Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-RM103 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Rabbit Anti-Becn2 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Beclin-2 is encoded by Becn2 gene in murine species. Beclin-2 is a member of the Atg6/Beclin family and is involved in 2 distinct lysosomal degradation pathways and acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. It regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. Beclin-2 family members are specific to mammals whereas Becln-1 subfamily members are present in more primitive vertebrates. Beclin-2 interacts with ATG14, AMBRA1, UVRAG and PIK3C3/VPS34 and this interaction is not disrupted by starvation. It is expressed in brain, skeletal muscle, placenta, thymus and uterus and expression is lower in liver, testis, stomach, and 17-day-old embryos. Disruption of Beclin-2 is shown to reduce embryonic viability and heterozygous knockout mice show defects in autophagy, increased levels of Cnr1 receptor, elevated food intake, and obesity and insulin resistance.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 _g
- Storage
- Stable for 1 year at 2-8°C from date of receipt.
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