:104387
Pharmacological research 2019 Sep;147:104387
Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer.
Liu X, Lu Y, Xu Y, Hou S, Huang J, Wang B, Zhao J, Xia S, Fan S, Yu X, Du Y, Hou L, Li Z, Ding Z, An S, Huang B, Li L, Tang J, Ju J, Guan H, Song B
Cancer letters 2019 Sep 10;459:122-134
Cancer letters 2019 Sep 10;459:122-134
Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.
Zhang Q, Cao WS, Wang XQ, Zhang M, Lu XM, Chen JQ, Chen Y, Ge MM, Zhong CY, Han HY
Phytotherapy research : PTR 2019 Oct;33(10):2783-2791
Phytotherapy research : PTR 2019 Oct;33(10):2783-2791
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Yang Q, Wang C, Jin Y, Ma X, Xie T, Wang J, Liu K, Sun H
Pharmacological research 2019 Oct;148:104414
Pharmacological research 2019 Oct;148:104414
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, Wang F
International journal of molecular sciences 2019 Oct 29;20(21)
International journal of molecular sciences 2019 Oct 29;20(21)
Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
Zhang J, Yao D, Song Y, Pan Y, Zhu L, Bai Y, Xu Y, Zhang J, Shao C
Scientific reports 2019 Oct 23;9(1):15221
Scientific reports 2019 Oct 23;9(1):15221
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Li F, Zhang Y, Lu X, Shi J, Gong Q
Life sciences 2019 Oct 1;234:116739
Life sciences 2019 Oct 1;234:116739
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
Hua S, Liu J, Zhang Y, Li J, Zhang X, Dong L, Zhao Y, Fu X
Food science & nutrition 2019 Nov;7(11):3443-3451
Food science & nutrition 2019 Nov;7(11):3443-3451
TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury.
Wu X, Kong Q, Zhan L, Qiu Z, Huang Q, Song X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Nov;68(11):981-992
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 Nov;68(11):981-992
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Yue G, Chen C, Bai L, Wang G, Huang Y, Wang Y, Cui H, Xiao Y
Molecular medicine reports 2019 Nov;20(5):4551-4557
Molecular medicine reports 2019 Nov;20(5):4551-4557
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Shen J, Wang J, Du J, Wang L, Zhou X, Chang X, Li Z, Zhai X, Zuo D, Wu Y
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway.
Yu Q, Wu L, Liu T, Li S, Feng J, Mao Y, Fan X, Guo C, Wu J
International immunopharmacology 2019 May;70:435-445
International immunopharmacology 2019 May;70:435-445
α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation.
Sun J, Feng Y, Wang Y, Ji Q, Cai G, Shi L, Wang Y, Huang Y, Zhang J, Li Q
International journal of oncology 2019 May;54(5):1601-1612
International journal of oncology 2019 May;54(5):1601-1612
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S, Yan Q
Journal of cellular physiology 2019 May;234(5):7435-7447
Journal of cellular physiology 2019 May;234(5):7435-7447
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
Fan J, Wu M, Wang J, Ren D, Zhao J, Yang G
Journal of cellular physiology 2019 May;234(5):6336-6349
Journal of cellular physiology 2019 May;234(5):6336-6349
Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.
Song F, Wei M, Wang J, Liu Y, Guo M, Li X, Luo J, Zhou J, Wang M, Guo D, Chen L, Sun G
Cancer science 2019 May;110(5):1633-1643
Cancer science 2019 May;110(5):1633-1643
Chondrocyte apoptosis in rat mandibular condyles induced by dental occlusion due to mitochondrial damage caused by nitric oxide.
Ren H, Yang H, Xie M, Wen Y, Liu Q, Li X, Liu J, Xu H, Tang W, Wang M
Archives of oral biology 2019 May;101:108-121
Archives of oral biology 2019 May;101:108-121
Mitochondrial Pathway Is Involved in Advanced Glycation End Products-Induced Apoptosis of Rabbit Annulus Fibrosus Cells.
Hu Y, Shao Z, Cai X, Liu Y, Shen M, Yao Y, Yuan T, Wang W, Ding F, Xiong L
Spine 2019 May 15;44(10):E585-E595
Spine 2019 May 15;44(10):E585-E595
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury.
Liu Z, Li T, Zhu F, Deng S, Li X, He Y
Cell death & disease 2019 Mar 7;10(3):227
Cell death & disease 2019 Mar 7;10(3):227
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
H2S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF/EGFR signaling.
Zhang Y, Gao J, Sun W, Wen X, Xi Y, Wang Y, Wei C, Xu C, Li H
Aging 2019 Mar 26;11(6):1745-1758
Aging 2019 Mar 26;11(6):1745-1758
Iron chelation effect of curcumin and baicalein on aplastic anemia mouse model with iron overload.
Dijiong W, Xiaowen W, Linlong X, Wenbin L, Huijin H, Baodong Y, Yuhong Z
Iranian journal of basic medical sciences 2019 Jun;22(6):660-668
Iranian journal of basic medical sciences 2019 Jun;22(6):660-668
Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.
Wang R, Li D, Ouyang J, Tian X, Zhao Y, Peng X, Li S, Yu G, Yang J
Toxicology 2019 Jun 15;422:1-13
Toxicology 2019 Jun 15;422:1-13
The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells.
Cui C, Li Z, Wu D
Biological research 2019 Jun 13;52(1):32
Biological research 2019 Jun 13;52(1):32
Synthesized glucocorticoid-induced leucine zipper peptide inhibits photoreceptor apoptosis and protects retinal function in light-induced retinal degeneration model.
