Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11614-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11614-1-AP, RRID:AB_2176095
- Product name
- RBM4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RBM4 antibody (Cat. #11614-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3'-leader region of genomic RNA.
Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency.
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression.
RBM4 regulates cellular senescence via miR1244/SERPINE1 axis.
The N6-methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4.
RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.
Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation.
G-Quadruplex Regulation of VEGFA mRNA Translation by RBM4.
Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein.
SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer.
Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge.
RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer.
Prognostic value of decreased expression of RBM4 in human gastric cancer.
A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation.
The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.
An oxygen-regulated switch in the protein synthesis machinery.
Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.
Fan L, Wang Y, Huang H, Wang Z, Liang C, Yang X, Ye P, Lin J, Shi W, Zhou Y, Yan H, Long Z, Wang Z, Liu L, Qian J
Emerging microbes & infections 2024 Dec;13(1):2300762
Emerging microbes & infections 2024 Dec;13(1):2300762
Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency.
Tsai YY, Shen CL, D D, Tsai CY, Tarn WY
Communications biology 2023 Sep 5;6(1):910
Communications biology 2023 Sep 5;6(1):910
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression.
Han H, Lin T, Wang Z, Song J, Fang Z, Zhang J, You X, Du Y, Ye J, Zhou G
Pharmacological research 2023 Jan;187:106593
Pharmacological research 2023 Jan;187:106593
RBM4 regulates cellular senescence via miR1244/SERPINE1 axis.
Wang L, Zhang X, Sheng J, Chen L, Zhi L, Zheng Q, Qi Y, Wang L, Zhang J, Zhao J, Wang Y, Liu SX, Sun MZ, Zhang W
Cell death & disease 2023 Jan 13;14(1):27
Cell death & disease 2023 Jan 13;14(1):27
The N6-methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4.
Xu M, Li B, Huang J, Jia R, Guo J
International endodontic journal 2023 Dec;56(12):1534-1549
International endodontic journal 2023 Dec;56(12):1534-1549
RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.
Chen L, Zhang W, Chen D, Yang Q, Sun S, Dai Z, Li Z, Liang X, Chen C, Jiao Y, Zhi L, Zhao L, Zhang J, Liu X, Zhao J, Li M, Wang Y, Qi Y
Signal transduction and targeted therapy 2023 Apr 21;8(1):159
Signal transduction and targeted therapy 2023 Apr 21;8(1):159
Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation.
Ji R, Shi Q, Cao Y, Zhang J, Zhao C, Zhao H, Sayyed Y, Fu L, Li LY
The Journal of biological chemistry 2022 Jun;298(6):102033
The Journal of biological chemistry 2022 Jun;298(6):102033
G-Quadruplex Regulation of VEGFA mRNA Translation by RBM4.
Niu K, Zhang X, Song Q, Feng Q
International journal of molecular sciences 2022 Jan 11;23(2)
International journal of molecular sciences 2022 Jan 11;23(2)
Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein.
Manet E, Polvèche H, Mure F, Mrozek-Gorska P, Roisné-Hamelin F, Hammerschmidt W, Auboeuf D, Gruffat H
Nucleic acids research 2021 Oct 11;49(18):10657-10676
Nucleic acids research 2021 Oct 11;49(18):10657-10676
SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer.
Lv Y, Zhang W, Zhao J, Sun B, Qi Y, Ji H, Chen C, Zhang J, Sheng J, Wang T, Dominguez D, Liu H, Liu Q, Meng S, Li X, Wang Y
Signal transduction and targeted therapy 2021 Mar 5;6(1):108
Signal transduction and targeted therapy 2021 Mar 5;6(1):108
Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge.
Yang T, Chen WC, Shi PC, Liu MR, Jiang T, Song H, Wang JQ, Fan RZ, Pei DS, Song J
Journal of experimental & clinical cancer research : CR 2020 Jul 20;39(1):139
Journal of experimental & clinical cancer research : CR 2020 Jul 20;39(1):139
RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer.
Yong H, Zhao W, Zhou X, Liu Z, Tang Q, Shi H, Cheng R, Zhang X, Qiu Z, Zhu J, Feng Z
Medical science monitor : international medical journal of experimental and clinical research 2019 May 30;25:4025-4034
Medical science monitor : international medical journal of experimental and clinical research 2019 May 30;25:4025-4034
Prognostic value of decreased expression of RBM4 in human gastric cancer.
Yong H, Zhu H, Zhang S, Zhao W, Wang W, Chen C, Ding G, Zhu L, Zhu Z, Liu H, Zhang Y, Wen J, Kang X, Zhu J, Feng Z, Liu B
Scientific reports 2016 Jun 21;6:28222
Scientific reports 2016 Jun 21;6:28222
A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation.
Qi Y, Yu J, Han W, Fan X, Qian H, Wei H, Tsai YH, Zhao J, Zhang W, Liu Q, Meng S, Wang Y, Wang Z
Nature communications 2016 Jun 13;7:ncomms11840
Nature communications 2016 Jun 13;7:ncomms11840
The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.
Wang Y, Chen D, Qian H, Tsai YS, Shao S, Liu Q, Dominguez D, Wang Z
Cancer cell 2014 Sep 8;26(3):374-389
Cancer cell 2014 Sep 8;26(3):374-389
An oxygen-regulated switch in the protein synthesis machinery.
Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S
Nature 2012 May 6;486(7401):126-9
Nature 2012 May 6;486(7401):126-9
Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.
Markus MA, Marques FZ, Morris BJ
PloS one 2011;6(12):e28926
PloS one 2011;6(12):e28926
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 11614-1-AP(RBM4 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using RBM4 antibody 11614-1-AP at 1:100 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-RBM4 (IP:11614-1-AP, 3ug; Detection:11614-1-AP 1:1000) with mouse heart tissue lysate 4000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 11614-1-AP(RBM4 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue