BS1540

antibody from Bioworld Technology, Inc

Targeting: IKBKB IKK-beta, IKK2, IKKB, NFKBIKB

Immunohistochemistry

Antibody data

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Validation data

Product number: BS1540 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS1540, RRID:AB_1662063
Product name: IKKÉÇ (L193) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 171-220 of Human IKKÉÇ.
Description: The transcription factor NF°ÙB is retained in the cytoplasm in an inactive form by the inhibitory protein I°ÙB. Activation of NF°ÙB requires that I°ÙB be phosphorylated on specific serine residues, which results in targeted degradation of I°ÙB. I°ÙB kinase Ï« (IKKÏ«), previously designated CHUK, interacts with I°ÙB-Ï« and specifically phosphorylates I°ÙB-Ï« on Serines 32 and 36, the sites that trigger its degradation. IKKÏ« appears to be critical for NF°ÙB activation in response to proinflammatory cytokines. Phosphorylation of I°ÙB by IKKÏ« is stimulated by the NF°ÙB inducing kinase (NIK), which itself is a central regulator for NF°ÙB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKÏ«, IKKÉÇ and IKKÎÛ (also designated NEMO), and each appear to make essential contributions to I°ÙB phosphorylation.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

IKBKB protein structure - BS1540 shown in red.