Gu R, Tang W, Lei B, Jiang C, Song F, Xu G
Clinical & experimental ophthalmology 2019 Jul;47(5):646-657
Clinical & experimental ophthalmology 2019 Jul;47(5):646-657
HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Sun X, Huang X, Zhu X, Liu L, Mo S, Wang H, Wei X, Lu S, Bai F, Wang D, Lin X, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway.
Ni B, Shen H, Wang W, Lu H, Jiang L
Journal of orthopaedic surgery and research 2019 Jul 29;14(1):241
Journal of orthopaedic surgery and research 2019 Jul 29;14(1):241
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Dong Q, Yang B, Han JG, Zhang MM, Liu W, Zhang X, Yu HL, Liu ZG, Zhang SH, Li T, Wu DD, Ji XY, Duan SF
Cancer letters 2019 Jul 28;455:60-72
Cancer letters 2019 Jul 28;455:60-72
Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats.
Uslusoy F, Nazıroğlu M, Övey İS, Sönmez TT
The Journal of pharmacy and pharmacology 2019 Jan;71(1):83-92
The Journal of pharmacy and pharmacology 2019 Jan;71(1):83-92
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q, Shen DY
Oncology reports 2019 Jan;41(1):213-223
Oncology reports 2019 Jan;41(1):213-223
Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.
Zheng L, Han X, Hu Y, Zhao X, Yin L, Xu L, Qi Y, Xu Y, Han X, Liu K, Peng J
Pharmacological research 2019 Jan;139:431-439
Pharmacological research 2019 Jan;139:431-439
The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.
Li Z, Li Q, Lv W, Jiang L, Geng C, Yao X, Shi X, Liu Y, Cao J
Free radical biology & medicine 2019 Jan;130:576-591
Free radical biology & medicine 2019 Jan;130:576-591
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.
Li L, Liu M, Zhang Z, Zhang W, Liu N, Sheng X, Wei P
Biological research 2019 Feb 27;52(1):8
Biological research 2019 Feb 27;52(1):8
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, Xu J
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, Zhao X
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy.
Wang Y, Mao X, Chen H, Feng J, Yan M, Wang Y, Yu Y
International immunopharmacology 2019 Aug;73:471-481
International immunopharmacology 2019 Aug;73:471-481
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.
Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, Meng Y, Chen Y, Wang X, Chen J, Zhang Q, Shao J, Zhong C
International journal of food sciences and nutrition 2019 Aug;70(5):570-578
International journal of food sciences and nutrition 2019 Aug;70(5):570-578
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Liu P, Zhang HM, Hu K, Zhou XF, Tang S
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy.
Wen J, Xu B, Sun Y, Lian M, Li Y, Lin Y, Chen D, Diao Y, Almoiliqy M, Wang L
Pharmacological research 2019 Aug;146:104308
Pharmacological research 2019 Aug;146:104308
Moderate activation of Wnt/β-catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence.
Li Z, Chen S, Chen S, Huang D, Ma K, Shao Z
Journal of cellular biochemistry 2019 Aug;120(8):12519-12533
Journal of cellular biochemistry 2019 Aug;120(8):12519-12533
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
Shang Y, Wang Q, Wu B, Zhao Q, Li J, Huang X, Chen W, Gui R
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
VceC Mediated IRE1 Pathway and Inhibited CHOP-induced Apoptosis to Support Brucella Replication in Goat Trophoblast Cells.
Zhi F, Zhou D, Bai F, Li J, Xiang C, Zhang G, Jin Y, Wang A
International journal of molecular sciences 2019 Aug 22;20(17)
International journal of molecular sciences 2019 Aug 22;20(17)
Protective effects of ethyl gallate on H2O2-induced mitochondrial dysfunction in PC12 cells.
Chen L, Wu X, Shen T, Wang X, Wang S, Wang J, Ren D
Metabolic brain disease 2019 Apr;34(2):545-555
Metabolic brain disease 2019 Apr;34(2):545-555
Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro.
Jing Z, Wang C, Yang Q, Wei X, Jin Y, Meng Q, Liu Q, Liu Z, Ma X, Liu K, Sun H, Liu M
Journal of cellular physiology 2019 Apr;234(4):4472-4490
Journal of cellular physiology 2019 Apr;234(4):4472-4490
Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non-small cell lung cancer by modulating Wnt/β-catenin pathway.
Li XY, Liu YR, Zhou JH, Li W, Guo HH, Ma HP
European review for medical and pharmacological sciences 2019 Apr;23(8):3366-3374
European review for medical and pharmacological sciences 2019 Apr;23(8):3366-3374
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.
Lu L, Chen G, Yang J, Ma Z, Yang Y, Hu Y, Lu Y, Cao Z, Wang Y, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108625
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108625
Knockdown MTMR14 promotes cell apoptosis and inhibits migration in liver cancer cells.
Li Z, Rong L, Lian H, Cheng J, Wu X, Li X
Gene 2019 Apr 5;691:106-113
Gene 2019 Apr 5;691:106-113
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Mao J, Yi M, Wang R, Huang Y, Chen M
Frontiers in pharmacology 2018;9:1469
Frontiers in pharmacology 2018;9:1469
Add-On therapy with Chinese herb medicine Bo-Er-Ning capsule (BENC) improves outcomes of gastric cancer patients: a randomized clinical trial followed with bioinformatics-assisted mechanism study.
Pan B, Zang J, He J, Wang Z, Liu L
American journal of cancer research 2018;8(6):1090-1105
American journal of cancer research 2018;8(6):1090-1105
Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study.
Hu XN, Wang JF, Huang YQ, Wang Z, Dong FY, Ma HF, Bao ZJ
PeerJ 2018;6:e5145
PeerJ 2018;6:e5145
HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an Autocrine Fashion and Predicts Poor Survival in Gastric Cancer.
