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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 344105 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#344105, RRID:AB_10900238
- Product name
- APC anti-human CD141 (Thrombomodulin)
- Antibody type
- Monoclonal
- Antigen
- CD141
- Description
- CD141 is a 75 kD, single chain, type I membrane glycoprotein also known as thrombomodulin, TM, THRM, THBD, and fetomodulin. CD141 is an important cofactor in the protein C anticoagulant system. After binding to its ligand thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. CD141 is expressed on macrophages, monocytes, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. Besides anti-coagulation function, CD141 is also involved in embryonic and atherosclerotic plaque development.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood monocytes were stimulated with LPS (overnight) and then stained with CD141 (clone M80) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram). Data shown was gated on the CD14+ cell population.
- Conjugate
- Red dye
