Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 301308 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#301308, RRID:AB_314160
- Product name
- PE/Cy5 anti-human CD11b
- Antibody type
- Monoclonal
- Antigen
- CD11b
- Description
- CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and Factor X.
- Reactivity
- Human, Porcine, Simian
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis.
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Thurlow LR, Thomas VC, Narayanan S, Olson S, Fleming SD, Hancock LE
Infection and immunity 2010 Nov;78(11):4936-43
Infection and immunity 2010 Nov;78(11):4936-43
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7
Nature medicine 2010 Jun;16(6):701-7
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes, monocytes, and granulocytes stained with ICRF44 PE/Cy5
- Conjugate
- Yellow dye