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- Antibody Data
- Antigen structure
- References [709]
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- Validations
- Western blot [3]
- Immunocytochemistry [7]
- Immunohistochemistry [1]
- Other assay [48]
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- Product number
- 33-9100 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- ZO-1 Monoclonal Antibody (ZO1-1A12)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- 33-9100 has been successfully used in ELISA, Immunofluorescence and Western Blot analysis of ZO-1.
- Reactivity
- Human, Mouse, Canine
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- ZO1-1A12
- Vial size
- 100 µg
- Concentration
- 0.5 mg/mL
- Storage
- -20°C
Submitted references The disconnect2 mutation disrupts the tjp1b gene that is required for electrical synapse formation.
FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis.
Differential expression and localization of tight junction proteins in the goat epididymis.
Effects of butyrate(-) on ruminal Ca(2+) transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels.
Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture.
Cell-Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis.
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction.
Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.
Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells.
Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome.
KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease.
Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs.
A medium composition containing normal resting glucose that supports differentiation of primary human airway cells.
Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.
Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health.
A chemically-defined plastic scaffold for the xeno-free production of human pluripotent stem cells.
Streptococcal autolysin promotes dysfunction of swine tracheal epithelium by interacting with vimentin.
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
Engineering rotating apical-out airway organoid for assessing respiratory cilia motility.
Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis.
Differential Mechanisms of Action and Efficacy of Vitamin E Components in Antioxidant Cytoprotection of Human Retinal Pigment Epithelium.
Regulation of Intestinal Epithelial Barrier and Immune Function by Activated T Cells.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures.
Variants of human CLDN9 cause mild to profound hearing loss.
A liquid culture cancer spheroid model reveals low PI3K/Akt pathway activity and low adhesiveness to the extracellular matrix.
CDKN2A-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome.
Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy.
Blood-Brain Barrier Permeability: Is 5-Hydroxytryptamine Receptor Type 4 a Game Changer?
Novel chicken two-dimensional intestinal model comprising all key epithelial cell types and a mesenchymal sub-layer.
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.
A cellular and spatial map of the choroid plexus across brain ventricles and ages.
Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration.
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice.
Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix.
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
A comparative analysis of SARS-CoV-2 antivirals characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19.
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor.
Inducible Slc4a11 Knockout Triggers Corneal Edema Through Perturbation of Corneal Endothelial Pump.
Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea.
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation.
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.
Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection.
LocalZProjector and DeProj: a toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.
Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis.
Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor.
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins.
Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.
Syncytialization and prolonged exposure to palmitate impacts BeWo respiration.
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds.
Localization and regulation of claudin-14 in experimental models of hypercalcemia.
Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China.
CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains.
A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19.
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin.
The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals.
Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.
MAP Kinase Pathways in Brain Endothelial Cells and Crosstalk with Pericytes and Astrocytes Mediate Contrast-Induced Blood-Brain Barrier Disruption.
Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells.
Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.
Electrical synaptic transmission requires a postsynaptic scaffolding protein.
Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
Osmotic regulation of aquaporin-8 expression in retinal pigment epithelial cells in vitro: Dependence on K(ATP) channel activation.
Mitochondrial and Peroxisomal Alterations Contribute to Energy Dysmetabolism in Riboflavin Transporter Deficiency.
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
No tight junctions in tight junction protein-1 expressing HeLa and fibroblast cells.
AhR activation defends gut barrier integrity against damage occurring in obesity.
Insulin-like growth factor 1 triggers salt secretion machinery in fish under acute salinity stress.
Zebrafish Crb1, Localizing Uniquely to the Cell Membranes around Cone Photoreceptor Axonemes, Alleviates Light Damage to Photoreceptors and Modulates Cones' Light Responsiveness.
Vitamin D Protects against Oxidative Stress and Inflammation in Human Retinal Cells.
Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure.
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
Intestinal vitamin D receptor signaling ameliorates dextran sulfate sodium-induced colitis by suppressing necroptosis of intestinal epithelial cells.
Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells.
FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.
A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples.
PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer.
Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear.
The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption.
A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities.
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome.
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens.
High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures.
16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development.
Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion.
Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner.
Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.
Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration.
Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo.
Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.
Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis.
Unlocking the Potential of Organ-on-Chip Models through Pumpless and Tubeless Microfluidics.
Transplantation of iPS-derived vascular endothelial cells improves white matter ischemic damage.
Host-Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model.
Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish.
The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine.
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Retinal microglia are critical for subretinal neovascular formation.
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
CRISP3 expression drives prostate cancer invasion and progression.
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish.
Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.
Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production.
Midkine-a Is Required for Cell Cycle Progression of Müller Glia during Neuronal Regeneration in the Vertebrate Retina.
Signs of Reduced Basal Progenitor Levels and Cortical Neurogenesis in Human Fetuses with Open Spina Bifida at 11-15 Weeks of Gestation.
Going Back and Forth: Episomal Vector Reprogramming of Peripheral Blood Mononuclear Cells to Induced Pluripotent Stem Cells and Subsequent Differentiation into Cardiomyocytes and Neuron-Astrocyte Co-cultures.
S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation.
Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity.
Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids.
Crosstalk between Long-Term Sublethal Oxidative Stress and Detrimental Inflammation as Potential Drivers for Age-Related Retinal Degeneration.
Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube.
Whole-mount Immunohistochemistry of Adult Zebrafish Retina for Advanced Imaging.
Mannheimia haemolytica and lipopolysaccharide induce airway epithelial inflammatory responses in an extensively developed ex vivo calf model.
Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.
Tau reduction in aged mice does not impact Microangiopathy.
Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus.
Centrosome anchoring regulates progenitor properties and cortical formation.
Robotic fluidic coupling and interrogation of multiple vascularized organ chips.
The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.
Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling.
Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death.
Light-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance.
Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.
MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity.
Fabricating retinal pigment epithelial cell sheets derived from human induced pluripotent stem cells in an automated closed culture system for regenerative medicine.
Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations.
The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses.
Role of Endoplasmic Reticulum Stress-Autophagy Axis in Severe Burn-Induced Intestinal Tight Junction Barrier Dysfunction in Mice.
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis.
miR-24 Is Elevated in Ulcerative Colitis Patients and Regulates Intestinal Epithelial Barrier Function.
PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation.
Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis.
Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.
Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells.
Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate.
Graft immaturity and safety concerns in transplanted human kidney organoids.
A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation.
Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates.
Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor.
The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish.
A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.
Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α-induced endothelial hyperpermeability by modulating β1 integrin activation.
Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model.
Mesencephalic origin of the inferior lobe in zebrafish.
Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons.
3D in vitro model for human corneal endothelial cell maturation.
Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression.
Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility.
Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.
A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling.
Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function.
Faecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier.
Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells.
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity.
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium.
Disruption of peripheral nerve development in a zebrafish model of hyperglycemia.
Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons.
Anti-H7N9 avian influenza A virus activity of interferon in pseudostratified human airway epithelium cell cultures.
A Cleared View on Retinal Organoids.
The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity.
penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina.
Acute effects of hyperglycemia on the peripheral nervous system in zebrafish ( Danio rerio) following nitroreductase-mediated β-cell ablation.
GPR40 receptor activation promotes tight junction assembly in airway epithelial cells via AMPK-dependent mechanisms.
Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC).
The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells.
Differential effects of depot formulations of GnRH agonist leuprorelin and antagonist degarelix on the seminiferous epithelium of the rat testis.
Generation of Retinal Organoids with Mature Rods and Cones from Urine-Derived Human Induced Pluripotent Stem Cells.
Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface.
Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4.
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents.
Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons.
The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.
Medium throughput breathing human primary cell alveolus-on-chip model.
Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.
Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer.
Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish.
In Vitro Wounding Models Using the Electric Cell-Substrate Impedance Sensing (ECIS)-Zθ Technology.
Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells.
CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.
Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys.
Chiral Cilia Orientation in the Left-Right Organizer.
Role of Alström syndrome 1 in the regulation of blood pressure and renal function.
Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication.
Vitamin D ameliorates neonatal necrotizing enterocolitis via suppressing TLR4 in a murine model.
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.
BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
Hamartoma-like lesions in the mouse retina: an animal model of Pten hamartoma tumour syndrome.
Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry.
Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.
Tension-dependent regulation of mammalian Hippo signaling through LIMD1.
Effects of Chemical Chaperones on Thyroid Hormone Transport by MCT8 Mutants in Patient-Derived Fibroblasts.
Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation.
A bioinspired microfluidic model of liquid plug-induced mechanical airway injury.
The Importance of Multifrequency Impedance Sensing of Endothelial Barrier Formation Using ECIS Technology for the Generation of a Strong and Durable Paracellular Barrier.
Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.
Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation.
Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease.
The protein kinase SIK downregulates the polarity protein Par3.
Development and optimization of a differentiated airway epithelial cell model of the bovine respiratory tract.
MEF2 transcription factors in human placenta and involvement in cytotrophoblast invasion and differentiation.
Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation.
Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue.
Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation.
Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip.
Calcium signaling mediates five types of cell morphological changes to form neural rosettes.
Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.
Dexamethasone enhances vasopressin-induced aquaporin-2 gene expression in the mpkCCD cells.
Mathematical-model-guided development of full-thickness epidermal equivalent.
HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo.
A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice.
Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction.
Cell injury triggers actin polymerization to initiate epithelial restitution.
A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage.
The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.
Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter.
(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance.
Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation.
Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.
Sertoli Cells Are Susceptible to ZIKV Infection in Mouse Testis.
Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops.
Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality.
Temporal dynamics of ovine airway epithelial cell differentiation at an air-liquid interface.
ECIS technology reveals that monocytes isolated by CD14+ve selection mediate greater loss of BBB integrity than untouched monocytes, which occurs to a greater extent with IL-1β activated endothelium in comparison to TNFα.
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.
Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function.
Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry.
Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
Adenohypophysis placodal precursors exhibit distinctive features within the rostral preplacodal ectoderm.
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease.
Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Asymmetry of an Intracellular Scaffold at Vertebrate Electrical Synapses.
Perineurial Glial Plasticity and the Role of TGF-β in the Development of the Blood-Nerve Barrier.
In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling.
Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage.
Par3 in chick lens placode development.
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.
A Bruch's membrane substitute fabricated from silk fibroin supports the function of retinal pigment epithelial cells in vitro.
NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma.
Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates).
Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway.
Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood-brain barrier.
Increased expression of the tight junction protein TJP1/ZO-1 is associated with upregulation of TAZ-TEAD activity and an adult tissue stem cell signature in carfilzomib-resistant multiple myeloma cells and high-risk multiple myeloma patients.
Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly.
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.
Target Intestinal Microbiota to Alleviate Disease Progression in Amyotrophic Lateral Sclerosis.
Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium.
The Physical Basis of Coordinated Tissue Spreading in Zebrafish Gastrulation.
Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1.
Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.
The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels.
Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.
An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.
Role and regulation of Yap in KrasG12D-induced lung cancer.
Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover.
The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching.
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells.
Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
Spontaneous acquisition of infinite proliferative capacity by a rabbit corneal endothelial cell line with maintenance of phenotypic and physiological characteristics.
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.
Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development.
Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis.
Efficient Differentiation of TBX18(+)/WT1(+) Epicardial-Like Cells from Human Pluripotent Stem Cells Using Small Molecular Compounds.
αT-catenin in restricted brain cell types and its potential connection to autism.
Differences in the Mechanical Properties of the Developing Cerebral Cortical Proliferative Zone between Mice and Ferrets at both the Tissue and Single-Cell Levels.
A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells.
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17.
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.
Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells.
Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition.
ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development.
Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Large-scale tissue clearing (PACT): Technical evaluation and new perspectives in immunofluorescence, histology, and ultrastructure.
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.
Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models.
Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria.
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.
HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24.
Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.
Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular Integrity.
Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.
Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates.
Skin-on-a-chip model simulating inflammation, edema and drug-based treatment.
Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle.
The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway.
Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.
Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.
Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier.
Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension.
A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development.
Chronic hypoxia down-regulates tight junction protein ZO-2 expression in children with cyanotic congenital heart defect.
Intracellular Golgi Complex organization reveals tissue specific polarity during zebrafish embryogenesis.
The C-terminal domain controls the mobility of Crumbs 3 isoforms.
Supplementation of Reduced Gluten Barley Diet with Oral Prolyl Endopeptidase Effectively Abrogates Enteropathy-Associated Changes in Gluten-Sensitive Macaques.
A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.
Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis.
Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.
3D map of the human corneal endothelial cell.
C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.
The barrier function of organotypic non-melanoma skin cancer models.
miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling.
The aPKC/Par3/Par6 Polarity Complex and Membrane Order Are Functionally Interdependent in Epithelia During Vertebrate Organogenesis.
Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors.
The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.
The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42.
Crim1 regulates integrin signaling in murine lens development.
Vitamin D/VDR signaling attenuates lipopolysaccharide‑induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier.
Isolated Human Pulmonary Artery Structure and Function Pre- and Post-Cardiopulmonary Bypass Surgery.
Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.
Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway.
Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology.
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation.
Vascular development in the vertebrate pancreas.
Functional Kidney Bioengineering with Pluripotent Stem-Cell-Derived Renal Progenitor Cells and Decellularized Kidney Scaffolds.
A critical role for NF2 and the Hippo pathway in branching morphogenesis.
tPA Deficiency in Mice Leads to Rearrangement in the Cerebrovascular Tree and Cerebroventricular Malformations.
NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.
Optimization of immunostaining on flat-mounted human corneas.
The human urothelial tight junction: claudin 3 and the ZO-1α(+) switch.
DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells.
Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells.
Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells.
Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks.
Stem cells from human exfoliated deciduous tooth exhibit stromal-derived inducing activity and lead to generation of neural crest cells from human embryonic stem cells.
Stem cells from human exfoliated deciduous tooth exhibit stromal-derived inducing activity and lead to generation of neural crest cells from human embryonic stem cells.
WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts.
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
Fstl1 is involved in the regulation of radial glial scaffold development.
Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells.
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium.
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.
High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells.
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty.
Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system.
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin.
Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.
Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.
LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.
Immune quiescence of the brain is set by astroglial connexin 43.
Effect of differentiation on endocytic profiles of endothelial and epithelial cell culture models.
Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.
Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes.
Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function.
Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells.
Expression and function of transcription factor AP-2? in early embryonic development of porcine parthenotes.
Neurobeachin is required postsynaptically for electrical and chemical synapse formation.
Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells.
Synthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions.
Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels.
The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.
Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.
A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.
Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model.
Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains.
Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling.
Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release.
Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures.
Claudin-7, -16, and -19 during mouse kidney development.
A novel dual-flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers.
Regulation of epithelial cell tight junctions by protease-activated receptor 2.
Hantavirus infection with severe proteinuria and podocyte foot-process effacement.
TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
Reconstruction of a seminiferous tubule-like structure in a 3 dimensional culture system of re-aggregated mouse neonatal testicular cells within a collagen matrix.
Keratin 76 is required for tight junction function and maintenance of the skin barrier.
Flattop regulates basal body docking and positioning in mono- and multiciliated cells.
Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.
Innate immune factors in the development and maintenance of pouchitis.
CAR expression in human embryos and hESC illustrates its role in pluripotency and tight junctions.
Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.
Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems.
Development of a cell sheet transportation technique for regenerative medicine.
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.
p38δ mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes.
Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling.
EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368.
Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion.
Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole.
Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread.
Crumbs3 is essential for proper epithelial development and viability.
LMX1B mutation with residual transcriptional activity as a cause of isolated glomerulopathy.
Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.
Notch3 establishes brain vascular integrity by regulating pericyte number.
Decreased expression of zonula occludens-1 and occludin in the bladder urothelium of patients with interstitial cystitis/painful bladder syndrome.
FGF signaling is required for brain left-right asymmetry and brain midline formation.
Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine.
Glial ankyrins facilitate paranodal axoglial junction assembly.
Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration.
Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.
Endothelial cells use dynamic actin to facilitate lymphocyte transendothelial migration and maintain the monolayer barrier.
Onset of aquaporin-4 expression in the developing mouse brain.
aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.
Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity.
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages.
E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.
The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling.
C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.
Isolation and culture of mouse proepicardium using serum-free conditions.
Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.
Norovirus binding to intestinal epithelial cells is independent of histo-blood group antigens.
Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells.
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis.
A three-dimensional engineered artery model for in vitro atherosclerosis research.
In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines.
Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation.
Morphogenetic analysis of peri-implantation development.
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.
Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling.
Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.
Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes.
tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium.
Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.
Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods.
Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells.
Intercellular Ca(2+) wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation.
Polyphenols protect the epithelial barrier function of Caco-2 cells exposed to indomethacin through the modulation of occludin and zonula occludens-1 expression.
Involvement of PI3K and ROCK signaling pathways in migration of bone marrow-derived mesenchymal stem cells through human brain microvascular endothelial cell monolayers.
Estrogen supports urothelial defense mechanisms.
LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.
ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation.
Differential expression of junctional adhesion molecules in different stages of systemic sclerosis.
Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod.
Cultures of astroglial cells derived from brain of adult cichlid fish.
Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.
aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation.
Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers.
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.
Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins.
SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling.
PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics.
Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea.
Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues.
Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination.
The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
Characterization of Pax2 expression in the goldfish optic nerve head during retina regeneration.
Simvastatin blocks blood-brain barrier disruptions induced by elevated cholesterol both in vivo and in vitro.
PAR6B is required for tight junction formation and activated PKCζ localization in breast cancer.
Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein.
SIRPα interacts with nephrin at the podocyte slit diaphragm.
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.
Human intestinal epithelial cells exhibit a cellular response indicating a potential toxicity upon exposure to hematite nanoparticles.
Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins.
3D single molecule tracking with multifocal plane microscopy reveals rapid intercellular transferrin transport at epithelial cell barriers.
Loss of N-cadherin from the endothelium causes stromal edema and epithelial dysgenesis in the mouse cornea.
GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier.
NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway.
Selective functionalization of nanofiber scaffolds to regulate salivary gland epithelial cell proliferation and polarity.
Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes.
Generation of functional thyroid from embryonic stem cells.
Myosin-X functions in polarized epithelial cells.
Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.
Label-free analysis of breast tissue polarity by Raman imaging of lipid phase.
Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression.
A mouse model for interstitial cystitis/painful bladder syndrome based on APF inhibition of bladder epithelial repair: a pilot study.
Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions.
Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus.
Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.
Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium.
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.
Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.
ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.
Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells.
In vitro culture of epicardial cells from adult zebrafish heart on a fibrin matrix.
A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish.
Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus.
The cell adhesion gene PVRL3 is associated with congenital ocular defects.
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function.
Short-term feedback regulation of bile salt uptake by bile salts in rodent liver.
Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis).
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia.
Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
Neural tube defects by NUAK1 and NUAK2 double mutation.
Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes.
Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Tight junction proteins expression and modulation in immune cells and multiple sclerosis.
EGFR regulation of epidermal barrier function.
Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.
Retinal degeneration progression changes lentiviral vector cell targeting in the retina.
Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish.
Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy.
Optimization of immunolocalization of cell cycle proteins in human corneal endothelial cells.
Osmotic pressure-adaptive responses in the eye tissues of rainbow smelt (Osmerus mordax).
Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer.
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.
Toll-like receptor responses of normal human urothelial cells to bacterial flagellin and lipopolysaccharide.
A novel gelatin hydrogel carrier sheet for corneal endothelial transplantation.
Adenosine receptor signaling modulates permeability of the blood-brain barrier.
Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.
Relocalization of cell adhesion molecules during neoplastic transformation of human fibroblasts.
Tissue engineering potential of urothelial cells from diseased bladders.
Matrigel improves functional properties of primary human salivary gland cells.
Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise.
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin.
Corticosteroid regulation of P-glycoprotein in the developing blood-brain barrier.
Comparison of tight junction protein expression in the ciliary epithelia of mouse, rabbit, cat and human eyes.
Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury.
Lactobacillus plantarum (VR1) isolated from an ayurvedic medicine (Kutajarista) ameliorates in vitro cellular damage caused by Aeromonas veronii.
Tight junction proteins vary in the choroid plexus of ewes according to photoperiod.
Effects of calcium oxalate monohydrate crystals on expression and function of tight junction of renal tubular epithelial cells.
The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.
Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis.
A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions.
Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary background.
Localization of AQP5 during development of the mouse submandibular salivary gland.
Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.
Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina.
Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.
Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion.
Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias.
Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.
Kv7.1 surface expression is regulated by epithelial cell polarization.
CD44 regulates tight-junction assembly and barrier function.
Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.
A novel method of culturing human oral mucosal epithelial cell sheet using post-mitotic human dermal fibroblast feeder cells and modified keratinocyte culture medium for ocular surface reconstruction.
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II.
Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B.
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry.
Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.
Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown.
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.
Trafficking and recycling of the connexin43 gap junction protein during mitosis.
Astroglial structures in the zebrafish brain.
Expression of semaphorin 3A in the rat corneal epithelium during wound healing.
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling.
A MicroRNA targeting dicer for metastasis control.
Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep.
Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation.
Fhit regulates invasion of lung tumor cells.
The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.
Validation system of tissue-engineered epithelial cell sheets for corneal regenerative medicine.
Visualization of transepithelial passage of the immunogenic 33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques.
Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers.
Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers.
The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria.
Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats.
CFTR expression but not Cl- transport is involved in the stimulatory effect of bile acids on apical Cl-/HCO3- exchange activity in human pancreatic duct cells.
CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.
Tight junctions in Hailey-Hailey and Darier's diseases.
Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure.
Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo.
Voltage-gated sodium channels in taste bud cells.
Residues in a highly conserved claudin-1 motif are required for hepatitis C virus entry and mediate the formation of cell-cell contacts.
Tight junction proteins in human Schwann cell autotypic junctions.
Novel sutureless keratoplasty with a chemically defined bioadhesive.
Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3.
Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos.
Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways.
Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish.
Neural reconnection in the transected spinal cord of the freshwater turtle Trachemys dorbignyi.
Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology.
Functional suppression of E-cadherin by protein kinase Cdelta.
Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro.
Barrier function of cultivated limbal and oral mucosal epithelial cell sheets.
Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells.
A cell polarity protein aPKClambda is required for eye lens formation and growth.
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.
FGF signalling during embryo development regulates cilia length in diverse epithelia.
Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.
Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia.
Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.
Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1.
Differential requirement for beta-catenin in epithelial and fiber cells during lens development.
Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus.
An immunochemical marker for goldfish Mauthner cells.
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.
Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum.
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line.
Interleukin 1 alpha (IL1A) is a novel regulator of the blood-testis barrier in the rat.
N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility.
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.
Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus.
Expression and localisation of apical junctional complex proteins in lens epithelial cells.
Early events in HIV transmission through a human reconstructed vaginal mucosa.
Effects of multipurpose solutions on corneal epithelial tight junctions.
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis.
Distribution of tight junction proteins in adult human salivary glands.
Generation of a functional, differentiated porcine urothelial tissue in vitro.
Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo.
Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.
aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables.
Localization of semaphorin 3A in the rat cornea.
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.
Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function.
Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis.
Tmod3 regulates polarized epithelial cell morphology.
Serosal mesothelium retains vasculogenic potential.
ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43.
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Zonula occludens-1 and connexin 43 expression in the failing human heart.
Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.
Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis.
Basal cells of the human adult airway surface epithelium retain transit-amplifying cell properties.
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex.
Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.
C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques.
Novel fibroblastic onion bulbs in a demyelinating avian peripheral neuropathy produced by riboflavin deficiency.
Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina.
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex.
Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling.
Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina.
A dileucine motif targets MCAM-l cell adhesion molecule to the basolateral membrane in MDCK cells.
Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.
Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions.
Tight junction proteins and perineurial cells in neurofibromas.
Altered expression of junctional adhesion molecule 4 in injured podocytes.
Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes.
PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.
Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.
Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation.
Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis.
Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.
sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.
The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain.
Functional organization of the bovine rumen epithelium.
Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells.
Localization of PDZ domain containing proteins Discs Large-1 and Scribble in the mouse eye.
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition.
Blood-testis barrier dynamics are regulated by {alpha}2-macroglobulin via the c-Jun N-terminal protein kinase pathway.
Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of beta1 integrin subsets.
Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation.
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.
Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms.
Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland.
The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction.
Expression of claudin-7 and -8 along the mouse nephron.
Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin development.
Regulation of blood-testis barrier dynamics: an in vivo study.
An in vitro model based on cell monolayers grown on the underside of large- pore filters in bicameral chambers for studying thyrocyte-lymphocyte interactions.
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
Bves is expressed in the epithelial components of the retina, lens, and cornea.
Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis.
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation.
CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells.
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.
Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus.
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.
Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression.
Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation.
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Rab8B GTPase and junction dynamics in the testis.
Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Applications of epithelial cell culture in studies of drug transport.
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.
Casein kinase 1 regulates connexin-43 gap junction assembly.
The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions.
JEAP, a novel component of tight junctions in exocrine cells.
Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes.
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability.
Michel JC, Lasseigne AM, Marsh AJ, Miller AC
microPublication biology 2022;2022
microPublication biology 2022;2022
FYN regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization via its effect on Arp3 in the mouse testis.
Yang Y, Yao M, Zeng J, Zheng D, Li Q, Ni Y, Xiao X
Frontiers in immunology 2022;13:915274
Frontiers in immunology 2022;13:915274
Differential expression and localization of tight junction proteins in the goat epididymis.
Kim SW, Jeong YD, Lee GY, Lee J, Lee JY, Kim CL, Ko YG, Lee SS, Kim B
Journal of animal science and technology 2022 May;64(3):500-514
Journal of animal science and technology 2022 May;64(3):500-514
Effects of butyrate(-) on ruminal Ca(2+) transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels.
Liebe F, Liebe H, Sponder G, Mergler S, Stumpff F
Pflugers Archiv : European journal of physiology 2022 Mar;474(3):315-342
Pflugers Archiv : European journal of physiology 2022 Mar;474(3):315-342
Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture.
Yamasaki S, Kuwahara A, Kishino A, Kimura T, Takahashi M, Mandai M
Regenerative therapy 2022 Mar;19:24-34
Regenerative therapy 2022 Mar;19:24-34
Cell-Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis.
Gomes de Almeida P, Rifes P, Martins-Jesus AP, Pinheiro GG, Andrade RP, Thorsteinsdóttir S
Cells 2022 Jun 22;11(13)
Cells 2022 Jun 22;11(13)
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction.
Chou HC, Cheng CM, Yang CH, Lin TY, Liu YW, Tan TH, Chen YR
Journal of biomedical science 2022 Jun 15;29(1):40
Journal of biomedical science 2022 Jun 15;29(1):40
Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.
Senabouth A, Daniszewski M, Lidgerwood GE, Liang HH, Hernández D, Mirzaei M, Keenan SN, Zhang R, Han X, Neavin D, Rooney L, Lopez Sanchez MIG, Gulluyan L, Paulo JA, Clarke L, Kearns LS, Gnanasambandapillai V, Chan CL, Nguyen U, Steinmann AM, McCloy RA, Farbehi N, Gupta VK, Mackey DA, Bylsma G, Verma N, MacGregor S, Watt MJ, Guymer RH, Powell JE, Hewitt AW, Pébay A
Nature communications 2022 Jul 26;13(1):4233
Nature communications 2022 Jul 26;13(1):4233
Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells.
Chen L, Perera ND, Karoukis AJ, Feathers KL, Ali RR, Thompson DA, Fahim AT
Scientific reports 2022 Jul 26;12(1):12694
Scientific reports 2022 Jul 26;12(1):12694
Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome.
Wahl JR, Vivek A, Palomino SM, Almuslim M, Cottier KE, Langlais PR, Streicher JM, Vanderah TW, Liktor-Busa E, Largent-Milnes TM
Pharmaceutics 2022 Jul 15;14(7)
Pharmaceutics 2022 Jul 15;14(7)
KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease.
Stalke A, Sgodda M, Cantz T, Skawran B, Lainka E, Hartleben B, Baumann U, Pfister ED
The Journal of pediatrics 2022 Jan;240:284-291.e9
The Journal of pediatrics 2022 Jan;240:284-291.e9
Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs.
Bieber JM, Sanman LE, Sun X, Hammerlindl H, Bao F, Roth MA, Koleske ML, Huang L, Aweeka F, Wu LF, Altschuler SJ
Communications biology 2022 Jan 27;5(1):99
Communications biology 2022 Jan 27;5(1):99
A medium composition containing normal resting glucose that supports differentiation of primary human airway cells.
Morgan R, Manfredi C, Easley KF, Watkins LD, Hunt WR, Goudy SL, Sorscher EJ, Koval M, Molina SA
Scientific reports 2022 Jan 27;12(1):1540
Scientific reports 2022 Jan 27;12(1):1540
Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.
Zotter B, Dagan O, Brady J, Baloui H, Samanta J, Salzer JL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Jan 12;42(2):183-201
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Jan 12;42(2):183-201
Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health.
Hamilton MK, Wall ES, Robinson CD, Guillemin K, Eisen JS
PLoS pathogens 2022 Feb;18(2):e1009989
PLoS pathogens 2022 Feb;18(2):e1009989
A chemically-defined plastic scaffold for the xeno-free production of human pluripotent stem cells.
Shimizu E, Iguchi H, Le MNT, Nakamura Y, Kobayashi D, Arai Y, Takakura K, Benno S, Yoshida N, Tsukahara M, Haneda S, Hasegawa K
Scientific reports 2022 Feb 15;12(1):2516
Scientific reports 2022 Feb 15;12(1):2516
Streptococcal autolysin promotes dysfunction of swine tracheal epithelium by interacting with vimentin.