Zhai E, Liang W, Lin Y, Huang L, He X, Cai S, Chen J, Zhang N, Li J, Zhang Q, He Y, Zeng Z, Chen M, Xu L, Peng S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(2):879-892
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(2):879-892
Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.
Zheng Q, Zhou F, Cui X, Liu M, Li Y, Liu S, Tan J, Yan Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2297-2310
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2297-2310
Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer.
Sun X, Zhan L, Chen Y, Wang G, He L, Wang Q, Zhou F, Yang F, Wu J, Wu Y, Xing J, He X, Huang Q
Signal transduction and targeted therapy 2018;3:8
Signal transduction and targeted therapy 2018;3:8
MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Tian ZQ, Jiang H, Lu ZB
Cellular & molecular biology letters 2018;23:41
Cellular & molecular biology letters 2018;23:41
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Zhang GY, Lu D, Duan SF, Gao YR, Liu SY, Hong Y, Dong PZ, Chen YG, Li T, Wang DY, Cheng XS, He F, Wei JS, Li GY, Zhang QY, Wu DD, Ji XY
Oxidative medicine and cellular longevity 2018;2018:9647809
Oxidative medicine and cellular longevity 2018;2018:9647809
The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
Yu Q, Liu T, Li S, Feng J, Wu L, Wang W, Chen K, Xia Y, Niu P, Xu L, Wang F, Dai W, Zhou Y, Guo C
Mediators of inflammation 2018;2018:4032484
Mediators of inflammation 2018;2018:4032484
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Zhang Y, Wang C, Jin Y, Yang Q, Meng Q, Liu Q, Dai Y, Cai L, Liu Z, Liu K, Sun H
Oxidative medicine and cellular longevity 2018;2018:2876350
Oxidative medicine and cellular longevity 2018;2018:2876350
Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.
Zhang HM, Liu P, Jiang C, Jin XQ, Liu RN, Li SQ, Zhao Y
PloS one 2018;13(2):e0193037
PloS one 2018;13(2):e0193037
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Li S, Wang C
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
Huang Y, Hu Z
Journal of cellular physiology 2018 Sep;233(9):7480-7496
Journal of cellular physiology 2018 Sep;233(9):7480-7496
Toosendanin induces caspase-dependent apoptosis through the p38 MAPK pathway in human gastric cancer cells.
Zhou Q, Wu X, Wen C, Wang H, Wang H, Liu H, Peng J
Biochemical and biophysical research communications 2018 Oct 20;505(1):261-266
Biochemical and biophysical research communications 2018 Oct 20;505(1):261-266
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Hu J, Wang H, Gu J, Liu X, Zhou X
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.
Qin T, Li B, Feng X, Fan S, Liu L, Liu D, Mao J, Lu Y, Yang J, Yu X, Zhang Q, Zhang J, Song B, Li M, Li L
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):287
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):287
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Wang J, Li H, Wang X, Shen T, Wang S, Ren D
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Loss of scinderin decreased expression of epidermal growth factor receptor and promoted apoptosis of castration-resistant prostate cancer cells.
Lai X, Su W, Zhao H, Yang S, Zeng T, Wu W, Wang D
FEBS open bio 2018 May;8(5):743-750
FEBS open bio 2018 May;8(5):743-750
The HER4-YAP1 axis promotes trastuzumab resistance in HER2-positive gastric cancer by inducing epithelial and mesenchymal transition.
Shi J, Li F, Yao X, Mou T, Xu Z, Han Z, Chen S, Li W, Yu J, Qi X, Liu H, Li G
Oncogene 2018 May;37(22):3022-3038
Oncogene 2018 May;37(22):3022-3038
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, Geng S, Wu J, Zhong C, Li M
Journal of cellular biochemistry 2018 May;119(5):4134-4141
Journal of cellular biochemistry 2018 May;119(5):4134-4141
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z
Free radical biology & medicine 2018 May 20;120:228-238
Free radical biology & medicine 2018 May 20;120:228-238
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Wu DD, Gao YR, Li T, Wang DY, Lu D, Liu SY, Hong Y, Ning HB, Liu JP, Shang J, Shi JF, Wei JS, Ji XY
BMC cancer 2018 May 2;18(1):499
BMC cancer 2018 May 2;18(1):499
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Exogenous hydrogen sulfide protects human umbilical vein endothelial cells against high glucose‑induced injury by inhibiting the necroptosis pathway.
Lin J, Chen M, Liu D, Guo R, Lin K, Deng H, Zhi X, Zhang W, Feng J, Wu W
International journal of molecular medicine 2018 Mar;41(3):1477-1486
International journal of molecular medicine 2018 Mar;41(3):1477-1486
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Liu S, Liu B
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.
Zhang Q, Li XT, Chen Y, Chen JQ, Zhu JY, Meng Y, Wang XQ, Li Y, Geng SS, Xie CF, Wu JS, Zhong CY, Han HY
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977
Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis.
