Antibody data
- Antibody Data
- Antigen structure
- References [26]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 15981-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15981-1-AP, RRID:AB_2126302
- Product name
- ISG15 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ISG15 antibody (Cat. #15981-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Identification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation.
Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA.
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.
Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.
Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.
Wei Y, Yang X, Gao L, Yang J, Zheng L, Gao L, Zhou X, Xiang X, Zhang J, Yi C
American journal of cancer research 2021;11(10):4826-4843
American journal of cancer research 2021;11(10):4826-4843
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Abraham HG, Ulintz PJ, Goo L, Yates JA, Little AC, Bao L, Wu Z, Merajver SD
Frontiers in oncology 2021;11:712041
Frontiers in oncology 2021;11:712041
Identification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation.
Song F, Zhang Y, Pan Z, Hu X, Yi Y, Zheng X, Wei H, Huang P
Cancer cell international 2021 Oct 25;21(1):559
Cancer cell international 2021 Oct 25;21(1):559
Degradation of WTAP blocks antiviral responses by reducing the m6 A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Meng X, Chen Y, Macip S, Leppard K
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
Bhushan J, Radke JB, Perng YC, Mcallaster M, Lenschow DJ, Virgin HW, Sibley LD
mBio 2020 Oct 6;11(5)
mBio 2020 Oct 6;11(5)
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Olah M, Menon V, Habib N, Taga MF, Ma Y, Yung CJ, Cimpean M, Khairallah A, Coronas-Samano G, Sankowski R, Grün D, Kroshilina AA, Dionne D, Sarkis RA, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Prinz M, Vonsattel JPG, Teich AF, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL
Nature communications 2020 Nov 30;11(1):6129
Nature communications 2020 Nov 30;11(1):6129
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Orfali N, Shan-Krauer D, O'Donovan TR, Mongan NP, Gudas LJ, Cahill MR, Tschan MP, McKenna SL
Molecular oncology 2020 Jun;14(6):1297-1309
Molecular oncology 2020 Jun;14(6):1297-1309
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
Li Y, Bai W, Zhang L
Pathology oncology research : POR 2020 Jan;26(1):443-452
Pathology oncology research : POR 2020 Jan;26(1):443-452
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
Dzimianski JV, Scholte FEM, Williams IL, Langley C, Freitas BT, Spengler JR, Bergeron É, Pegan SD
PloS one 2019;14(12):e0226415
PloS one 2019;14(12):e0226415
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS pathogens 2019 Mar;15(3):e1007667
PLoS pathogens 2019 Mar;15(3):e1007667
Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.
Yao Z, Jia X, Megger DA, Chen J, Liu Y, Li J, Sitek B, Yuan Z
Journal of proteome research 2019 Mar 1;18(3):855-864
Journal of proteome research 2019 Mar 1;18(3):855-864
Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples.
Lin P, Yao Z, Sun Y, Li W, Liu Y, Liang K, Liu Y, Qin J, Hou X, Chen L
Journal of proteomics 2019 Jul 30;204:103414
Journal of proteomics 2019 Jul 30;204:103414
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Bianco C, Mohr I
eLife 2019 Dec 16;8
eLife 2019 Dec 16;8
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C
mBio 2019 Aug 27;10(4)
mBio 2019 Aug 27;10(4)
The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.
Welch SR, Scholte FEM, Albariño CG, Kainulainen MH, Coleman-McCray JD, Guerrero LW, Chakrabarti AK, Klena JD, Nichol ST, Spengler JR, Spiropoulou CF
Frontiers in cellular and infection microbiology 2018;8:240
Frontiers in cellular and infection microbiology 2018;8:240
Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.
Chauché C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza AI, Gu Q, Parrish CR, Martínez-Sobrido L, Marshall JF, Murcia PR
Journal of virology 2018 Mar 1;92(5)
Journal of virology 2018 Mar 1;92(5)
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Yuan H, Zhou W, Yang Y, Xue L, Liu L, Song Y
Experimental cell research 2018 Jun 1;367(1):47-55
Experimental cell research 2018 Jun 1;367(1):47-55
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Alandijany T, Roberts APE, Conn KL, Loney C, McFarlane S, Orr A, Boutell C
PLoS pathogens 2018 Jan;14(1):e1006769
PLoS pathogens 2018 Jan;14(1):e1006769
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
Bianco C, Mohr I
Journal of virology 2017 May 1;91(9)
Journal of virology 2017 May 1;91(9)
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F
Nature communications 2016 Nov 24;7:13588
Nature communications 2016 Nov 24;7:13588
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Zeng X, Wang S, Chi X, Chen SL, Huang S, Lin Q, Xie B, Chen JL
Research in veterinary science 2016 Feb;104:40-9
Research in veterinary science 2016 Feb;104:40-9
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Care MA, Stephenson SJ, Barnes NA, Fan I, Zougman A, El-Sherbiny YM, Vital EM, Westhead DR, Tooze RM, Doody GM
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1447-59
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1447-59
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
Zhang W, Zhang L, Wu Z, Tien P
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.
Sainz B Jr, Martín B, Tatari M, Heeschen C, Guerra S
Cancer research 2014 Dec 15;74(24):7309-20
Cancer research 2014 Dec 15;74(24):7309-20
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 15981-1-AP(ISG15 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ISG15 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ISG15. This antibody recognizes human antigen. The ISG15 antibody has been validated for the following applications: ELISA, WB, IHC analysis.