Meng Y, Wang Q, Ma Z, Li W, Niu K, Zhu T, Lin H, Lu C, Fan H
PLoS pathogens 2022 Aug;18(8):e1010765
PLoS pathogens 2022 Aug;18(8):e1010765
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
Gonschior H, Schmied C, Van der Veen RE, Eichhorst J, Himmerkus N, Piontek J, Günzel D, Bleich M, Furuse M, Haucke V, Lehmann M
Nature communications 2022 Aug 25;13(1):4985
Nature communications 2022 Aug 25;13(1):4985
Engineering rotating apical-out airway organoid for assessing respiratory cilia motility.
Wijesekara P, Yadav P, Perkins LA, Stolz DB, Franks JM, Watkins SC, Reinoso Jacome E, Brody SL, Horani A, Xu J, Barati Farimani A, Ren X
iScience 2022 Aug 19;25(8):104730
iScience 2022 Aug 19;25(8):104730
Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis.
Peng Y, Wang ZN, Xu AR, Fang ZF, Chen SY, Hou XT, Zhou ZQ, Lin HM, Xie JX, Tang XX, Wang DY, Zhong NS
Frontiers in cell and developmental biology 2021;9:810842
Frontiers in cell and developmental biology 2021;9:810842
Differential Mechanisms of Action and Efficacy of Vitamin E Components in Antioxidant Cytoprotection of Human Retinal Pigment Epithelium.
Duncan RS, Hurtado DT, Hall CW, Koulen P
Frontiers in pharmacology 2021;12:798938
Frontiers in pharmacology 2021;12:798938
Regulation of Intestinal Epithelial Barrier and Immune Function by Activated T Cells.
Le N, Mazahery C, Nguyen K, Levine AD
Cellular and molecular gastroenterology and hepatology 2021;11(1):55-76
Cellular and molecular gastroenterology and hepatology 2021;11(1):55-76
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Abraham HG, Ulintz PJ, Goo L, Yates JA, Little AC, Bao L, Wu Z, Merajver SD
Frontiers in oncology 2021;11:712041
Frontiers in oncology 2021;11:712041
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Zhang L, Zhou L, Bao L, Liu J, Zhu H, Lv Q, Liu R, Chen W, Tong W, Wei Q, Xu Y, Deng W, Gao H, Xue J, Song Z, Yu P, Han Y, Zhang Y, Sun X, Yu X, Qin C
Signal transduction and targeted therapy 2021 Sep 6;6(1):337
Signal transduction and targeted therapy 2021 Sep 6;6(1):337
Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures.
Gkatzis K, Panza P, Peruzzo S, Stainier DY
eLife 2021 Sep 29;10
eLife 2021 Sep 29;10
Variants of human CLDN9 cause mild to profound hearing loss.
Ramzan M, Philippe C, Belyantseva IA, Nakano Y, Fenollar-Ferrer C, Tona R, Yousaf R, Basheer R, Imtiaz A, Faridi R, Munir Z, Idrees H, Salman M, Nambot S, Vitobello A, Kartti S, Zarrik O, Witmer PD, Sobreria N, Ibrahimi A, Banfi B, Moutton S, Friedman TB, Naz S
Human mutation 2021 Oct;42(10):1321-1335
Human mutation 2021 Oct;42(10):1321-1335
A liquid culture cancer spheroid model reveals low PI3K/Akt pathway activity and low adhesiveness to the extracellular matrix.
Abe-Fukasawa N, Watanabe R, Gen Y, Nishino T, Itasaki N
The FEBS journal 2021 Oct;288(19):5650-5667
The FEBS journal 2021 Oct;288(19):5650-5667
CDKN2A-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome.
Merkle J, Breunig M, Schmid M, Allgöwer C, Krüger J, Melzer MK, Bens S, Siebert R, Perkhofer L, Azoitei N, Seufferlein T, Heller S, Meier M, Müller M, Kleger A, Hohwieler M
Cancers 2021 Oct 13;13(20)
Cancers 2021 Oct 13;13(20)
Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy.
Kim JW, Nam SA, Seo E, Lee JY, Kim D, Ju JH, Lim SW, Kim HL, Kim HW, Yang CW, Kim J, Kim DS, Kim YK
The Korean journal of internal medicine 2021 Nov;36(6):1420-1436
The Korean journal of internal medicine 2021 Nov;36(6):1420-1436
Blood-Brain Barrier Permeability: Is 5-Hydroxytryptamine Receptor Type 4 a Game Changer?
Becker G, Da Silva S, Sabo AN, Antal MC, Kemmel V, Monassier L
Pharmaceutics 2021 Nov 3;13(11)
Pharmaceutics 2021 Nov 3;13(11)
Novel chicken two-dimensional intestinal model comprising all key epithelial cell types and a mesenchymal sub-layer.
Orr B, Sutton K, Christian S, Nash T, Niemann H, Hansen LL, McGrew MJ, Jensen SR, Vervelde L
Veterinary research 2021 Nov 24;52(1):142
Veterinary research 2021 Nov 24;52(1):142
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.
Manian KV, Galloway CA, Dalvi S, Emanuel AA, Mereness JA, Black W, Winschel L, Soto C, Li Y, Song Y, DeMaria W, Kumar A, Slukvin I, Schwartz MP, Murphy WL, Anand-Apte B, Chung M, Benoit DSW, Singh R
Cell stem cell 2021 May 6;28(5):846-862.e8
Cell stem cell 2021 May 6;28(5):846-862.e8
A cellular and spatial map of the choroid plexus across brain ventricles and ages.
Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ, Prochazka J, Prochazkova M, Sedlacek R, Zhang F, Bryja V, Rozenblatt-Rosen O, Habib N, Regev A, Lehtinen MK
Cell 2021 May 27;184(11):3056-3074.e21
Cell 2021 May 27;184(11):3056-3074.e21
Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration.
Park SY, Jang H, Kim SY, Kim D, Park Y, Kee SH
Bioengineering (Basel, Switzerland) 2021 May 11;8(5)
Bioengineering (Basel, Switzerland) 2021 May 11;8(5)
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice.
Sheng Z, Gao N, Fan D, Wu N, Zhang Y, Han D, Zhang Y, Tan W, Wang P, An J
PLoS neglected tropical diseases 2021 Mar;15(3):e0009211
PLoS neglected tropical diseases 2021 Mar;15(3):e0009211
Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix.
Singh R, Cottle L, Loudovaris T, Xiao D, Yang P, Thomas HE, Kebede MA, Thorn P
Stem cells translational medicine 2021 Mar;10(3):492-505
Stem cells translational medicine 2021 Mar;10(3):492-505
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Huang X, Oshima T, Tomita T, Fukui H, Miwa H
Biology 2021 Mar 9;10(3)
Biology 2021 Mar 9;10(3)
A comparative analysis of SARS-CoV-2 antivirals characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19.
de Vries M, Mohamed AS, Prescott RA, Valero-Jimenez AM, Desvignes L, O'Connor R, Steppan C, Devlin JC, Ivanova E, Herrera A, Schinlever A, Loose P, Ruggles K, Koralov SB, Anderson AS, Binder J, Dittmann M
Journal of virology 2021 Mar 10;95(7)
Journal of virology 2021 Mar 10;95(7)
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Breunig M, Merkle J, Wagner M, Melzer MK, Barth TFE, Engleitner T, Krumm J, Wiedenmann S, Cohrs CM, Perkhofer L, Jain G, Krüger J, Hermann PC, Schmid M, Madácsy T, Varga Á, Griger J, Azoitei N, Müller M, Wessely O, Robey PG, Heller S, Dantes Z, Reichert M, Günes C, Bolenz C, Kuhn F, Maléth J, Speier S, Liebau S, Sipos B, Kuster B, Seufferlein T, Rad R, Meier M, Hohwieler M, Kleger A
Cell stem cell 2021 Jun 3;28(6):1105-1124.e19
Cell stem cell 2021 Jun 3;28(6):1105-1124.e19
MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor.
Alghamri MS, Sharma P, Williamson TL, Readler JM, Yan R, Rider SD Jr, Hostetler HA, Cool DR, Kolawole AO, Excoffon KJDA
Journal of virology 2021 Jun 10;95(13):e0004621
Journal of virology 2021 Jun 10;95(13):e0004621
Inducible Slc4a11 Knockout Triggers Corneal Edema Through Perturbation of Corneal Endothelial Pump.
Ogando DG, Shyam R, Kim ET, Wang YC, Liu CY, Bonanno JA
Investigative ophthalmology & visual science 2021 Jun 1;62(7):28
Investigative ophthalmology & visual science 2021 Jun 1;62(7):28
Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea.
Billings SE, Myers NM, Quiruz L, Cheng AG
Development (Cambridge, England) 2021 Jun 1;148(11)
Development (Cambridge, England) 2021 Jun 1;148(11)
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation.
Yang Q, Xue SL, Chan CJ, Rempfler M, Vischi D, Maurer-Gutierrez F, Hiiragi T, Hannezo E, Liberali P
Nature cell biology 2021 Jul;23(7):733-744
Nature cell biology 2021 Jul;23(7):733-744
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault PE, Blazer LL, Adams JJ, Zhang L, Roehrich H, Jo HN, Seshagiri S, Sidhu SS, Junge HJ, Angers S
EMBO molecular medicine 2021 Jul 7;13(7):e13977
EMBO molecular medicine 2021 Jul 7;13(7):e13977
Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection.
Torices S, Cabrera R, Stangis M, Naranjo O, Fattakhov N, Teglas T, Adesse D, Toborek M
Journal of neuroinflammation 2021 Jul 29;18(1):167
Journal of neuroinflammation 2021 Jul 29;18(1):167
LocalZProjector and DeProj: a toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.
Herbert S, Valon L, Mancini L, Dray N, Caldarelli P, Gros J, Esposito E, Shorte SL, Bally-Cuif L, Aulner N, Levayer R, Tinevez JY
BMC biology 2021 Jul 2;19(1):136
BMC biology 2021 Jul 2;19(1):136
Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis.
Soto-Pantoja DR, Gaber M, Arnone AA, Bronson SM, Cruz-Diaz N, Wilson AS, Clear KYJ, Ramirez MU, Kucera GL, Levine EA, Lelièvre SA, Chaboub L, Chiba A, Yadav H, Vidi PA, Cook KL
Cancer research 2021 Jul 15;81(14):3890-3904
Cancer research 2021 Jul 15;81(14):3890-3904
Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor.
Leventea E, Zhu Z, Fang X, Nikolaeva Y, Markham E, Hirst RA, van Eeden FJM, Malicki JJ
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 13;118(28)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 13;118(28)
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Pastushenko I, Mauri F, Song Y, de Cock F, Meeusen B, Swedlund B, Impens F, Van Haver D, Opitz M, Thery M, Bareche Y, Lapouge G, Vermeersch M, Van Eycke YR, Balsat C, Decaestecker C, Sokolow Y, Hassid S, Perez-Bustillo A, Agreda-Moreno B, Rios-Buceta L, Jaen P, Redondo P, Sieira-Gil R, Millan-Cayetano JF, Sanmatrtin O, D'Haene N, Moers V, Rozzi M, Blondeau J, Lemaire S, Scozzaro S, Janssens V, De Troya M, Dubois C, Pérez-Morga D, Salmon I, Sotiriou C, Helmbacher F, Blanpain C
Nature 2021 Jan;589(7842):448-455
Nature 2021 Jan;589(7842):448-455
Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins.
Winkler L, Blasig R, Breitkreuz-Korff O, Berndt P, Dithmer S, Helms HC, Puchkov D, Devraj K, Kaya M, Qin Z, Liebner S, Wolburg H, Andjelkovic AV, Rex A, Blasig IE, Haseloff RF
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 Jan;41(1):132-145
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 Jan;41(1):132-145
Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.
De La Cena KOC, Ho RX, Amraei R, Woolf N, Tashjian JY, Zhao Q, Richards S, Walker J, Huang J, Chitalia VC, Rahimi N
The American journal of pathology 2021 Jan;191(1):157-167
The American journal of pathology 2021 Jan;191(1):157-167
Syncytialization and prolonged exposure to palmitate impacts BeWo respiration.
Easton ZJW, Delhaes F, Mathers K, Zhao L, Vanderboor CMG, Regnault TRH
Reproduction (Cambridge, England) 2021 Jan;161(1):73-88
Reproduction (Cambridge, England) 2021 Jan;161(1):73-88
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds.
Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Görne J, Wallingford JB, Hammes A, Feistel K
Development (Cambridge, England) 2021 Jan 26;148(2)
Development (Cambridge, England) 2021 Jan 26;148(2)
Localization and regulation of claudin-14 in experimental models of hypercalcemia.
Frische S, Alexander RT, Ferreira P, Tan RSG, Wang W, Svenningsen P, Skjødt K, Dimke H
American journal of physiology. Renal physiology 2021 Jan 1;320(1):F74-F86
American journal of physiology. Renal physiology 2021 Jan 1;320(1):F74-F86
Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China.
Zhang H, Su B, Jiao L, Xu ZH, Zhang CJ, Nie J, Gao ML, Zhang YV, Jin ZB
Annals of translational medicine 2021 Feb;9(3):245
Annals of translational medicine 2021 Feb;9(3):245
CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains.
Kimura T, Saito H, Kawasaki M, Takeichi M
Development (Cambridge, England) 2021 Feb 5;148(3)
Development (Cambridge, England) 2021 Feb 5;148(3)
A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19.
de Vries M, Mohamed AS, Prescott RA, Valero-Jimenez AM, Desvignes L, O'Connor R, Steppan C, Devlin JC, Ivanova E, Herrera A, Schinlever A, Loose P, Ruggles K, Koralov SB, Anderson AS, Binder J, Dittmann M
bioRxiv : the preprint server for biology 2021 Feb 19;
bioRxiv : the preprint server for biology 2021 Feb 19;
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin.
O'Sullivan MJ, Mitchel JA, Mwase C, McGill M, Kanki P, Park JA
American journal of physiology. Lung cellular and molecular physiology 2021 Feb 1;320(2):L246-L253
American journal of physiology. Lung cellular and molecular physiology 2021 Feb 1;320(2):L246-L253
The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals.
Torrillas de la Cal A, Paniagua-Torija B, Arevalo-Martin A, Faulkes CG, Jiménez AJ, Ferrer I, Molina-Holgado E, Garcia-Ovejero D
Cells 2021 Aug 28;10(9)
Cells 2021 Aug 28;10(9)
Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.
Huang TW, Iyer AA, Manalo JM, Woo J, Bosquez Huerta NA, McGovern MM, Schrewe H, Pereira FA, Groves AK, Ohlemiller KK, Deneen B
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 25;41(34):7171-7181
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 25;41(34):7171-7181
MAP Kinase Pathways in Brain Endothelial Cells and Crosstalk with Pericytes and Astrocytes Mediate Contrast-Induced Blood-Brain Barrier Disruption.
Matsunaga Y, Nakagawa S, Morofuji Y, Dohgu S, Watanabe D, Horie N, Izumo T, Niwa M, Walter FR, Santa-Maria AR, Deli MA, Matsuo T
Pharmaceutics 2021 Aug 17;13(8)
Pharmaceutics 2021 Aug 17;13(8)
Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells.
Ishii M, Tsuchiya T, Doi R, Morofuji Y, Fujimoto T, Muto H, Suematsu T, Mori R, Matsumoto K, Miyazaki T, Tomoshige K, Watanabe H, Iwatake M, Nagayasu T
Pharmaceutics 2021 Aug 16;13(8)
Pharmaceutics 2021 Aug 16;13(8)
Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
Droessler L, Cornelius V, Markov AG, Amasheh S
International journal of molecular sciences 2021 Aug 14;22(16)
International journal of molecular sciences 2021 Aug 14;22(16)
The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.
Morgani SM, Su J, Nichols J, Massagué J, Hadjantonakis AK
eLife 2021 Apr 30;10
eLife 2021 Apr 30;10
Electrical synaptic transmission requires a postsynaptic scaffolding protein.
Lasseigne AM, Echeverry FA, Ijaz S, Michel JC, Martin EA, Marsh AJ, Trujillo E, Marsden KC, Pereda AE, Miller AC
eLife 2021 Apr 28;10
eLife 2021 Apr 28;10
Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
Yoshida S, Wei X, Zhang G, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L
The Journal of clinical investigation 2021 Apr 1;131(7)
The Journal of clinical investigation 2021 Apr 1;131(7)
Osmotic regulation of aquaporin-8 expression in retinal pigment epithelial cells in vitro: Dependence on K(ATP) channel activation.
Schnabel B, Kuhrt H, Wiedemann P, Bringmann A, Hollborn M
Molecular vision 2020;26:797-817
Molecular vision 2020;26:797-817
Mitochondrial and Peroxisomal Alterations Contribute to Energy Dysmetabolism in Riboflavin Transporter Deficiency.
Colasuonno F, Niceforo A, Marioli C, Fracassi A, Stregapede F, Massey K, Tartaglia M, Bertini E, Compagnucci C, Moreno S
Oxidative medicine and cellular longevity 2020;2020:6821247
Oxidative medicine and cellular longevity 2020;2020:6821247
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Xu X, Zhang X, Gao L, Liu C, You K
Oxidative medicine and cellular longevity 2020;2020:2641461
Oxidative medicine and cellular longevity 2020;2020:2641461
No tight junctions in tight junction protein-1 expressing HeLa and fibroblast cells.
Shi Y, Li R, Yang J, Li X
International journal of physiology, pathophysiology and pharmacology 2020;12(2):70-78
International journal of physiology, pathophysiology and pharmacology 2020;12(2):70-78
AhR activation defends gut barrier integrity against damage occurring in obesity.
Postal BG, Ghezzal S, Aguanno D, André S, Garbin K, Genser L, Brot-Laroche E, Poitou C, Soula H, Leturque A, Clément K, Carrière V
Molecular metabolism 2020 Sep;39:101007
Molecular metabolism 2020 Sep;39:101007
Insulin-like growth factor 1 triggers salt secretion machinery in fish under acute salinity stress.
Yan JJ, Lee YC, Tsou YL, Tseng YC, Hwang PP
The Journal of endocrinology 2020 Sep;246(3):277-288
The Journal of endocrinology 2020 Sep;246(3):277-288
Zebrafish Crb1, Localizing Uniquely to the Cell Membranes around Cone Photoreceptor Axonemes, Alleviates Light Damage to Photoreceptors and Modulates Cones' Light Responsiveness.
Guo C, Deveau C, Zhang C, Nelson R, Wei X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Sep 9;40(37):7065-7079
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Sep 9;40(37):7065-7079
Vitamin D Protects against Oxidative Stress and Inflammation in Human Retinal Cells.
Fernandez-Robredo P, González-Zamora J, Recalde S, Bilbao-Malavé V, Bezunartea J, Hernandez M, Garcia-Layana A
Antioxidants (Basel, Switzerland) 2020 Sep 8;9(9)
Antioxidants (Basel, Switzerland) 2020 Sep 8;9(9)
Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure.
Hanyu H, Yokoi Y, Nakamura K, Ayabe T, Tanaka K, Uno K, Miyajima K, Saito Y, Iwatsuki K, Shimizu M, Tadaishi M, Kobayashi-Hattori K
Toxins 2020 Sep 24;12(10)
Toxins 2020 Sep 24;12(10)
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP
Molecular biology of the cell 2020 Sep 15;31(20):2249-2258
Molecular biology of the cell 2020 Sep 15;31(20):2249-2258
N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
Pérez AG, Andrade-Da-Costa J, De Souza WF, De Souza Ferreira M, Boroni M, De Oliveira IM, Freire-Neto CA, Fernandes PV, De Lanna CA, Souza-Santos PT, Morgado-Díaz JA, De-Freitas-Junior JCM
Oncology reports 2020 Oct;44(4):1649-1661
Oncology reports 2020 Oct;44(4):1649-1661
Intestinal vitamin D receptor signaling ameliorates dextran sulfate sodium-induced colitis by suppressing necroptosis of intestinal epithelial cells.
Shi Y, Cui X, Sun Y, Zhao Q, Liu T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13494-13506
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13494-13506
Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells.
Love H, Evans R, Humes HD, Roy S, Zent R, Harris R, Wilson M, Fissell WH
Tissue engineering. Part A 2020 Oct;26(19-20):1091-1098
Tissue engineering. Part A 2020 Oct;26(19-20):1091-1098
FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.
Wang Z, Higashikawa K, Yasui H, Kuge Y, Ohno Y, Kihara A, Midori YA, Houkin K, Kawabori M
Translational stroke research 2020 Oct;11(5):1103-1116
Translational stroke research 2020 Oct;11(5):1103-1116
A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples.
Tamminen I, Lehto K, Hannula M, Ojansivu M, Johansson L, Kellomäki M, Miettinen S, Aula A, Ihalainen T, Hyttinen J
Communications biology 2020 Oct 2;3(1):548
Communications biology 2020 Oct 2;3(1):548
PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer.
Lin LL, Kost ER, Lin CL, Valente P, Wang CM, Kolonin MG, Daquinag AC, Tan X, Lucio N, Hung CN, Wang CP, Kirma NB, Huang TH
Cell reports 2020 Oct 13;33(2):108253
Cell reports 2020 Oct 13;33(2):108253
Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear.
Cohen R, Amir-Zilberstein L, Hersch M, Woland S, Loza O, Taiber S, Matsuzaki F, Bergmann S, Avraham KB, Sprinzak D
Nature communications 2020 Oct 12;11(1):5137
Nature communications 2020 Oct 12;11(1):5137
The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption.
Aguanno D, Coquant G, Postal BG, Osinski C, Wieckowski M, Stockholm D, Grill JP, Carrière V, Seksik P, Thenet S
Tissue barriers 2020 Oct 1;8(4):1832877
Tissue barriers 2020 Oct 1;8(4):1832877
A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities.
Malankhanova T, Suldina L, Grigor'eva E, Medvedev S, Minina J, Morozova K, Kiseleva E, Zakian S, Malakhova A
Journal of personalized medicine 2020 Nov 9;10(4)
Journal of personalized medicine 2020 Nov 9;10(4)
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
Vázquez-Rosa E, Shin MK, Dhar M, Chaubey K, Cintrón-Pérez CJ, Tang X, Liao X, Miller E, Koh Y, Barker S, Franke K, Crosby DR, Schroeder R, Emery J, Yin TC, Fujioka H, Reynolds JD, Harper MM, Jain MK, Pieper AA
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27667-27675
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27667-27675
Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome.
Gemel J, Mao Y, Lapping-Carr G, Beyer EC
International journal of molecular sciences 2020 Nov 24;21(23)
International journal of molecular sciences 2020 Nov 24;21(23)
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Ristori E, Cicaloni V, Salvini L, Tinti L, Tinti C, Simons M, Corti F, Donnini S, Ziche M
Cells 2020 Nov 19;9(11)
Cells 2020 Nov 19;9(11)
Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens.
Hao Y, Zhou Y, Yu Y, Zheng M, Weng K, Kou Z, Liang J, Zhang Q, Tang X, Xu P, Link BA, Yao K, Zou J
Development (Cambridge, England) 2020 Nov 19;147(22)
Development (Cambridge, England) 2020 Nov 19;147(22)
High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures.
Minn KT, Fu YC, He S, Dietmann S, George SC, Anastasio MA, Morris SA, Solnica-Krezel L
eLife 2020 Nov 18;9
eLife 2020 Nov 18;9
16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development.
Roth JG, Muench KL, Asokan A, Mallett VM, Gai H, Verma Y, Weber S, Charlton C, Fowler JL, Loh KM, Dolmetsch RE, Palmer TD
eLife 2020 Nov 10;9
eLife 2020 Nov 10;9
Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion.
Teo JL, Tomatis VM, Coburn L, Lagendijk AK, Schouwenaar IM, Budnar S, Hall TE, Verma S, McLachlan RW, Hogan BM, Parton RG, Yap AS, Gomez GA
Molecular biology of the cell 2020 Nov 1;31(23):2557-2569
Molecular biology of the cell 2020 Nov 1;31(23):2557-2569
Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner.
Stephens M, von der Weid PY
Gut microbes 2020 May 3;11(3):421-432
Gut microbes 2020 May 3;11(3):421-432
Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.
Flasse L, Yennek S, Cortijo C, Barandiaran IS, Kraus MR, Grapin-Botton A
Cell reports 2020 May 26;31(8):107677
Cell reports 2020 May 26;31(8):107677
Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration.
Chen CM, Wu ML, Ho YC, Gung PY, Tsai MH, Orekhov AN, Sobenin IA, Lin P, Yet SF
International journal of molecular sciences 2020 May 13;21(10)
International journal of molecular sciences 2020 May 13;21(10)
Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo.
Orts-Del'Immagine A, Cantaut-Belarif Y, Thouvenin O, Roussel J, Baskaran A, Langui D, Koëth F, Bivas P, Lejeune FX, Bardet PL, Wyart C
Current biology : CB 2020 Mar 9;30(5):827-839.e4
Current biology : CB 2020 Mar 9;30(5):827-839.e4
Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.
Aoki H, Yamashita M, Hashita T, Iwao T, Matsunaga T
Fluids and barriers of the CNS 2020 Mar 30;17(1):25
Fluids and barriers of the CNS 2020 Mar 30;17(1):25
Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis.
Kinoshita N, Hashimoto Y, Yasue N, Suzuki M, Cristea IM, Ueno N
Cell reports 2020 Mar 17;30(11):3875-3888.e3
Cell reports 2020 Mar 17;30(11):3875-3888.e3
Unlocking the Potential of Organ-on-Chip Models through Pumpless and Tubeless Microfluidics.
Delon LC, Nilghaz A, Cheah E, Prestidge C, Thierry B
Advanced healthcare materials 2020 Jun;9(11):e1901784
Advanced healthcare materials 2020 Jun;9(11):e1901784
Transplantation of iPS-derived vascular endothelial cells improves white matter ischemic damage.
Xu B, Kurachi M, Shimauchi-Ohtaki H, Yoshimoto Y, Ishizaki Y
Journal of neurochemistry 2020 Jun;153(6):759-771
Journal of neurochemistry 2020 Jun;153(6):759-771
Host-Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model.
Pharo EA, Williams SM, Boyd V, Sundaramoorthy V, Durr PA, Baker ML
Viruses 2020 Jun 24;12(6)
Viruses 2020 Jun 24;12(6)
Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish.
Banote RK, Chebli J, Şatır TM, Varshney GK, Camacho R, Ledin J, Burgess SM, Abramsson A, Zetterberg H
Scientific reports 2020 Jun 23;10(1):10127
Scientific reports 2020 Jun 23;10(1):10127
The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine.
Troutwine BR, Gontarz P, Konjikusic MJ, Minowa R, Monstad-Rios A, Sepich DS, Kwon RY, Solnica-Krezel L, Gray RS
Current biology : CB 2020 Jun 22;30(12):2353-2362.e3
Current biology : CB 2020 Jun 22;30(12):2353-2362.e3
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A
Cell reports 2020 Jun 2;31(9):107711
Cell reports 2020 Jun 2;31(9):107711
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Samson AL, Zhang Y, Geoghegan ND, Gavin XJ, Davies KA, Mlodzianoski MJ, Whitehead LW, Frank D, Garnish SE, Fitzgibbon C, Hempel A, Young SN, Jacobsen AV, Cawthorne W, Petrie EJ, Faux MC, Shield-Artin K, Lalaoui N, Hildebrand JM, Silke J, Rogers KL, Lessene G, Hawkins ED, Murphy JM
Nature communications 2020 Jun 19;11(1):3151
Nature communications 2020 Jun 19;11(1):3151
Retinal microglia are critical for subretinal neovascular formation.
Usui-Ouchi A, Usui Y, Kurihara T, Aguilar E, Dorrell MI, Ideguchi Y, Sakimoto S, Bravo S, Friedlander M
JCI insight 2020 Jun 18;5(12)
JCI insight 2020 Jun 18;5(12)
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Shi Y, Liu Z, Cui X, Zhao Q, Liu T
Cell death & disease 2020 Jun 15;11(6):461
Cell death & disease 2020 Jun 15;11(6):461
CRISP3 expression drives prostate cancer invasion and progression.
Volpert M, Furic L, Hu J, O'Connor AE, Rebello RJ, Keerthikumar S, Evans J, Merriner DJ, Pedersen J, Risbridger GP, McIntyre P, O'Bryan MK
Endocrine-related cancer 2020 Jul;27(7):415-430
Endocrine-related cancer 2020 Jul;27(7):415-430
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR
Circulation research 2020 Jul 3;127(2):e28-e43
Circulation research 2020 Jul 3;127(2):e28-e43
Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly.
Haas AJ, Zihni C, Ruppel A, Hartmann C, Ebnet K, Tada M, Balda MS, Matter K
Cell reports 2020 Jul 21;32(3):107924
Cell reports 2020 Jul 21;32(3):107924
Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected.
Liu C, Miyajima T, Melangath G, Miyai T, Vasanth S, Deshpande N, Kumar V, Ong Tone S, Gupta R, Zhu S, Vojnovic D, Chen Y, Rogan EG, Mondal B, Zahid M, Jurkunas UV
Proceedings of the National Academy of Sciences of the United States of America 2020 Jan 7;117(1):573-583
Proceedings of the National Academy of Sciences of the United States of America 2020 Jan 7;117(1):573-583
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
Liu Y, Zhang Y, Li T, Han J, Wang Y
Nature communications 2020 Jan 30;11(1):589
Nature communications 2020 Jan 30;11(1):589
Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish.