Chen S, Lv X, Hu B, Zhao L, Li S, Li Z, Qing X, Liu H, Xu J, Shao Z
Apoptosis : an international journal on programmed cell death 2018 Jun;23(5-6):299-313
Apoptosis : an international journal on programmed cell death 2018 Jun;23(5-6):299-313
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Che C, Liu J, Yang J, Ma L, Bai N, Zhang Q
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
Zhang Y, Li H, Yang X, Jin G, Zhang Y
International journal of biological macromolecules 2018 Jun;112:788-795
International journal of biological macromolecules 2018 Jun;112:788-795
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Lu X, Liu T, Chen K, Xia Y, Dai W, Xu S, Xu L, Wang F, Wu L, Li J, Li S, Wang W, Yu Q, Feng J, Fan X, Zhou Y, Niu P, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Zhang J, Liu L, Wang J, Ren B, Zhang L, Li W
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Zhang ZF, Zhang HR, Zhang QY, Lai SY, Feng YZ, Zhou Y, Zheng SR, Shi R, Zhou JY
Journal of translational medicine 2018 Jan 19;16(1):9
Journal of translational medicine 2018 Jan 19;16(1):9
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, Li Z, Ye X, Li X
Life sciences 2018 Jan 1;192:259-269
Life sciences 2018 Jan 1;192:259-269
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.
Wang J, Tian L, Khan MN, Zhang L, Chen Q, Zhao Y, Yan Q, Fu L, Liu J
Cancer letters 2018 Feb 28;415:73-85
Cancer letters 2018 Feb 28;415:73-85
Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.
Zhao W, Che C, Liu K, Zhang J, Jiang N, Yuan K, Zhao G
Cornea 2018 Dec;37(12):1579-1585
Cornea 2018 Dec;37(12):1579-1585
Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.
Chen Y, Li Y, Wang XQ, Meng Y, Zhang Q, Zhu JY, Chen JQ, Cao WS, Wang XQ, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH
Cancers 2018 Dec 31;11(1)
Cancers 2018 Dec 31;11(1)
Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.
Liu L, Wang Q, Mao J, Qin T, Sun Y, Yang J, Han Y, Li L, Li Q
Chemico-biological interactions 2018 Dec 25;296:145-153
Chemico-biological interactions 2018 Dec 25;296:145-153
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Bai Z, Gao M, Xu X, Zhang H, Xu J, Guan Q, Wang Q, Du J, Li Z, Zuo D, Zhang W, Wu Y
Cell proliferation 2018 Aug;51(4):e12450
Cell proliferation 2018 Aug;51(4):e12450
Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease.
He J, Chen Q, Gu H, Chen J, Zhang E, Guo X, Huang X, Yan H, He D, Yang Y, Zhao Y, Wang G, He H, Yi Q, Cai Z
Haematologica 2018 Aug;103(8):1369-1379
Haematologica 2018 Aug;103(8):1369-1379
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Zhang H, Cao Y, Chen Y, Li G, Yu H
Oncology letters 2018 Apr;15(4):5739-5743
Oncology letters 2018 Apr;15(4):5739-5743
Inhibition of the TRPM2 and TRPV1 Channels through Hypericum perforatum in Sciatic Nerve Injury-induced Rats Demonstrates their Key Role in Apoptosis and Mitochondrial Oxidative Stress of Sciatic Nerve and Dorsal Root Ganglion.
Uslusoy F, Nazıroğlu M, Çiğ B
Frontiers in physiology 2017;8:335
Frontiers in physiology 2017;8:335
Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, Wang Y, Wei C, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2017;7:67
Cell & bioscience 2017;7:67
Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy.
Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH
Frontiers in cellular and infection microbiology 2017;7:223
Frontiers in cellular and infection microbiology 2017;7:223
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
Liu LS, Bai XQ, Gao Y, Wu Q, Ren Z, Li Q, Pan LH, He NY, Peng J, Tang ZH
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.
Zou J, Zhang Y, Sun J, Wang X, Tu H, Geng S, Liu R, Chen Y, Bi Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(5):1812-1821
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(5):1812-1821
Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model.
Zong S, Liu T, Wan F, Chen P, Luo P, Xiao H
Audiology & neuro-otology 2017;22(3):160-168
Audiology & neuro-otology 2017;22(3):160-168
Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway.
Wu L, Zhang Q, Dai W, Li S, Feng J, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Zhou Y, Fan X, Guo C
Gastroenterology research and practice 2017;2017:9724217
Gastroenterology research and practice 2017;2017:9724217
Sensitization of Radioresistant Prostate Cancer Cells by Resveratrol Isolated from Arachis hypogaea Stems.
Chen YA, Lien HM, Kao MC, Lo UG, Lin LC, Lin CJ, Chang SJ, Chen CC, Hsieh JT, Lin H, Tang CH, Lai CH
PloS one 2017;12(1):e0169204
PloS one 2017;12(1):e0169204
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice.
Feng J, Zhang Q, Mo W, Wu L, Li S, Li J, Liu T, Xu S, Fan X, Guo C
Drug design, development and therapy 2017;11:1989-2006
Drug design, development and therapy 2017;11:1989-2006
Cloning, expression pattern, and potential role of apoptosis inhibitor 5 in the termination of embryonic diapause and early embryo development of Artemia sinica.
Zhang S, Yao F, Jing T, Zhang M, Zhao W, Zou X, Sui L, Hou L
Gene 2017 Sep 10;628:170-179
Gene 2017 Sep 10;628:170-179
Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.
Zhou H, Zheng L, Lu K, Gao Y, Guo L, Xu W, Wang X
Medical science monitor : international medical journal of experimental and clinical research 2017 Oct 7;23:4817-4825
Medical science monitor : international medical journal of experimental and clinical research 2017 Oct 7;23:4817-4825
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, Liu S, Tan J, Yan Q
Cell death & disease 2017 Oct 26;8(10):e3145
Cell death & disease 2017 Oct 26;8(10):e3145
Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
Sheng N, Yan L, You W, Tan G, Gong J, Chen H, Yang Y, Hu L, Wang Z
Acta biochimica et biophysica Sinica 2017 Oct 1;49(10):926-934
Acta biochimica et biophysica Sinica 2017 Oct 1;49(10):926-934
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Zhao Y, Jing Z, Lv J, Zhang Z, Lin J, Cao X, Zhao Z, Liu P, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide.
