Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS4107 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IkB ÷ (phospho S22) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic phosphopeptide derived from human IkB-÷ around the phosphorylation site of Serine 22.
- Description
- IkB-÷ (I-kappa-B-epsilon), also known as NFKBIE (NF°ÙB inhibitor epsilon) or IKBE, is a 500 amino acid protein that belongs to the NF°ÙB inhibitor family. Localizing to the cytoplasm, IkB-÷ is highly expressed in spleen, testis and lung, with lower levels of expression found in kidney, pancreas, heart, placenta, brain, granulocytes and macrophages. IkB-÷ inhibits c-Rel and NF°ÙB subunits p50, p52 and p65 by forming a complex with them in the cytoplasm, preventing them from activating genes in the nucleus. IkB-÷ undergoes serine phosphorylation, resulting in the protein being marked for destruction via the ubiquitination pathway.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of p-IkB-¦Å (S22) pAb at 1:500 dilutionLane1:Hela cell lysate treated with LPSLane2:NIH-3T3 cell lysate treated with LPSLane3:Raw cell lysate treated with H2O2Lane4:PC12 cell lysate treated with H2O2