abx016029

antibody from Abbexa

Targeting: IKBKB IKK-beta, IKK2, IKKB, NFKBIKB

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx016029

Provider

Abbexa

Product name

Inhibitor of Nuclear Factor Kappa B Kinase Subunit Beta (IKBKB) Antibody

Antibody type

Monoclonal

Description

IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP.Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination.IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta.Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1.Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response.Additionally, IKK-beta activity can also be regulated by MEKK-1.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.