Tan MJ, Cao XW, Li PF, Zhai YZ, Zhou Y, Liu YJ, Zhao J, Wang FJ
Biotechnology and applied biochemistry 2017 Nov;64(6):918-926
Biotechnology and applied biochemistry 2017 Nov;64(6):918-926
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Peng Z, Gong X, Yang Y, Huang L, Zhang Q, Zhang P, Wan R, Zhang B
International immunopharmacology 2017 Nov;52:281-289
International immunopharmacology 2017 Nov;52:281-289
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, He K
International immunopharmacology 2017 Nov;52:168-175
International immunopharmacology 2017 Nov;52:168-175
Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury.
Hu JB, Song GL, Liu D, Li SJ, Wu JH, Kang XQ, Qi J, Jin FY, Wang XJ, Xu XL, Ying XY, Yu L, You J, Du YZ
Drug delivery 2017 Nov;24(1):1856-1867
Drug delivery 2017 Nov;24(1):1856-1867
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Xu S, Niu P, Chen K, Xia Y, Yu Q, Liu N, Li J, Li S, Wu L, Feng J, Wang W, Lu X, Liu T, Wang F, Dai W, Fan X, Mo W, Xu L, Guo C
Scientific reports 2017 Nov 9;7(1):15175
Scientific reports 2017 Nov 9;7(1):15175
Inhibited effects of CAPE-pNO2 on cervical carcinoma in vivo and in vitro and its detected metabolites.
Yao X, Tang H, Ren Q, Zhao X, Zuo H, Li Z
Oncotarget 2017 Nov 7;8(55):94197-94209
Oncotarget 2017 Nov 7;8(55):94197-94209
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, Tan N
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.
Khan SH, Zhao D, Shah SZ, Hassan MF, Zhu T, Song Z, Zhou X, Yang L
Cellular and molecular neurobiology 2017 May;37(4):717-728
Cellular and molecular neurobiology 2017 May;37(4):717-728
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
Liu S, Sun Z, Chu P, Li H, Ahsan A, Zhou Z, Zhang Z, Sun B, Wu J, Xi Y, Han G, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
Zhu Y, Jiang Y, Shi L, Du L, Xu X, Wang E, Sun Y, Guo X, Zou B, Wang H, Wang C, Sun L, Zhen Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways.
Gao Y, Xiao X, Zhang C, Yu W, Guo W, Zhang Z, Li Z, Feng X, Hao J, Zhang K, Xiao B, Chen M, Huang W, Xiong S, Wu X, Deng W
Journal of pineal research 2017 Mar;62(2)
Journal of pineal research 2017 Mar;62(2)
Protective Effects of Fucoidan on Aβ25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice.
Wei H, Gao Z, Zheng L, Zhang C, Liu Z, Yang Y, Teng H, Hou L, Yin Y, Zou X
Marine drugs 2017 Mar 16;15(3)
Marine drugs 2017 Mar 16;15(3)
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, Li Y, Wang X, Meng Y, Zhu M, Ma X, Huang C, Wu R, Xie C, Geng S, Wu J, Zhong C, Han H
The Journal of nutritional biochemistry 2017 Jun;44:80-91
The Journal of nutritional biochemistry 2017 Jun;44:80-91
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Xie XC, Zhao N, Xu QH, Yang X, Xia WK, Chen Q, Wang M, Fei X
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, Han HY
Nutrients 2017 Jun 3;9(6)
Nutrients 2017 Jun 3;9(6)
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Lu SY, Wang CY, Jin Y, Meng Q, Liu Q, Liu ZH, Liu KX, Sun HJ, Liu MZ
Scientific reports 2017 Jun 13;7(1):3331
Scientific reports 2017 Jun 13;7(1):3331
LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1.
Wang ZB, Zhang S, Li Y, Wang RM, Tong LC, Wang Y, Liu WY, Su DF, Tu Y, Zhang LC, Li L
Acta pharmacologica Sinica 2017 Jul;38(7):1009-1023
Acta pharmacologica Sinica 2017 Jul;38(7):1009-1023
Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats.
Gu R, Tang W, Lei B, Ding X, Jiang C, Xu G
Investigative ophthalmology & visual science 2017 Jul 1;58(9):3656-3668
Investigative ophthalmology & visual science 2017 Jul 1;58(9):3656-3668
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Ma X, Geng S, Wu J, Zhong C
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, Ma H, He K, Wang Y, Han B, Ye X, Li X
Scientific reports 2017 Feb 6;7:38524
Scientific reports 2017 Feb 6;7:38524
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378
Cell biology international 2017 Dec;41(12):1367-1378
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, Zhao Y, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M
Chemosphere 2017 Dec;189:489-497
Chemosphere 2017 Dec;189:489-497
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Liu M, Liu S, Tan W, Tang F, Long J, Li Z, Liang B, Chu C, Yang J
Molecular medicine reports 2017 Dec;16(6):8953-8963
Molecular medicine reports 2017 Dec;16(6):8953-8963
Antitumor effects of baicalin on ovarian cancer cells through induction of cell apoptosis and inhibition of cell migration in vitro.
Gao C, Zhou Y, Li H, Cong X, Jiang Z, Wang X, Cao R, Tian W
Molecular medicine reports 2017 Dec;16(6):8729-8734
Molecular medicine reports 2017 Dec;16(6):8729-8734
Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium.
