Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 21775-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21775-1-AP, RRID:AB_10734593
- Product name
- IFIH1/MDA5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFIH1/MDA5 antibody (Cat. #21775-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection.
Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses.
Murine norovirus replicase augments RIG-I-like receptors-mediated antiviral interferon response.
ALS-associated genes in SCA2 mouse spinal cord transcriptomes.
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.
ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress.
Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65.
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Charman M, McFarlane S, Wojtus JK, Sloan E, Dewar R, Leeming G, Al-Saadi M, Hunter L, Carroll MW, Stewart JP, Digard P, Hutchinson E, Boutell C
Frontiers in cellular and infection microbiology 2021;11:689707
Frontiers in cellular and infection microbiology 2021;11:689707
Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.
Zheng J, Xu Y, Khan A, Sun P, Sun Y, Fan K, Yin W, Wang S, Li H, Sun N
BMC veterinary research 2021 Sep 30;17(1):318
BMC veterinary research 2021 Sep 30;17(1):318
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, Ke Y, Wu T, Sun R, Qian J, Du Y
Cell reports 2021 Jun 22;35(12):109272
Cell reports 2021 Jun 22;35(12):109272
Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses.
Mikhalkevich N, O'Carroll IP, Tkavc R, Lund K, Sukumar G, Dalgard CL, Johnson KR, Li W, Wang T, Nath A, Iordanskiy S
PLoS pathogens 2021 Feb;17(2):e1009305
PLoS pathogens 2021 Feb;17(2):e1009305
Murine norovirus replicase augments RIG-I-like receptors-mediated antiviral interferon response.
Yu P, Li Y, Li Y, Miao Z, Wang Y, Peppelenbosch MP, Pan Q
Antiviral research 2020 Oct;182:104877
Antiviral research 2020 Oct;182:104877
ALS-associated genes in SCA2 mouse spinal cord transcriptomes.
Scoles DR, Dansithong W, Pflieger LT, Paul S, Gandelman M, Figueroa KP, Rigo F, Bennett CF, Pulst SM
Human molecular genetics 2020 Jun 27;29(10):1658-1672
Human molecular genetics 2020 Jun 27;29(10):1658-1672
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.
Dhanwani R, Takahashi M, Mathews IT, Lenzi C, Romanov A, Watrous JD, Pieters B, Hedrick CC, Benedict CA, Linden J, Nilsson R, Jain M, Sharma S
Science advances 2020 Jul;6(30):eaba3688
Science advances 2020 Jul;6(30):eaba3688
ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress.
Guallar D, Fuentes-Iglesias A, Souto Y, Ameneiro C, Freire-Agulleiro O, Pardavila JA, Escudero A, Garcia-Outeiral V, Moreira T, Saenz C, Xiong H, Liu D, Xiao S, Hou Y, Wu K, Torrecilla D, Hartner JC, Blanco MG, Lee LJ, López M, Walkley CR, Wang J, Fidalgo M
Cell stem cell 2020 Aug 6;27(2):300-314.e11
Cell stem cell 2020 Aug 6;27(2):300-314.e11
Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy.
Lee AK, Pan D, Bao X, Hu M, Li F, Li CY
Radiation research 2020 Apr;193(4):305-317
Radiation research 2020 Apr;193(4):305-317
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Bianco C, Mohr I
eLife 2019 Dec 16;8
eLife 2019 Dec 16;8
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y
Nature communications 2018 Mar 28;9(1):1243
Nature communications 2018 Mar 28;9(1):1243
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.
Shang J, Xia T, Han QQ, Zhao X, Hu MM, Shu HB, Guo L
Proteomics 2018 Jan;18(2)
Proteomics 2018 Jan;18(2)
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Akiyama H, Miller CM, Ettinger CR, Belkina AC, Snyder-Cappione JE, Gummuluru S
Nature communications 2018 Aug 27;9(1):3450
Nature communications 2018 Aug 27;9(1):3450
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65.
Meng J, Yao Z, He Y, Zhang R, Zhang Y, Yao X, Yang H, Chen L, Zhang Z, Zhang H, Bao X, Hu G, Wu T, Cheng J
Cell death & disease 2017 Jun 8;8(6):e2866
Cell death & disease 2017 Jun 8;8(6):e2866
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Lang X, Tang T, Jin T, Ding C, Zhou R, Jiang W
The Journal of experimental medicine 2017 Feb;214(2):459-473
The Journal of experimental medicine 2017 Feb;214(2):459-473
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G
Journal of virology 2016 Nov 15;90(22):10259-10270
Journal of virology 2016 Nov 15;90(22):10259-10270
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism.
Wang Y, Liu L
mBio 2016 Feb 9;7(1):e01872-15
mBio 2016 Feb 9;7(1):e01872-15
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P
The Journal of general virology 2015 Jan;96(Pt 1):170-182
The Journal of general virology 2015 Jan;96(Pt 1):170-182
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The IFIH1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IFIH1. This antibody recognizes human antigen. The IFIH1 antibody has been validated for the following applications: ELISA, WB analysis.