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- Product number
- NBP1-90560 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-90560, RRID:AB_11004491
- Product name
- Rabbit Polyclonal CCDC39 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human CCDC39 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references DYX1C1 is required for axonemal dynein assembly and ciliary motility.
CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs.
Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, Köhler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K, UK10K., Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H
Nature genetics 2013 Sep;45(9):995-1003
Nature genetics 2013 Sep;45(9):995-1003
CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs.
Merveille AC, Davis EE, Becker-Heck A, Legendre M, Amirav I, Bataille G, Belmont J, Beydon N, Billen F, Clément A, Clercx C, Coste A, Crosbie R, de Blic J, Deleuze S, Duquesnoy P, Escalier D, Escudier E, Fliegauf M, Horvath J, Hill K, Jorissen M, Just J, Kispert A, Lathrop M, Loges NT, Marthin JK, Momozawa Y, Montantin G, Nielsen KG, Olbrich H, Papon JF, Rayet I, Roger G, Schmidts M, Tenreiro H, Towbin JA, Zelenika D, Zentgraf H, Georges M, Lequarré AS, Katsanis N, Omran H, Amselem S
Nature genetics 2011 Jan;43(1):72-8
Nature genetics 2011 Jan;43(1):72-8
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: CCDC39 Antibody [NBP1-90560] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-108
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: CCDC39 Antibody [NBP1-90560] - Analysis in human cell line RPMI-8226.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining of human tonsil shows no positivity in lymphoid cells as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining of human testis shows strong cytoplasmic positivity in spermatozoa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining in human testis and tonsil tissues.. Corresponding CCDC39 RNA-seq data are presented for the same tissues.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining of human fallopian tube shows strong positivity in cilia in glandular cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining of human bronchus shows strong positivity in cilia in glandular cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining of human bronchus, fallopian tube, rectum and tonsil using Anti-CCDC39 antibody NBP1-90560 (A) shows similar protein distribution across tissues to independent antibody NBP2-33999 (B).
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CCDC39 Antibody [NBP1-90560] - Staining of human rectum shows no positivity in glandular cells as expected.