Yüksel E, Nazıroğlu M, Şahin M, Çiğ B
Scientific reports 2017 Dec 13;7(1):17543
Scientific reports 2017 Dec 13;7(1):17543
Epigallocatechin-3-gallate inhibits H2O2-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Yan X, Li Y, Yu H, Wang W, Wu C, Yang Y, Hu Y, Shi X, Li J
Scientific reports 2017 Aug 10;7(1):7774
Scientific reports 2017 Aug 10;7(1):7774
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, Sun B, Song Y, Lin Y, Peng J, Tang Z
Vascular pharmacology 2017 Apr;91:26-35
Vascular pharmacology 2017 Apr;91:26-35
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, Huang C, Wu R, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
He J, Shi J, Zhang K, Xue J, Li J, Yang J, Chen J, Wei J, Ren H, Liu X
Molecular medicine reports 2017 Apr;15(4):1693-1701
Molecular medicine reports 2017 Apr;15(4):1693-1701
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Shah SZA, Zhao D, Taglialatela G, Khan SH, Hussain T, Dong H, Lai M, Zhou X, Yang L
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Li L, Li M, Li Y, Sun W, Wang Y, Bai S, Li H, Wu B, Yang G, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2016;6:26
Cell & bioscience 2016;6:26
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Cui Y, Zhao D, Sreevatsan S, Liu C, Yang W, Song Z, Yang L, Barrow P, Zhou X
Frontiers in cellular and infection microbiology 2016;6:182
Frontiers in cellular and infection microbiology 2016;6:182
ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.
Zhou Y, Zhang S, Deng S, Dai C, Tang S, Yang X, Li D, Zhao K, Xiao X
Toxicology mechanisms and methods 2016;26(1):11-21
Toxicology mechanisms and methods 2016;26(1):11-21
Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis.
Li J, Chen K, Li S, Liu T, Wang F, Xia Y, Lu J, Zhou Y, Guo C
PloS one 2016;11(4):e0152570
PloS one 2016;11(4):e0152570
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Li Y, Jiang Z, Xue D, Deng G, Li M, Liu X, Wang Y
BMC microbiology 2016 Sep 23;16(1):222
BMC microbiology 2016 Sep 23;16(1):222
Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway.
Tang D, Wang C, Gao Y, Pu J, Long J, Xu W
Neuroscience letters 2016 Oct 6;632:79-85
Neuroscience letters 2016 Oct 6;632:79-85
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Sun B, Gao L, Ahsan A, Chu P, Song Y, Li H, Zhang Z, Lin Y, Peng J, Song Z, Wang S, Tang Z
International immunopharmacology 2016 Nov;40:400-409
International immunopharmacology 2016 Nov;40:400-409
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, Shen L, Luo A, Wang S
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels.
Akpınar H, Nazıroğlu M, Övey İS, Çiğ B, Akpınar O
Scientific reports 2016 Nov 22;6:37196
Scientific reports 2016 Nov 22;6:37196
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu K, Sun H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
Liu W, Ning R, Chen RN, Huang XF, Dai QS, Hu JH, Wang YW, Wu LL, Xiong J, Hu G, Guo QL, Yang J, Wang H
Molecular carcinogenesis 2016 May;55(5):440-57
Molecular carcinogenesis 2016 May;55(5):440-57
Inhibition of Human Glioma Cell Proliferation Caused by Knockdown of Utrophin Using a Lentivirus-Mediated System.
Shen SH, Yu N, Xu H, Liu XY, Tan GW, Wang ZX
Cancer biotherapy & radiopharmaceuticals 2016 May;31(4):133-8
Cancer biotherapy & radiopharmaceuticals 2016 May;31(4):133-8
Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells.
Wang L, Wang C, Jia Y, Liu Z, Shu X, Liu K
Journal of cellular biochemistry 2016 May;117(5):1233-9
Journal of cellular biochemistry 2016 May;117(5):1233-9
Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure.
Öz A, Çelik Ö
Molecular membrane biology 2016 May - Aug;33(3-5):76-88
Molecular membrane biology 2016 May - Aug;33(3-5):76-88
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
Aziz F, Wang X, Liu J, Yan Q
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Sun Z, Lan X, Ahsan A, Xi Y, Liu S, Zhang Z, Chu P, Song Y, Piao F, Peng J, Lin Y, Han G, Tang Z
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, Xu Y, Wang C, Peng J
European journal of pharmacology 2016 Mar 5;774:105-17
European journal of pharmacology 2016 Mar 5;774:105-17
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Lei X, Cui K, Li Z, Su J, Jiang J, Zhang H, Liu Q, Shi D
Theriogenology 2016 Mar 15;85(5):999-1012
Theriogenology 2016 Mar 15;85(5):999-1012
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways.
Zou M, Duan Y, Wang P, Gao R, Chen X, Ou Y, Liang M, Wang Z, Yuan Y, Wang L, Zhu H
Scientific reports 2016 Jun 2;6:27331
Scientific reports 2016 Jun 2;6:27331
HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia.
Zhe N, Chen S, Zhou Z, Liu P, Lin X, Yu M, Cheng B, Zhang Y, Wang J
Cancer biology & therapy 2016 Jun 2;17(6):625-34
Cancer biology & therapy 2016 Jun 2;17(6):625-34
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis.
Zhao Y, Jing Z, Li Y, Mao W
Oncology reports 2016 Jul;36(1):567-72
Oncology reports 2016 Jul;36(1):567-72
Enhanced anti-tumor activity of trichosanthin after combination with a human-derived cell-penetrating peptide, and a possible mechanism of activity.
Lu YZ, Li PF, Li YZ, Luo F, Guo C, Lin B, Cao XW, Zhao J, Wang FJ
Fitoterapia 2016 Jul;112:183-90
Fitoterapia 2016 Jul;112:183-90
Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway.