Arora P, Dongre S, Raman R, Sonawane M
eLife 2020 Jan 22;9
eLife 2020 Jan 22;9
Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.
Findlay AS, McKie L, Keighren M, Clementson-Mobbs S, Sanchez-Pulido L, Wells S, Cross SH, Jackson IJ
Scientific reports 2020 Jan 16;10(1):437
Scientific reports 2020 Jan 16;10(1):437
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.
Kasendra M, Luc R, Yin J, Manatakis DV, Kulkarni G, Lucchesi C, Sliz J, Apostolou A, Sunuwar L, Obrigewitch J, Jang KJ, Hamilton GA, Donowitz M, Karalis K
eLife 2020 Jan 14;9
eLife 2020 Jan 14;9
Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production.
Ghezzal S, Postal BG, Quevrain E, Brot L, Seksik P, Leturque A, Thenet S, Carrière V
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Feb;1865(2):158530
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Feb;1865(2):158530
Midkine-a Is Required for Cell Cycle Progression of Müller Glia during Neuronal Regeneration in the Vertebrate Retina.
Nagashima M, D'Cruz TS, Danku AE, Hesse D, Sifuentes C, Raymond PA, Hitchcock PF
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Feb 5;40(6):1232-1247
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Feb 5;40(6):1232-1247
Signs of Reduced Basal Progenitor Levels and Cortical Neurogenesis in Human Fetuses with Open Spina Bifida at 11-15 Weeks of Gestation.
Fietz SA, Namba T, Kirsten H, Huttner WB, Lachmann R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Feb 19;40(8):1766-1777
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Feb 19;40(8):1766-1777
Going Back and Forth: Episomal Vector Reprogramming of Peripheral Blood Mononuclear Cells to Induced Pluripotent Stem Cells and Subsequent Differentiation into Cardiomyocytes and Neuron-Astrocyte Co-cultures.
de Leeuw VC, van Oostrom CTM, Imholz S, Piersma AH, Hessel EVS, Dollé MET
Cellular reprogramming 2020 Dec;22(6):300-310
Cellular reprogramming 2020 Dec;22(6):300-310
S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation.
Yang W, Wu YH, Liu SQ, Sheng ZY, Zhen ZD, Gao RQ, Cui XY, Fan DY, Qin ZH, Zheng AH, Wang PG, An J
PLoS pathogens 2020 Dec;16(12):e1009019
PLoS pathogens 2020 Dec;16(12):e1009019
Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity.
Pongkorpsakol P, Turner JR, Zuo L
Current protocols in immunology 2020 Dec;131(1):e112
Current protocols in immunology 2020 Dec;131(1):e112
Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids.
Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ
International journal of molecular sciences 2020 Dec 30;22(1)
International journal of molecular sciences 2020 Dec 30;22(1)
Crosstalk between Long-Term Sublethal Oxidative Stress and Detrimental Inflammation as Potential Drivers for Age-Related Retinal Degeneration.
Macchioni L, Chiasserini D, Mezzasoma L, Davidescu M, Orvietani PL, Fettucciari K, Salviati L, Cellini B, Bellezza I
Antioxidants (Basel, Switzerland) 2020 Dec 29;10(1)
Antioxidants (Basel, Switzerland) 2020 Dec 29;10(1)
Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube.
Symonds AC, Buckley CE, Williams CA, Clarke JDW
Development (Cambridge, England) 2020 Dec 23;147(24)
Development (Cambridge, England) 2020 Dec 23;147(24)
Whole-mount Immunohistochemistry of Adult Zebrafish Retina for Advanced Imaging.
Nagashima M, Hitchcock PF
Bio-protocol 2020 Dec 20;10(24):e3848
Bio-protocol 2020 Dec 20;10(24):e3848
Mannheimia haemolytica and lipopolysaccharide induce airway epithelial inflammatory responses in an extensively developed ex vivo calf model.
Cai Y, Varasteh S, van Putten JPM, Folkerts G, Braber S
Scientific reports 2020 Aug 3;10(1):13042
Scientific reports 2020 Aug 3;10(1):13042
Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.
Cottarelli A, Corada M, Beznoussenko GV, Mironov AA, Globisch MA, Biswas S, Huang H, Dimberg A, Magnusson PU, Agalliu D, Lampugnani MG, Dejana E
Development (Cambridge, England) 2020 Aug 24;147(16)
Development (Cambridge, England) 2020 Aug 24;147(16)
Tau reduction in aged mice does not impact Microangiopathy.
Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT
Acta neuropathologica communications 2020 Aug 18;8(1):137
Acta neuropathologica communications 2020 Aug 18;8(1):137
Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus.
Zhou X, Zhong S, Peng H, Liu J, Ding W, Sun L, Ma Q, Liu Z, Chen R, Wu Q, Wang X
Nature communications 2020 Aug 13;11(1):4063
Nature communications 2020 Aug 13;11(1):4063
Centrosome anchoring regulates progenitor properties and cortical formation.
Shao W, Yang J, He M, Yu XY, Lee CH, Yang Z, Joyner AL, Anderson KV, Zhang J, Tsou MB, Shi H, Shi SH
Nature 2020 Apr;580(7801):106-112
Nature 2020 Apr;580(7801):106-112
Robotic fluidic coupling and interrogation of multiple vascularized organ chips.
Novak R, Ingram M, Marquez S, Das D, Delahanty A, Herland A, Maoz BM, Jeanty SSF, Somayaji MR, Burt M, Calamari E, Chalkiadaki A, Cho A, Choe Y, Chou DB, Cronce M, Dauth S, Divic T, Fernandez-Alcon J, Ferrante T, Ferrier J, FitzGerald EA, Fleming R, Jalili-Firoozinezhad S, Grevesse T, Goss JA, Hamkins-Indik T, Henry O, Hinojosa C, Huffstater T, Jang KJ, Kujala V, Leng L, Mannix R, Milton Y, Nawroth J, Nestor BA, Ng CF, O'Connor B, Park TE, Sanchez H, Sliz J, Sontheimer-Phelps A, Swenor B, Thompson G 2nd, Touloumes GJ, Tranchemontagne Z, Wen N, Yadid M, Bahinski A, Hamilton GA, Levner D, Levy O, Przekwas A, Prantil-Baun R, Parker KK, Ingber DE
Nature biomedical engineering 2020 Apr;4(4):407-420
Nature biomedical engineering 2020 Apr;4(4):407-420
The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.
Cross SH, Mckie L, Hurd TW, Riley S, Wills J, Barnard AR, Young F, MacLaren RE, Jackson IJ
PLoS genetics 2020 Apr;16(4):e1008583
PLoS genetics 2020 Apr;16(4):e1008583
Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling.
Winkler TE, Feil M, Stronkman EFGJ, Matthiesen I, Herland A
Lab on a chip 2020 Apr 7;20(7):1212-1226
Lab on a chip 2020 Apr 7;20(7):1212-1226
Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death.
Dziengelewski C, Rodrigue MA, Caillier A, Jacquet K, Boulanger MC, Bergeman J, Fuchs M, Lambert H, Laprise P, Richard DE, Bordeleau F, Huot MÉ, Lavoie JN
The Journal of cell biology 2020 Apr 6;219(4)
The Journal of cell biology 2020 Apr 6;219(4)
Light-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance.
Naso F, Intartaglia D, Falanga D, Soldati C, Polishchuk E, Giamundo G, Tiberi P, Marrocco E, Scudieri P, Di Malta C, Trapani I, Nusco E, Salierno FG, Surace EM, Galietta LJ, Banfi S, Auricchio A, Ballabio A, Medina DL, Conte I
The EMBO journal 2020 Apr 15;39(8):e102468
The EMBO journal 2020 Apr 15;39(8):e102468
Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.
Boles NC, Fernandes M, Swigut T, Srinivasan R, Schiff L, Rada-Iglesias A, Wang Q, Saini JS, Kiehl T, Stern JH, Wysocka J, Blenkinsop TA, Temple S
Stem cell reports 2020 Apr 14;14(4):631-647
Stem cell reports 2020 Apr 14;14(4):631-647
MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity.
Andrieu C, Montigny A, Bibonne A, Despin-Guitard E, Alfandari D, Théveneau E
Development (Cambridge, England) 2020 Apr 12;147(7)
Development (Cambridge, England) 2020 Apr 12;147(7)
Fabricating retinal pigment epithelial cell sheets derived from human induced pluripotent stem cells in an automated closed culture system for regenerative medicine.
Matsumoto E, Koide N, Hanzawa H, Kiyama M, Ohta M, Kuwabara J, Takeda S, Takahashi M
PloS one 2019;14(3):e0212369
PloS one 2019;14(3):e0212369
Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations.
Li G, Gao G, Wang P, Song X, Xu P, Xie B, Zhou T, Pan G, Peng F, Zhang Q, Ge J, Zhong X
Frontiers in molecular neuroscience 2019;12:212
Frontiers in molecular neuroscience 2019;12:212
The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses.
Vielle NJ, García-Nicolás O, Oliveira Esteves BI, Brügger M, Summerfield A, Alves MP
Frontiers in microbiology 2019;10:811
Frontiers in microbiology 2019;10:811
Role of Endoplasmic Reticulum Stress-Autophagy Axis in Severe Burn-Induced Intestinal Tight Junction Barrier Dysfunction in Mice.
Huang Y, Wang Y, Feng Y, Wang P, He X, Ren H, Wang F
Frontiers in physiology 2019;10:606
Frontiers in physiology 2019;10:606
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
Yang Z, Huang C, Wu Y, Chen B, Zhang W, Zhang J
Frontiers in physiology 2019;10:2
Frontiers in physiology 2019;10:2
Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis.
Cremonini E, Daveri E, Mastaloudis A, Adamo AM, Mills D, Kalanetra K, Hester SN, Wood SM, Fraga CG, Oteiza PI
Redox biology 2019 Sep;26:101269
Redox biology 2019 Sep;26:101269
miR-24 Is Elevated in Ulcerative Colitis Patients and Regulates Intestinal Epithelial Barrier Function.
Soroosh A, Rankin CR, Polytarchou C, Lokhandwala ZA, Patel A, Chang L, Pothoulakis C, Iliopoulos D, Padua DM
The American journal of pathology 2019 Sep;189(9):1763-1774
The American journal of pathology 2019 Sep;189(9):1763-1774
PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation.
Navajas Acedo J, Voas MG, Alexander R, Woolley T, Unruh JR, Li H, Moens C, Piotrowski T
Nature communications 2019 Sep 5;10(1):3993
Nature communications 2019 Sep 5;10(1):3993
Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis.
Vancamelbeke M, Laeremans T, Vanhove W, Arnauts K, Ramalho AS, Farré R, Cleynen I, Ferrante M, Vermeire S
Journal of Crohn's & colitis 2019 Sep 27;13(10):1351-1361
Journal of Crohn's & colitis 2019 Sep 27;13(10):1351-1361
Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.
Beutel O, Maraspini R, Pombo-García K, Martin-Lemaitre C, Honigmann A
Cell 2019 Oct 31;179(4):923-936.e11
Cell 2019 Oct 31;179(4):923-936.e11
Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells.
Gamero-Estevez E, Andonian S, Jean-Claude B, Gupta I, Ryan AK
International journal of molecular sciences 2019 Oct 2;20(19)
International journal of molecular sciences 2019 Oct 2;20(19)
Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate.
Liberti DC, Zepp JA, Bartoni CA, Liberti KH, Zhou S, Lu M, Morley MP, Morrisey EE
Developmental biology 2019 Oct 15;454(2):108-117
Developmental biology 2019 Oct 15;454(2):108-117
Graft immaturity and safety concerns in transplanted human kidney organoids.
Nam SA, Seo E, Kim JW, Kim HW, Kim HL, Kim K, Kim TM, Ju JH, Gomez IG, Uchimura K, Humphreys BD, Yang CW, Lee JY, Kim J, Cho DW, Freedman BS, Kim YK
Experimental & molecular medicine 2019 Nov 28;51(11):1-13
Experimental & molecular medicine 2019 Nov 28;51(11):1-13
A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation.
Thestrup MI, Caviglia S, Cayuso J, Heyne RLS, Ahmad R, Hofmeister W, Satriano L, Wilkinson DG, Andersen JB, Ober EA
Nature communications 2019 Nov 19;10(1):5220
Nature communications 2019 Nov 19;10(1):5220
Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates.
Hays C, Touak G, Bouaboud A, Fouet A, Guignot J, Poyart C, Tazi A
eLife 2019 Nov 11;8
eLife 2019 Nov 11;8
Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor.
Tang W, Guo R, Shen SJ, Zheng Y, Lu YT, Jiang MM, Cui X, Jiang CZ, Xie X
Acta pharmacologica Sinica 2019 May;40(5):620-629
Acta pharmacologica Sinica 2019 May;40(5):620-629
The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish.
Jiménez-Amilburu V, Stainier DYR
Development (Cambridge, England) 2019 May 7;146(9)
Development (Cambridge, England) 2019 May 7;146(9)
A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.
Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC
Cell stem cell 2019 May 2;24(5):802-811.e5
Cell stem cell 2019 May 2;24(5):802-811.e5
Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α-induced endothelial hyperpermeability by modulating β1 integrin activation.
Lee TH, Hsieh ST, Chiang HY
Journal of biomedical science 2019 May 16;26(1):37
Journal of biomedical science 2019 May 16;26(1):37
Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model.
Khan AM, Korzeniowska B, Gorshkov V, Tahir M, Schrøder H, Skytte L, Rasmussen KL, Khandige S, Møller-Jensen J, Kjeldsen F
Nanotoxicology 2019 Mar;13(2):221-239
Nanotoxicology 2019 Mar;13(2):221-239
Mesencephalic origin of the inferior lobe in zebrafish.
Bloch S, Thomas M, Colin I, Galant S, Machado E, Affaticati P, Jenett A, Yamamoto K
BMC biology 2019 Mar 8;17(1):22
BMC biology 2019 Mar 8;17(1):22
Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.
Kolliopoulos C, Raja E, Razmara M, Heldin P, Heldin CH, Moustakas A, van der Heide LP
The Journal of biological chemistry 2019 Mar 15;294(11):4119-4136
The Journal of biological chemistry 2019 Mar 15;294(11):4119-4136
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN
Cell stem cell 2019 Jun 6;24(6):995-1005.e6
Cell stem cell 2019 Jun 6;24(6):995-1005.e6
Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons.
Stachniak TJ, Sylwestrak EL, Scheiffele P, Hall BJ, Ghosh A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jun 5;39(23):4461-4474
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jun 5;39(23):4461-4474
3D in vitro model for human corneal endothelial cell maturation.
Hutcheon AEK, Zieske JD, Guo X
Experimental eye research 2019 Jul;184:183-191
Experimental eye research 2019 Jul;184:183-191
Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression.
Muenchau S, Deutsch R, de Castro IJ, Hielscher T, Heber N, Niesler B, Lusic M, Stanifer ML, Boulant S
Molecular and cellular biology 2019 Jul 15;39(14)
Molecular and cellular biology 2019 Jul 15;39(14)
Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility.
Søgaard PP, Ito N, Sato N, Fujita Y, Matter K, Itoh Y
Life science alliance 2019 Feb;2(1)
Life science alliance 2019 Feb;2(1)
Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.
Co JY, Margalef-Català M, Li X, Mah AT, Kuo CJ, Monack DM, Amieva MR
Cell reports 2019 Feb 26;26(9):2509-2520.e4
Cell reports 2019 Feb 26;26(9):2509-2520.e4
A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling.
Mirando AC, Shen J, Silva RLE, Chu Z, Sass NC, Lorenc VE, Green JJ, Campochiaro PA, Popel AS, Pandey NB
JCI insight 2019 Feb 21;4(4)
JCI insight 2019 Feb 21;4(4)
Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function.
Dumm RE, Fiege JK, Waring BM, Kuo CT, Langlois RA, Heaton NS
Nature communications 2019 Feb 15;10(1):779
Nature communications 2019 Feb 15;10(1):779
Faecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier.
Hoffman S, Aviv Cohen N, Carroll IM, Tulchinsky H, Borovok I, Dotan I, Maharshak N
Journal of Crohn's & colitis 2019 Dec 10;13(12):1558-1568
Journal of Crohn's & colitis 2019 Dec 10;13(12):1558-1568
Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells.
Moonwiriyakit A, Koval M, Muanprasat C
International immunopharmacology 2019 Aug;73:353-361
International immunopharmacology 2019 Aug;73:353-361
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
Awadia S, Huq F, Arnold TR, Goicoechea SM, Sun YJ, Hou T, Kreider-Letterman G, Massimi P, Banks L, Fuentes EJ, Miller AL, Garcia-Mata R
The Journal of cell biology 2019 Aug 5;218(8):2699-2725
The Journal of cell biology 2019 Aug 5;218(8):2699-2725
Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity.
Wang G, Lou HH, Salit J, Leopold PL, Driscoll S, Schymeinsky J, Quast K, Visvanathan S, Fine JS, Thomas MJ, Crystal RG
Respiratory research 2019 Aug 23;20(1):196
Respiratory research 2019 Aug 23;20(1):196
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Hsu KS, Otsu W, Li Y, Wang HC, Chen S, Tsang SH, Chuang JZ, Sung CH
Scientific reports 2019 Aug 22;9(1):12247
Scientific reports 2019 Aug 22;9(1):12247
Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium.
Johansson JK, Karema-Jokinen VI, Hakanen S, Jylhä A, Uusitalo H, Vihinen-Ranta M, Skottman H, Ihalainen TO, Nymark S
BMC biology 2019 Aug 15;17(1):63
BMC biology 2019 Aug 15;17(1):63
Disruption of peripheral nerve development in a zebrafish model of hyperglycemia.
Ennerfelt H, Voithofer G, Tibbo M, Miller D, Warfield R, Allen S, Kennett Clark J
Journal of neurophysiology 2019 Aug 1;122(2):862-871
Journal of neurophysiology 2019 Aug 1;122(2):862-871
Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons.
Desban L, Prendergast A, Roussel J, Rosello M, Geny D, Wyart C, Bardet PL
PLoS biology 2019 Apr;17(4):e3000235
PLoS biology 2019 Apr;17(4):e3000235
Anti-H7N9 avian influenza A virus activity of interferon in pseudostratified human airway epithelium cell cultures.
Chen AJ, Dong J, Yuan XH, Bo H, Li SZ, Wang C, Duan ZJ, Zheng LS
Virology journal 2019 Apr 3;16(1):44
Virology journal 2019 Apr 3;16(1):44
A Cleared View on Retinal Organoids.
Cora V, Haderspeck J, Antkowiak L, Mattheus U, Neckel PH, Mack AF, Bolz S, Ueffing M, Pashkovskaia N, Achberger K, Liebau S
Cells 2019 Apr 28;8(5)
Cells 2019 Apr 28;8(5)
The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity.
Elbediwy A, Zhang Y, Cobbaut M, Riou P, Tan RS, Roberts SK, Tynan C, George R, Kjaer S, Martin-Fernandez ML, Thompson BJ, McDonald NQ, Parker PJ
Journal of cell science 2019 Apr 25;132(8)
Journal of cell science 2019 Apr 25;132(8)
penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina.
Kujawski S, Sonawane M, Knust E
Biology open 2019 Apr 23;8(4)
Biology open 2019 Apr 23;8(4)
Acute effects of hyperglycemia on the peripheral nervous system in zebrafish ( Danio rerio) following nitroreductase-mediated β-cell ablation.
Rocker A, Howell J, Voithofer G, Clark JK
American journal of physiology. Regulatory, integrative and comparative physiology 2019 Apr 1;316(4):R395-R405
American journal of physiology. Regulatory, integrative and comparative physiology 2019 Apr 1;316(4):R395-R405
GPR40 receptor activation promotes tight junction assembly in airway epithelial cells via AMPK-dependent mechanisms.
Moonwiriyakit A, Wattanaphichet P, Chatsudthipong V, Muanprasat C
Tissue barriers 2018;6(2):1-12
Tissue barriers 2018;6(2):1-12
Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ
Cellular and molecular gastroenterology and hepatology 2018;5(4):669-677.e2
Cellular and molecular gastroenterology and hepatology 2018;5(4):669-677.e2
Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC).
Senger S, Ingano L, Freire R, Anselmo A, Zhu W, Sadreyev R, Walker WA, Fasano A
Cellular and molecular gastroenterology and hepatology 2018;5(4):549-568
Cellular and molecular gastroenterology and hepatology 2018;5(4):549-568
The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells.
Zacharopoulou N, Tsapara A, Kallergi G, Schmid E, Alkahtani S, Alarifi S, Tsichlis PN, Kampranis SC, Stournaras C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):368-377
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):368-377
Differential effects of depot formulations of GnRH agonist leuprorelin and antagonist degarelix on the seminiferous epithelium of the rat testis.
Hori JI, Koga D, Kakizaki H, Watanabe T
Biomedical research (Tokyo, Japan) 2018;39(4):197-214
Biomedical research (Tokyo, Japan) 2018;39(4):197-214
Generation of Retinal Organoids with Mature Rods and Cones from Urine-Derived Human Induced Pluripotent Stem Cells.
Li G, Xie B, He L, Zhou T, Gao G, Liu S, Pan G, Ge J, Peng F, Zhong X
Stem cells international 2018;2018:4968658
Stem cells international 2018;2018:4968658
Optimisation of growth conditions for ovine airway epithelial cell differentiation at an air-liquid interface.
O'Boyle N, Sutherland E, Berry CC, Davies RL
PloS one 2018;13(3):e0193998
PloS one 2018;13(3):e0193998
Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4.
Hehr CL, Halabi R, McFarlane S
Cell adhesion & migration 2018;12(5):489-502
Cell adhesion & migration 2018;12(5):489-502
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
Shigemoto-Mogami Y, Hoshikawa K, Sato K
Frontiers in cellular neuroscience 2018;12:494
Frontiers in cellular neuroscience 2018;12:494
Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents.
Römer S, Bender H, Knabe W, Zimmermann E, Rübsamen R, Seeger J, Fietz SA
Frontiers in neuroanatomy 2018;12:29
Frontiers in neuroanatomy 2018;12:29
Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons.
Garcia-Pradas L, Gleiser C, Wizenmann A, Wolburg H, Mack AF
Frontiers in molecular neuroscience 2018;11:367
Frontiers in molecular neuroscience 2018;11:367
The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.
Li J, Liu J, Li P, Zhou C, Liu P
Experimental biology and medicine (Maywood, N.J.) 2018 Sep;243(13):1066-1073
Experimental biology and medicine (Maywood, N.J.) 2018 Sep;243(13):1066-1073
Medium throughput breathing human primary cell alveolus-on-chip model.
Stucki JD, Hobi N, Galimov A, Stucki AO, Schneider-Daum N, Lehr CM, Huwer H, Frick M, Funke-Chambour M, Geiser T, Guenat OT
Scientific reports 2018 Sep 25;8(1):14359
Scientific reports 2018 Sep 25;8(1):14359
Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.
Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC
eLife 2018 Oct 9;7
eLife 2018 Oct 9;7
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.
Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI
eLife 2018 Oct 25;7
eLife 2018 Oct 25;7
Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer.
Schaal CM, Bora-Singhal N, Kumar DM, Chellappan SP
Molecular cancer 2018 Oct 15;17(1):149
Molecular cancer 2018 Oct 15;17(1):149
Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish.
Mochizuki T, Kojima Y, Nishiwaki Y, Harakuni T, Masai I
Development (Cambridge, England) 2018 Oct 15;145(20)
Development (Cambridge, England) 2018 Oct 15;145(20)
In Vitro Wounding Models Using the Electric Cell-Substrate Impedance Sensing (ECIS)-Zθ Technology.
Gu AY, Kho DT, Johnson RH, Graham ES, O'Carroll SJ
Biosensors 2018 Oct 11;8(4)
Biosensors 2018 Oct 11;8(4)
Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells.
Eguchi H, Akizuki R, Maruhashi R, Tsukimoto M, Furuta T, Matsunaga T, Endo S, Ikari A
Scientific reports 2018 Oct 11;8(1):15157
Scientific reports 2018 Oct 11;8(1):15157
CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.
Revinski DR, Zaragosi LE, Boutin C, Ruiz-Garcia S, Deprez M, Thomé V, Rosnet O, Gay AS, Mercey O, Paquet A, Pons N, Ponzio G, Marcet B, Kodjabachian L, Barbry P
Nature communications 2018 Nov 7;9(1):4668
Nature communications 2018 Nov 7;9(1):4668
Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys.
Kang Y, Ai Z, Duan K, Si C, Wang Y, Zheng Y, He J, Yin Y, Zhao S, Niu B, Zhu X, Liu L, Xiang L, Zhang L, Niu Y, Ji W, Li T
Cell reports 2018 Nov 27;25(9):2563-2576.e9
Cell reports 2018 Nov 27;25(9):2563-2576.e9
Chiral Cilia Orientation in the Left-Right Organizer.
Ferreira RR, Pakula G, Klaeyle L, Fukui H, Vilfan A, Supatto W, Vermot J
Cell reports 2018 Nov 20;25(8):2008-2016.e4
Cell reports 2018 Nov 20;25(8):2008-2016.e4
Role of Alström syndrome 1 in the regulation of blood pressure and renal function.
Jaykumar AB, Caceres PS, King-Medina KN, Liao TD, Datta I, Maskey D, Naggert JK, Mendez M, Beierwaltes WH, Ortiz PA
JCI insight 2018 Nov 2;3(21)
JCI insight 2018 Nov 2;3(21)
Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Hübner K, Cabochette P, Diéguez-Hurtado R, Wiesner C, Wakayama Y, Grassme KS, Hubert M, Guenther S, Belting HG, Affolter M, Adams RH, Vanhollebeke B, Herzog W
Nature communications 2018 Nov 19;9(1):4860
Nature communications 2018 Nov 19;9(1):4860
Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication.
Wohlgemuth N, Lane AP, Pekosz A
Journal of virology 2018 Nov 15;92(22)
Journal of virology 2018 Nov 15;92(22)
Vitamin D ameliorates neonatal necrotizing enterocolitis via suppressing TLR4 in a murine model.
Shi Y, Liu T, Zhao X, Yao L, Hou A, Fu J, Xue X
Pediatric research 2018 May;83(5):1024-1030
Pediatric research 2018 May;83(5):1024-1030
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B
Nature 2018 May;557(7706):580-584
Nature 2018 May;557(7706):580-584
Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.
Wagoner MD, Bohrer LR, Aldrich BT, Greiner MA, Mullins RF, Worthington KS, Tucker BA, Wiley LA
Biology open 2018 May 8;7(5)
Biology open 2018 May 8;7(5)
BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
Raykhel I, Moafi F, Myllymäki SM, Greciano PG, Matlin KS, Moyano JV, Manninen A, Myllyharju J
Journal of cell science 2018 May 23;131(10)
Journal of cell science 2018 May 23;131(10)
Hamartoma-like lesions in the mouse retina: an animal model of Pten hamartoma tumour syndrome.
Tachibana N, Touahri Y, Dixit R, David LA, Adnani L, Cantrup R, Aavani T, Wong RO, Logan C, Kurek KC, Schuurmans C
Disease models & mechanisms 2018 May 21;11(5)
Disease models & mechanisms 2018 May 21;11(5)
Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry.
Juan T, Géminard C, Coutelis JB, Cerezo D, Polès S, Noselli S, Fürthauer M
Nature communications 2018 May 16;9(1):1942
Nature communications 2018 May 16;9(1):1942
Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.
Schwab RHM, Amin N, Flanagan DJ, Johanson TM, Phesse TJ, Vincan E
Developmental dynamics : an official publication of the American Association of Anatomists 2018 Mar;247(3):521-530
Developmental dynamics : an official publication of the American Association of Anatomists 2018 Mar;247(3):521-530
Tension-dependent regulation of mammalian Hippo signaling through LIMD1.
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine KD
Journal of cell science 2018 Mar 2;131(5)
Journal of cell science 2018 Mar 2;131(5)
Effects of Chemical Chaperones on Thyroid Hormone Transport by MCT8 Mutants in Patient-Derived Fibroblasts.
Groeneweg S, van den Berge A, Meima ME, Peeters RP, Visser TJ, Visser WE
Endocrinology 2018 Mar 1;159(3):1290-1302
Endocrinology 2018 Mar 1;159(3):1290-1302
Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation.
Zhan R, Zhao M, Zhou T, Chen Y, Yu W, Zhao L, Zhang T, Wang H, Yang H, Jin Y, He Q, Yang X, Guo X, Willard B, Pan B, Huang Y, Chen Y, Chui D, Zheng L
Cell death & disease 2018 Jun 7;9(6):683
Cell death & disease 2018 Jun 7;9(6):683
A bioinspired microfluidic model of liquid plug-induced mechanical airway injury.
Song JW, Paek J, Park KT, Seo J, Huh D
Biomicrofluidics 2018 Jul;12(4):042211
Biomicrofluidics 2018 Jul;12(4):042211
The Importance of Multifrequency Impedance Sensing of Endothelial Barrier Formation Using ECIS Technology for the Generation of a Strong and Durable Paracellular Barrier.
