Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B1823 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-IKK beta polyclonal antibody
- Antibody type
- Polyclonal
- Description
- IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquitination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 _g
- Concentration
- Please refer to lot specific datasheet.
- Storage
- Stable for 1 year at 2-8°C from date of receipt.
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