Wang C, Li T, Tang S, Zhao D, Zhang C, Zhang S, Deng S, Zhou Y, Xiao X
Environmental toxicology and pharmacology 2016 Jan;41:167-79
Environmental toxicology and pharmacology 2016 Jan;41:167-79
Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells.
Zhao C, Su G, Wang X, Zhang X, Guo S, Zhao Y
Biotechnology letters 2016 Jan;38(1):43-50
Biotechnology letters 2016 Jan;38(1):43-50
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
Peng X, Zhang YY, Wang J, Ji Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):865-76
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):865-76
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Radiation research 2016 Jan;185(1):77-86
Radiation research 2016 Jan;185(1):77-86
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice.
Wang X, Tian J, Yong KT, Zhu X, Lin MC, Jiang W, Li J, Huang Q, Lin G
Journal of nanobiotechnology 2016 Feb 4;14:10
Journal of nanobiotechnology 2016 Feb 4;14:10
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
Zhao L, Wen Q, Yang G, Huang Z, Shen T, Li H, Ren D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Jiang G, Liu J, Ren B, Tang Y, Owusu L, Li M, Zhang J, Liu L, Li W
Journal of ethnopharmacology 2016 Dec 4;193:368-376
Journal of ethnopharmacology 2016 Dec 4;193:368-376
Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells.
Wen C, Chen J, Zhang D, Wang H, Che J, Qin Q, He L, Cai Z, Lin M, Lou Q, Huang L, Chen D, Iwamoto A, Ren D, Wang L, Lan P, Wang J, Liu H, Yang X
Cancer letters 2016 Dec 28;383(2):295-308
Cancer letters 2016 Dec 28;383(2):295-308
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Tang Q, Ji F, Sun W, Wang J, Guo J, Guo L, Li Y, Bao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin.
Tang Q, Ji F, Guo J, Wang J, Li Y, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:693-703
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:693-703
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Ju D, Yamaguchi F, Zhan G, Higuchi T, Asakura T, Morita A, Orimo H, Hu S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway.
Chen X, Wang L, Zhao Y, Yuan S, Wu Q, Zhu X, Niang B, Wang S, Zhang J
Oncotarget 2016 Aug 9;7(32):51955-51964
Oncotarget 2016 Aug 9;7(32):51955-51964
CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
Xia ZX, Li ZX, Zhang M, Sun LM, Zhang QF, Qiu XS
Experimental and molecular pathology 2016 Apr;100(2):353-60
Experimental and molecular pathology 2016 Apr;100(2):353-60
Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice.
Mao Y, Wang J, Yu F, Cheng J, Li H, Guo C, Fan X
Drug design, development and therapy 2015;9:5385-96
Drug design, development and therapy 2015;9:5385-96
Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis.
Chen K, Dai W, Wang F, Xia Y, Li J, Li S, Liu T, Zhang R, Wang J, Lu W, Zhou Y, Yin Q, Zheng Y, Abudumijiti H, Chen R, Lu J, Zhou Y, Guo C
OncoTargets and therapy 2015;8:3585-93
OncoTargets and therapy 2015;8:3585-93
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Fu C, Xu D, Wang CY, Jin Y, Liu Q, Meng Q, Liu KX, Sun HJ, Liu MZ
Journal of cellular physiology 2015 Sep;230(9):2184-201
Journal of cellular physiology 2015 Sep;230(9):2184-201
Impaired unfolded protein response in the degeneration of cochlea cells in a mouse model of age-related hearing loss.
Wang W, Sun Y, Chen S, Zhou X, Wu X, Kong W, Kong W
Experimental gerontology 2015 Oct;70:61-70
Experimental gerontology 2015 Oct;70:61-70
Cold-inducible RNA-binding protein inhibits neuron apoptosis through the suppression of mitochondrial apoptosis.
Zhang HT, Xue JH, Zhang ZW, Kong HB, Liu AJ, Li SC, Xu DG
Brain research 2015 Oct 5;1622:474-83
Brain research 2015 Oct 5;1622:474-83
XRCC2 as a predictive biomarker for radioresistance in locally advanced rectal cancer patients undergoing preoperative radiotherapy.
Qin CJ, Song XM, Chen ZH, Ren XQ, Xu KW, Jing H, He YL
Oncotarget 2015 Oct 13;6(31):32193-204
Oncotarget 2015 Oct 13;6(31):32193-204
Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells.
Wen C, Huang L, Chen J, Lin M, Li W, Lu B, Rutnam ZJ, Iwamoto A, Wang Z, Yang X, Liu H
International journal of oncology 2015 Nov;47(5):1663-71
International journal of oncology 2015 Nov;47(5):1663-71
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis.
Guo LD, Shen YQ, Zhao XH, Guo LJ, Yu ZJ, Wang D, Liu LM, Liu JZ
Phytotherapy research : PTR 2015 Mar;29(3):357-65
Phytotherapy research : PTR 2015 Mar;29(3):357-65
Lentivirus mediated silencing of ubiquitin specific peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro.
Pan Z, Pan H, Zhang J, Yang Y, Liu H, Yang Y, Huang G, Ni J, Huang J, Zhou W
Biological research 2015 Mar 19;48(1):18
Biological research 2015 Mar 19;48(1):18
MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.
Yang T, Thakur A, Chen T, Yang L, Lei G, Liang Y, Zhang S, Ren H, Chen M
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4357-65
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4357-65
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Deng S, Tang S, Zhang S, Zhang C, Wang C, Zhou Y, Dai C, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jan;75:173-86
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jan;75:173-86
Role of gap junction intercellular communication in testicular leydig cell apoptosis induced by oxaliplatin via the mitochondrial pathway.