Robilliard LD, Kho DT, Johnson RH, Anchan A, O'Carroll SJ, Graham ES
Biosensors 2018 Jul 4;8(3)
Biosensors 2018 Jul 4;8(3)
Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.
Neelathi UM, Dalle Nogare D, Chitnis AB
Development (Cambridge, England) 2018 Jul 30;145(14)
Development (Cambridge, England) 2018 Jul 30;145(14)
Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation.
Griggs RB, Yermakov LM, Drouet DE, Nguyen DVM, Susuki K
ASN neuro 2018 Jan-Dec;10:1759091418766175
ASN neuro 2018 Jan-Dec;10:1759091418766175
Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease.
Vanhove W, Nys K, Arijs I, Cleynen I, Noben M, De Schepper S, Van Assche G, Ferrante M, Vermeire S
Journal of Crohn's & colitis 2018 Jan 24;12(2):178-187
Journal of Crohn's & colitis 2018 Jan 24;12(2):178-187
The protein kinase SIK downregulates the polarity protein Par3.
Vanlandewijck M, Dadras MS, Lomnytska M, Mahzabin T, Lee Miller M, Busch C, Brunak S, Heldin CH, Moustakas A
Oncotarget 2018 Jan 19;9(5):5716-5735
Oncotarget 2018 Jan 19;9(5):5716-5735
Development and optimization of a differentiated airway epithelial cell model of the bovine respiratory tract.
Cozens D, Grahame E, Sutherland E, Taylor G, Berry CC, Davies RL
Scientific reports 2018 Jan 16;8(1):853
Scientific reports 2018 Jan 16;8(1):853
MEF2 transcription factors in human placenta and involvement in cytotrophoblast invasion and differentiation.
Li L, Rubin LP, Gong X
Physiological genomics 2018 Jan 1;50(1):10-19
Physiological genomics 2018 Jan 1;50(1):10-19
Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation.
Yuan J, Deng W, Cha J, Sun X, Borg JP, Dey SK
Nature communications 2018 Feb 9;9(1):603
Nature communications 2018 Feb 9;9(1):603
Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue.
Hatte G, Prigent C, Tassan JP
Journal of cell science 2018 Feb 5;131(3)
Journal of cell science 2018 Feb 5;131(3)
Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation.
Singh AP, Sharma S, Pagarware K, Siraji RA, Ansari I, Mandal A, Walling P, Aijaz S
Scientific reports 2018 Feb 27;8(1):3719
Scientific reports 2018 Feb 27;8(1):3719
Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip.
Jalili-Firoozinezhad S, Prantil-Baun R, Jiang A, Potla R, Mammoto T, Weaver JC, Ferrante TC, Kim HJ, Cabral JMS, Levy O, Ingber DE
Cell death & disease 2018 Feb 14;9(2):223
Cell death & disease 2018 Feb 14;9(2):223
Calcium signaling mediates five types of cell morphological changes to form neural rosettes.
Hříbková H, Grabiec M, Klemová D, Slaninová I, Sun YM
Journal of cell science 2018 Feb 12;131(3)
Journal of cell science 2018 Feb 12;131(3)
Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.
Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi JM, Gangarossa G, Marchi N
Neuroscience 2018 Feb 1;370:130-138
Neuroscience 2018 Feb 1;370:130-138
Dexamethasone enhances vasopressin-induced aquaporin-2 gene expression in the mpkCCD cells.
Kuo KT, Yang CW, Yu MJ
American journal of physiology. Renal physiology 2018 Feb 1;314(2):F219-F229
American journal of physiology. Renal physiology 2018 Feb 1;314(2):F219-F229
Mathematical-model-guided development of full-thickness epidermal equivalent.
Kumamoto J, Nakanishi S, Makita M, Uesaka M, Yasugahira Y, Kobayashi Y, Nagayama M, Denda S, Denda M
Scientific reports 2018 Dec 20;8(1):17999
Scientific reports 2018 Dec 20;8(1):17999
HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo.
Frum T, Murphy TM, Ralston A
eLife 2018 Dec 11;7
eLife 2018 Dec 11;7
A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice.
Sure VN, Sakamuri SSVP, Sperling JA, Evans WR, Merdzo I, Mostany R, Murfee WL, Busija DW, Katakam PVG
GeroScience 2018 Aug;40(4):365-375
GeroScience 2018 Aug;40(4):365-375
Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction.
Paatero I, Sauteur L, Lee M, Lagendijk AK, Heutschi D, Wiesner C, Guzmán C, Bieli D, Hogan BM, Affolter M, Belting HG
Nature communications 2018 Aug 31;9(1):3545
Nature communications 2018 Aug 31;9(1):3545
Cell injury triggers actin polymerization to initiate epithelial restitution.
Aihara E, Medina-Candelaria NM, Hanyu H, Matthis AL, Engevik KA, Gurniak CB, Witke W, Turner JR, Zhang T, Montrose MH
Journal of cell science 2018 Aug 20;131(16)
Journal of cell science 2018 Aug 20;131(16)
A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage.
Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J
Anaerobe 2018 Apr;50:85-92
Anaerobe 2018 Apr;50:85-92
The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.
Ohlemiller KK, Kaur T, Warchol ME, Withnell RH
Hearing research 2018 Apr;361:138-151
Hearing research 2018 Apr;361:138-151
Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter.
Shinoda T, Nagasaka A, Inoue Y, Higuchi R, Minami Y, Kato K, Suzuki M, Kondo T, Kawaue T, Saito K, Ueno N, Fukazawa Y, Nagayama M, Miura T, Adachi T, Miyata T
PLoS biology 2018 Apr;16(4):e2004426
PLoS biology 2018 Apr;16(4):e2004426
(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance.
Cremonini E, Wang Z, Bettaieb A, Adamo AM, Daveri E, Mills DA, Kalanetra KM, Haj FG, Karakas S, Oteiza PI
Redox biology 2018 Apr;14:588-599
Redox biology 2018 Apr;14:588-599
Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation.
Zenker J, White MD, Gasnier M, Alvarez YD, Lim HYG, Bissiere S, Biro M, Plachta N
Cell 2018 Apr 19;173(3):776-791.e17
Cell 2018 Apr 19;173(3):776-791.e17
Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V
American journal of physiology. Heart and circulatory physiology 2018 Apr 1;314(4):H693-H703
American journal of physiology. Heart and circulatory physiology 2018 Apr 1;314(4):H693-H703
Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.
Pervolaraki K, Stanifer ML, Münchau S, Renn LA, Albrecht D, Kurzhals S, Senís E, Grimm D, Schröder-Braunstein J, Rabin RL, Boulant S
Frontiers in immunology 2017;8:459
Frontiers in immunology 2017;8:459
Sertoli Cells Are Susceptible to ZIKV Infection in Mouse Testis.
Sheng ZY, Gao N, Wang ZY, Cui XY, Zhou DS, Fan DY, Chen H, Wang PG, An J
Frontiers in cellular and infection microbiology 2017;7:272
Frontiers in cellular and infection microbiology 2017;7:272
Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops.
Gehne N, Lamik A, Lehmann M, Haseloff RF, Andjelkovic AV, Blasig IE
PloS one 2017;12(8):e0182106
PloS one 2017;12(8):e0182106
Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality.
Kim JG, Bae SJ, Lee HS, Park JH, Kim KW
PloS one 2017;12(8):e0182047
PloS one 2017;12(8):e0182047
Temporal dynamics of ovine airway epithelial cell differentiation at an air-liquid interface.
O'Boyle N, Sutherland E, Berry CC, Davies RL
PloS one 2017;12(7):e0181583
PloS one 2017;12(7):e0181583
ECIS technology reveals that monocytes isolated by CD14+ve selection mediate greater loss of BBB integrity than untouched monocytes, which occurs to a greater extent with IL-1β activated endothelium in comparison to TNFα.
Kho DT, Johnson R, Robilliard L, du Mez E, McIntosh J, O'Carroll SJ, Angel CE, Graham ES
PloS one 2017;12(7):e0180267
PloS one 2017;12(7):e0180267
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
Geng Z, Walsh PJ, Truong V, Hill C, Ebeling M, Kapphahn RJ, Montezuma SR, Yuan C, Roehrich H, Ferrington DA, Dutton JR
PloS one 2017;12(3):e0173575
PloS one 2017;12(3):e0173575
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Zheng C, Wang Y, Yang L, Zhou S, Gao Y, Li F, Feng Y, Wang Z, Zhan L, Yan Q, Zhu X, Wong KK, Chen Z, Ji H
Scientific reports 2017 Sep 4;7(1):10407
Scientific reports 2017 Sep 4;7(1):10407
Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.
Cao J, Wang J, Jackman CP, Cox AH, Trembley MA, Balowski JJ, Cox BD, De Simone A, Dickson AL, Di Talia S, Small EM, Kiehart DP, Bursac N, Poss KD
Developmental cell 2017 Sep 25;42(6):600-615.e4
Developmental cell 2017 Sep 25;42(6):600-615.e4
Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function.
Sagar A, Arif E, Solanki AK, Srivastava P, Janech MG, Kim SH, Lipschutz JH, Kwon SH, Ashish, Nihalani D
Scientific reports 2017 Sep 21;7(1):12047
Scientific reports 2017 Sep 21;7(1):12047
Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry.
Yin P, Li Y, Zhang L
Journal of virology 2017 Sep 15;91(18)
Journal of virology 2017 Sep 15;91(18)
Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
Vasileva E, Sluysmans S, Bochaton-Piallat ML, Citi S
Annals of the New York Academy of Sciences 2017 Oct;1405(1):160-176
Annals of the New York Academy of Sciences 2017 Oct;1405(1):160-176
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA
eLife 2017 Oct 10;6
eLife 2017 Oct 10;6
Adenohypophysis placodal precursors exhibit distinctive features within the rostral preplacodal ectoderm.
Sanchez-Arrones L, Sandonís Á, Cardozo MJ, Bovolenta P
Development (Cambridge, England) 2017 Oct 1;144(19):3521-3532
Development (Cambridge, England) 2017 Oct 1;144(19):3521-3532
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease.
Cruz NM, Song X, Czerniecki SM, Gulieva RE, Churchill AJ, Kim YK, Winston K, Tran LM, Diaz MA, Fu H, Finn LS, Pei Y, Himmelfarb J, Freedman BS
Nature materials 2017 Nov;16(11):1112-1119
Nature materials 2017 Nov;16(11):1112-1119
Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Kim BJ, Bee OB, McDonagh MA, Stebbins MJ, Palecek SP, Doran KS, Shusta EV
mSphere 2017 Nov-Dec;2(6)
mSphere 2017 Nov-Dec;2(6)
Asymmetry of an Intracellular Scaffold at Vertebrate Electrical Synapses.
Marsh AJ, Michel JC, Adke AP, Heckman EL, Miller AC
Current biology : CB 2017 Nov 20;27(22):3561-3567.e4
Current biology : CB 2017 Nov 20;27(22):3561-3567.e4
Perineurial Glial Plasticity and the Role of TGF-β in the Development of the Blood-Nerve Barrier.
Morris AD, Lewis GM, Kucenas S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 May 3;37(18):4790-4807
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 May 3;37(18):4790-4807
In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling.
Yamamizu K, Iwasaki M, Takakubo H, Sakamoto T, Ikuno T, Miyoshi M, Kondo T, Nakao Y, Nakagawa M, Inoue H, Yamashita JK
Stem cell reports 2017 Mar 14;8(3):634-647
Stem cell reports 2017 Mar 14;8(3):634-647
Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage.
Yang R, Zhang Y, Huang D, Luo X, Zhang L, Zhu X, Zhang X, Liu Z, Han JY, Xiong JW
Disease models & mechanisms 2017 Mar 1;10(3):337-348
Disease models & mechanisms 2017 Mar 1;10(3):337-348
Par3 in chick lens placode development.
Melo MO, Moraes Borges R, Yan CYI
Genesis (New York, N.Y. : 2000) 2017 Jun;55(6)
Genesis (New York, N.Y. : 2000) 2017 Jun;55(6)
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.
Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF
Nature cell biology 2017 Jun;19(6):653-665
Nature cell biology 2017 Jun;19(6):653-665
A Bruch's membrane substitute fabricated from silk fibroin supports the function of retinal pigment epithelial cells in vitro.
Shadforth AMA, Suzuki S, Theodoropoulos C, Richardson NA, Chirila TV, Harkin DG
Journal of tissue engineering and regenerative medicine 2017 Jun;11(6):1915-1924
Journal of tissue engineering and regenerative medicine 2017 Jun;11(6):1915-1924
NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma.
Neri L, Lasa M, Elosegui-Artola A, D'Avola D, Carte B, Gazquez C, Alve S, Roca-Cusachs P, Iñarrairaegui M, Herrero J, Prieto J, Sangro B, Aldabe R
Oncotarget 2017 Jun 20;8(25):40967-40981
Oncotarget 2017 Jun 20;8(25):40967-40981
Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates).
Xavier AL, Fontaine R, Bloch S, Affaticati P, Jenett A, Demarque M, Vernier P, Yamamoto K
The Journal of comparative neurology 2017 Jun 15;525(9):2265-2283
The Journal of comparative neurology 2017 Jun 15;525(9):2265-2283
Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway.
Stewart T, Koval WT, Molina SA, Bock SM, Lillard JW Jr, Ross RF, Desai TA, Koval M
Experimental cell research 2017 Jun 15;355(2):153-161
Experimental cell research 2017 Jun 15;355(2):153-161
Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood-brain barrier.
Biemans EALM, Jäkel L, de Waal RMW, Kuiperij HB, Verbeek MM
Journal of neuroscience research 2017 Jul;95(7):1513-1522
Journal of neuroscience research 2017 Jul;95(7):1513-1522
Increased expression of the tight junction protein TJP1/ZO-1 is associated with upregulation of TAZ-TEAD activity and an adult tissue stem cell signature in carfilzomib-resistant multiple myeloma cells and high-risk multiple myeloma patients.
Riz I, Hawley RG
Oncoscience 2017 Jul;4(7-8):79-94
Oncoscience 2017 Jul;4(7-8):79-94
Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly.
Bloomekatz J, Singh R, Prall OW, Dunn AC, Vaughan M, Loo CS, Harvey RP, Yelon D
eLife 2017 Jan 18;6
eLife 2017 Jan 18;6
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P
Cell death & disease 2017 Jan 12;8(1):e2546
Cell death & disease 2017 Jan 12;8(1):e2546
ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.
Priya R, Liang X, Teo JL, Duszyc K, Yap AS, Gomez GA
Molecular biology of the cell 2017 Jan 1;28(1):12-20
Molecular biology of the cell 2017 Jan 1;28(1):12-20
Target Intestinal Microbiota to Alleviate Disease Progression in Amyotrophic Lateral Sclerosis.
Zhang YG, Wu S, Yi J, Xia Y, Jin D, Zhou J, Sun J
Clinical therapeutics 2017 Feb;39(2):322-336
Clinical therapeutics 2017 Feb;39(2):322-336
Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium.
Zhang W, Li H, Ogando DG, Li S, Feng M, Price FW Jr, Tennessen JM, Bonanno JA
EBioMedicine 2017 Feb;16:292-301
EBioMedicine 2017 Feb;16:292-301
The Physical Basis of Coordinated Tissue Spreading in Zebrafish Gastrulation.
Morita H, Grigolon S, Bock M, Krens SF, Salbreux G, Heisenberg CP
Developmental cell 2017 Feb 27;40(4):354-366.e4
Developmental cell 2017 Feb 27;40(4):354-366.e4
Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1.
Van Itallie CM, Tietgens AJ, Anderson JM
Molecular biology of the cell 2017 Feb 15;28(4):524-534
Molecular biology of the cell 2017 Feb 15;28(4):524-534
Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.
Kim YK, Refaeli I, Brooks CR, Jing P, Gulieva RE, Hughes MR, Cruz NM, Liu Y, Churchill AJ, Wang Y, Fu H, Pippin JW, Lin LY, Shankland SJ, Vogl AW, McNagny KM, Freedman BS
Stem cells (Dayton, Ohio) 2017 Dec;35(12):2366-2378
Stem cells (Dayton, Ohio) 2017 Dec;35(12):2366-2378
The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels.
Mazzoni J, Smith JR, Shahriar S, Cutforth T, Ceja B, Agalliu D
Neuron 2017 Dec 6;96(5):1055-1069.e6
Neuron 2017 Dec 6;96(5):1055-1069.e6
Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.
Roh-Johnson M, Shah AN, Stonick JA, Poudel KR, Kargl J, Yang GH, di Martino J, Hernandez RE, Gast CE, Zarour LR, Antoku S, Houghton AM, Bravo-Cordero JJ, Wong MH, Condeelis J, Moens CB
Developmental cell 2017 Dec 4;43(5):549-562.e6
Developmental cell 2017 Dec 4;43(5):549-562.e6
An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.
Taniguchi K, Shao Y, Townshend RF, Cortez CL, Harris CE, Meshinchi S, Kalantry S, Fu J, O'Shea KS, Gumucio DL
The Journal of cell biology 2017 Dec 4;216(12):3981-3990
The Journal of cell biology 2017 Dec 4;216(12):3981-3990
Role and regulation of Yap in KrasG12D-induced lung cancer.
Mao Y, Sun S, Irvine KD
Oncotarget 2017 Dec 19;8(67):110877-110889
Oncotarget 2017 Dec 19;8(67):110877-110889
Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover.
Thévenin AF, Margraf RA, Fisher CG, Kells-Andrews RM, Falk MM
Molecular biology of the cell 2017 Dec 1;28(25):3595-3608
Molecular biology of the cell 2017 Dec 1;28(25):3595-3608
The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching.
Hildebrand S, Hultin S, Subramani A, Petropoulos S, Zhang Y, Cao X, Mpindi J, Kalloniemi O, Johansson S, Majumdar A, Lanner F, Holmgren L
Scientific reports 2017 Aug 25;7(1):9540
Scientific reports 2017 Aug 25;7(1):9540
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells.
Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K
Cellular signalling 2017 Apr;32:1-11
Cellular signalling 2017 Apr;32:1-11
Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
Lesage J, Suarez-Carmona M, Neyrinck-Leglantier D, Grelet S, Blacher S, Hunziker W, Birembaut P, Noël A, Nawrocki-Raby B, Gilles C, Polette M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1678-1688
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1678-1688
Spontaneous acquisition of infinite proliferative capacity by a rabbit corneal endothelial cell line with maintenance of phenotypic and physiological characteristics.
Kageyama T, Hayashi R, Hara S, Yoshikawa K, Ishikawa Y, Yamato M, Nishida K
Journal of tissue engineering and regenerative medicine 2017 Apr;11(4):1057-1064
Journal of tissue engineering and regenerative medicine 2017 Apr;11(4):1057-1064
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.
Li P, Wang Y, Mao X, Jiang Y, Liu J, Li J, Wang J, Wang R, She J, Zhang J, Yang J, Liu Y, Liu P
Oncogenesis 2017 Apr 24;6(4):e322
Oncogenesis 2017 Apr 24;6(4):e322
Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development.
Thomas-Jinu S, Gordon PM, Fielding T, Taylor R, Smith BN, Snowden V, Blanc E, Vance C, Topp S, Wong CH, Bielen H, Williams KL, McCann EP, Nicholson GA, Pan-Vazquez A, Fox AH, Bond CS, Talbot WS, Blair IP, Shaw CE, Houart C
Neuron 2017 Apr 19;94(2):322-336.e5
Neuron 2017 Apr 19;94(2):322-336.e5
Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis.
Sauteur L, Affolter M, Belting HG
Development (Cambridge, England) 2017 Apr 15;144(8):1554-1565
Development (Cambridge, England) 2017 Apr 15;144(8):1554-1565
Efficient Differentiation of TBX18(+)/WT1(+) Epicardial-Like Cells from Human Pluripotent Stem Cells Using Small Molecular Compounds.
Zhao J, Cao H, Tian L, Huo W, Zhai K, Wang P, Ji G, Ma Y
Stem cells and development 2017 Apr 1;26(7):528-540
Stem cells and development 2017 Apr 1;26(7):528-540
αT-catenin in restricted brain cell types and its potential connection to autism.
Folmsbee SS, Wilcox DR, Tyberghein K, De Bleser P, Tourtellotte WG, van Hengel J, van Roy F, Gottardi CJ
Journal of molecular psychiatry 2016;4:2
Journal of molecular psychiatry 2016;4:2
Differences in the Mechanical Properties of the Developing Cerebral Cortical Proliferative Zone between Mice and Ferrets at both the Tissue and Single-Cell Levels.
Nagasaka A, Shinoda T, Kawaue T, Suzuki M, Nagayama K, Matsumoto T, Ueno N, Kawaguchi A, Miyata T
Frontiers in cell and developmental biology 2016;4:139
Frontiers in cell and developmental biology 2016;4:139
A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells.
Di Lauro S, Rodriguez-Crespo D, Gayoso MJ, Garcia-Gutierrez MT, Pastor JC, Srivastava GK, Fernandez-Bueno I
Molecular vision 2016;22:243-53
Molecular vision 2016;22:243-53
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17.
Yuki T, Tobiishi M, Kusaka-Kikushima A, Ota Y, Tokura Y
PloS one 2016;11(9):e0161759
PloS one 2016;11(9):e0161759
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.
Huang LY, Stuart C, Takeda K, D'Agnillo F, Golding B
PloS one 2016;11(8):e0160875
PloS one 2016;11(8):e0160875
Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells.
Pollock LM, Gupta N, Chen X, Luna EJ, McDermott BM Jr
PloS one 2016;11(7):e0158349
PloS one 2016;11(7):e0158349
Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition.
Alluri H, Wilson RL, Anasooya Shaji C, Wiggins-Dohlvik K, Patel S, Liu Y, Peng X, Beeram MR, Davis ML, Huang JH, Tharakan B
PloS one 2016;11(5):e0154427
PloS one 2016;11(5):e0154427
ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development.
Kwon J, Jeong SM, Choi I, Kim NH
PloS one 2016;11(4):e0152921
PloS one 2016;11(4):e0152921
Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.
Ichise H, Ichise T, Yoshida N
PloS one 2016;11(3):e0150521
PloS one 2016;11(3):e0150521
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Boussadia B, Gangarossa G, Mselli-Lakhal L, Rousset MC, de Bock F, Lassere F, Ghosh C, Pascussi JM, Janigro D, Marchi N
Experimental neurology 2016 Sep;283(Pt A):39-48
Experimental neurology 2016 Sep;283(Pt A):39-48
Large-scale tissue clearing (PACT): Technical evaluation and new perspectives in immunofluorescence, histology, and ultrastructure.
Neckel PH, Mattheus U, Hirt B, Just L, Mack AF
Scientific reports 2016 Sep 29;6:34331
Scientific reports 2016 Sep 29;6:34331
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.
Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, Désilets A, Leduc R, Turner JR, MacNaughton WK
American journal of physiology. Gastrointestinal and liver physiology 2016 Sep 1;311(3):G466-79
American journal of physiology. Gastrointestinal and liver physiology 2016 Sep 1;311(3):G466-79
Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models.
Booth JL, Duggan ES, Patel VI, Langer M, Wu W, Braun A, Coggeshall KM, Metcalf JP
Microbes and infection 2016 Oct;18(10):615-626
Microbes and infection 2016 Oct;18(10):615-626
Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria.
Gallego-Delgado J, Basu-Roy U, Ty M, Alique M, Fernandez-Arias C, Movila A, Gomes P, Weinstock A, Xu W, Edagha I, Wassmer SC, Walther T, Ruiz-Ortega M, Rodriguez A
The Journal of clinical investigation 2016 Oct 3;126(10):4016-4029
The Journal of clinical investigation 2016 Oct 3;126(10):4016-4029
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.
Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M
Nature 2016 Oct 20;538(7625):350-355
Nature 2016 Oct 20;538(7625):350-355
HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24.
Teo WW, Merino VF, Cho S, Korangath P, Liang X, Wu RC, Neumann NM, Ewald AJ, Sukumar S
Oncogene 2016 Oct 20;35(42):5539-5551
Oncogene 2016 Oct 20;35(42):5539-5551
Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.
Cronan MR, Beerman RW, Rosenberg AF, Saelens JW, Johnson MG, Oehlers SH, Sisk DM, Jurcic Smith KL, Medvitz NA, Miller SE, Trinh LA, Fraser SE, Madden JF, Turner J, Stout JE, Lee S, Tobin DM
Immunity 2016 Oct 18;45(4):861-876
Immunity 2016 Oct 18;45(4):861-876
Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular Integrity.
Rydeen AB, Waxman JS
PLoS biology 2016 Nov;14(11):e2000504
PLoS biology 2016 Nov;14(11):e2000504
Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.
Bassett EA, Tokarew N, Allemano EA, Mazerolle C, Morin K, Mears AJ, McNeill B, Ringuette R, Campbell C, Smiley S, Pokrajac NT, Dubuc AM, Ramaswamy V, Northcott PA, Remke M, Monnier PP, Potter D, Paes K, Kirkpatrick LL, Coker KJ, Rice DS, Perez-Iratxeta C, Taylor MD, Wallace VA
eLife 2016 Nov 8;5
eLife 2016 Nov 8;5
Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates.
Coburn L, Lopez H, Caldwell BJ, Moussa E, Yap C, Priya R, Noppe A, Roberts AP, Lobaskin V, Yap AS, Neufeld Z, Gomez GA
Molecular biology of the cell 2016 Nov 7;27(22):3436-3448
Molecular biology of the cell 2016 Nov 7;27(22):3436-3448
Skin-on-a-chip model simulating inflammation, edema and drug-based treatment.
Wufuer M, Lee G, Hur W, Jeon B, Kim BJ, Choi TH, Lee S
Scientific reports 2016 Nov 21;6:37471
Scientific reports 2016 Nov 21;6:37471
Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
Priya R, Wee K, Budnar S, Gomez GA, Yap AS, Michael M
Cell cycle (Georgetown, Tex.) 2016 Nov 16;15(22):3033-3041
Cell cycle (Georgetown, Tex.) 2016 Nov 16;15(22):3033-3041
Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle.
Kantarci H, Gerberding A, Riley BB
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 1;113(44):E6840-E6848
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 1;113(44):E6840-E6848
The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway.
Takeo Y, Kurabayashi N, Nguyen MD, Sanada K
Scientific reports 2016 May 4;6:25180
Scientific reports 2016 May 4;6:25180
Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.
Hatzold J, Beleggia F, Herzig H, Altmüller J, Nürnberg P, Bloch W, Wollnik B, Hammerschmidt M
eLife 2016 May 30;5
eLife 2016 May 30;5
Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.
Ni TK, Kuperwasser C
eLife 2016 May 20;5
eLife 2016 May 20;5
Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier.
Yang S, Krug SM, Heitmann J, Hu L, Reinhold AK, Sauer S, Bosten J, Sommer C, Fromm M, Brack A, Rittner HL
Biomaterials 2016 Mar;82:20-33
Biomaterials 2016 Mar;82:20-33
Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension.
Lee NK, Fok KW, White A, Wilson NH, O'Leary CJ, Cox HL, Michael M, Yap AS, Cooper HM
Nature communications 2016 Mar 31;7:11082
Nature communications 2016 Mar 31;7:11082
A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development.
Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y
The Journal of biological chemistry 2016 Mar 11;291(11):5817-5831
The Journal of biological chemistry 2016 Mar 11;291(11):5817-5831
Chronic hypoxia down-regulates tight junction protein ZO-2 expression in children with cyanotic congenital heart defect.
Jenkins EL, Caputo M, Angelini GD, Ghorbel MT
ESC heart failure 2016 Jun;3(2):131-137
ESC heart failure 2016 Jun;3(2):131-137
Intracellular Golgi Complex organization reveals tissue specific polarity during zebrafish embryogenesis.
Sepich DS, Solnica-Krezel L
Developmental dynamics : an official publication of the American Association of Anatomists 2016 Jun;245(6):678-91
Developmental dynamics : an official publication of the American Association of Anatomists 2016 Jun;245(6):678-91
The C-terminal domain controls the mobility of Crumbs 3 isoforms.
Djuric I, Siebrasse JP, Schulze U, Granado D, Schlüter MA, Kubitscheck U, Pavenstädt H, Weide T
Biochimica et biophysica acta 2016 Jun;1863(6 Pt A):1208-17
Biochimica et biophysica acta 2016 Jun;1863(6 Pt A):1208-17
Supplementation of Reduced Gluten Barley Diet with Oral Prolyl Endopeptidase Effectively Abrogates Enteropathy-Associated Changes in Gluten-Sensitive Macaques.
Sestak K, Thwin H, Dufour J, Liu DX, Alvarez X, Laine D, Clarke A, Doyle A, Aye PP, Blanchard J, Moehs CP
Nutrients 2016 Jun 28;8(7)
Nutrients 2016 Jun 28;8(7)
A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.
Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Kind J, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB
JCI insight 2016 Jun 16;1(9)
JCI insight 2016 Jun 16;1(9)
Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis.
Santos AJM, Durkin CH, Helaine S, Boucrot E, Holden DW
Infection and immunity 2016 Jul;84(7):2149-2158
Infection and immunity 2016 Jul;84(7):2149-2158
Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.
Martovetsky G, Bush KT, Nigam SK
Drug metabolism and disposition: the biological fate of chemicals 2016 Jul;44(7):1050-60
Drug metabolism and disposition: the biological fate of chemicals 2016 Jul;44(7):1050-60
3D map of the human corneal endothelial cell.
