BS7851

antibody from Bioworld Technology, Inc
Targeting: DIAPH1 DFNA1, hDIA1, LFHL1
Provider product page for BS7851
Western blot
Immunohistochemistry

Antibody data

Product number
BS7851 - Provider product page
Provider
Bioworld Technology, Inc
Product name
DIAPH1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human DIAPH1.
Description
Dia 1 (also designated p140mDia) and Dia 2 (also designated p134mDia 2), mammalian homologs of Drosophila Diaphanous, belong to a family of formin-homology (FH) proteins, which are characterized by having tandemly aligned FH1 and FH2 domains in their carboxy terminal regions. The amino terminus of inactivated Dia 1 binds to the FH1 and FH2 domains, and is activated when GTP-bound Rho disrupts the intramolecular interaction of Dia 1 and converts it to an open conformation. Once activated, Dia 1 co-localizes with profilin and RhoA in dynamic plasma-membrane structures, and induces the formation of stress fibers in conjunction with the ROCK mediated signaling pathway. However, Dia 1 and ROCK activities antagonize each other in order to determine the thickness and density of the stress fibers formed. Dia 1 has also been implicated as the gene responsible for non-syndromic deafness.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
DIAPH1 protein structure - BS7851 shown in red.