Tong X, Han X, Yu B, Yu M, Jiang G, Ji J, Dong S
Oncology reports 2015 Jan;33(1):207-14
Oncology reports 2015 Jan;33(1):207-14
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
Li X, Liu X, Xu Y, He Y, Liu J, Xie M
International journal of oncology 2015 Feb;46(2):677-84
International journal of oncology 2015 Feb;46(2):677-84
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
Shi Q, Song X, Fu J, Su C, Xia X, Song E, Song Y
International immunopharmacology 2015 Dec;29(2):722-729
International immunopharmacology 2015 Dec;29(2):722-729
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Gao L, Wang Y, Xu Z, Li X, Wu J, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
Ahsan A, Han G, Pan J, Liu S, Padhiar AA, Chu P, Sun Z, Zhang Z, Sun B, Wu J, Irshad A, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW
International journal of oncology 2015 Aug;47(2):701-9
International journal of oncology 2015 Aug;47(2):701-9
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis.
Yuan MM, Xu YY, Chen L, Li XY, Qin J, Shen Y
BMC cancer 2015 Apr 9;15:245
BMC cancer 2015 Apr 9;15:245
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1.
Yuan L, Zhou C, Lu Y, Hong M, Zhang Z, Zhang Z, Chang Y, Zhang C, Li X
Cancer letters 2015 Apr 1;359(1):136-47
Cancer letters 2015 Apr 1;359(1):136-47
Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice.
Wang T, Li Y, Wang Y, Zhou R, Ma L, Hao Y, Jin S, Du J, Zhao C, Sun T, Yu J
PloS one 2014;9(3):e90780
PloS one 2014;9(3):e90780
Total flavonoids of litsea coreana enhance the cytotoxicity of oxaliplatin by increasing gap junction intercellular communication.
Yu BB, Dong SY, Yu ML, Jiang GJ, Ji J, Tong XH
Biological & pharmaceutical bulletin 2014;37(8):1315-22
Biological & pharmaceutical bulletin 2014;37(8):1315-22
Apoptosis Induction by the Total Flavonoids from Arachniodes exilis in HepG2 Cells through Reactive Oxygen Species-Mediated Mitochondrial Dysfunction Involving MAPK Activation.
Li H, Chen J, Xiong C, Wei H, Yin C, Ruan J
Evidence-based complementary and alternative medicine : eCAM 2014;2014:906941
Evidence-based complementary and alternative medicine : eCAM 2014;2014:906941
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Li W, Wang C, Peng J, Liang J, Jin Y, Liu Q, Meng Q, Liu K, Sun H
Current pharmaceutical biotechnology 2014;15(12):1173-82
Current pharmaceutical biotechnology 2014;15(12):1173-82
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
Xia X, Su C, Fu J, Zhang P, Jiang X, Xu D, Hu L, Song E, Song Y
International immunopharmacology 2014 Oct;22(2):293-302
International immunopharmacology 2014 Oct;22(2):293-302
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
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Protective effects of dioscin against alcohol-induced liver injury.
Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53
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Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.
Sun Q, Wang R, Wang Y, Luo J, Wang P, Cheng B
Oncology reports 2014 Feb;31(2):933-9
Oncology reports 2014 Feb;31(2):933-9
Inhibition of autophagy promotes caspase-mediated apoptosis by tunicamycin in HepG2 cells.
Zhang S, Wang C, Tang S, Deng S, Zhou Y, Dai C, Yang X, Xiao X
Toxicology mechanisms and methods 2014 Dec;24(9):654-65
Toxicology mechanisms and methods 2014 Dec;24(9):654-65
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Yu H, Zheng L, Yin L, Xu L, Qi Y, Han X, Xu Y, Liu K, Peng J
International immunopharmacology 2014 Apr;19(2):233-44
International immunopharmacology 2014 Apr;19(2):233-44
The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice.
An J, Zhang X, Qin J, Wan Y, Hu Y, Liu T, Li J, Dong W, Du E, Pan C, Zeng W
Cell death & disease 2014 Apr 24;5:e1196
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Phytotherapy research : PTR 2013 Feb;27(2):251-7
Phytotherapy research : PTR 2013 Feb;27(2):251-7
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Yin X, Yu B, Tang Z, He B, Ren J, Xiao X, Tang W
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Cancer gene therapy 2013 Feb;20(2):77-81
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Zhang C, Wang C, Tang S, Sun Y, Zhao D, Zhang S, Deng S, Zhou Y, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:825-38
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International journal of molecular medicine 2013 Aug;32(2):389-95
International journal of molecular medicine 2013 Aug;32(2):389-95
The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents.
Jia Y, Dong X, Zhou P, Liu X, Pan L, Xin H, Zhu YZ, Wang Y
European journal of medicinal chemistry 2012 Sep;55:176-87
European journal of medicinal chemistry 2012 Sep;55:176-87
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International journal of molecular medicine 2012 Oct;30(4):877-83
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PloS one 2011;6(6):e21064
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European journal of pharmacology 2011 Mar 11;654(3):209-16
European journal of pharmacology 2011 Mar 11;654(3):209-16
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Biochemical pharmacology 2010 Jul 15;80(2):247-54
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Apoptosis : an international journal on programmed cell death 2006 Nov;11(11):1923-32
Apoptosis : an international journal on programmed cell death 2006 Nov;11(11):1923-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10380-1-AP(CASP9 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CASP9 antibody 10380-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CASP9 (IP:10380-1-AP, 3ug; Detection:10380-1-AP 1:200) with HeLa cells lysate 2500ug.
- Sample type
- cell line