He Z, Forest F, Gain P, Rageade D, Bernard A, Acquart S, Peoc'h M, Defoe DM, Thuret G
Scientific reports 2016 Jul 6;6:29047
Scientific reports 2016 Jul 6;6:29047
C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.
Priego N, Arechederra M, Sequera C, Bragado P, Vázquez-Carballo A, Gutiérrez-Uzquiza Á, Martín-Granado V, Ventura JJ, Kazanietz MG, Guerrero C, Porras A
Oncotarget 2016 Jul 19;7(29):45060-45078
Oncotarget 2016 Jul 19;7(29):45060-45078
The barrier function of organotypic non-melanoma skin cancer models.
Zoschke C, Ulrich M, Sochorová M, Wolff C, Vávrová K, Ma N, Ulrich C, Brandner JM, Schäfer-Korting M
Journal of controlled release : official journal of the Controlled Release Society 2016 Jul 10;233:10-8
Journal of controlled release : official journal of the Controlled Release Society 2016 Jul 10;233:10-8
miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling.
Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel B
Development (Cambridge, England) 2016 Jul 1;143(13):2292-304
Development (Cambridge, England) 2016 Jul 1;143(13):2292-304
The aPKC/Par3/Par6 Polarity Complex and Membrane Order Are Functionally Interdependent in Epithelia During Vertebrate Organogenesis.
Abu-Siniyeh A, Owen DM, Benzing C, Rinkwitz S, Becker TS, Majumdar A, Gaus K
Traffic (Copenhagen, Denmark) 2016 Jan;17(1):66-79
Traffic (Copenhagen, Denmark) 2016 Jan;17(1):66-79
Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors.
Wiltshire R, Nelson V, Kho DT, Angel CE, O'Carroll SJ, Graham ES
Scientific reports 2016 Jan 27;6:19814
Scientific reports 2016 Jan 27;6:19814
The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.
Grego-Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson KV
eLife 2016 Jan 26;5:e12034
eLife 2016 Jan 26;5:e12034
The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42.
Tien SC, Lee HH, Yang YC, Lin MH, Chen YJ, Chang ZF
Nature communications 2016 Jan 19;7:10420
Nature communications 2016 Jan 19;7:10420
Crim1 regulates integrin signaling in murine lens development.
Zhang Y, Fan J, Ho JW, Hu T, Kneeland SC, Fan X, Xi Q, Sellarole MA, de Vries WN, Lu W, Lachke SA, Lang RA, John SW, Maas RL
Development (Cambridge, England) 2016 Jan 15;143(2):356-66
Development (Cambridge, England) 2016 Jan 15;143(2):356-66
Vitamin D/VDR signaling attenuates lipopolysaccharide‑induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier.
Shi YY, Liu TJ, Fu JH, Xu W, Wu LL, Hou AN, Xue XD
Molecular medicine reports 2016 Feb;13(2):1186-94
Molecular medicine reports 2016 Feb;13(2):1186-94
Isolated Human Pulmonary Artery Structure and Function Pre- and Post-Cardiopulmonary Bypass Surgery.
Dora KA, Stanley CP, Al Jaaly E, Fiorentino F, Ascione R, Reeves BC, Angelini GD
Journal of the American Heart Association 2016 Feb 23;5(2)
Journal of the American Heart Association 2016 Feb 23;5(2)
Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.
Ramkumar N, Omelchenko T, Silva-Gagliardi NF, McGlade CJ, Wijnholds J, Anderson KV
Nature cell biology 2016 Dec;18(12):1281-1291
Nature cell biology 2016 Dec;18(12):1281-1291
Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway.
Lin Z, Zhang YG, Xia Y, Xu X, Jiao X, Sun J
The Journal of biological chemistry 2016 Dec 23;291(52):26837-26849
The Journal of biological chemistry 2016 Dec 23;291(52):26837-26849
Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology.
Sauer V, Tchaikovskaya T, Wang X, Li Y, Zhang W, Tar K, Polgar Z, Ding J, Guha C, Fox IJ, Roy-Chowdhury N, Roy-Chowdhury J
Cell transplantation 2016 Dec 13;25(12):2221-2243
Cell transplantation 2016 Dec 13;25(12):2221-2243
Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation.
Yuan J, Cha J, Deng W, Bartos A, Sun X, Ho HH, Borg JP, Yamaguchi TP, Yang Y, Dey SK
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 13;113(50):E8079-E8088
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 13;113(50):E8079-E8088
Vascular development in the vertebrate pancreas.
Azizoglu DB, Chong DC, Villasenor A, Magenheim J, Barry DM, Lee S, Marty-Santos L, Fu S, Dor Y, Cleaver O
Developmental biology 2016 Dec 1;420(1):67-78
Developmental biology 2016 Dec 1;420(1):67-78
Functional Kidney Bioengineering with Pluripotent Stem-Cell-Derived Renal Progenitor Cells and Decellularized Kidney Scaffolds.
Du C, Narayanan K, Leong MF, Ibrahim MS, Chua YP, Khoo VM, Wan AC
Advanced healthcare materials 2016 Aug;5(16):2080-91
Advanced healthcare materials 2016 Aug;5(16):2080-91
A critical role for NF2 and the Hippo pathway in branching morphogenesis.
Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H
Nature communications 2016 Aug 2;7:12309
Nature communications 2016 Aug 2;7:12309
tPA Deficiency in Mice Leads to Rearrangement in the Cerebrovascular Tree and Cerebroventricular Malformations.
Stefanitsch C, Lawrence AL, Olverling A, Nilsson I, Fredriksson L
Frontiers in cellular neuroscience 2015;9:456
Frontiers in cellular neuroscience 2015;9:456
NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.
Ward C, Schlingmann B, Stecenko AA, Guidot DM, Koval M
Tissue barriers 2015;3(1-2):e982424
Tissue barriers 2015;3(1-2):e982424
Optimization of immunostaining on flat-mounted human corneas.
Forest F, Thuret G, Gain P, Dumollard JM, Peoc'h M, Perrache C, He Z
Molecular vision 2015;21:1345-56
Molecular vision 2015;21:1345-56
The human urothelial tight junction: claudin 3 and the ZO-1α(+) switch.
Smith NJ, Hinley J, Varley CL, Eardley I, Trejdosiewicz LK, Southgate J
Bladder (San Francisco, Calif.) 2015;2(1):e9
Bladder (San Francisco, Calif.) 2015;2(1):e9
DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells.
Kontro H, Cannino G, Rustin P, Dufour E, Kainulainen H
PloS one 2015;10(7):e0131990
PloS one 2015;10(7):e0131990
Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells.
Maggiorani D, Dissard R, Belloy M, Saulnier-Blache JS, Casemayou A, Ducasse L, Grès S, Bellière J, Caubet C, Bascands JL, Schanstra JP, Buffin-Meyer B
PloS one 2015;10(7):e0131416
PloS one 2015;10(7):e0131416
Computational Model of Ca2+ Wave Propagation in Human Retinal Pigment Epithelial ARPE-19 Cells.
Vainio I, Abu Khamidakh A, Paci M, Skottman H, Juuti-Uusitalo K, Hyttinen J, Nymark S
PloS one 2015;10(6):e0128434
PloS one 2015;10(6):e0128434
Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks.
Fredriksson K, Van Itallie CM, Aponte A, Gucek M, Tietgens AJ, Anderson JM
PloS one 2015;10(3):e0117074
PloS one 2015;10(3):e0117074
Stem cells from human exfoliated deciduous tooth exhibit stromal-derived inducing activity and lead to generation of neural crest cells from human embryonic stem cells.
Karbalaie K, Tanhaei S, Rabiei F, Kiani-Esfahani A, Masoudi NS, Nasr-Esfahani MH, Baharvand H
Cell journal 2015 Spring;17(1):37-48
Cell journal 2015 Spring;17(1):37-48
Stem cells from human exfoliated deciduous tooth exhibit stromal-derived inducing activity and lead to generation of neural crest cells from human embryonic stem cells.
Karbalaie K, Tanhaei S, Rabiei F, Kiani-Esfahani A, Masoudi NS, Nasr-Esfahani MH, Baharvand H
Cell journal 2015 Spring;17(1):37-48
Cell journal 2015 Spring;17(1):37-48
WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts.
Krivega M, Essahib W, Van de Velde H
Molecular human reproduction 2015 Sep;21(9):711-22
Molecular human reproduction 2015 Sep;21(9):711-22
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL
The Journal of cell biology 2015 Sep 28;210(7):1055-63
The Journal of cell biology 2015 Sep 28;210(7):1055-63
Fstl1 is involved in the regulation of radial glial scaffold development.
Liu R, Yang Y, Shen J, Chen H, Zhang Q, Ba R, Wei Y, Li KC, Zhang X, Zhao C
Molecular brain 2015 Sep 17;8:53
Molecular brain 2015 Sep 17;8:53
Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.
Molina SA, Stauffer B, Moriarty HK, Kim AH, McCarty NA, Koval M
American journal of physiology. Lung cellular and molecular physiology 2015 Sep 1;309(5):L475-87
American journal of physiology. Lung cellular and molecular physiology 2015 Sep 1;309(5):L475-87
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Priya R, Gomez GA, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS
Nature cell biology 2015 Oct;17(10):1282-93
Nature cell biology 2015 Oct;17(10):1282-93
Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells.
Thuringer D, Berthenet K, Cronier L, Solary E, Garrido C
Oncotarget 2015 Oct 6;6(30):28800-15
Oncotarget 2015 Oct 6;6(30):28800-15
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV
Nature communications 2015 Oct 23;6:8715
Nature communications 2015 Oct 23;6:8715
A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium.
Raredon MS, Ghaedi M, Calle EA, Niklason LE
Cell medicine 2015 Oct 1;7(3):109-21
Cell medicine 2015 Oct 1;7(3):109-21
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.
Barrows D, Schoenfeld SM, Hodakoski C, Silkov A, Honig B, Couvillon A, Shymanets A, Nürnberg B, Asara JM, Parsons R
The Journal of biological chemistry 2015 Nov 27;290(48):28915-31
The Journal of biological chemistry 2015 Nov 27;290(48):28915-31
High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells.
Shukla P, Vogl C, Wallner B, Rigler D, Müller M, Macho-Maschler S
BMC genomics 2015 Nov 16;16:944
BMC genomics 2015 Nov 16;16:944
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty.
Dixon D, Coates J, del Carpio Pons A, Horabin J, Walker A, Abdul N, Kalson NS, Brewster NT, Weir DJ, Deehan DJ, Mann DA, Borthwick LA
Scientific reports 2015 Nov 10;5:16466
Scientific reports 2015 Nov 10;5:16466
Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system.
Muramatsu R, Kuroda M, Matoba K, Lin H, Takahashi C, Koyama Y, Yamashita T
The Journal of biological chemistry 2015 May 1;290(18):11515-25
The Journal of biological chemistry 2015 May 1;290(18):11515-25
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin.
Durak O, de Anda FC, Singh KK, Leussis MP, Petryshen TL, Sklar P, Tsai LH
Molecular psychiatry 2015 Mar;20(3):388-97
Molecular psychiatry 2015 Mar;20(3):388-97
Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.
Wong AP, Chin S, Xia S, Garner J, Bear CE, Rossant J
Nature protocols 2015 Mar;10(3):363-81
Nature protocols 2015 Mar;10(3):363-81
Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.
Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J
Biochemical and biophysical research communications 2015 Mar 27;459(1):87-93
Biochemical and biophysical research communications 2015 Mar 27;459(1):87-93
LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.
Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R
The Journal of cell biology 2015 Mar 16;208(6):703-11
The Journal of cell biology 2015 Mar 16;208(6):703-11
Immune quiescence of the brain is set by astroglial connexin 43.
Boulay AC, Mazeraud A, Cisternino S, Saubaméa B, Mailly P, Jourdren L, Blugeon C, Mignon V, Smirnova M, Cavallo A, Ezan P, Avé P, Dingli F, Loew D, Vieira P, Chrétien F, Cohen-Salmon M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Mar 11;35(10):4427-39
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Mar 11;35(10):4427-39
Effect of differentiation on endocytic profiles of endothelial and epithelial cell culture models.
Ilina P, Partti S, Niklander J, Ruponen M, Lou YR, Yliperttula M
Experimental cell research 2015 Mar 1;332(1):89-101
Experimental cell research 2015 Mar 1;332(1):89-101
Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.
Sugiyama Y, Shelley EJ, Badouel C, McNeill H, McAvoy JW
Investigative ophthalmology & visual science 2015 Jun;56(6):4099-107
Investigative ophthalmology & visual science 2015 Jun;56(6):4099-107
Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes.
Gianfelice A, Le PH, Rigano LA, Saila S, Dowd GC, McDivitt T, Bhattacharya N, Hong W, Stagg SM, Ireton K
Cellular microbiology 2015 Jun;17(6):876-92
Cellular microbiology 2015 Jun;17(6):876-92
Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
Preuße K, Tveriakhina L, Schuster-Gossler K, Gaspar C, Rosa AI, Henrique D, Gossler A, Stauber M
PLoS genetics 2015 Jun;11(6):e1005328
PLoS genetics 2015 Jun;11(6):e1005328
The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function.
Overgaard CE, Schlingmann B, Dorsainvil White S, Ward C, Fan X, Swarnakar S, Brown LA, Guidot DM, Koval M
American journal of physiology. Lung cellular and molecular physiology 2015 Jun 15;308(12):L1212-23
American journal of physiology. Lung cellular and molecular physiology 2015 Jun 15;308(12):L1212-23
Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells.
O'Carroll SJ, Kho DT, Wiltshire R, Nelson V, Rotimi O, Johnson R, Angel CE, Graham ES
Journal of neuroinflammation 2015 Jul 8;12:131
Journal of neuroinflammation 2015 Jul 8;12:131
Expression and function of transcription factor AP-2? in early embryonic development of porcine parthenotes.
Lee SH, Kwon JW, Choi I, Kim NH
Reproduction, fertility, and development 2015 Jan 7;
Reproduction, fertility, and development 2015 Jan 7;
Neurobeachin is required postsynaptically for electrical and chemical synapse formation.
Miller AC, Voelker LH, Shah AN, Moens CB
Current biology : CB 2015 Jan 5;25(1):16-28
Current biology : CB 2015 Jan 5;25(1):16-28
Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
Pienaar IS, Lee CH, Elson JL, McGuinness L, Gentleman SM, Kalaria RN, Dexter DT
Neurobiology of disease 2015 Feb;74:392-405
Neurobiology of disease 2015 Feb;74:392-405
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Momeny M, Saunus JM, Marturana F, McCart Reed AE, Black D, Sala G, Iacobelli S, Holland JD, Yu D, Da Silva L, Simpson PT, Khanna KK, Chenevix-Trench G, Lakhani SR
Oncotarget 2015 Feb 28;6(6):3932-46
Oncotarget 2015 Feb 28;6(6):3932-46
Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells.
Taniguchi K, Shao Y, Townshend RF, Tsai YH, DeLong CJ, Lopez SA, Gayen S, Freddo AM, Chue DJ, Thomas DJ, Spence JR, Margolis B, Kalantry S, Fu J, O'Shea KS, Gumucio DL
Stem cell reports 2015 Dec 8;5(6):954-962
Stem cell reports 2015 Dec 8;5(6):954-962
Synthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions.
Bong KW, Kim JJ, Cho H, Lim E, Doyle PS, Irimia D
Langmuir : the ACS journal of surfaces and colloids 2015 Dec 8;31(48):13165-71
Langmuir : the ACS journal of surfaces and colloids 2015 Dec 8;31(48):13165-71
Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels.
Fujimura K, Choi S, Wyse M, Strnadel J, Wright T, Klemke R
The Journal of biological chemistry 2015 Dec 11;290(50):29907-19
The Journal of biological chemistry 2015 Dec 11;290(50):29907-19
The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.
Arya P, Rainey MA, Bhattacharyya S, Mohapatra BC, George M, Kuracha MR, Storck MD, Band V, Govindarajan V, Band H
Developmental biology 2015 Dec 1;408(1):41-55
Developmental biology 2015 Dec 1;408(1):41-55
Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.
Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R
Journal of cell science 2015 Dec 1;128(23):4293-305
Journal of cell science 2015 Dec 1;128(23):4293-305
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.
Baruch K, Rosenzweig N, Kertser A, Deczkowska A, Sharif AM, Spinrad A, Tsitsou-Kampeli A, Sarel A, Cahalon L, Schwartz M
Nature communications 2015 Aug 18;6:7967
Nature communications 2015 Aug 18;6:7967
A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.
Van Itallie CM, Tietgens AJ, Krystofiak E, Kachar B, Anderson JM
Molecular biology of the cell 2015 Aug 1;26(15):2769-87
Molecular biology of the cell 2015 Aug 1;26(15):2769-87
Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model.
Wu S, Yi J, Zhang YG, Zhou J, Sun J
Physiological reports 2015 Apr;3(4)
Physiological reports 2015 Apr;3(4)
Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains.
Grego-Bessa J, Hildebrand J, Anderson KV
Development (Cambridge, England) 2015 Apr 1;142(7):1305-14
Development (Cambridge, England) 2015 Apr 1;142(7):1305-14
Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling.
Doughton G, Wei J, Tapon N, Welham MJ, Chalmers AD
PloS one 2014;9(4):e95434
PloS one 2014;9(4):e95434
Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release.
Fiorentino M, Levine MM, Sztein MB, Fasano A
PloS one 2014;9(1):e85211
PloS one 2014;9(1):e85211
Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures.
Price DB, Ackland ML, Burks W, Knight MI, Suphioglu C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(6):1758-77
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(6):1758-77
Claudin-7, -16, and -19 during mouse kidney development.
Khairallah H, El Andalousi J, Simard A, Haddad N, Chen YH, Hou J, Ryan AK, Gupta IR
Tissue barriers 2014;2(4):e964547
Tissue barriers 2014;2(4):e964547
A novel dual-flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers.
Giusti S, Sbrana T, La Marca M, Di Patria V, Martinucci V, Tirella A, Domenici C, Ahluwalia A
Biotechnology journal 2014 Sep;9(9):1175-84
Biotechnology journal 2014 Sep;9(9):1175-84
Regulation of epithelial cell tight junctions by protease-activated receptor 2.
Enjoji S, Ohama T, Sato K
The Journal of veterinary medical science 2014 Sep;76(9):1225-9
The Journal of veterinary medical science 2014 Sep;76(9):1225-9
Hantavirus infection with severe proteinuria and podocyte foot-process effacement.
Boehlke C, Hartleben B, Huber TB, Hopfer H, Walz G, Neumann-Haefelin E
American journal of kidney diseases : the official journal of the National Kidney Foundation 2014 Sep;64(3):452-6
American journal of kidney diseases : the official journal of the National Kidney Foundation 2014 Sep;64(3):452-6
TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
Alpern D, Langer D, Ballester B, Le Gras S, Romier C, Mengus G, Davidson I
eLife 2014 Sep 10;3:e03613
eLife 2014 Sep 10;3:e03613
Reconstruction of a seminiferous tubule-like structure in a 3 dimensional culture system of re-aggregated mouse neonatal testicular cells within a collagen matrix.
Zhang J, Hatakeyama J, Eto K, Abe S
General and comparative endocrinology 2014 Sep 1;205:121-32
General and comparative endocrinology 2014 Sep 1;205:121-32
Keratin 76 is required for tight junction function and maintenance of the skin barrier.
DiTommaso T, Cottle DL, Pearson HB, Schlüter H, Kaur P, Humbert PO, Smyth IM
PLoS genetics 2014 Oct;10(10):e1004706
PLoS genetics 2014 Oct;10(10):e1004706
Flattop regulates basal body docking and positioning in mono- and multiciliated cells.
Gegg M, Böttcher A, Burtscher I, Hasenoeder S, Van Campenhout C, Aichler M, Walch A, Grant SG, Lickert H
eLife 2014 Oct 8;3
eLife 2014 Oct 8;3
Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.
Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM
Journal of cellular physiology 2014 Nov;229(11):1802-16
Journal of cellular physiology 2014 Nov;229(11):1802-16
Innate immune factors in the development and maintenance of pouchitis.
Landy J, Al-Hassi HO, Ronde E, English NR, Mann ER, Bernardo D, Ciclitira PJ, Clark SK, Knight SC, Hart AL
Inflammatory bowel diseases 2014 Nov;20(11):1942-9
Inflammatory bowel diseases 2014 Nov;20(11):1942-9
CAR expression in human embryos and hESC illustrates its role in pluripotency and tight junctions.
Krivega M, Geens M, Van de Velde H
Reproduction (Cambridge, England) 2014 Nov;148(5):531-44
Reproduction (Cambridge, England) 2014 Nov;148(5):531-44
Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.
Yao C, Vanderpool KG, Delfiner M, Eddy V, Lucaci AG, Soto-Riveros C, Yasumura T, Rash JE, Pereda AE
Journal of neurophysiology 2014 Nov 1;112(9):2102-13
Journal of neurophysiology 2014 Nov 1;112(9):2102-13
Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems.
Jeon JS, Bersini S, Whisler JA, Chen MB, Dubini G, Charest JL, Moretti M, Kamm RD
Integrative biology : quantitative biosciences from nano to macro 2014 May;6(5):555-63
Integrative biology : quantitative biosciences from nano to macro 2014 May;6(5):555-63
Development of a cell sheet transportation technique for regenerative medicine.
Oie Y, Nozaki T, Takayanagi H, Hara S, Hayashi R, Takeda S, Mori K, Moriya N, Soma T, Tsujikawa M, Saito K, Nishida K
Tissue engineering. Part C, Methods 2014 May;20(5):373-82
Tissue engineering. Part C, Methods 2014 May;20(5):373-82
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion.
Hultin S, Zheng Y, Mojallal M, Vertuani S, Gentili C, Balland M, Milloud R, Belting HG, Affolter M, Helker CS, Adams RH, Herzog W, Uhlen P, Majumdar A, Holmgren L
Nature communications 2014 May 7;5:3743
Nature communications 2014 May 7;5:3743
p38δ mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes.
Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, Kähäri VM, Peltonen S
Archives of dermatological research 2014 Mar;306(2):131-41
Archives of dermatological research 2014 Mar;306(2):131-41
Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling.
Alvers AL, Ryan S, Scherz PJ, Huisken J, Bagnat M
Development (Cambridge, England) 2014 Mar;141(5):1110-9
Development (Cambridge, England) 2014 Mar;141(5):1110-9
EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368.
Fong JT, Nimlamool W, Falk MM
FEBS letters 2014 Mar 3;588(5):836-44
FEBS letters 2014 Mar 3;588(5):836-44
Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion.
Ebert AM, Childs SJ, Hehr CL, Cechmanek PB, McFarlane S
Development (Cambridge, England) 2014 Jun;141(12):2473-82
Development (Cambridge, England) 2014 Jun;141(12):2473-82
Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole.
Herrera A, Saade M, Menendez A, Marti E, Pons S
Nature communications 2014 Jun 19;5:4168
Nature communications 2014 Jun 19;5:4168
Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread.
Rigano LA, Dowd GC, Wang Y, Ireton K
Cellular microbiology 2014 Jul;16(7):1068-79
Cellular microbiology 2014 Jul;16(7):1068-79
Crumbs3 is essential for proper epithelial development and viability.
Whiteman EL, Fan S, Harder JL, Walton KD, Liu CJ, Soofi A, Fogg VC, Hershenson MB, Dressler GR, Deutsch GH, Gumucio DL, Margolis B
Molecular and cellular biology 2014 Jan;34(1):43-56
Molecular and cellular biology 2014 Jan;34(1):43-56
LMX1B mutation with residual transcriptional activity as a cause of isolated glomerulopathy.
Isojima T, Harita Y, Furuyama M, Sugawara N, Ishizuka K, Horita S, Kajiho Y, Miura K, Igarashi T, Hattori M, Kitanaka S
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014 Jan;29(1):81-8
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014 Jan;29(1):81-8
Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.
Fukuda T, Kominami K, Wang S, Togashi H, Hirata K, Mizoguchi A, Rikitake Y, Takai Y
Development (Cambridge, England) 2014 Jan;141(2):399-409
Development (Cambridge, England) 2014 Jan;141(2):399-409
Notch3 establishes brain vascular integrity by regulating pericyte number.
Wang Y, Pan L, Moens CB, Appel B
Development (Cambridge, England) 2014 Jan;141(2):307-17
Development (Cambridge, England) 2014 Jan;141(2):307-17
Decreased expression of zonula occludens-1 and occludin in the bladder urothelium of patients with interstitial cystitis/painful bladder syndrome.
Lee JD, Lee MH
Journal of the Formosan Medical Association = Taiwan yi zhi 2014 Jan;113(1):17-22
Journal of the Formosan Medical Association = Taiwan yi zhi 2014 Jan;113(1):17-22
FGF signaling is required for brain left-right asymmetry and brain midline formation.
Neugebauer JM, Yost HJ
Developmental biology 2014 Feb 1;386(1):123-34
Developmental biology 2014 Feb 1;386(1):123-34
Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine.
Gumber S, Nusrat A, Villinger F
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2014 Dec;66(9-10):437-44
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2014 Dec;66(9-10):437-44
Glial ankyrins facilitate paranodal axoglial junction assembly.
Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN
Nature neuroscience 2014 Dec;17(12):1673-81
Nature neuroscience 2014 Dec;17(12):1673-81
Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration.
Glotfelty LG, Zahs A, Hodges K, Shan K, Alto NM, Hecht GA
Cellular microbiology 2014 Dec;16(12):1767-83
Cellular microbiology 2014 Dec;16(12):1767-83
Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.
Nacer A, Movila A, Sohet F, Girgis NM, Gundra UM, Loke P, Daneman R, Frevert U
PLoS pathogens 2014 Dec;10(12):e1004528
PLoS pathogens 2014 Dec;10(12):e1004528
Endothelial cells use dynamic actin to facilitate lymphocyte transendothelial migration and maintain the monolayer barrier.
Mooren OL, Li J, Nawas J, Cooper JA
Molecular biology of the cell 2014 Dec 15;25(25):4115-29
Molecular biology of the cell 2014 Dec 15;25(25):4115-29
Onset of aquaporin-4 expression in the developing mouse brain.
Fallier-Becker P, Vollmer JP, Bauer HC, Noell S, Wolburg H, Mack AF
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2014 Aug;36:81-9
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2014 Aug;36:81-9
aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.
Satoh D, Hirose T, Harita Y, Daimon C, Harada T, Kurihara H, Yamashita A, Ohno S
Journal of biochemistry 2014 Aug;156(2):115-28
Journal of biochemistry 2014 Aug;156(2):115-28
Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity.
Sojka S, Amin NM, Gibbs D, Christine KS, Charpentier MS, Conlon FL
Development (Cambridge, England) 2014 Aug;141(15):3040-9
Development (Cambridge, England) 2014 Aug;141(15):3040-9
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
Spadaro D, Tapia R, Jond L, Sudol M, Fanning AS, Citi S
The Journal of biological chemistry 2014 Aug 8;289(32):22500-11
The Journal of biological chemistry 2014 Aug 8;289(32):22500-11
Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages.
Wang J, Zhu HH, Chu M, Liu Y, Zhang C, Liu G, Yang X, Yang R, Gao WQ
Nature communications 2014 Aug 28;5:4758
Nature communications 2014 Aug 28;5:4758
E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.
McEwen AE, Maher MT, Mo R, Gottardi CJ
Molecular biology of the cell 2014 Aug 15;25(16):2365-74
Molecular biology of the cell 2014 Aug 15;25(16):2365-74
The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling.
Mashukova A, Kozhekbaeva Z, Forteza R, Dulam V, Figueroa Y, Warren R, Salas PJ
Journal of cell science 2014 Aug 15;127(Pt 16):3568-77
Journal of cell science 2014 Aug 15;127(Pt 16):3568-77
C-terminal COOH of integrin β1 is necessary for β1 association with the kindlin-2 adapter protein.
Fitzpatrick P, Shattil SJ, Ablooglu AJ
The Journal of biological chemistry 2014 Apr 18;289(16):11183-11193
The Journal of biological chemistry 2014 Apr 18;289(16):11183-11193
Isolation and culture of mouse proepicardium using serum-free conditions.
Garriock RJ, Mikawa T, Yamaguchi TP
Methods (San Diego, Calif.) 2014 Apr 1;66(3):365-9
Methods (San Diego, Calif.) 2014 Apr 1;66(3):365-9
Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.
Wittchen ES, Nishimura E, McCloskey M, Wang H, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME
PloS one 2013;8(9):e73070
PloS one 2013;8(9):e73070
Norovirus binding to intestinal epithelial cells is independent of histo-blood group antigens.
Murakami K, Kurihara C, Oka T, Shimoike T, Fujii Y, Takai-Todaka R, Park Y, Wakita T, Matsuda T, Hokari R, Miura S, Katayama K
PloS one 2013;8(6):e66534
PloS one 2013;8(6):e66534
Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells.
Boehlke C, Kotsis F, Buchholz B, Powelske C, Eckardt KU, Walz G, Nitschke R, Kuehn EW
PloS one 2013;8(5):e62165
PloS one 2013;8(5):e62165
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
D'Agnillo F, Williams MC, Moayeri M, Warfel JM
PloS one 2013;8(4):e62576
PloS one 2013;8(4):e62576
Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis.
