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- Antibody Data
- Antigen structure
- References [20]
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- Product number
- H00000875-A01 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00000875-A01, RRID:AB_537458
- Product name
- Mouse Polyclonal CBS Antibody
- Antibody type
- Polyclonal
- Description
- Unpurified. CBS - cystathionine-beta-synthase
- Reactivity
- Human, Mouse, Rat, Simian, Yeast
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.05 ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.
In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies.
CBS mutations are good predictors for B6-responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients.
Distinctive expression pattern of cystathionine-β-synthase and cystathionine-γ-lyase identifies mesenchymal stromal cells transition to mineralizing osteoblasts.
Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency.
Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration.
Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.
Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.
Arsenite-induced changes in hepatic protein abundance in cynomolgus monkeys (Macaca fascicularis).
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance.
Correction of cystathionine β-synthase deficiency in mice by treatment with proteasome inhibitors.
Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells.
Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia.
Surrogate genetics and metabolic profiling for characterization of human disease alleles.
Ischemia/reperfusion reduces transcription factor Sp1-mediated cystathionine beta-synthase expression in the kidney.
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.
Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation.
Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae.
Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway.
Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats.
Partearroyo T, Murillo-Cuesta S, Vallecillo N, Bermúdez-Muñoz JM, Rodríguez-de la Rosa L, Mandruzzato G, Celaya AM, Zeisel SH, Pajares MA, Varela-Moreiras G, Varela-Nieto I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):5942-5956
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):5942-5956
In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies.
Ismail HM, Krishnamoorthy N, Al-Dewik N, Zayed H, Mohamed NA, Giacomo VD, Gupta S, Häberle J, Thöny B, Blom HJ, Kruger WD, Ben-Omran T, Nasrallah GK
Human mutation 2019 Feb;40(2):230-240
Human mutation 2019 Feb;40(2):230-240
CBS mutations are good predictors for B6-responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients.
Poloni S, Sperb-Ludwig F, Borsatto T, Weber Hoss G, Doriqui MJR, Embiruçu EK, Boa-Sorte N, Marques C, Kim CA, Fischinger Moura de Souza C, Rocha H, Ribeiro M, Steiner CE, Moreno CA, Bernardi P, Valadares E, Artigalas O, Carvalho G, Wanderley HYC, Kugele J, Walter M, Gallego-Villar L, Blom HJ, Schwartz IVD
Molecular genetics & genomic medicine 2018 Mar;6(2):160-170
Molecular genetics & genomic medicine 2018 Mar;6(2):160-170
Distinctive expression pattern of cystathionine-β-synthase and cystathionine-γ-lyase identifies mesenchymal stromal cells transition to mineralizing osteoblasts.
Gambari L, Lisignoli G, Gabusi E, Manferdini C, Paolella F, Piacentini A, Grassi F
Journal of cellular physiology 2017 Dec;232(12):3574-3585
Journal of cellular physiology 2017 Dec;232(12):3574-3585
Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency.
Grassi F, Tyagi AM, Calvert JW, Gambari L, Walker LD, Yu M, Robinson J, Li JY, Lisignoli G, Vaccaro C, Adams J, Pacifici R
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 May;31(5):949-63
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 May;31(5):949-63
Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration.
Saha S, Chakraborty PK, Xiong X, Dwivedi SK, Mustafi SB, Leigh NR, Ramchandran R, Mukherjee P, Bhattacharya R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Jan;30(1):441-56
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Jan;30(1):441-56
Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.
Martínez-Vega R, Garrido F, Partearroyo T, Cediel R, Zeisel SH, Martínez-Álvarez C, Varela-Moreiras G, Varela-Nieto I, Pajares MA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Feb;29(2):418-32
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Feb;29(2):418-32
Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.
Martínez-Vega R, Partearroyo T, Vallecillo N, Varela-Moreiras G, Pajares MA, Varela-Nieto I
The Journal of nutritional biochemistry 2015 Dec;26(12):1424-33
The Journal of nutritional biochemistry 2015 Dec;26(12):1424-33
Arsenite-induced changes in hepatic protein abundance in cynomolgus monkeys (Macaca fascicularis).
Kim S, Lee SH, Lee S, Park JD, Ryu DY
Proteomics 2014 Aug;14(15):1833-43
Proteomics 2014 Aug;14(15):1833-43
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance.
Bhattacharyya S, Saha S, Giri K, Lanza IR, Nair KS, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Basal E, Weaver AL, Visscher DW, Cliby W, Sood AK, Bhattacharya R, Mukherjee P
PloS one 2013;8(11):e79167
PloS one 2013;8(11):e79167
Correction of cystathionine β-synthase deficiency in mice by treatment with proteasome inhibitors.
Gupta S, Wang L, Anderl J, Slifker MJ, Kirk C, Kruger WD
Human mutation 2013 Aug;34(8):1085-93
Human mutation 2013 Aug;34(8):1085-93
Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells.
Conrad C, Gregorio J, Wang YH, Ito T, Meller S, Hanabuchi S, Anderson S, Atkinson N, Ramirez PT, Liu YJ, Freedman R, Gilliet M
Cancer research 2012 Oct 15;72(20):5240-9
Cancer research 2012 Oct 15;72(20):5240-9
Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia.
Sen U, Sathnur PB, Kundu S, Givvimani S, Coley DM, Mishra PK, Qipshidze N, Tyagi N, Metreveli N, Tyagi SC
American journal of physiology. Cell physiology 2012 Jul 1;303(1):C41-51
American journal of physiology. Cell physiology 2012 Jul 1;303(1):C41-51
Surrogate genetics and metabolic profiling for characterization of human disease alleles.
Mayfield JA, Davies MW, Dimster-Denk D, Pleskac N, McCarthy S, Boydston EA, Fink L, Lin XX, Narain AS, Meighan M, Rine J
Genetics 2012 Apr;190(4):1309-23
Genetics 2012 Apr;190(4):1309-23
Ischemia/reperfusion reduces transcription factor Sp1-mediated cystathionine beta-synthase expression in the kidney.
Wu N, Siow YL, O K
The Journal of biological chemistry 2010 Jun 11;285(24):18225-33
The Journal of biological chemistry 2010 Jun 11;285(24):18225-33
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.
Singh LR, Gupta S, Honig NH, Kraus JP, Kruger WD
PLoS genetics 2010 Jan;6(1):e1000807
PLoS genetics 2010 Jan;6(1):e1000807
Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation.
d'Emmanuele di Villa Bianca R, Sorrentino R, Maffia P, Mirone V, Imbimbo C, Fusco F, De Palma R, Ignarro LJ, Cirino G
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 17;106(11):4513-8
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 17;106(11):4513-8
Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae.
Singh LR, Kruger WD
The Journal of biological chemistry 2009 Feb 13;284(7):4238-45
The Journal of biological chemistry 2009 Feb 13;284(7):4238-45
Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway.
Ali MY, Whiteman M, Low CM, Moore PK
The Journal of endocrinology 2007 Oct;195(1):105-12
The Journal of endocrinology 2007 Oct;195(1):105-12
Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats.
Li N, Chen L, Muh RW, Li PL
Hypertension (Dallas, Tex. : 1979) 2006 Jun;47(6):1094-100
Hypertension (Dallas, Tex. : 1979) 2006 Jun;47(6):1094-100
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: CBS Antibody [H00000875-A01] - Analysis of CBS expression in K-562 (Cat # L009V1).
