APR06897G

antibody from Leading Biology

Targeting: BECN2 BECN1P1

Western blot

Immunocytochemistry

Immunohistochemistry

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Validation data

Product number: APR06897G - Provider product page
Provider: Leading Biology
Product name: Beclin 2 Antibody
Antibody type: Polyclonal
Description: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin 2 is a mammalian specific homolog of the autophagy protein Beclin 1 (3). Like Beclin 1, Beclin 2 interacts with Bcl-2 and class III PI3K complex components. However, Beclin 2 functions in an additional lysosomal degradation pathway and is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (3). Beclin 2 is also required for agonist-induced lysosome-mediated degradation of EGFR in lung cancer cells, suggesting that it may also play a role in regulating other intracellular signaling pathways (4).
Reactivity: Human
Host: Rabbit
Isotype: IgG
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

BECN2 protein structure - APR06897G shown in red.