Rachow S, Zorn-Kruppa M, Ohnemus U, Kirschner N, Vidal-y-Sy S, von den Driesch P, Börnchen C, Eberle J, Mildner M, Vettorazzi E, Rosenthal R, Moll I, Brandner JM
PloS one 2013;8(2):e55116
PloS one 2013;8(2):e55116
A three-dimensional engineered artery model for in vitro atherosclerosis research.
Robert J, Weber B, Frese L, Emmert MY, Schmidt D, von Eckardstein A, Rohrer L, Hoerstrup SP
PloS one 2013;8(11):e79821
PloS one 2013;8(11):e79821
In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines.
Fiorentino M, Lammers KM, Levine MM, Sztein MB, Fasano A
Frontiers in immunology 2013;4:17
Frontiers in immunology 2013;4:17
Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation.
Dunphy KA, Seo JH, Kim DJ, Roberts AL, Tao L, DiRenzo J, Balboni AL, Crisi GM, Hagen MJ, Chandrasekaran T, Gauger KJ, Schneider SS, Jerry DJ
Cancer cell international 2013;13:74
Cancer cell international 2013;13:74
Morphogenetic analysis of peri-implantation development.
Wallingford MC, Angelo JR, Mager J
Developmental dynamics : an official publication of the American Association of Anatomists 2013 Sep;242(9):1110-20
Developmental dynamics : an official publication of the American Association of Anatomists 2013 Sep;242(9):1110-20
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
Guichard A, Cruz-Moreno B, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E
Cell host & microbe 2013 Sep 11;14(3):294-305
Cell host & microbe 2013 Sep 11;14(3):294-305
Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.
Elsum IA, Martin C, Humbert PO
Journal of cell science 2013 Sep 1;126(Pt 17):3990-9
Journal of cell science 2013 Sep 1;126(Pt 17):3990-9
Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling.
Lenkowski JR, Qin Z, Sifuentes CJ, Thummel R, Soto CM, Moens CB, Raymond PA
Glia 2013 Oct;61(10):1687-97
Glia 2013 Oct;61(10):1687-97
Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.
Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV
Journal of the American Society of Nephrology : JASN 2013 Oct;24(10):1571-86
Journal of the American Society of Nephrology : JASN 2013 Oct;24(10):1571-86
Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes.
Lázaro-Diéguez F, Cohen D, Fernandez D, Hodgson L, van Ijzendoorn SC, Müsch A
The Journal of cell biology 2013 Oct 28;203(2):251-64
The Journal of cell biology 2013 Oct 28;203(2):251-64
tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium.
Schumacher JA, Bloomekatz J, Garavito-Aguilar ZV, Yelon D
Developmental biology 2013 Nov 15;383(2):214-26
Developmental biology 2013 Nov 15;383(2):214-26
Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.
Kirschner N, Rosenthal R, Furuse M, Moll I, Fromm M, Brandner JM
The Journal of investigative dermatology 2013 May;133(5):1161-9
The Journal of investigative dermatology 2013 May;133(5):1161-9
Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods.
Szczepkowska A, Lagaraine C, Robert V, Dufourny L, Thiéry JC, Skipor J
Neurotoxicology and teratology 2013 May-Jun;37:63-7
Neurotoxicology and teratology 2013 May-Jun;37:63-7
Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells.
Fiorentino M, Ding H, Blanchard TG, Czinn SJ, Sztein MB, Fasano A
Infection and immunity 2013 Mar;81(3):876-83
Infection and immunity 2013 Mar;81(3):876-83
Intercellular Ca(2+) wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation.
Abu Khamidakh AE, Juuti-Uusitalo K, Larsson K, Skottman H, Hyttinen J
Experimental eye research 2013 Mar;108:129-39
Experimental eye research 2013 Mar;108:129-39
Polyphenols protect the epithelial barrier function of Caco-2 cells exposed to indomethacin through the modulation of occludin and zonula occludens-1 expression.
Carrasco-Pozo C, Morales P, Gotteland M
Journal of agricultural and food chemistry 2013 Jun 5;61(22):5291-7
Journal of agricultural and food chemistry 2013 Jun 5;61(22):5291-7
Involvement of PI3K and ROCK signaling pathways in migration of bone marrow-derived mesenchymal stem cells through human brain microvascular endothelial cell monolayers.
Lin MN, Shang DS, Sun W, Li B, Xu X, Fang WG, Zhao WD, Cao L, Chen YH
Brain research 2013 Jun 4;1513:1-8
Brain research 2013 Jun 4;1513:1-8
Estrogen supports urothelial defense mechanisms.
Lüthje P, Brauner H, Ramos NL, Ovregaard A, Gläser R, Hirschberg AL, Aspenström P, Brauner A
Science translational medicine 2013 Jun 19;5(190):190ra80
Science translational medicine 2013 Jun 19;5(190):190ra80
LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.
Xu X, Jin D, Durgan J, Hall A
Molecular and cellular biology 2013 Jul;33(14):2671-82
Molecular and cellular biology 2013 Jul;33(14):2671-82
ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation.
Herder C, Swiercz JM, Müller C, Peravali R, Quiring R, Offermanns S, Wittbrodt J, Loosli F
Development (Cambridge, England) 2013 Jul;140(13):2787-97
Development (Cambridge, England) 2013 Jul;140(13):2787-97
Differential expression of junctional adhesion molecules in different stages of systemic sclerosis.
Manetti M, Guiducci S, Romano E, Rosa I, Ceccarelli C, Mello T, Milia AF, Conforti ML, Ibba-Manneschi L, Matucci-Cerinic M
Arthritis and rheumatism 2013 Jan;65(1):247-57
Arthritis and rheumatism 2013 Jan;65(1):247-57
Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod.
Buckley CE, Ren X, Ward LC, Girdler GC, Araya C, Green MJ, Clark BS, Link BA, Clarke JD
The EMBO journal 2013 Jan 9;32(1):30-44
The EMBO journal 2013 Jan 9;32(1):30-44
Cultures of astroglial cells derived from brain of adult cichlid fish.
Mack AF, Tiedemann K
Journal of neuroscience methods 2013 Jan 30;212(2):269-75
Journal of neuroscience methods 2013 Jan 30;212(2):269-75
Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.
Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JB
American journal of physiology. Gastrointestinal and liver physiology 2013 Jan 15;304(2):G142-56
American journal of physiology. Gastrointestinal and liver physiology 2013 Jan 15;304(2):G142-56
aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation.
Hartleben B, Widmeier E, Suhm M, Worthmann K, Schell C, Helmstädter M, Wiech T, Walz G, Leitges M, Schiffer M, Huber TB
Journal of the American Society of Nephrology : JASN 2013 Feb;24(2):253-67
Journal of the American Society of Nephrology : JASN 2013 Feb;24(2):253-67
Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers.
Elamin EE, Masclee AA, Dekker J, Pieters HJ, Jonkers DM
The Journal of nutrition 2013 Dec;143(12):1872-81
The Journal of nutrition 2013 Dec;143(12):1872-81
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.
Lee RT, Nagai H, Nakaya Y, Sheng G, Trainor PA, Weston JA, Thiery JP
Development (Cambridge, England) 2013 Dec;140(24):4890-902
Development (Cambridge, England) 2013 Dec;140(24):4890-902
A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.
Andersen MN, Krzystanek K, Petersen F, Bomholtz SH, Olesen SP, Abriel H, Jespersen T, Rasmussen HB
The Journal of biological chemistry 2013 Dec 27;288(52):36841-54
The Journal of biological chemistry 2013 Dec 27;288(52):36841-54
Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins.
Rowland TJ, Blaschke AJ, Buchholz DE, Hikita ST, Johnson LV, Clegg DO
Journal of tissue engineering and regenerative medicine 2013 Aug;7(8):642-53
Journal of tissue engineering and regenerative medicine 2013 Aug;7(8):642-53
SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling.
Jordan NV, Prat A, Abell AN, Zawistowski JS, Sciaky N, Karginova OA, Zhou B, Golitz BT, Perou CM, Johnson GL
Molecular and cellular biology 2013 Aug;33(15):3011-25
Molecular and cellular biology 2013 Aug;33(15):3011-25
PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N
Cerebral cortex (New York, N.Y. : 1991) 2013 Aug;23(8):1824-35
Cerebral cortex (New York, N.Y. : 1991) 2013 Aug;23(8):1824-35
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
Termén S, Tan EJ, Heldin CH, Moustakas A
Journal of cellular physiology 2013 Apr;228(4):801-13
Journal of cellular physiology 2013 Apr;228(4):801-13
NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics.
Wong EW, Cheng CY
Spermatogenesis 2013 Apr 1;3(2):e25465
Spermatogenesis 2013 Apr 1;3(2):e25465
Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea.
Ritchie JM, Rui H, Zhou X, Iida T, Kodoma T, Ito S, Davis BM, Bronson RT, Waldor MK
PLoS pathogens 2012;8(3):e1002593
PLoS pathogens 2012;8(3):e1002593
Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues.
Kuo KL, Zhu H, McNamara PJ, Leggas M
PloS one 2012;7(6):e39641
PloS one 2012;7(6):e39641
Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination.
Hartsock A, Nelson WJ
PloS one 2012;7(5):e37476
PloS one 2012;7(5):e37476
The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
Dukes JD, Whitley P, Chalmers AD
PloS one 2012;7(3):e28659
PloS one 2012;7(3):e28659
Characterization of Pax2 expression in the goldfish optic nerve head during retina regeneration.
Parrilla M, Lillo C, Herrero-Turrión MJ, Arévalo R, Aijón J, Lara JM, Velasco A
PloS one 2012;7(2):e32348
PloS one 2012;7(2):e32348
Simvastatin blocks blood-brain barrier disruptions induced by elevated cholesterol both in vivo and in vitro.
Jiang X, Guo M, Su J, Lu B, Ma D, Zhang R, Yang L, Wang Q, Ma Y, Fan Y
International journal of Alzheimer's disease 2012;2012:109324
International journal of Alzheimer's disease 2012;2012:109324
PAR6B is required for tight junction formation and activated PKCζ localization in breast cancer.
Cunliffe HE, Jiang Y, Fornace KM, Yang F, Meltzer PS
American journal of cancer research 2012;2(5):478-91
American journal of cancer research 2012;2(5):478-91
Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein.
Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, Huan LJ, Ratjen F, Ellis J, Rossant J
Nature biotechnology 2012 Sep;30(9):876-82
Nature biotechnology 2012 Sep;30(9):876-82
SIRPα interacts with nephrin at the podocyte slit diaphragm.
Kajiho Y, Harita Y, Kurihara H, Horita S, Matsunaga A, Tsurumi H, Kanda S, Sugawara N, Miura K, Sekine T, Hattori S, Hattori M, Igarashi T
The FEBS journal 2012 Sep;279(17):3010-21
The FEBS journal 2012 Sep;279(17):3010-21
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.
Iden S, van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG
Cancer cell 2012 Sep 11;22(3):389-403
Cancer cell 2012 Sep 11;22(3):389-403
Human intestinal epithelial cells exhibit a cellular response indicating a potential toxicity upon exposure to hematite nanoparticles.
Kalive M, Zhang W, Chen Y, Capco DG
Cell biology and toxicology 2012 Oct;28(5):343-68
Cell biology and toxicology 2012 Oct;28(5):343-68
Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins.
Sanyas I, Bozon M, Moret F, Castellani V
Development (Cambridge, England) 2012 Oct;139(19):3633-43
Development (Cambridge, England) 2012 Oct;139(19):3633-43
3D single molecule tracking with multifocal plane microscopy reveals rapid intercellular transferrin transport at epithelial cell barriers.
Ram S, Kim D, Ober RJ, Ward ES
Biophysical journal 2012 Oct 3;103(7):1594-603
Biophysical journal 2012 Oct 3;103(7):1594-603
Loss of N-cadherin from the endothelium causes stromal edema and epithelial dysgenesis in the mouse cornea.
Vassilev VS, Mandai M, Yonemura S, Takeichi M
Investigative ophthalmology & visual science 2012 Oct 17;53(11):7183-93
Investigative ophthalmology & visual science 2012 Oct 17;53(11):7183-93
GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier.
Moran GW, O'Neill C, McLaughlin JT
Regulatory peptides 2012 Oct 10;178(1-3):95-101
Regulatory peptides 2012 Oct 10;178(1-3):95-101
NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway.
Castellani S, Guerra L, Favia M, Di Gioia S, Casavola V, Conese M
Laboratory investigation; a journal of technical methods and pathology 2012 Nov;92(11):1527-40
Laboratory investigation; a journal of technical methods and pathology 2012 Nov;92(11):1527-40
Selective functionalization of nanofiber scaffolds to regulate salivary gland epithelial cell proliferation and polarity.
Cantara SI, Soscia DA, Sequeira SJ, Jean-Gilles RP, Castracane J, Larsen M
Biomaterials 2012 Nov;33(33):8372-82
Biomaterials 2012 Nov;33(33):8372-82
Generation of hESC-derived retinal pigment epithelium on biopolymer coated polyimide membranes.
Subrizi A, Hiidenmaa H, Ilmarinen T, Nymark S, Dubruel P, Uusitalo H, Yliperttula M, Urtti A, Skottman H
Biomaterials 2012 Nov;33(32):8047-54
Biomaterials 2012 Nov;33(32):8047-54
Generation of functional thyroid from embryonic stem cells.
Antonica F, Kasprzyk DF, Opitz R, Iacovino M, Liao XH, Dumitrescu AM, Refetoff S, Peremans K, Manto M, Kyba M, Costagliola S
Nature 2012 Nov 1;491(7422):66-71
Nature 2012 Nov 1;491(7422):66-71
Myosin-X functions in polarized epithelial cells.
Liu KC, Jacobs DT, Dunn BD, Fanning AS, Cheney RE
Molecular biology of the cell 2012 May;23(9):1675-87
Molecular biology of the cell 2012 May;23(9):1675-87
Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.
Cammas L, Wolfe J, Choi SY, Dedhar S, Beggs HE
Investigative ophthalmology & visual science 2012 May 17;53(6):3067-81
Investigative ophthalmology & visual science 2012 May 17;53(6):3067-81
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV
Nature 2012 May 16;485(7399):512-6
Nature 2012 May 16;485(7399):512-6
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.
Cui J, Chen S, Zhang C, Meng F, Wu W, Hu R, Hadass O, Lehmidi T, Blair GJ, Lee M, Chang M, Mobashery S, Sun GY, Gu Z
Molecular neurodegeneration 2012 May 15;7:21
Molecular neurodegeneration 2012 May 15;7:21
Label-free analysis of breast tissue polarity by Raman imaging of lipid phase.
Yue S, Cárdenas-Mora JM, Chaboub LS, Lelièvre SA, Cheng JX
Biophysical journal 2012 Mar 7;102(5):1215-23
Biophysical journal 2012 Mar 7;102(5):1215-23
Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression.
Adijanto J, Castorino JJ, Wang ZX, Maminishkis A, Grunwald GB, Philp NJ
The Journal of biological chemistry 2012 Jun 8;287(24):20491-503
The Journal of biological chemistry 2012 Jun 8;287(24):20491-503
A mouse model for interstitial cystitis/painful bladder syndrome based on APF inhibition of bladder epithelial repair: a pilot study.
Keay S, Leitzell S, Ochrzcin A, Clements G, Zhan M, Johnson D
BMC urology 2012 Jun 8;12:17
BMC urology 2012 Jun 8;12:17
Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions.
Ting LH, Jahn JR, Jung JI, Shuman BR, Feghhi S, Han SJ, Rodriguez ML, Sniadecki NJ
American journal of physiology. Heart and circulatory physiology 2012 Jun 1;302(11):H2220-9
American journal of physiology. Heart and circulatory physiology 2012 Jun 1;302(11):H2220-9
Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus.
Rhett JM, Ongstad EL, Jourdan J, Gourdie RG
The Journal of membrane biology 2012 Jul;245(7):411-22
The Journal of membrane biology 2012 Jul;245(7):411-22
Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.
Saund RS, Kanai-Azuma M, Kanai Y, Kim I, Lucero MT, Saijoh Y
Development (Cambridge, England) 2012 Jul;139(13):2426-35
Development (Cambridge, England) 2012 Jul;139(13):2426-35
Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium.
Peng S, Gan G, Rao VS, Adelman RA, Rizzolo LJ
Investigative ophthalmology & visual science 2012 Jul 27;53(8):5016-28
Investigative ophthalmology & visual science 2012 Jul 27;53(8):5016-28
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.
Magudia K, Lahoz A, Hall A
The Journal of cell biology 2012 Jul 23;198(2):185-94
The Journal of cell biology 2012 Jul 23;198(2):185-94
Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.
Koning H, Sayers I, Stewart CE, de Jong D, Ten Hacken NH, Postma DS, van Oosterhout AJ, Nawijn MC, Koppelman GH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jan;26(1):439-48
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jan;26(1):439-48
ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.
Daley WP, Gervais EM, Centanni SW, Gulfo KM, Nelson DA, Larsen M
Development (Cambridge, England) 2012 Jan;139(2):411-22
Development (Cambridge, England) 2012 Jan;139(2):411-22
Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells.
Brysse A, Mestdagt M, Polette M, Luczka E, Hunziker W, Noël A, Birembaut P, Foidart JM, Gilles C
Molecular cancer research : MCR 2012 Jan;10(1):121-32
Molecular cancer research : MCR 2012 Jan;10(1):121-32
In vitro culture of epicardial cells from adult zebrafish heart on a fibrin matrix.
Kim J, Rubin N, Huang Y, Tuan TL, Lien CL
Nature protocols 2012 Jan 19;7(2):247-55
Nature protocols 2012 Jan 19;7(2):247-55
A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Sarró E, Jacobs-Cachá C, Itarte E, Meseguer A
Toxicology and applied pharmacology 2012 Jan 15;258(2):275-87
Toxicology and applied pharmacology 2012 Jan 15;258(2):275-87
Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY
Developmental biology 2012 Jan 1;361(1):68-78
Developmental biology 2012 Jan 1;361(1):68-78
Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish.
Münzel EJ, Schaefer K, Obirei B, Kremmer E, Burton EA, Kuscha V, Becker CG, Brösamle C, Williams A, Becker T
Glia 2012 Feb;60(2):253-70
Glia 2012 Feb;60(2):253-70
Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus.
Kelava I, Reillo I, Murayama AY, Kalinka AT, Stenzel D, Tomancak P, Matsuzaki F, Lebrand C, Sasaki E, Schwamborn JC, Okano H, Huttner WB, Borrell V
Cerebral cortex (New York, N.Y. : 1991) 2012 Feb;22(2):469-81
Cerebral cortex (New York, N.Y. : 1991) 2012 Feb;22(2):469-81
The cell adhesion gene PVRL3 is associated with congenital ocular defects.
Lachke SA, Higgins AW, Inagaki M, Saadi I, Xi Q, Long M, Quade BJ, Talkowski ME, Gusella JF, Fujimoto A, Robinson ML, Yang Y, Duong QT, Shapira I, Motro B, Miyoshi J, Takai Y, Morton CC, Maas RL
Human genetics 2012 Feb;131(2):235-50
Human genetics 2012 Feb;131(2):235-50
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
Shi Y, Kirwan P, Smith J, Robinson HP, Livesey FJ
Nature neuroscience 2012 Feb 5;15(3):477-86, S1
Nature neuroscience 2012 Feb 5;15(3):477-86, S1
Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function.
Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP
Infection and immunity 2012 Dec;80(12):4374-87
Infection and immunity 2012 Dec;80(12):4374-87
Short-term feedback regulation of bile salt uptake by bile salts in rodent liver.
Mühlfeld S, Domanova O, Berlage T, Stross C, Helmer A, Keitel V, Häussinger D, Kubitz R
Hepatology (Baltimore, Md.) 2012 Dec;56(6):2387-97
Hepatology (Baltimore, Md.) 2012 Dec;56(6):2387-97
Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis).
Kinoshita S, Kawasaki S, Kitazawa K, Shinomiya K
Transactions of the American Ophthalmological Society 2012 Dec;110:166-77
Transactions of the American Ophthalmological Society 2012 Dec;110:166-77
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia.
Scudieri P, Caci E, Bruno S, Ferrera L, Schiavon M, Sondo E, Tomati V, Gianotti A, Zegarra-Moran O, Pedemonte N, Rea F, Ravazzolo R, Galietta LJ
The Journal of physiology 2012 Dec 1;590(23):6141-55
The Journal of physiology 2012 Dec 1;590(23):6141-55
Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
Cheung TM, Ganatra MP, Peters EB, Truskey GA
American journal of physiology. Heart and circulatory physiology 2012 Dec 1;303(11):H1374-83
American journal of physiology. Heart and circulatory physiology 2012 Dec 1;303(11):H1374-83
Neural tube defects by NUAK1 and NUAK2 double mutation.
Ohmura T, Shioi G, Hirano M, Aizawa S
Developmental dynamics : an official publication of the American Association of Anatomists 2012 Aug;241(8):1350-64
Developmental dynamics : an official publication of the American Association of Anatomists 2012 Aug;241(8):1350-64
Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes.
Raiko L, Siljamäki E, Mahoney MG, Putaala H, Suominen E, Peltonen J, Peltonen S
Experimental dermatology 2012 Aug;21(8):586-91
Experimental dermatology 2012 Aug;21(8):586-91
Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C, Meij IC, Bachmann S, Bleich M, Willnow TE, Müller D
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14241-6
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14241-6
Tight junction proteins expression and modulation in immune cells and multiple sclerosis.
Mandel I, Paperna T, Glass-Marmor L, Volkowich A, Badarny S, Schwartz I, Vardi P, Koren I, Miller A
Journal of cellular and molecular medicine 2012 Apr;16(4):765-75
Journal of cellular and molecular medicine 2012 Apr;16(4):765-75
EGFR regulation of epidermal barrier function.
Tran QT, Kennedy LH, Leon Carrion S, Bodreddigari S, Goodwin SB, Sutter CH, Sutter TR
Physiological genomics 2012 Apr 15;44(8):455-69
Physiological genomics 2012 Apr 15;44(8):455-69
Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
Paschoud S, Guillemot L, Citi S
The Journal of biological chemistry 2012 Apr 13;287(16):13159-69
The Journal of biological chemistry 2012 Apr 13;287(16):13159-69
ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.
Llauradó M, Abal M, Castellví J, Cabrera S, Gil-Moreno A, Pérez-Benavente A, Colás E, Doll A, Dolcet X, Matias-Guiu X, Vazquez-Levin M, Reventós J, Ruiz A
International journal of cancer 2012 Apr 1;130(7):1532-43
International journal of cancer 2012 Apr 1;130(7):1532-43
Retinal degeneration progression changes lentiviral vector cell targeting in the retina.
Calame M, Cachafeiro M, Philippe S, Schouwey K, Tekaya M, Wanner D, Sarkis C, Kostic C, Arsenijevic Y
PloS one 2011;6(8):e23782
PloS one 2011;6(8):e23782
Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish.
Gao W, Xu L, Guan R, Liu X, Han Y, Wu Q, Xiao Y, Qi F, Zhu Z, Lin S, Zhang B
PloS one 2011;6(8):e23386
PloS one 2011;6(8):e23386
Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy.
Zhao X, Zhang Y, Li L, Mann D, Imig JD, Emmett N, Gibbons G, Jin LM
American journal of nephrology 2011;34(3):268-80
American journal of nephrology 2011;34(3):268-80
Optimization of immunolocalization of cell cycle proteins in human corneal endothelial cells.
He Z, Campolmi N, Ha Thi BM, Dumollard JM, Peoc'h M, Garraud O, Piselli S, Gain P, Thuret G
Molecular vision 2011;17:3494-511
Molecular vision 2011;17:3494-511
Osmotic pressure-adaptive responses in the eye tissues of rainbow smelt (Osmerus mordax).
Gendron RL, Armstrong E, Paradis H, Haines L, Desjardins M, Short CE, Clow KA, Driedzic WR
Molecular vision 2011;17:2596-604
Molecular vision 2011;17:2596-604
Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer.
Ortega-Cava CF, Raja SM, Laiq Z, Bailey TA, Luan H, Mohapatra B, Williams SH, Ericsson AC, Goswami R, Dimri M, Duan L, Band V, Naramura M, Band H
Journal of carcinogenesis 2011;10:29
Journal of carcinogenesis 2011;10:29
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.
Dukes JD, Fish L, Richardson JD, Blaikley E, Burns S, Caunt CJ, Chalmers AD, Whitley P
Molecular biology of the cell 2011 Sep;22(17):3192-205
Molecular biology of the cell 2011 Sep;22(17):3192-205
Toll-like receptor responses of normal human urothelial cells to bacterial flagellin and lipopolysaccharide.
Smith NJ, Varley CL, Eardley I, Feather S, Trejdosiewicz LK, Southgate J
The Journal of urology 2011 Sep;186(3):1084-92
The Journal of urology 2011 Sep;186(3):1084-92
A novel gelatin hydrogel carrier sheet for corneal endothelial transplantation.
Watanabe R, Hayashi R, Kimura Y, Tanaka Y, Kageyama T, Hara S, Tabata Y, Nishida K
Tissue engineering. Part A 2011 Sep;17(17-18):2213-9
Tissue engineering. Part A 2011 Sep;17(17-18):2213-9
Adenosine receptor signaling modulates permeability of the blood-brain barrier.
Carman AJ, Mills JH, Krenz A, Kim DG, Bynoe MS
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 14;31(37):13272-80
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 14;31(37):13272-80
Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.
Grosse AS, Pressprich MF, Curley LB, Hamilton KL, Margolis B, Hildebrand JD, Gumucio DL
Development (Cambridge, England) 2011 Oct;138(20):4423-32
Development (Cambridge, England) 2011 Oct;138(20):4423-32
Relocalization of cell adhesion molecules during neoplastic transformation of human fibroblasts.
Belgiovine C, Chiodi I, Mondello C
International journal of oncology 2011 Nov;39(5):1199-204
International journal of oncology 2011 Nov;39(5):1199-204
Tissue engineering potential of urothelial cells from diseased bladders.
Subramaniam R, Hinley J, Stahlschmidt J, Southgate J
The Journal of urology 2011 Nov;186(5):2014-20
The Journal of urology 2011 Nov;186(5):2014-20
Matrigel improves functional properties of primary human salivary gland cells.
Maria OM, Zeitouni A, Gologan O, Tran SD
Tissue engineering. Part A 2011 May;17(9-10):1229-38
Tissue engineering. Part A 2011 May;17(9-10):1229-38
Low abundance of sweat duct Cl- channel CFTR in both healthy and cystic fibrosis athletes with exceptionally salty sweat during exercise.
Brown MB, Haack KK, Pollack BP, Millard-Stafford M, McCarty NA
American journal of physiology. Regulatory, integrative and comparative physiology 2011 Mar;300(3):R605-15
American journal of physiology. Regulatory, integrative and comparative physiology 2011 Mar;300(3):R605-15
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin.
Butt OI, Buehler PW, D'Agnillo F
The American journal of pathology 2011 Mar;178(3):1316-28
The American journal of pathology 2011 Mar;178(3):1316-28
Corticosteroid regulation of P-glycoprotein in the developing blood-brain barrier.
Iqbal M, Gibb W, Matthews SG
Endocrinology 2011 Mar;152(3):1067-79
Endocrinology 2011 Mar;152(3):1067-79
Comparison of tight junction protein expression in the ciliary epithelia of mouse, rabbit, cat and human eyes.
Karim MJ, Biswas S, Bhattacherjee P, Paterson CA
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2011 Jun;86(3):161-7
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2011 Jun;86(3):161-7
Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury.
Wu W, Huang Q, He F, Xiao M, Pang S, Guo X, Brunk UT, Zhao K, Zhao M
Shock (Augusta, Ga.) 2011 Jun;35(6):618-25
Shock (Augusta, Ga.) 2011 Jun;35(6):618-25
Lactobacillus plantarum (VR1) isolated from an ayurvedic medicine (Kutajarista) ameliorates in vitro cellular damage caused by Aeromonas veronii.
Kumar H, Rangrez AY, Dayananda KM, Atre AN, Patole MS, Shouche YS
BMC microbiology 2011 Jun 27;11:152
BMC microbiology 2011 Jun 27;11:152
Tight junction proteins vary in the choroid plexus of ewes according to photoperiod.
Lagaraine C, Skipor J, Szczepkowska A, Dufourny L, Thiery JC
Brain research 2011 Jun 1;1393:44-51
Brain research 2011 Jun 1;1393:44-51
Effects of calcium oxalate monohydrate crystals on expression and function of tight junction of renal tubular epithelial cells.
Peerapen P, Thongboonkerd V
Laboratory investigation; a journal of technical methods and pathology 2011 Jan;91(1):97-105
Laboratory investigation; a journal of technical methods and pathology 2011 Jan;91(1):97-105
The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.
Wallace SW, Magalhaes A, Hall A
Molecular and cellular biology 2011 Jan;31(1):81-91
Molecular and cellular biology 2011 Jan;31(1):81-91
Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis.
Aman A, Nguyen M, Piotrowski T
Developmental biology 2011 Jan 15;349(2):470-82
Developmental biology 2011 Jan 15;349(2):470-82
A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions.
Kranjec C, Banks L
Journal of virology 2011 Feb;85(4):1757-64
Journal of virology 2011 Feb;85(4):1757-64
Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary background.
Ingthorsson S, Halldorsson T, Sigurdsson V, Friðriksdottir AJ, Bodvarsdottir SK, Steinarsdottir M, Johannsson O, Magnusson MK, Ogmundsdottir HM, Gudjonsson T
In vitro cellular & developmental biology. Animal 2011 Feb;47(2):139-48
In vitro cellular & developmental biology. Animal 2011 Feb;47(2):139-48
Localization of AQP5 during development of the mouse submandibular salivary gland.
Larsen HS, Aure MH, Peters SB, Larsen M, Messelt EB, Kanli Galtung H
Journal of molecular histology 2011 Feb;42(1):71-81
Journal of molecular histology 2011 Feb;42(1):71-81
Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.
Paschoud S, Yu D, Pulimeno P, Jond L, Turner JR, Citi S
Molecular membrane biology 2011 Feb;28(2):123-35
Molecular membrane biology 2011 Feb;28(2):123-35
Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina.
Hilgen G, von Maltzahn J, Willecke K, Weiler R, Dedek K
The Journal of comparative neurology 2011 Feb 15;519(3):433-50
The Journal of comparative neurology 2011 Feb 15;519(3):433-50
Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.
Chai Z, Goodenough DA, Paul DL
Molecular biology of the cell 2011 Dec;22(23):4503-12
Molecular biology of the cell 2011 Dec;22(23):4503-12
Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion.
Knauf F, Ko N, Jiang Z, Robertson WG, Van Itallie CM, Anderson JM, Aronson PS
Journal of the American Society of Nephrology : JASN 2011 Dec;22(12):2247-55
Journal of the American Society of Nephrology : JASN 2011 Dec;22(12):2247-55
Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias.
Schneckenleithner C, Bago-Horvath Z, Dolznig H, Neugebauer N, Kollmann K, Kolbe T, Decker T, Kerjaschki D, Wagner KU, Müller M, Stoiber D, Sexl V
Oncotarget 2011 Dec;2(12):1043-54
Oncotarget 2011 Dec;2(12):1043-54
Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.
Sun Z, Shushanov S, LeRoith D, Wood TL
Endocrinology 2011 Aug;152(8):3233-45
Endocrinology 2011 Aug;152(8):3233-45
Kv7.1 surface expression is regulated by epithelial cell polarization.
Andersen MN, Olesen SP, Rasmussen HB
American journal of physiology. Cell physiology 2011 Apr;300(4):C814-24
American journal of physiology. Cell physiology 2011 Apr;300(4):C814-24
CD44 regulates tight-junction assembly and barrier function.
Kirschner N, Haftek M, Niessen CM, Behne MJ, Furuse M, Moll I, Brandner JM
The Journal of investigative dermatology 2011 Apr;131(4):932-43
The Journal of investigative dermatology 2011 Apr;131(4):932-43
Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.
Tanigawa S, Wang H, Yang Y, Sharma N, Tarasova N, Ajima R, Yamaguchi TP, Rodriguez LG, Perantoni AO
Developmental biology 2011 Apr 1;352(1):58-69
Developmental biology 2011 Apr 1;352(1):58-69
A novel method of culturing human oral mucosal epithelial cell sheet using post-mitotic human dermal fibroblast feeder cells and modified keratinocyte culture medium for ocular surface reconstruction.
Oie Y, Hayashi R, Takagi R, Yamato M, Takayanagi H, Tano Y, Nishida K
The British journal of ophthalmology 2010 Sep;94(9):1244-50
The British journal of ophthalmology 2010 Sep;94(9):1244-50
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, Tanioka H, Nagata-Takaoka M, Hamuro J, Kinoshita S
The American journal of pathology 2010 Sep;177(3):1344-55
The American journal of pathology 2010 Sep;177(3):1344-55
Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II.
Hirota Y, Meunier A, Huang S, Shimozawa T, Yamada O, Kida YS, Inoue M, Ito T, Kato H, Sakaguchi M, Sunabori T, Nakaya MA, Nonaka S, Ogura T, Higuchi H, Okano H, Spassky N, Sawamoto K
Development (Cambridge, England) 2010 Sep;137(18):3037-46
Development (Cambridge, England) 2010 Sep;137(18):3037-46
Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B.
Wallace SW, Durgan J, Jin D, Hall A
Molecular biology of the cell 2010 Sep 1;21(17):2996-3006
Molecular biology of the cell 2010 Sep 1;21(17):2996-3006
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
Leal EC, Martins J, Voabil P, Liberal J, Chiavaroli C, Bauer J, Cunha-Vaz J, Ambrósio AF
Diabetes 2010 Oct;59(10):2637-45
Diabetes 2010 Oct;59(10):2637-45
Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry.
Ablooglu AJ, Tkachenko E, Kang J, Shattil SJ
Development (Cambridge, England) 2010 Oct;137(20):3449-58
Development (Cambridge, England) 2010 Oct;137(20):3449-58
Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.
Garavito-Aguilar ZV, Riley HE, Yelon D
Development (Cambridge, England) 2010 Oct;137(19):3215-20
Development (Cambridge, England) 2010 Oct;137(19):3215-20
Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown.
Haarmann A, Deiss A, Prochaska J, Foerch C, Weksler B, Romero I, Couraud PO, Stoll G, Rieckmann P, Buttmann M
PloS one 2010 Oct 21;5(10):e13568
PloS one 2010 Oct 21;5(10):e13568
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.
Ponsaerts R, De Vuyst E, Retamal M, D'hondt C, Vermeire D, Wang N, De Smedt H, Zimmermann P, Himpens B, Vereecke J, Leybaert L, Bultynck G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4378-95
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4378-95
Trafficking and recycling of the connexin43 gap junction protein during mitosis.
Boassa D, Solan JL, Papas A, Thornton P, Lampe PD, Sosinsky GE
Traffic (Copenhagen, Denmark) 2010 Nov;11(11):1471-86
Traffic (Copenhagen, Denmark) 2010 Nov;11(11):1471-86
Astroglial structures in the zebrafish brain.
Grupp L, Wolburg H, Mack AF
The Journal of comparative neurology 2010 Nov 1;518(21):4277-87
The Journal of comparative neurology 2010 Nov 1;518(21):4277-87
Expression of semaphorin 3A in the rat corneal epithelium during wound healing.
Morishige N, Ko JA, Morita Y, Nishida T
Biochemical and biophysical research communications 2010 May 14;395(4):451-7
Biochemical and biophysical research communications 2010 May 14;395(4):451-7
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling.
Fietz SA, Kelava I, Vogt J, Wilsch-Bräuninger M, Stenzel D, Fish JL, Corbeil D, Riehn A, Distler W, Nitsch R, Huttner WB
Nature neuroscience 2010 Jun;13(6):690-9
Nature neuroscience 2010 Jun;13(6):690-9
A MicroRNA targeting dicer for metastasis control.
Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, Parenti AR, Daidone MG, Bicciato S, Piccolo S
Cell 2010 Jun 25;141(7):1195-207
Cell 2010 Jun 25;141(7):1195-207
Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep.
Sadowska GB, Malaeb SN, Stonestreet BS
American journal of physiology. Heart and circulatory physiology 2010 Jan;298(1):H179-88
American journal of physiology. Heart and circulatory physiology 2010 Jan;298(1):H179-88
Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation.
Semenov OV, Koestenbauer S, Riegel M, Zech N, Zimmermann R, Zisch AH, Malek A
American journal of obstetrics and gynecology 2010 Feb;202(2):193.e1-193.e13
American journal of obstetrics and gynecology 2010 Feb;202(2):193.e1-193.e13
Fhit regulates invasion of lung tumor cells.
Joannes A, Bonnomet A, Bindels S, Polette M, Gilles C, Burlet H, Cutrona J, Zahm JM, Birembaut P, Nawrocki-Raby B
Oncogene 2010 Feb 25;29(8):1203-13
Oncogene 2010 Feb 25;29(8):1203-13
The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.
Liu M, Sakamaki T, Casimiro MC, Willmarth NE, Quong AA, Ju X, Ojeifo J, Jiao X, Yeow WS, Katiyar S, Shirley LA, Joyce D, Lisanti MP, Albanese C, Pestell RG
Cancer research 2010 Dec 15;70(24):10464-73
Cancer research 2010 Dec 15;70(24):10464-73
Validation system of tissue-engineered epithelial cell sheets for corneal regenerative medicine.
Hayashi R, Yamato M, Takayanagi H, Oie Y, Kubota A, Hori Y, Okano T, Nishida K
Tissue engineering. Part C, Methods 2010 Aug;16(4):553-60
Tissue engineering. Part C, Methods 2010 Aug;16(4):553-60
Visualization of transepithelial passage of the immunogenic 33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques.
Mazumdar K, Alvarez X, Borda JT, Dufour J, Martin E, Bethune MT, Khosla C, Sestak K
PloS one 2010 Apr 19;5(4):e10228
PloS one 2010 Apr 19;5(4):e10228
Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers.
LeSimple P, Liao J, Robert R, Gruenert DC, Hanrahan JW
The Journal of physiology 2010 Apr 15;588(Pt 8):1195-209
The Journal of physiology 2010 Apr 15;588(Pt 8):1195-209
Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers.
Jeanes A, Smutny M, Leerberg JM, Yap AS
Journal of molecular histology 2009 Oct;40(5-6):395-405
Journal of molecular histology 2009 Oct;40(5-6):395-405
The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria.
Rajabian T, Gavicherla B, Heisig M, Müller-Altrock S, Goebel W, Gray-Owen SD, Ireton K
Nature cell biology 2009 Oct;11(10):1212-8
Nature cell biology 2009 Oct;11(10):1212-8
Effects of di(2-ethylhexyl) phthalate on gap and tight junction protein expression in the testis of prepubertal rats.
Sobarzo CM, Lustig L, Ponzio R, Suescun MO, Denduchis B
Microscopy research and technique 2009 Nov;72(11):868-77
Microscopy research and technique 2009 Nov;72(11):868-77
CFTR expression but not Cl- transport is involved in the stimulatory effect of bile acids on apical Cl-/HCO3- exchange activity in human pancreatic duct cells.
Ignáth I, Hegyi P, Venglovecz V, Székely CA, Carr G, Hasegawa M, Inoue M, Takács T, Argent BE, Gray MA, Rakonczay Z Jr
Pancreas 2009 Nov;38(8):921-9
Pancreas 2009 Nov;38(8):921-9
CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.
Lozovatsky L, Abayasekara N, Piawah S, Walther Z
Molecular biology of the cell 2009 Nov;20(21):4489-99
Molecular biology of the cell 2009 Nov;20(21):4489-99
Tight junctions in Hailey-Hailey and Darier's diseases.
Raiko L, Leinonen P, Hägg PM, Peltonen J, Oikarinen A, Peltonen S
Dermatology reports 2009 Nov 16;1(1):e1
Dermatology reports 2009 Nov 16;1(1):e1
Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure.
Li HC, Collier JH, Shawki A, Rudra JS, Li EY, Mackenzie B, Soleimani M
The Journal of membrane biology 2009 Mar;228(2):111-24
The Journal of membrane biology 2009 Mar;228(2):111-24
Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo.
Burtscher I, Lickert H
Development (Cambridge, England) 2009 Mar;136(6):1029-38
Development (Cambridge, England) 2009 Mar;136(6):1029-38
Voltage-gated sodium channels in taste bud cells.
Gao N, Lu M, Echeverri F, Laita B, Kalabat D, Williams ME, Hevezi P, Zlotnik A, Moyer BD
BMC neuroscience 2009 Mar 12;10:20
BMC neuroscience 2009 Mar 12;10:20
Residues in a highly conserved claudin-1 motif are required for hepatitis C virus entry and mediate the formation of cell-cell contacts.
Cukierman L, Meertens L, Bertaux C, Kajumo F, Dragic T
Journal of virology 2009 Jun;83(11):5477-84
Journal of virology 2009 Jun;83(11):5477-84
Tight junction proteins in human Schwann cell autotypic junctions.
Alanne MH, Pummi K, Heape AM, Grènman R, Peltonen J, Peltonen S
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Jun;57(6):523-9
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Jun;57(6):523-9
Novel sutureless keratoplasty with a chemically defined bioadhesive.
Takaoka M, Nakamura T, Sugai H, Bentley AJ, Nakajima N, Yokoi N, Fullwood NJ, Hyon SH, Kinoshita S
Investigative ophthalmology & visual science 2009 Jun;50(6):2679-85
Investigative ophthalmology & visual science 2009 Jun;50(6):2679-85
Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3.
Elwi AN, Damaraju VL, Kuzma ML, Mowles DA, Baldwin SA, Young JD, Sawyer MB, Cass CE
American journal of physiology. Renal physiology 2009 Jun;296(6):F1439-51
American journal of physiology. Renal physiology 2009 Jun;296(6):F1439-51
Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos.
Montero-Balaguer M, Swirsding K, Orsenigo F, Cotelli F, Mione M, Dejana E
PloS one 2009 Jun 3;4(6):e5772
PloS one 2009 Jun 3;4(6):e5772
Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways.
Matsumoto M, Oyamada K, Takahashi H, Sato T, Hatakeyama S, Nakayama KI
Proteomics 2009 Jul;9(13):3549-63
Proteomics 2009 Jul;9(13):3549-63
Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish.
Roberts RK, Appel B
Developmental dynamics : an official publication of the American Association of Anatomists 2009 Jul;238(7):1638-48
Developmental dynamics : an official publication of the American Association of Anatomists 2009 Jul;238(7):1638-48
Neural reconnection in the transected spinal cord of the freshwater turtle Trachemys dorbignyi.
Rehermann MI, Marichal N, Russo RE, Trujillo-Cenóz O
The Journal of comparative neurology 2009 Jul 10;515(2):197-214
The Journal of comparative neurology 2009 Jul 10;515(2):197-214
Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology.
Catanuto P, Espinosa-Heidmann D, Pereira-Simon S, Sanchez P, Salas P, Hernandez E, Cousins SW, Elliot SJ
Experimental eye research 2009 Jan;88(1):99-105
Experimental eye research 2009 Jan;88(1):99-105
Functional suppression of E-cadherin by protein kinase Cdelta.
Chen CL, Chen HC
Journal of cell science 2009 Feb 15;122(Pt 4):513-23
Journal of cell science 2009 Feb 15;122(Pt 4):513-23
Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro.
Rubenwolf PC, Georgopoulos NT, Clements LA, Feather S, Holland P, Thomas DF, Southgate J
European urology 2009 Dec;56(6):1013-23
European urology 2009 Dec;56(6):1013-23
Barrier function of cultivated limbal and oral mucosal epithelial cell sheets.
Shimazaki J, Higa K, Kato N, Satake Y
Investigative ophthalmology & visual science 2009 Dec;50(12):5672-80
Investigative ophthalmology & visual science 2009 Dec;50(12):5672-80
Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells.
Natoli M, Felsani A, Ferruzza S, Sambuy Y, Canali R, Scarino ML
Toxicology in vitro : an international journal published in association with BIBRA 2009 Dec;23(8):1510-5
Toxicology in vitro : an international journal published in association with BIBRA 2009 Dec;23(8):1510-5
A cell polarity protein aPKClambda is required for eye lens formation and growth.
Sugiyama Y, Akimoto K, Robinson ML, Ohno S, Quinlan RA
Developmental biology 2009 Dec 15;336(2):246-56
Developmental biology 2009 Dec 15;336(2):246-56
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.
Huber TB, Hartleben B, Winkelmann K, Schneider L, Becker JU, Leitges M, Walz G, Haller H, Schiffer M
Journal of the American Society of Nephrology : JASN 2009 Apr;20(4):798-806
Journal of the American Society of Nephrology : JASN 2009 Apr;20(4):798-806
FGF signalling during embryo development regulates cilia length in diverse epithelia.
Neugebauer JM, Amack JD, Peterson AG, Bisgrove BW, Yost HJ
Nature 2009 Apr 2;458(7238):651-4
Nature 2009 Apr 2;458(7238):651-4
Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.
Birnie R, Bryce SD, Roome C, Dussupt V, Droop A, Lang SH, Berry PA, Hyde CF, Lewis JL, Stower MJ, Maitland NJ, Collins AT
Genome biology 2008;9(5):R83
Genome biology 2008;9(5):R83
Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia.
McCaffrey G, Seelbach MJ, Staatz WD, Nametz N, Quigley C, Campos CR, Brooks TA, Davis TP
Journal of neurochemistry 2008 Sep;106(6):2395-409
Journal of neurochemistry 2008 Sep;106(6):2395-409
Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.
Nokes RL, Fields IC, Collins RN, Fölsch H
The Journal of cell biology 2008 Sep 8;182(5):845-53
The Journal of cell biology 2008 Sep 8;182(5):845-53
Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1.
Li X, Kamasawa N, Ciolofan C, Olson CO, Lu S, Davidson KG, Yasumura T, Shigemoto R, Rash JE, Nagy JI
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Sep 24;28(39):9769-89
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Sep 24;28(39):9769-89
Differential requirement for beta-catenin in epithelial and fiber cells during lens development.
Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU
Developmental biology 2008 Sep 15;321(2):420-33
Developmental biology 2008 Sep 15;321(2):420-33
Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus.
Norsted E, Gömüç B, Meister B
Journal of chemical neuroanatomy 2008 Oct;36(2):107-21
Journal of chemical neuroanatomy 2008 Oct;36(2):107-21
An immunochemical marker for goldfish Mauthner cells.
Flores CE, Ene S, Pereda AE
Journal of neuroscience methods 2008 Oct 30;175(1):64-9
Journal of neuroscience methods 2008 Oct 30;175(1):64-9
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.
Yang W, Hood BL, Chadwick SL, Liu S, Watkins SC, Luo G, Conrads TP, Wang T
Hepatology (Baltimore, Md.) 2008 Nov;48(5):1396-403
Hepatology (Baltimore, Md.) 2008 Nov;48(5):1396-403
Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum.
Chen X, Lan X, Roche I, Liu R, Geiger JD
Journal of neurochemistry 2008 Nov;107(4):1147-57
Journal of neurochemistry 2008 Nov;107(4):1147-57
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line.
Aono S, Hirai Y
Experimental cell research 2008 Nov 1;314(18):3326-39
Experimental cell research 2008 Nov 1;314(18):3326-39
Interleukin 1 alpha (IL1A) is a novel regulator of the blood-testis barrier in the rat.
Sarkar O, Mathur PP, Cheng CY, Mruk DD
Biology of reproduction 2008 Mar;78(3):445-54
Biology of reproduction 2008 Mar;78(3):445-54
N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility.
Li J, Levin MD, Xiong Y, Petrenko N, Patel VV, Radice GL
Journal of molecular and cellular cardiology 2008 Mar;44(3):597-606
Journal of molecular and cellular cardiology 2008 Mar;44(3):597-606
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.
Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H
Mechanisms of development 2008 Mar-Apr;125(3-4):270-83
Mechanisms of development 2008 Mar-Apr;125(3-4):270-83
Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus.
Yang W, Qiu C, Biswas N, Jin J, Watkins SC, Montelaro RC, Coyne CB, Wang T
The Journal of biological chemistry 2008 Mar 28;283(13):8643-53
The Journal of biological chemistry 2008 Mar 28;283(13):8643-53
Expression and localisation of apical junctional complex proteins in lens epithelial cells.
Sugiyama Y, Prescott AR, Tholozan FM, Ohno S, Quinlan RA
Experimental eye research 2008 Jul;87(1):64-70
Experimental eye research 2008 Jul;87(1):64-70
Early events in HIV transmission through a human reconstructed vaginal mucosa.
Bouschbacher M, Bomsel M, Verronèse E, Gofflo S, Ganor Y, Dezutter-Dambuyant C, Valladeau J
AIDS (London, England) 2008 Jul 11;22(11):1257-66
AIDS (London, England) 2008 Jul 11;22(11):1257-66
Effects of multipurpose solutions on corneal epithelial tight junctions.
Imayasu M, Shiraishi A, Ohashi Y, Shimada S, Cavanagh HD
Eye & contact lens 2008 Jan;34(1):50-5
Eye & contact lens 2008 Jan;34(1):50-5
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Paschoud S, Citi S
Molecular membrane biology 2008 Jan;25(1):1-13
Molecular membrane biology 2008 Jan;25(1):1-13
Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis.
Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F
Nature cell biology 2008 Jan;10(1):93-101
Nature cell biology 2008 Jan;10(1):93-101
Distribution of tight junction proteins in adult human salivary glands.
Maria OM, Kim JW, Gerstenhaber JA, Baum BJ, Tran SD
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Dec;56(12):1093-8
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Dec;56(12):1093-8
Generation of a functional, differentiated porcine urothelial tissue in vitro.
Turner AM, Subramaniam R, Thomas DF, Southgate J
European urology 2008 Dec;54(6):1423-32
European urology 2008 Dec;54(6):1423-32
Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo.
Dunworth WP, Fritz-Six KL, Caron KM
Peptides 2008 Dec;29(12):2243-9
Peptides 2008 Dec;29(12):2243-9
Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.
Neuhaus W, Wirth M, Plattner VE, Germann B, Gabor F, Noe CR
Neuroscience letters 2008 Dec 3;446(2-3):59-64
Neuroscience letters 2008 Dec 3;446(2-3):59-64
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.
Roberts LM, Black DS, Raman C, Woodford K, Zhou M, Haggerty JE, Yan AT, Cwirla SE, Grindstaff KK
Neuroscience 2008 Aug 13;155(2):423-38
Neuroscience 2008 Aug 13;155(2):423-38
aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables.
Kishikawa M, Suzuki A, Ohno S
Journal of cell science 2008 Aug 1;121(Pt 15):2481-92
Journal of cell science 2008 Aug 1;121(Pt 15):2481-92
Localization of semaphorin 3A in the rat cornea.
Morishige N, Ko JA, Liu Y, Chikama T, Nishida T
Experimental eye research 2008 Apr;86(4):669-74
Experimental eye research 2008 Apr;86(4):669-74
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.
Chen X, Gawryluk JW, Wagener JF, Ghribi O, Geiger JD
Journal of neuroinflammation 2008 Apr 3;5:12
Journal of neuroinflammation 2008 Apr 3;5:12
Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function.
Mandell KJ, Berglin L, Severson EA, Edelhauser HF, Parkos CA
Investigative ophthalmology & visual science 2007 Sep;48(9):3928-36
Investigative ophthalmology & visual science 2007 Sep;48(9):3928-36
Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis.
Mruk DD, Lau AS, Sarkar O, Xia W
Journal of andrology 2007 Sep-Oct;28(5):742-54
Journal of andrology 2007 Sep-Oct;28(5):742-54
Tmod3 regulates polarized epithelial cell morphology.
Weber KL, Fischer RS, Fowler VM
Journal of cell science 2007 Oct 15;120(Pt 20):3625-32
Journal of cell science 2007 Oct 15;120(Pt 20):3625-32
Serosal mesothelium retains vasculogenic potential.
Kawaguchi M, Bader DM, Wilm B
Developmental dynamics : an official publication of the American Association of Anatomists 2007 Nov;236(11):2973-9
Developmental dynamics : an official publication of the American Association of Anatomists 2007 Nov;236(11):2973-9
ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43.
Akoyev V, Takemoto DJ
Cellular signalling 2007 May;19(5):958-67
Cellular signalling 2007 May;19(5):958-67
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Peltonen S, Riehokainen J, Pummi K, Peltonen J
The British journal of dermatology 2007 Mar;156(3):466-72
The British journal of dermatology 2007 Mar;156(3):466-72
Zonula occludens-1 and connexin 43 expression in the failing human heart.
Kostin S
Journal of cellular and molecular medicine 2007 Jul-Aug;11(4):892-5
Journal of cellular and molecular medicine 2007 Jul-Aug;11(4):892-5
Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.
Skowron-zwarg M, Boland S, Caruso N, Coraux C, Marano F, Tournier F
Experimental cell research 2007 Jul 15;313(12):2695-702
Experimental cell research 2007 Jul 15;313(12):2695-702
Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis.
Endemann M, Bergmeister H, Bidmon B, Boehm M, Csaicsich D, Malaga-Dieguez L, Arbeiter K, Regele H, Herkner K, Aufricht C
American journal of physiology. Renal physiology 2007 Jan;292(1):F47-56
American journal of physiology. Renal physiology 2007 Jan;292(1):F47-56
Basal cells of the human adult airway surface epithelium retain transit-amplifying cell properties.
Hajj R, Baranek T, Le Naour R, Lesimple P, Puchelle E, Coraux C
Stem cells (Dayton, Ohio) 2007 Jan;25(1):139-48
Stem cells (Dayton, Ohio) 2007 Jan;25(1):139-48
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex.
Anstrom JA, Thore CR, Moody DM, Brown WR
Histochemistry and cell biology 2007 Feb;127(2):205-13
Histochemistry and cell biology 2007 Feb;127(2):205-13
Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.
McCaffrey G, Staatz WD, Quigley CA, Nametz N, Seelbach MJ, Campos CR, Brooks TA, Egleton RD, Davis TP
Journal of neurochemistry 2007 Dec;103(6):2540-55
Journal of neurochemistry 2007 Dec;103(6):2540-55
C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques.
Maass K, Shibayama J, Chase SE, Willecke K, Delmar M
Circulation research 2007 Dec 7;101(12):1283-91
Circulation research 2007 Dec 7;101(12):1283-91
Novel fibroblastic onion bulbs in a demyelinating avian peripheral neuropathy produced by riboflavin deficiency.
Cai Z, Blumbergs PC, Finnie JW, Manavis J, Thompson PD
Acta neuropathologica 2007 Aug;114(2):187-94
Acta neuropathologica 2007 Aug;114(2):187-94
Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina.
Ciolofan C, Lynn BD, Wellershaus K, Willecke K, Nagy JI
Neuroscience 2007 Aug 24;148(2):473-88
Neuroscience 2007 Aug 24;148(2):473-88
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex.
Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T, Ohno S
Development (Cambridge, England) 2006 May;133(9):1735-44
Development (Cambridge, England) 2006 May;133(9):1735-44
Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling.
Mandell KJ, Holley GP, Parkos CA, Edelhauser HF
Investigative ophthalmology & visual science 2006 Jun;47(6):2408-16
Investigative ophthalmology & visual science 2006 Jun;47(6):2408-16
Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina.
Ciolofan C, Li XB, Olson C, Kamasawa N, Gebhardt BR, Yasumura T, Morita M, Rash JE, Nagy JI
Neuroscience 2006 Jun 30;140(2):433-51
Neuroscience 2006 Jun 30;140(2):433-51
A dileucine motif targets MCAM-l cell adhesion molecule to the basolateral membrane in MDCK cells.
Guezguez B, Vigneron P, Alais S, Jaffredo T, Gavard J, Mège RM, Dunon D
FEBS letters 2006 Jun 26;580(15):3649-56
FEBS letters 2006 Jun 26;580(15):3649-56
Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.
Yan HHN, Cheng CY
The Journal of biological chemistry 2006 Jun 23;281(25):17286-17303
The Journal of biological chemistry 2006 Jun 23;281(25):17286-17303
Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions.
Sarkar O, Xia W, Mruk DD
Journal of cellular physiology 2006 Jul;208(1):175-87
Journal of cellular physiology 2006 Jul;208(1):175-87
Tight junction proteins and perineurial cells in neurofibromas.
Pummi KP, Aho HJ, Laato MK, Peltonen JT, Peltonen SA
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Jan;54(1):53-61
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Jan;54(1):53-61
Altered expression of junctional adhesion molecule 4 in injured podocytes.
Harita Y, Miyauchi N, Karasawa T, Suzuki K, Han GD, Koike H, Igarashi T, Shimizu F, Kawachi H
American journal of physiology. Renal physiology 2006 Feb;290(2):F335-44
American journal of physiology. Renal physiology 2006 Feb;290(2):F335-44
Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes.
Li MW, Xia W, Mruk DD, Wang CQ, Yan HH, Siu MK, Lui WY, Lee WM, Cheng CY
The Journal of endocrinology 2006 Aug;190(2):313-29
The Journal of endocrinology 2006 Aug;190(2):313-29
PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.
Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T
Development (Cambridge, England) 2006 Apr;133(7):1389-98
Development (Cambridge, England) 2006 Apr;133(7):1389-98
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.
Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, Collins JE
Laboratory investigation; a journal of technical methods and pathology 2005 Sep;85(9):1139-62
Laboratory investigation; a journal of technical methods and pathology 2005 Sep;85(9):1139-62
Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.
Polette M, Gilles C, Nawrocki-Raby B, Lohi J, Hunziker W, Foidart JM, Birembaut P
Cancer research 2005 Sep 1;65(17):7691-8
Cancer research 2005 Sep 1;65(17):7691-8
Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation.
Caruso-Neves C, Kwon SH, Guggino WB
Proceedings of the National Academy of Sciences of the United States of America 2005 Nov 29;102(48):17513-8
Proceedings of the National Academy of Sciences of the United States of America 2005 Nov 29;102(48):17513-8
Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis.
Hyenne V, Louvet-Vallée S, El-Amraoui A, Petit C, Maro B, Simmler MC
Developmental biology 2005 Nov 1;287(1):180-91
Developmental biology 2005 Nov 1;287(1):180-91
Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.
Wei CJ, Francis R, Xu X, Lo CW
The Journal of biological chemistry 2005 May 20;280(20):19925-36
The Journal of biological chemistry 2005 May 20;280(20):19925-36
sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.
Yoshii T, Mizuno K, Hirose T, Nakajima A, Sekihara H, Ohno S
American journal of physiology. Gastrointestinal and liver physiology 2005 Mar;288(3):G564-70
American journal of physiology. Gastrointestinal and liver physiology 2005 Mar;288(3):G564-70
The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.
Lopez C, Métral S, Eladari D, Drevensek S, Gane P, Chambrey R, Bennett V, Cartron JP, Le Van Kim C, Colin Y
The Journal of biological chemistry 2005 Mar 4;280(9):8221-8
The Journal of biological chemistry 2005 Mar 4;280(9):8221-8
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain.
Penes MC, Li X, Nagy JI
The European journal of neuroscience 2005 Jul;22(2):404-18
The European journal of neuroscience 2005 Jul;22(2):404-18
Functional organization of the bovine rumen epithelium.
Graham C, Simmons NL
American journal of physiology. Regulatory, integrative and comparative physiology 2005 Jan;288(1):R173-81
American journal of physiology. Regulatory, integrative and comparative physiology 2005 Jan;288(1):R173-81
Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells.
Lipschutz JH, Li S, Arisco A, Balkovetz DF
The Journal of biological chemistry 2005 Feb 4;280(5):3780-8
The Journal of biological chemistry 2005 Feb 4;280(5):3780-8
Localization of PDZ domain containing proteins Discs Large-1 and Scribble in the mouse eye.
Nguyen MM, Rivera C, Griep AE
Molecular vision 2005 Dec 28;11:1183-99
Molecular vision 2005 Dec 28;11:1183-99
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
Brooks TA, Hawkins BT, Huber JD, Egleton RD, Davis TP
American journal of physiology. Heart and circulatory physiology 2005 Aug;289(2):H738-43
American journal of physiology. Heart and circulatory physiology 2005 Aug;289(2):H738-43
Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition.
Slattery C, Campbell E, McMorrow T, Ryan MP
The American journal of pathology 2005 Aug;167(2):395-407
The American journal of pathology 2005 Aug;167(2):395-407
Blood-testis barrier dynamics are regulated by {alpha}2-macroglobulin via the c-Jun N-terminal protein kinase pathway.
Wong CH, Mruk DD, Siu MK, Cheng CY
Endocrinology 2005 Apr;146(4):1893-908
Endocrinology 2005 Apr;146(4):1893-908
Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of beta1 integrin subsets.
Furuya M, Kato H, Nishimura N, Ishiwata I, Ikeda H, Ito R, Yoshiki T, Ishikura H
Cancer research 2005 Apr 1;65(7):2617-25
Cancer research 2005 Apr 1;65(7):2617-25
Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation.
Zeng R, Li X, Gorodeski GI
The Journal of clinical endocrinology and metabolism 2004 Oct;89(10):5145-55
The Journal of clinical endocrinology and metabolism 2004 Oct;89(10):5145-55
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP
Proceedings of the National Academy of Sciences of the United States of America 2004 Oct 12;101(41):14877-82
Proceedings of the National Academy of Sciences of the United States of America 2004 Oct 12;101(41):14877-82
Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.
Moeller MJ, Soofi A, Braun GS, Li X, Watzl C, Kriz W, Holzman LB
The EMBO journal 2004 Oct 1;23(19):3769-79
The EMBO journal 2004 Oct 1;23(19):3769-79
Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
Badizadegan K, Wheeler HE, Fujinaga Y, Lencer WI
American journal of physiology. Cell physiology 2004 Nov;287(5):C1453-62
American journal of physiology. Cell physiology 2004 Nov;287(5):C1453-62
Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms.
McLaughlin J, Padfield PJ, Burt JP, O'Neill CA
American journal of physiology. Cell physiology 2004 Nov;287(5):C1412-7
American journal of physiology. Cell physiology 2004 Nov;287(5):C1412-7
Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland.
Li X, Olson C, Lu S, Nagy JI
Histochemistry and cell biology 2004 Nov;122(5):485-98
Histochemistry and cell biology 2004 Nov;122(5):485-98
The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction.
Coyne CB, Voelker T, Pichla SL, Bergelson JM
The Journal of biological chemistry 2004 Nov 12;279(46):48079-84
The Journal of biological chemistry 2004 Nov 12;279(46):48079-84
Expression of claudin-7 and -8 along the mouse nephron.
Li WY, Huey CL, Yu AS
American journal of physiology. Renal physiology 2004 Jun;286(6):F1063-71
American journal of physiology. Renal physiology 2004 Jun;286(6):F1063-71
Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin development.
Watanabe T, Miyatani S, Katoh I, Kobayashi S, Ikawa Y
Biochemical and biophysical research communications 2004 Jan 9;313(2):263-70
Biochemical and biophysical research communications 2004 Jan 9;313(2):263-70
Regulation of blood-testis barrier dynamics: an in vivo study.
Wong CH, Mruk DD, Lui WY, Cheng CY
Journal of cell science 2004 Feb 15;117(Pt 5):783-98
Journal of cell science 2004 Feb 15;117(Pt 5):783-98
An in vitro model based on cell monolayers grown on the underside of large- pore filters in bicameral chambers for studying thyrocyte-lymphocyte interactions.
Estienne V, Brisbarre N, Blanchin S, Durand-Gorde JM, Carayon P, Ruf J
American journal of physiology. Cell physiology 2004 Dec;287(6):C1763-8
American journal of physiology. Cell physiology 2004 Dec;287(6):C1763-8
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
Pummi KP, Heape AM, Grénman RA, Peltonen JT, Peltonen SA
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Aug;52(8):1037-46
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Aug;52(8):1037-46
Bves is expressed in the epithelial components of the retina, lens, and cornea.
Ripley AN, Chang MS, Bader DM
Investigative ophthalmology & visual science 2004 Aug;45(8):2475-83
Investigative ophthalmology & visual science 2004 Aug;45(8):2475-83
Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
Li X, Olson C, Lu S, Kamasawa N, Yasumura T, Rash JE, Nagy JI
The European journal of neuroscience 2004 Apr;19(8):2132-46
The European journal of neuroscience 2004 Apr;19(8):2132-46
Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis.
Slobodov G, Feloney M, Gran C, Kyker KD, Hurst RE, Culkin DJ
The Journal of urology 2004 Apr;171(4):1554-8
The Journal of urology 2004 Apr;171(4):1554-8
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T
Nature 2004 Apr 15;428(6984):758-63
Nature 2004 Apr 15;428(6984):758-63
The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation.
Parker LH, Schmidt M, Jin SW, Gray AM, Beis D, Pham T, Frantz G, Palmieri S, Hillan K, Stainier DY, De Sauvage FJ, Ye W
Nature 2004 Apr 15;428(6984):754-8
Nature 2004 Apr 15;428(6984):754-8
CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells.
Berryman MA, Goldenring JR
Cell motility and the cytoskeleton 2003 Nov;56(3):159-72
Cell motility and the cytoskeleton 2003 Nov;56(3):159-72
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
Yu AS, Enck AH, Lencer WI, Schneeberger EE
The Journal of biological chemistry 2003 May 9;278(19):17350-9
The Journal of biological chemistry 2003 May 9;278(19):17350-9
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Anders M, Christian C, McMahon M, McCormick F, Korn WM
Cancer research 2003 May 1;63(9):2088-95
Cancer research 2003 May 1;63(9):2088-95
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.
Colegio OR, Van Itallie C, Rahner C, Anderson JM
American journal of physiology. Cell physiology 2003 Jun;284(6):C1346-54
American journal of physiology. Cell physiology 2003 Jun;284(6):C1346-54
Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus.
Inagaki M, Irie K, Deguchi-Tawarada M, Ikeda W, Ohtsuka T, Takeuchi M, Takai Y
The Journal of comparative neurology 2003 Jun 9;460(4):514-24
The Journal of comparative neurology 2003 Jun 9;460(4):514-24
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.
Lu Z, Ghosh S, Wang Z, Hunter T
Cancer cell 2003 Dec;4(6):499-515
Cancer cell 2003 Dec;4(6):499-515
Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression.
Witt KA, Mark KS, Hom S, Davis TP
American journal of physiology. Heart and circulatory physiology 2003 Dec;285(6):H2820-31
American journal of physiology. Heart and circulatory physiology 2003 Dec;285(6):H2820-31
Isolation and characterization of human esophageal microvascular endothelial cells: mechanisms of inflammatory activation.
Rafiee P, Ogawa H, Heidemann J, Li MS, Aslam M, Lamirand TH, Fisher PJ, Graewin SJ, Dwinell MB, Johnson CP, Shaker R, Binion DG
American journal of physiology. Gastrointestinal and liver physiology 2003 Dec;285(6):G1277-92
American journal of physiology. Gastrointestinal and liver physiology 2003 Dec;285(6):G1277-92
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Malminen M, Koivukangas V, Peltonen J, Karvonen SL, Oikarinen A, Peltonen S
The British journal of dermatology 2003 Aug;149(2):255-60
The British journal of dermatology 2003 Aug;149(2):255-60
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Malminen M, Koivukangas V, Peltonen J, Karvonen SL, Oikarinen A, Peltonen S
The British journal of dermatology 2003 Aug;149(2):255-60
The British journal of dermatology 2003 Aug;149(2):255-60
Rab8B GTPase and junction dynamics in the testis.
Lau AS, Mruk DD
Endocrinology 2003 Apr;144(4):1549-63
Endocrinology 2003 Apr;144(4):1549-63
Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP, Sukumar S
Oncogene 2003 Apr 3;22(13):2021-33
Oncogene 2003 Apr 3;22(13):2021-33
Applications of epithelial cell culture in studies of drug transport.
Tavelin S, Gråsjö J, Taipalensuu J, Ocklind G, Artursson P
Methods in molecular biology (Clifton, N.J.) 2002;188:233-72
Methods in molecular biology (Clifton, N.J.) 2002;188:233-72
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.
Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S
Developmental dynamics : an official publication of the American Association of Anatomists 2002 Sep;225(1):61-9
Developmental dynamics : an official publication of the American Association of Anatomists 2002 Sep;225(1):61-9
Casein kinase 1 regulates connexin-43 gap junction assembly.
Cooper CD, Lampe PD
The Journal of biological chemistry 2002 Nov 22;277(47):44962-8
The Journal of biological chemistry 2002 Nov 22;277(47):44962-8
The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions.
Roh MH, Liu CJ, Laurinec S, Margolis B
The Journal of biological chemistry 2002 Jul 26;277(30):27501-9
The Journal of biological chemistry 2002 Jul 26;277(30):27501-9
JEAP, a novel component of tight junctions in exocrine cells.
Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y
The Journal of biological chemistry 2002 Feb 15;277(7):5583-7
The Journal of biological chemistry 2002 Feb 15;277(7):5583-7
Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes.
Pummi K, Malminen M, Aho H, Karvonen SL, Peltonen J, Peltonen S
The Journal of investigative dermatology 2001 Nov;117(5):1050-8
The Journal of investigative dermatology 2001 Nov;117(5):1050-8
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability.
Van Itallie C, Rahner C, Anderson JM
The Journal of clinical investigation 2001 May;107(10):1319-27
The Journal of clinical investigation 2001 May;107(10):1319-27
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- Lane 1 was probed with Rb anti-ZO-3 (Mid) (Product # 36-4000) and Lane 2 was probed with Ms anti-ZO-1 (Product # 33-9100).
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- Western blot analysis of T84 cell lysates using Ms anti-ZO-1 (Product # 33-9100).
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- Western blot was performed using Anti-ZO-1 Monoclonal Antibody (ZO1-1A12) (Product # 33-9100) and a 225 kDa band corresponding to ZO-1 was observed across along with uncharacterized band. Membrane enriched extracts (40 µg lysate) of Caco-2 (Lane 1), Caco-2 treated with IFN Gamma (50 ng/mL for 24hrs) (Lane 2), A-431 (Lane 3), HEL 92.1.7 (Lane 4) and Jurkat (Lane 5). Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001) after equilibrating with ethanol .Relative Expression of ZO-1 was observed to be high in Caco-2 and A-431 in comparison to low or negative in Jurkat and HEL 92.1.7, the downregulation of protein was also observed with IFN Gamma treatment, The blot was probed with the primary antibody (2 µg/mL) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:4000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005).
Supportive validation
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- Image courtesy of Dr. Alan S. Fanning, University of North Carolina at Chapel Hill, NC.
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- MDCK canine cells stained with Mouse anti-ZO-1 (Product # 33-9100) and Zymed's ZyMAX FITC-Goat Anti-Mouse IgG (H+L) (Product # 81-6511).
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- Immunofluorescent analysis of ZO-1 (green) in Caco-2 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes and blocked with 3% Blocker BSA (Product # 37525) in PBS for 15 minutes at room temperature. Cells were stained with or without ZO-1 mouse monoclonal antibody (Product # 33-9100), at a concentration of 5 µg/mL for 1 hour at room temperature, and then incubated with a Goat anti-Mouse IgG (H+L) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution of 1:1000 for 1 hour s at room temperature (both panels, green). Nuclei (both panels, blue) were stained with Hoechst 33342 dye (Product # 62249). Images were taken on a Thermo Scientific ToxInsight at 20X magnification.
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- Immunofluorescent detection of Zo-1 in MDCK cells. Confluent monolayers were fixed in 50%methanol/50%Acetone, blocked for at least 30 minutes in 1% BSA then incubated 2 hours with a Zo-1 monoclonal antibody (Product # 33-9100) at 5 µg/mL, washed, then incubated 1 hour with Alexa Fluor 488 conjugated Donkey anti-Mouse secondary antibody (Product # A-21202) at a dilution of 1:2000. Cells were counterstained with DAPI (blue). Coverslips were mounted with Prolong Gold Antifade reagent (Product # P36930) and imaged at 40X. Images generated by Joell Solan in Paul Lampe Lab at the Fred Hutchinson cancer Research Center.
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- Immunofluorescence analysis of ZO-1 was performed using 90% confluent log phase Caco-2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with ZO-1 Monoclonal Antibody (ZO1-1A12) (Product # 33-9100) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32766), (1:2000 dilution), for 45 minutes at room temperature (Panel a: Green). Nuclei (Panel b:Blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415, 1:300 dilution). Panel d represents the merged image showing Junctional localization. Panel e represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.
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- Knockdown of ZO-1 was achieved by transfecting Caco-2 cells with ZO-1 specific siRNA (Silencer® select Product # s14155, s14156). Immunofluorescence analysis was performed on untransfected Caco-2 cells (panel a-d), transfected with non-specific scrambled siRNA (panels e-h) and transfected with ZO-1 specific siRNA (panel i-l). Cells were fixed, permeabilized, and labelled with ZO-1 Monoclonal Antibody (ZO1-1A12) (Product # 33-9100, 5 µg/mL) followed by Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32766), (1:2000 dilution). Nuclei (blue) were stained using ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962), and Rhodamine Phalloidin (Product # R415, 1:300 dilution) was used for cytoskeletal F-actin (Green) staining. Reduction in signal of specific signal was observed upon siRNA mediated knockdown (panel i-l) confirming specificity of the antibody to ZO-1 (Green). The Images were captured at 60X magnification.
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- Immunofluorescence analysis of H3K4me3 (green) and ZO-1 (red) in Rhesus Macaques. Cells were stained with a recombinant monoclonal H3K4me3 antibody (Product # 703849) and monoclonal ZO-1 antibody (Product # 33-9100) followed by incubation with secondary Alexa Fluor ® 488 conjugate antibody (Product # A11034) (panel b: green) and secondary secondary Alexa Fluor ® 555 conjugate antibody (Product # A21432) (panel c: red) . Nuclei (panel a: blue) were stained with DAPI. Panel d is a merged image of panels a, b and c. Images were taken on EVOS2 at 20X magnification. Data courtesy of J. Arredondo and S. Dandekar at UC Davis.
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- Immunofluorescent analysis of ZO-1 (red) and SOX2 (grey) in human iPSC-derived forebrain organoids derived at Day 40. The organoids were fixed with 4% PFA for 1 hour at room temperature, followed by incubation with 30% sucrose solution overnight at 4°C. The organoids were then embedded in OCT and cryosectioned at 5 µm, permeabilized with 0.2% Triton X-100 for 20 min, and blocked with 10% donkey serum in PBS for 30 min at room temperature. Organoid slices were stained with a Mouse ZO-1 monoclonal antibody (red; Product # 33-9100) at a dilution of 1:500, a Rabbit SOX2 polyclonal antibody (grey; Product # PA1-094X) at a dilution of 1:500, and a Chicken MAP2 polyclonal antibody (green) at a dilution of 1:1000 in blocking buffer overnight at 4°C, and then incubated with Donkey anti-Mouse Alexa Fluor 568 (Product # A10037), Donkey anti-Rabbit Alexa Fluor 647 (Product # A-31573), and Donkey Anti-Chicken Alexa Fluor 488 at a dilution of 1:1000 as well as DAPI (blue; 1:25000) in blocking solution at room temperature for 1 hour. Images were taken at 20X magnification. Scale bar: 50 µm. Data courtesy of Dr. Zhexing Wen at Emory University.
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- Figure 6 Retinal-induced cell differentiation in MCF10A is compromised when HOXA5 is repressed A . Western blot analysis of HOXA5 and CDH1 expression in MCF10A-tet-sh528 cells with dox-induced depletion of HOXA5 over 96 hours. beta-actin serves as the loading control. B . Flow cytometry analysis of CD24 expression in MCF10A-tet-HOXA5 with doxycycline-induced depletion of HOXA5 shows decrease of CD24+ population (7-AAD negative) from 47% to 24% over 96 hours. C . Flow sorted CD24 - population was treated with DMSO, 1 uM retinal (ATAL) or 1 uM ATAL + 100 nM doxycycline (DOX) and cultured for 1 week. Flow cytometry analysis of CD24 (x-axis) and CD44 (y-axis). Quantitative analysis is shown in the bar graph. D . Quantitative RT-PCR analysis of HOXA5, CD24, CDH1, Occludin, CLDN7 and ALDH1A3 in MCF10A-tet-sh528 cells treated with DMSO, 1 uM retinal (ATAL) or 1 uM ATAL + 100 nM doxycycline (DOX) and cultured for 1 week. E . Western blot analysis of HOXA5, CDH1, p21, ZO-1, Occludin, CLDN7 and CK18 in cells treated with DMSO, ATAL and ATAL+ doxycycline as in (D). beta-actin serves as the loading control.
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- Figure 4 SW620 cell-secreted factors overexpress the endothelial Cx32 favoring tubulogenesis A. Endothelial cell localization of Cx32 in CRC cell-conditioned media. HMEC were stimulated with SW480-CM or SW620-CM for 6 h and double-stained for ZO-1 and Cx32. Representative micrographs showing the strong labelling of Cx32 induced by SW620-CM and the combined image of co-localization with ZO-1 (yellow); DAPI staining of nuclei ( n = 3, bar 20 mum). B. SW620-CM increase the Cx32 expression in HMEC. A higher Cx32 protein level was detected in response to SW620-CM compared with SW480-CM by immune-blot analysis (no cell expression in unstimulated HMEC). Representative of 5 experiments (Hsc70 as loading control; 150 mug/lane). C-D. In vitro tubulogenesis assay of HMEC pretreated or not (control IgG) with inhibitory monoclonal antibody against Cx32 (anti-Cx32 mAb). HMEC were plated on Matrigel-coated 24-well plates, incubated with SW620-CM for 6 h, and photographed. C. Representative photos of tube formation in HMEC intracellularly delivered with 0.2 mug anti-Cx32 mAb or control IgG (Bar 80 mum). The dotted areas are enlarged in the inserts on the right. Arrows indicated branch points. D. Number of branch points per field of view was quantified (at least 80 single cells were scored; mean +- SD, n = 4; * P < 0.01 vs control).
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- Figure 3 Down-regulation of zonula occludens protein 2 (ZO-2) protein expression in myocardium of cyanotic compared with acyanotic patients. Myocardium biopsies were lysed to isolate protein content and western blot analysis performed probing for ZO-2, ZO-1, N-cadherin, beta -catenin, and GAPDH. ZO-2 protein expression was significantly down-regulated in cyanotic biopsies compared with acyanotic, whereas no difference in any other adherens junction expressed proteins was detected. All results were normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) levels. Data are mean +- SEM * = P < 0.05 ( n = 5).
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- Figure 4 Down-regulation of zonula occludens protein 2 (ZO-2) levels in rat cardiomyocytes following 24 h hypoxic treatment. Cells were treated with hypoxic conditions by incubating in a chamber with 5% CO 2 / 0.2% O 2 . After 24 h, cells were lysed, and western blot analysis performed probing for ZO-2, ZO-1, N-cadherin, beta -catenin, and beta -actin, normalizing all results to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) levels. ZO-2 protein expression was significantly down-regulated in hypoxic treated cells compared with untreated cells (control), whereas no difference in ZO-1, N-cadherin, beta -catenin, or beta -actin levels was detected between treated and untreated cells. Data are mean +- SEM ** = P < 0.01 ( n = 4).
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- FIGURE 3: CRISPR-mediated knockout of TOCA-1 does not alter levels or localization of tight or adherens junction proteins. (A) Sequencing of PCR products amplified from genomic MDCK cell DNA in a region around the site of the putative CRISPR-mediated showed knockout cells had a 5-base pair deletion upstream of the PAM site (red GG) relative to wild-type DNA, resulting in a frameshift in the coding sequence and a premature stop codon at amino acid 36. (B) Comparison of expression by immunofluorescence analysis demonstrates that ZO-1 signal is identical in control and knockout cells (left and right). Junctional TOCA-1 staining is evident only in control cells, although the polyclonal TOCA-1 antibody generates some background signal in knockout cells (middle). (C) Enlargement of control ZO-1 and TOCA-1 staining reveals strong junctional colocalization (yellow signal). (D) E-cadherin (Ecad) localization is similar in control (top) and knockout cell lines (bottom). (E) In contrast to clear colocalization of TOCA-1 with ZO-1, enlargement of merge image between E-cadherin and TOCA-1 reveals that most E-cadherin is distributed along the lateral membrane, with little of the yellow signal suggestive of colocalization that is evident in C. Immunoblot (F) and immunofluorescence (G) analyses used to compare expression and localization of TOCA-1 and tight junction proteins in control and TOCA-1-knockout cell lines. Cldn2, claudin-2; Ocln, occludin. Bar, 15 mum.
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- Fig 1 Expression of TJPs in different leukocyte subsets. Immunofluorescence staining of PBLs from healthy controls with antibodies against claudin 1 or claudin 5 (green) and CD20 (A,B), CD14 (C,D), CD3 (E,F), CD4 (G,H), CD8 (I,J), ZO-1 (K,L) and ZO-2 (M,N) (all red) and a nuclear dye (TO-PRO 3-blue). Scale bar: 5 mum. Representative results from three independent experiments are shown.
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- Figure 4 Inhibition of zonula occludens type 1 (ZO-1) expression in CBA/J/Hsd mouse bladders following 14 days of treatment with as -APF. Bladder sections from mice treated with as -APF following bladder epithelial injury show decreased ZO-1 immunofluorescence staining (shown by small junctions between cells indicated by arrows) as compared to mice treated with PBS or inactive control nonglycosylated peptide. Representative data shown for the 3 mice in each treatment group from one experiment; experiment performed three times. (500X final magnification).
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- Fig 4 DLL4 expressed from the Dll1 locus rescues DLL1 loss-of-function in the retina. (A) Dll1 mutant retinas show epithelial disruption with formation of polarised rosettes in which the apical markers N-Cadherin (NCad, a) and ZO-1 (ZO1, b) are abnormally present at the central lumen. Ectopic proliferating progenitors, labelled with PHH3 (b, arrowheads), are located close to the apical lumen of these rosettes. (B) In contrast, the neuroepithelium of homozygous Dll1 Dll1ki and Dll1 Dll4ki embryos is correctly organised without rosettes, and N-Cadherin shows the normal apical localisation close to the retinal pigmented epithelium (a,b). Mitotic progenitors (PHH3+) are only detected at the apical region of the neuroepithelium (a,b arrowheads). A normal stratification of CHX10+ progenitors and P27+ differentiating neurons is also observed (c,d). (C, D) E13.5 homozygous Dll1 Dll1ki and Dll1 Dll4ki retinas show no significant difference in the number of ISL1+ RGCs (C) and CRABP+ amacrine cells (D). Cells immunopositive for Islet-1 and Crabp were counted and related to the total number of cells in the retina (DAPI+). Percentages are shown as mean +- SEM; ns, not significant. (E) Expression of DLL4 in homozygous Dll1 Dll1ki (a,c) and in homozygous Dll1 Dll4ki (b,d) E13.5 retinas as detected by an anti-DLL4 antibody. (c) and (d) are magnifications of (a) and (b), respectively. Endogenous plus transgenic DLL4 is expressed in more cells in Dll1 Dll4ki/Dll4ki as compared to endogeno
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- Figure 6 Immunocytochemistry of brain endothelial junctional space following growth in either Enriched Media or Minimal Media. Cells were seeded at time 0 h at 20,000 cells per 0.3 cm 2 . ( A ) ECIS resistance and R b measurements over 120 h. Cells were grown in either Enriched Media or Minimal Media from T = 0 h, with media changed at T = 48 h (I). Data shown is the mean +- SD (n = 3 wells) of one independent experiment representative of three experimental repeats; ( B ) Cell number count of Hoechst stained nuclei at time point II, obtained through Image J Software analysis. Data shown is the mean +- SEM (n = 18 wells) of 1 independent experiment representative of 3 experimental repeats; ( C ) The junctional space following growth in either Enriched Media or Minimal Media 72 h post seeding. The time point of fixation corresponds to the second vertical dotted line (II) shown on the ECIS traces. Representative GFP/DAPI and GFP monochrome images for the junctional proteins CD144, ZO-1, beta-catenin, and alpha-catenin are shown. Each panel shows cells grown in Minimal Media on the left and cells grown in Enriched Media on the right. The corresponding Alexa Fluor 488 (GFP) monochrome image is shown below each merged image. Green--junctional protein, blue--nuclei. Scale bar is 200 um. Immunocytochemistry data show one representative image from one independent experiment, which is representative of three experimental repeats. Graphical representations of p values are * p
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- Figure 7 Immunocytochemistry of brain endothelial junctional space following growth in either Enriched Media or Minimal Media. Cells were seeded at time 0 h at 20,000 cells per 0.3 cm 2 . ( A ) ECIS resistance and R b measurements over 120 h. Cells were grown in either Enriched Media or Minimal Media from T = 0 h, with media changed at T = 48 h (I). Data shown is the mean +- S.D. (n = 3 wells) of 1 independent experiment representative of 3 experimental repeats; ( B ) Cell number count of Hoechst stained nuclei at time point II, obtained through Image J Software analysis. Data shown is the mean +- SEM (n = 18 wells) of 1 independent experiment representative of 3 experimental repeats; ( C ) The junctional space following growth in either Enriched Media or Minimal Media 72 h post seeding. The time point of fixation corresponds to the second vertical dotted line (II) shown on the ECIS traces. Representative GFP/DAPI and GFP monochrome images for the junctional proteins CD144, ZO-1, beta-catenin and alpha-catenin are shown. Each panel shows cells grown in Minimal Media on the left and cells grown in Enriched Media on the right. The corresponding Alexa Fluor 488 (GFP) monochrome image is shown below each merged image. Green--junctional protein, blue--nuclei. Scale bar is 200 um. Immunocytochemistry data shows 1 representative image from 1 independent experiment, which is representative of 3 experimental repeats. Graphical representations of p values are * p
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- FIGURE 6 Double-immunostains for the tight junction proteins (green) claudin-3 (a) and claudin-19 (b) and for the adaptor protein ZO-1 (red, a,b ). The nerve fiber layer (NFL) shown at high magnification in the right images, is strongly positive for both claudin antibodies. Immunoreactivity for ZO-1 was also detected in the NFL, as well as in the outer limiting membrane (OLM). In the NFL, claudin and ZO-1 stains largely overlap with the claudins showing more continuous label strands often but not always running parallel to nerve fibers. Scale bar 20 mum for low power, 5 mum for high power images.
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- Figure 6 FEnS monolayer development and characterization. ( A ) Transmitted electron microscopy of F11-derived monolayer showed the presence of polarized enterocytes with developed microvilli. Tight junctions ( red arrow ) and desmosomes ( green arrow ) also were observed sealing the paracellular space. Scale bar : 0.2 mum. ( B ) Immunofluorescence staining F22.5-derived monolayer with anti-tight junction protein1/zonula occludens 1 ( red ) and anti-mucin2 ( green ) showed the presence of tight junctions and goblet cells, respectively. ( C ) Immunofluorescence staining of F22.5-derived monolayer using ulex europaeus agglutinin 1-FITC ( green ) and antibody directed against sucrase isomaltase (red) identified the presence of, respectively, immature enterocytes (ulex europaeus agglutinin-positive low), M-cells (ulex europaeus agglutinin-positive high), and mature enterocytes (sucrose isomaltase positive); 4'-6'-diamino-2phenylindole ( blue ) was used for nuclei counterstaining. Scale bar : 100 mum. ( D ) Time course of TEER measurement to assess monolayer development of FEnS (F11, F15, F17.5, and F22.5) and AD15 (representative for AEnS). Experiments were repeated at least 3 times in triplicate. Averages and SDs are reported. ( E ) Paracellular permeability measured in FEnS and AEnS (AD15) by 4-kilodalton dextran-FITC passage in the basolateral side after 4 hours of incubation. The fluorescence reads were normalized vs the apical dextran-FITC pool and were represented as arb
